Guillermo Giovambattista

Guillermo Giovambattista
Universidad Nacional de La Plata | UNLP · Facultad de Ciencias Veterinarias

PhD

About

204
Publications
15,814
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1,635
Citations
Citations since 2016
48 Research Items
871 Citations
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2016201720182019202020212022050100150200
2016201720182019202020212022050100150200
2016201720182019202020212022050100150200

Publications

Publications (204)
Article
Full-text available
Trace minerals participate in reproductive processes and are crucial for oocyte maturation. The objective of the present study was to investigate the effect of combined supplementation with copper (Cu), manganese (Mn), selenium (Se) and zinc (Zn) during bovine in vitro maturation (IVM) on subsequent embryo development and quality. The IVM medium wa...
Article
Brangus is a composite cattle breed developed with the objective of combining the advantages of Angus and Zebuine breeds (Brahman, mainly) in tropical climates. The aim of this work was to estimate breed composition both genome‐wide and locally, at the chromosome level, and to uncover genomic regions evidencing positive selection in the Argentinean...
Preprint
Full-text available
Canine forms of osteoarthritis (OA) are very similar to those in humans and represent a welfare problem in the dog world population. In this study, we investigated the transcriptomic profile of peripheral blood in German Shepherd dogs with OA in order to identify putative diagnosis biomarkers. The bulk RNA-seq experiment was performed in a cohort o...
Article
Full-text available
In Bolivia, beef production is mainly based on two genotypes, Bos taurus (Creole cattle) and B. indicus (zebu), being weight gain the main selection criteria used by farmers. However, meat quality and especially tenderness must be incorporated in the selection process. Meat tenderness is partly determined by the calpain CAPN1)/ calpastatin (CAST) p...
Article
Over 65% of the world's cattle population resides in warm areas where heat stress conditions limit the breed of European taurine cattle. Composite breeds were developed to retain the main traits of both parental breeds. The skin plays a central role in animal response to heat stress. Research on the genetic architecture of skin traits has identifie...
Article
Full-text available
Autochthonous Sudanese cattle breeds, namely Baggara for beef and Butana and Kenana for dairy, are characterized by their adaptive characteristics and high performance in hot and dry agro-ecosystems. They are thus used largely by nomadic and semi-nomadic pastoralists. We analyzed the diversity and genetic structure of the BoLA-DRB3 gene, a genetic...
Article
Full-text available
El complejo principal de histocompatibilidad o MHC (denominado en la especie bovina “antígeno leucocitario bovino, BoLA”) está compuesto por un gran número de genes involucrados en la respuesta inmune dentro de una misma región cromosómica. Muchos de estos genes presentan niveles extraordinarios de polimorfismo. Además, estos loci han sido asociado...
Article
Full-text available
El complejo principal de histocompatibilidad o MHC(denominado en la especie bovina “antígenoleucocitario bovino, BoLA”) está compuesto por un gran número de genes involucrados en la respuesta inmune dentro de una misma región cromosómica. Muchos de estos genes presentan niveles extraordinarios de polimorfismo. Además, estos loci hansido asociados a...
Article
Full-text available
The genetic diversity of the BoLA‐DRB3 gene has been reported in different cattle breeds owing to its central role in the immune response. However, it is still unknown in hundreds of cattle breeds, especially native populations. Here, we studied BoLA‐DRB3 genetic diversity in Highland Creole cattle (CrAl) from Western Bolivia, raised at altitudes b...
Article
Objective The aim of this study was to investigate the prevalence of cranial cruciate ligament rupture and patellar luxation and the associated risk factors in dogs. Materials and Methods A total of 13,072 clinical records of dogs were reviewed from School Hospital (Faculty of Veterinary Sciences, National University of La Plata). Data of age, bree...
Article
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An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Article
Full-text available
Background: Myanmar cattle populations predominantly consist of native cattle breeds (Pyer Sein and Shwe), characterized by their geographical location and coat color, and the Holstein-Friesian crossbreed, which is highly adapted to the harsh tropical climates of this region. Here, we analyzed the diversity and genetic structure of the BoLA-DRB3 g...
Preprint
Full-text available
Autochthonous Sudanese cattle breeds, namely Baggara for beef and Butana and Kenana for dairy, are characterized by their adaptive characteristics and high performance in hot and dry agro-ecosystems, are used largely by nomadic and semi-nomadic pastoralists. Here we analyzed the diversity and genetic structure of the BoLA-DRB3 gene, a genetic locus...
Article
Cattle are a monotocous species, despite naturally conceived multiple births are sometimes observed. Although the number of twins has consistently increased, triplet and quadruplet pregnancies represent 0.015 and 0.004% of the total births, respectively. Multiple births are the result of multiple ovulation and/or the spontaneous cleavage of one fer...
Article
Chia, sesame and flax seeds are becoming increasingly more frequent components of functional foods because of their proven health benefits. The identification of plant components in complex matrices is generally performed using DNA typing. This method is a fast and economic tool widely applied to assess the genetic origin and authenticity of produc...
Preprint
Full-text available
Background: Myanmar cattle populations predominantly consist of native cattle breeds, characterized by their geographical location and coat color, and the Holstein-Friesian crossbreed, which is highly adapted to the harsh tropical climates of this region. Here, we analyzed the diversity and genetic structure of the BoLA-DRB3 gene, a genetic locus t...
Preprint
Full-text available
Background: Myanmar cattle populations predominantly consist of native cattle breeds (Pyer Sein and Shwe), characterized by their geographical location and coat color, and the Holstein-Friesian crossbreed, which is highly adapted to the harsh tropical climates of this region. Here, we analyzed the diversity and genetic structure of the BoLA-DRB3 ge...
Preprint
Full-text available
Background: Myanmar cattle populations predominantly consist of native cattle breeds (Pyer Sein and Shwe), characterized by their geographical location and coat color, and the Holstein-Friesian crossbreed, which is highly adapted to the harsh tropical climates of this region. Here, we analyzed the diversity and genetic structure of the BoLA-DRB3 ge...
Preprint
Full-text available
Background: Myanmar cattle populations predominantly consist of native cattle breeds (Pyer Sein and Shwe), characterized by their geographical location and coat color, and the Holstein-Friesian crossbreed, which is highly adapted to the harsh tropical climates of this region. Here, we analyzed the diversity and genetic structure of the BoLA-DRB3 ge...
Article
Full-text available
Background: Longitudinal data analysis contributes to detect differences in the growing curve by exploiting all the information involved in repeated measurements, allowing to distinguish changes over time within individuals, from differences in the baseline levels among groups. In this research longitudinal and cross-sectional analysis were compar...
Article
Full-text available
Cattle imported from the Iberian Peninsula spread throughout America in the early years of discovery and colonization to originate Creole breeds, which adapted to a wide diversity of environments and later received influences from other origins, including zebu cattle in more recent years. We analyzed uniparental genetic markers and autosomal micros...
Article
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Polledness has been shown to have autosomal Mendelian inheritance, with the polled locus being dominant to the horned locus. This trait was mapped to the BTA1 centromeric end in several breeds. One of the distinctive attributes of Creole cattle, such as the Argentinean Creole, is the presence of long, lyre‐shaped horns. However, polled native anima...
Article
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Los ovinos fueron introducidos por los españoles durante la colonia, a partir del año 1525, transportados como animales de consumo en los buques desde los puertos de Sevilla, Cádiz y las Islas Canarias. Así, ingresaron a las islas del Caribe y posteriormente al continente Americano. Con el propósito de conocer los orígenes genéticos de los ovinos c...
Article
Copy number variation (CNV) has been proved to be widespread in human, animal and plant genomes. Together with single nucleotide polymorphisms (SNPs), CVNs play a key role in genetic diversity. In this study, genome-wide detection of CNVs was performed based on SNP data from 24 Criollo Argentino horses genotyped with the GGP Equine70k array. Overal...
Article
Full-text available
Background: Bovine leukocyte antigens (BoLAs) are used extensively as markers of disease and immunological traits in cattle. However, until now, characterization of BoLA gene polymorphisms in Zebu breeds using high resolution typing methods has been poor. Here, we used a polymerase chain reaction sequence-based typing (PCR-SBT) method to sequence...
Article
The development of high-throughput technologies in the last decade produced an exponential increase in the amount of biological data available. The case of redox biology and apoptosis is not an exception, and nowadays there is a need to integrate information from multiple “omics” studies. Therefore, validation of proposed discoveries is essential....
Article
Full-text available
The analysis of runs of homozygosity (ROH), using high throughput genomic data, has become a valuable and frequently used methodology to characterize the genomic and inbreeding variation of livestock and wildlife animal populations. However, this methodology has been scarcely used in highly inbred domestic animals. Here, we analyzed and characteriz...
Data
Descriptive statistics of ROH length per chromosome and group of individuals. Footnote: Statistical differences were estimated between groups per chromosome using a T test. (DOCX)
Data
ROH identification parameters at each length size per chromosome. Footnote: L: minimum number of SNPs; nH: number of heterozygous genotypes allowed per ROH; nM: number of missing genotypes allowed per ROH. (DOCX)
Data
Descriptive statistics of ROH occurrence per chromosome and group of individuals. Footnote: Statistical differences were estimated between groups per chromosome using a T test. (DOCX)
Data
Correlation between recombination rate and ROH abundance per chromosome. Footnote: Data was analyzed by chromosome in the whole population (WP) as well in HI and LI separately, using ROH abundance of any length or ROH>8Mb. Spearman correlation. Correlations were estimated per SNP within chromosome. (DOCX)
Article
El gen ABCB1 codifica para la glicoproteína P (Pgp), una proteína de membrana que transporta múltiples fármacos fuera de la célula. Este gen se expresa principalmente en la barrera hematoencefálica, cumpliendo también importantes funciones en otros órganos. En caninos, se ha informado una deleción de 4 pb en el exón 4, que genera una terminación pr...
Article
Inbreeding depression is associated with emergence of deleterious effects and loss of genetic variability. Widespread use of genotyping technologies and new approaches for identification of runs-of-homozygosity (ROH) provide valuable tools to better understand the effects of inbreeding depression. We have previously demonstrated that inbreeding aff...
Article
von Willebrand disease (vWD) is the most common inherited coagulopathy in dogs, particularly in Doberman Pinschers. We developed a pyrosequencing-based assay to estimate the frequency of the c.7437G>A mutation associated with vWD type 1 in the Doberman Pinscher population of Buenos Aires, Argentina. We found a 0.41 frequency for the mutated allele,...
Article
Full-text available
Creole sheep are the founders of sheep farming in Argentina and have contributed in a sustained way to the economic, social and cultural development of some regions of this country. However, it is a scarcely valorised and poorly studied genetic resource. In order to genetically characterize the Argentinian Creole sheep, DNA samples were taken from...
Article
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In Bolivia, there are currently three types of Creole cattle: Altiplano, Valleys, and Plains. The cattle of the Valleys comprise isolated populations which have been little studied so far. The objective of the present study was to perform the genetic characterization of the Creole cattle from the Valleys of Santa Cruz. We analyzed 17 autosomal micr...
Article
Puberty is a stage of sexual development determined by the interaction of environmental factors and genetic mechanisms. Among them, thyroid function plays a key role in sexual development and spermatogenic function and is under the control of several genes, including the well-described thyroglobulin gene (TG). Previous reports have shown genetic as...
Article
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The Brangus breed was developed to combine the superior characteristics of both of its founder breeds, Angus and Brahman. It combines the high adaptability to tropical and subtropical environments, disease resistance, and overall hardiness of Zebu cattle with the reproductive potential and carcass quality of Angus. It is known that the major histoc...
Article
FABP4 is a protein primarily expressed in adipocytes and macrophages that plays a key role in fatty acid trafficking and lipid hydrolysis. FABP4 gene polymorphisms have been associated with meat quality traits in cattle, mostly in Asian breeds under feedlot conditions. The objectives of this work were to characterize FABP4 genetic variation in seve...
Article
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Bovine leukemia virus (BLV) is a member of retroviridae family, together with human T cell leukemia virus types 1 and 2 (HTLV-1 and -2) belonging to the genes deltaretrovirus, and infects cattle worldwide. Previous studies have classified the env sequences of BLV provirus from different geographic locations into eight genetic groups. To investigate...
Article
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Background: Peroxisome proliferator-activated receptor gamma (PPARG), CCAAT/enhancer binding protein alpha (CEBPA) and retinoid X receptor alpha (RXRA) are nuclear transcription factors that play important roles in regulation of adipogenesis and fat deposition. The objectives of this study were to characterise the variability of these three candid...
Article
Full-text available
EBL is a disease of adult cattle caused by the retrovirus, bovine leukemia. It can manifest: aleukemic an asymptomatic form, with a normal number of B lymphocytes in the blood; a form of permanent lymphocytosis, with an increase in the number of B lymphocytes and finally a lymphoproliferative tumor presenta­tion in the form of lymphosarcoma. The al...
Article
Dog fecal samples were collected at the crime scene and from the shoes of the suspect to see whether they could be linked. DNA was genotyped using a 145 bp fragment containing a 60 bp hotspot region of the mitochondrial DNA (mtDNA) control region. Once the species origin was identified, sequences were aligned with the 23 canine haplotypes defined,...
Article
Holstein cattle dominate the global milk production industry because of their outstanding milk production, however, this breed is susceptible to tropical endemic pathogens and suffers from heat stress and thus fewer Holstein populations are raised in tropical areas. The bovine major histocompatibility complex (BoLA)-DRB3 class II gene is used as a...
Article
Breed assignment has proved to be useful to control meat trade and protect the value of special productions. Meat-related frauds have been detected in China; therefore, 95 SNPs selected from the ISAG core panel were evaluated to develop an automated and technologically updated tool to screen breed label fraud in the Chinese meat market. A total of...
Article
The biochemical bases of meat color are determined by the concentration and redox state of myoglobin, hemoglobin, cytochromes, and other pigments. Post-mortem depletion of cellular oxygen results in oxidative stresses that consume NADH and affects reducing activity, while enzymatic detoxification influences the cellular oxidative processes, both af...
Article
Full-text available
Age at puberty is an important component of reproductive performance in cattle, so it is important to identify genes that contribute to the regulation of the onset of puberty and polymorphisms that explain differences between bulls. In a previous study, we found putative associations between age at puberty in Angus bulls and single-nucleotide polym...
Article
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RESUMEN Se determinaron los linajes maternos y paternos de 33 bovinos Criollo (27 hembras y 6 machos) del Centro de Ecología Aplicada Simón I. Patiño (Ceasip) mediante marcadores genéticos del ADN genómico, mitocondrial y del cromosoma Y. El ADN genómico se extrajo utilizando el kit Wizard ® Genomic Purification. Los linajes maternos se determinaro...
Article
Full-text available
LIPE is an intracellular neutral lipase, which is capable of hydrolyzing a variety of esters and plays a key role in the mobilization of fatty acids from diacylglycerols. The objectives of this study were to characterize the genetic polymorphism of bovine LIPE gene and to evaluate the possible association between three SNPs in the coding regions of...
Article
Bovine leukocyte antigens (BoLAs) are used extensively as markers for bovine disease and immunological traits. In this study, we estimated BoLA-DRB3 allele frequencies using 888 cattle from 10 groups, including seven cattle breeds and three crossbreeds: 99 Red Angus, 100 Black Angus, 81 Chilean Wagyu, 49 Hereford, 95 Hereford × Angus, 71 Hereford ×...
Article
In bovine, there are significant differences among and within breeds in the time when bulls reach puberty. Reported data indicate that age at puberty has a strong genetic component and is a multigenic trait. However, despite significant advancements in the field, the gene network controlling puberty is very complex, containing a host of genes that...
Article
Full-text available
The genetic diversity and structure of 72 Appaloosa horses belonging to a closed breeding population from an ecological reserve in Buenos Aires, Argentina, was investigated using eight microsatellite markers from the International Society for Animal Genetics panel. Our data showed that this Appaloosa horse population had an elevated degree of genet...
Article
Full-text available
Puberty is a stage of sexual development determined by the interaction of many loci and environmental factors. Identification of genes contributing to genetic variation in this character can assist with selection for early pubertal bulls, improving genetic progress in livestock breeding. Thyroid hormones play an important role in sexual development...
Article
Short tandem repeats (STR)s have been the eligible markers for forensic animal genetics, despite single-nucleotide polymorphisms (SNP)s became acceptable. The technology, the type, and amount of markers could limit the investigation in degraded forensic samples. The performance of a 32-SNP panel genotyped through OpenArraysTM (real-time PCR based)...
Article
Polymorphisms of the BoLA-DRB3 gene are located primarily in the second exon [antigen binding site (ABS)] and, to a lesser extent, in the upstream regulatory region (URR). It can be hypothesised that exon 2 and the URR are under different types of natural selection. The aim of this work was to determine the URR-exon 2 haplotypes; 34 Holstein sample...