Guillem Navarra-Ventura

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Verified

Guillem verified their affiliation via an institutional email.

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• PhD
• Professor (Assistant) at University of the Balearic Islands

Background Desvenlafaxine, a serotonin-norepinephrine reuptake inhibitor, has demonstrated efficacy in improving affective symptoms of Major Depressive Disorder (MDD); however, its effects on associated cognitive and functional difficulties remain underexplored. This study seeks to assess the antidepressant effects of desvenlafaxine in patients wit...

Background Experiencing a critical illness may be a stressful life event that is also associated with cognitive dysfunction during and after the intensive care unit (ICU) stay. A deep-tech solution based on non-immersive virtual reality, gamification and motion capture called Rehabilitation Gaming System for Intensive Care Units (RGS-ICU) has been...

Studies integrating an exhaustive longitudinal long-term follow-up of postintensive care syndrome (PICS) in critically ill COVID-19 survivors are scarce. We aimed to 1) describe PICS-related sequelae over a 12-month period after intensive care unit (ICU) discharge, 2) identify relevant demographic and clinical factors related to PICS, and 3) explor...

Background: Intensive care unit (ICU) admission and invasive mechanical ventilation (IMV) are associated with psychological distress and trauma. The COVID-19 pandemic brought with it a series of additional long-lasting stressful and traumatic experiences. However, little is known about comorbid depression and post-traumatic stress disorder (PTSD)....

Background: Bipolar disorder (BD) is characterized by episodic mood dysregulation, although a significant portion of patients suffer persistent cognitive impairment during euthymia. Previous magnetic resonance imaging (MRI) research suggests BD patients may have accelerated brain aging, observed as lower grey matter volumes. How these neurostructur...

Patients with depressive disorders are especially prone to suicide risk. Among the clinical predictors of suicidality, those specifically related to depressive disorders have not been accurately detailed. Our aim was to conduct a systematic review and meta-analysis of studies reporting longitudinal predictors of suicidal ideation, suicide attempts...

Background: The purpose of this exploratory study is to examine the role of sociodemographic, clinical, and cognitive - both objective and subjective - factors in overall and in specific domains of psychosocial functioning, in patients with depression at different clinical states of the disease (remitted and non-remitted). Methods: A sample of 3...

Introduction: The usage of immersive virtual reality (iVR) in the context of an intensive care unit (ICU) is scarce. Our objective was to assess the feasibility of the usage of iVR in critical patients with or without mechanical ventilation (MV) and to determine the anxiety degree before and after each session. Methods: Analytical, descriptive,...

Introduction There is a high prevalence of mental health problems among university students. Better prediction and treatment access for this population is needed. In recent years, short-term dynamic factors, which can be assessed using experience sampling methods (ESM), have presented promising results for predicting mental health problems. Method...

Abstract Background Intensive Care Unit (ICU) COVID-19 survivors may present long-term cognitive and emotional difficulties after hospital discharge. This study aims to characterize the neuropsychological dysfunction of COVID-19 survivors 12 months after ICU discharge, and to study whether the use of a measure of perceived cognitive deficit allows...

Impaired executive function (EF) is a key feature of patients with major depressive disorder (MDD) that several studies have linked to suicidal ideation and suicide attempts. This is the first longitudinal study to examine the association between impaired EF and suicide risk in adult patients with MDD. Longitudinal prospective study with 3 assessme...

Introduction Delirium is common among patients admitted to the Intensive Care Unit (ICU) and its impact on the neurocognitive and psychiatric state of survivors is of great interest. These new-onset or worsening conditions, together with physical alterations, are called Post Intensive Care Syndrome (PICS). Our aim is to update on the latest screen...

Background Patients with bipolar disorder (BD) frequently suffer from neurocognitive deficits that can persist during periods of clinical stability. Specifically, impairments in executive functioning such as working memory and in self-processing have been identified as the main components of the neurocognitive profile observed in euthymic BD patien...

Many individuals with major depression disorder (MDD) who achieve remission of depressive symptoms, do not perceive themselves as fully recovered. This study explores whether clinical remission is related to functional remission and to patient’s perception of recovery, as well as, which factors are associated with their functional and subjective re...

Some evidence suggests that patients with bipolar disorder (BD) have better Theory of Mind (ToM) skills than patients with schizophrenia/schizoaffective disorder (SCH). However, this difference is not consistently reported across studies, so rather than being global, it may be restricted to specific aspects of ToM. Our primary objective was to comp...

Objectives: To characterize clusters of double triggering and ineffective inspiratory efforts throughout mechanical ventilation and investigate their associations with mortality and duration of ICU stay and mechanical ventilation. Design: Registry-based, real-world study. Background: Asynchronies during invasive mechanical ventilation can occu...

This study focuses on the application of a non‐immersive virtual reality (VR)‐based neurocognitive intervention in critically ill patients. Our aim was to assess the feasibility of direct outcome measures to detect the impact of this digital therapy on patients’ cognitive and emotional outcomes. Seventy‐two mechanically ventilated adult patients we...

Introduction. Post-Intensive Care Syndrome(PICS) affects 30–50% of the ICU survivors (1–5), and may last years after ICU discharge, impacting on their quality of life (6–8). Acute Respiratory Distress Syndrome (ARDS) patients undergoing invasive mechanical ventilation (IMV) are highly vulnerable to develop PICS-related sequelae, i.e. ICU-acquired m...

Introduction. Survivors of critical illness often suffer from Post-Intensive Care Syndrome (PICS), an acquired debilitating condition that leads to significant functional and quality of life deficits. Objectives. To evaluate the efficacy of a virtual reality (VR)-based early neurocognitive intervention to prevent cognitive and emotional deficits re...

Background: Impairment of social cognition is documented in bipolar disorder (BD) and schizophrenia/schizoaffective disorder (SCH). In healthy individuals, women perform better than men in some of its sub-domains. However, in BD and SCH the results are mixed. Our aim was to compare emotion recognition, affective Theory of Mind (ToM) and first- and...

Background To date, 750 000 patients with COVID-19 worldwide have required mechanical ventilation and thus are at high risk of acute brain dysfunction (coma and delirium). We aimed to investigate the prevalence of delirium and coma, and risk factors for delirium in critically ill patients with COVID-19, to aid the development of strategies to mitig...

Objetivo: Un tercio de los pacientes que sobreviven a una enfermedad crítica presentan alteraciones neurocognitivas de gravedad leve-moderada asociadas al síndrome post-UCI. Estas alteraciones persisten en el tiempo, impactando negativamente en su capacidad funcional y en la calidad de vida. Nuestro objetivo es evaluar la eficacia de una intervenci...

Background ICU patients undergoing invasive mechanical ventilation experience cognitive decline associated with their critical illness and its management. The early detection of different cognitive phenotypes might reveal the involvement of diverse pathophysiological mechanisms and help to clarify the role of the precipitating and predisposing fact...

Background.: This study aimed to identify clinical and cognitive factors associated with increased risk for difficult-to-treat depression (DTD) or treatment-resistant depression (TRD). Methods.: A total of 229 adult outpatients with major depression were recruited from the mental health unit at a public hospital. Participants were subdivided int...

Background Heterogeneity in cognitive functioning among major depressive disorder (MDD) patients could have been the reason for the small-to-moderate differences reported so far when it is compared to other psychiatric conditions or to healthy controls. Additionally, most of these studies did not take into account clinical and sociodemographic char...

Resumen Introducción Las personas con esquizofrenia presentan déficits tanto neurocognitivos como en la cognición social. Numerosos estudios han constatado deterioro en estos dominios en pacientes crónicos con esquizofrenia. Sin embargo, dichas alteraciones durante la fase temprana de la enfermedad han sido menos estudiadas. Objetivo El objetivo...

Background: Mechanical ventilation is common in critically ill patients. This life-saving treatment can cause complications and is also associated with long-term sequelae. Patient-ventilator asynchronies are frequent but underdiagnosed, and they have been associated with worse outcomes. Main body: Asynchronies occur when ventilator assistance do...

Background and objectives Healthy people with intact cognitive functioning may also experience subjective cognitive deficits (SCD). However, no study has thoroughly explored these symptoms in healthy Spaniards. Therefore, we aimed to: (i) describe the pattern of SCD in this population, (ii) report magnitude categories of SCD, and (iii) correlate SC...

Our sample consisted of 4301 students in the age range of 17 to 30 years (mean age 21.13, 3179 females and 1116 males). Group comparisons were examined using t-student and chi-square tests and a statistical significance set at α=0.005. The cut-points for the Perceived Stress Scale (PSS) were established by quartiles, while for the Generalised Anxie...

Objective and subjective cognitive measures are altered in major depressive disorder (MDD), but there is a poor correlation between them. This study aims to explore such discrepancy and the characteristics explaining this phenomenon. 229 patients with MDD subdivided into remitted (n = 57), partially remitted (n = 90) and acute (n = 82) underwent a...

Background: Objective cognitive dysfunction in Major Depressive Disorder (MDD) is a well-documented finding. Compared to non-depressed subjects, up to 80% of patients may also suffer distress due to their subjective cognitive deficits, but their relationship with objective cognitive measures has been found to be poor. The main factor explaining suc...

Objectives: This study had 2 objectives: First, to explore the gender-related differences in emotional processing (EP) and theory of mind-both cognitive (CToM) and affective (AToM)-in patients with schizophrenia and in a control group of healthy subjects; and, second, to examine, from a gender perspective, the possible association between EP and CT...

Objectives: This study had 2 objectives: First, to explore the gender-related differences in emotional processing (EP) and theory of mind-both cognitive (CToM) and affective (AToM)-in patients with schizophrenia and in a control group of healthy subjects; and, second, to examine, from a gender perspective, the possible association between EP and C...

Background: Social cognition is severely disrupted in schizophrenia patients, but gender-related differences in this domain are almost unexplored. Aims: Our main objective was to study the possible gender-related differences in the emotional processing (EP) skills and in the theory of mind (ToM) abilities, both cognitive (CToM) and affective (AToM)...

Schizophrenia and mood disorders -including unipolar depression and bipolar disorder-, are severe mental diseases with a highly heterogeneous symptomatology, among which cognitive dysfunction has progressively emerged as a key cornerstone. Patients suffering from these illnesses show significant deficits in different neurocognitive and social cogni...

Introduction Major depression cognitive impairments lasts in remission periods, have an impact on treatment outcome and hamper psychosocial functioning. Thus, its accurate detection and specific treatment has become a crucial step. Objectives In order to assess objective cognitive functioning (OCF), a neuropsychological battery was administered. F...

Introduction Life functioning difficulties are a relevant but undervalued consequence of major depression. Mood symptoms and cognitive deficits have a significant, and somehow independent, impact on them. Therefore, cognitive difficulties should be considered a potential target to improve patients’ functioning. Aims To examine the degree in which...

Introduction: deficits across multiple Social Cognition (SC) domains have been found in schizophrenia. However, gender-related differences in specific aspects of SC, such as Theory of Mind (ToM) and Emotional Processing (EP), are almost unexplored. Objective: to study possible gender-related differences in affective and cognitive ToM (AToM and CToM...