Guillermo A. VEGA LOPEZ

• PhD
• CONICET Researcher at National University of Tucumán

Animal models are useful to study the molecular, cellular, and morphogenetic mechanisms underlying normal and pathological development. Cell‐based study models have emerged as an alternative approach to study many aspects of human embryonic development and disease. The neural crest (NC) is a transient, multipotent, and migratory embryonic cell popu...

The neural crest (NC) is a transient multipotent cell population that originates in the dorsal neural tube. Cells of the NC are highly migratory, as they travel considerable distances through the body to reach their final sites. Derivatives of the NC are neurons and glia of the peripheral nervous system (PNS) and the enteric nervous system as well...

Figure 2: Contribution of neural crest cells to the formation of cranial nerves I, III, V, VII, VIII, IX, X, and XI. These selected cranial nerves are formed by the contribution of cranial placodes and neural crest cells, indicated in green. Neural crest-derived Schwann cells produce peripheral myelination of cranial nerves III-XII. The sensory ner...

Figure 3. Gene regulatory network involved in neural crest contribution to the formation of cranial nerves. The cranial ganglia and cranial nerves are formed in precise positions along the dorso-ventral and antero-posterior axes of the midbrain/hindbrain region. (A) The drawing represents a human embryo at stage 13 (30 days, 32 somites), equivalent...

Figure 1. Neural crest origin, regions in human and mouse embryos and some of its cranial derivatives. (A) The top-left part of the scheme shows the origin of the neural crest cells (green) that migrate through the embryo. On the top-right side, the level of axial origin (see axial color key) of different regions of the neural crest is represented...

The neural crest (NC), discovered by Wilhelm His 150 years ago, gives rise to a multipotent migratory embryonic cell population that generates a remarkably diverse and important array of cell types during the development of the vertebrate embryo. These cells originate in the neural plate border (NPB), which is the ectoderm between the neural plate...

Yeasts population associated with grapes from Northwest Argentina, a region with a significant vine-growing increase over the past years, was evaluated. Ten species of non-Saccharomyces yeasts were identified from four grape varieties (Malbec, Merlot, Syrah and Torrontes) being Hanseniaspora uvarum the dominant species. Typing of isolates revealed...

The neural crest (NC) comprises a multipotent cell population that produces peripheral neurons, cartilage, and smooth muscle cells, among other phenotypes. The participation of Hes1 and Msx1 when expressed in mouse embryonic stem cells (mESCs) undergoing NC differentiation is unexplored. In this work, we generated stable mESCs transfected with cons...

The neural crest (NC) comprises a multipotent cell population that produces peripheral neurons, cartilage, and smooth muscle cells, among other phenotypes. The participation of Hes1 and Msx1 when expressed in mouse embryonic stem cells (mESCs) undergoing NC differentiation is unexplored. In this work, we generated stable mESCs transfected with cons...

The neural crest (NC) is a multipotent migratory embryonic population that is formed during late gastrulation and gives rise to a wide array of derivatives, including cells from the peripheral nervous system (PNS), the craniofacial bones and cartilages, peripheral glial cells, and melanocyte cells, among others. In this work we analyzed the role of...

The neural crest (NC) is a transient, multipotent and migratory cell population that generates an astonishingly diverse array of cell types during vertebrate development. These cells, which originate from the ectoderm in a region lateral to the neural plate in the neural fold, give rise to neurons, glia, melanocytes, chondrocytes, smooth muscle cel...

Abstract: The anti-pathogenic activity of Acantholippia deserticola, Haplopappus baylahuen, Lippia integrifolia and Satureja parvifolia herbs used as traditional infusion was investigated. The extracts obtained were compared with respect to chromatographic profiles and antimicrobial activities. The dichloromethane and methanol extracts of the four...

Neural crest cells (NCCs) are a multipotent, migratory cell population that generates an astonishingly diverse array of cell types during vertebrate development. The trunk neural crest has long been considered of particular signifiance. First, it has been held that the trunk neural crest has a morphogenetic role, acting to coordinate the developmen...

3D Model of the Trunk Neural Crest Migratory Streams (Fig.2).

List of antibodies used in the study. DOI: http://dx.doi.org/10.7554/eLife.08488.020

Sequences of Morpholino oligonucleotides and primers used in the study. DOI: http://dx.doi.org/10.7554/eLife.08488.019

Sequences used in the NanoString experiment. DOI: http://dx.doi.org/10.7554/eLife.08488.021

The adult frog retina retains a reservoir of active neural stem cells that contribute to continuous eye growth throughout life. We found that Yap, a downstream effector of the Hippo pathway, is specifically expressed in these stem cells. Yap knock-down leads to an accelerated S-phase and an abnormal progression of DNA replication, a phenotype likel...

Neural crest formation is one of the fundamental processes in the early stages of embryonic development in vertebrates. This transient and multipotent embryonic cell population is able to generate a variety of tissues and cell types in the adult body. hairy genes are transcription factors that contain a bHLH domain which binds to DNA. In Xenopus th...

Background: The neural crest is a transient multipotent migratory cell population unique to vertebrates. These cells undergo an epithelial-to-mesenchymal transition and migrate extensively through the embryo. They differentiate into numerous diverse derivatives including the peripheral nervous system, melanocytes,and craniofacial cartilages. The d...

Neural crest induction is the result of the combined action at the neural plate border of FGF, BMP, and Wnt signals from the neural plate, mesoderm and nonneural ectoderm. In this work we show that the expression of Indian hedgehog (Ihh, formerly named Banded hedgehog) and members of the Hedgehog pathway occurs at the prospective neural fold, in th...