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Guillem Cuatrecasas

Guillem Cuatrecasas
CPEN S.L. Hospital Quiron-Teknon, Clinica Sagrada Familia, Barcelona · Endocrinology

M.D

About

55
Publications
6,433
Reads
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2,007
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Introduction
Endocrinologist Cofounder of CPEN S.L, an organisation which provides the Endocrinology Departments in Hospital Quiron-Teknon and Clinica Sagrada Familia, both in Barcelona His current research field is the therapeutic use of growth hormone in low-IGF1 fibromyalgia and also in GH-defficient spine injury
Additional affiliations
January 2012 - present
CM Teknon
Position
  • GH to improve rehab in spine-injury patients
Description
  • with the colaboration of Ipsen Pharma and Step by Step Foundation
January 2006 - present
Merck
Position
  • Growth hormone use in fibromyalgia syndrome
January 2001 - December 2005
Fundación Teknon
Position
  • Type 2 diabetes
Description
  • International clinical trials Novartis and GSK (DPP4), Novonordisk (GLP), Sanofi (insulin), Mannkind and Pfyzer (inhaled insulin devices)
Education
January 1994 - December 1998
Germans Trias i Pujol, Universitat Autònoma Barcelona
Field of study
  • Endocrinology
June 1992 - September 1992
Institute for Cardiovascular Research del Massachussetts General Hospital- Harvard School Medicine
Field of study
June 1988 - September 1988
Brookdale Center for Molecular Biology, Mount Sinai School of Medicine
Field of study

Publications

Publications (55)
Article
Full-text available
Background: Digital health interventions and mobile technologies can help to reduce the rates of obesity and overweight conditions. Although weight management apps are widely used, they usually lack professional content and evaluation, so the quality of these apps cannot be guaranteed. The EVALAPPS project aims to design and validate a tool to ass...
Article
Optimal management of cardiovascular disease should start with the identification of subjects at subclinical stages. However, available tools are not always accurate or affordable. We assess the usefulness of ultrasound-guided measurement of abdominal fat layers as a surrogate marker of cardiovascular risk. We performed a cross-sectional, case-cont...
Article
Full-text available
Objective Abdominal fat ultrasound (US) is a simple clinical tool that may allow measures of fat depots not visible using common dual‐energy X‐ray absorptiometry (DEXA) or computerized tomography (CT) imaging. The aim of this study was to validate the technique, give measures of superficial and profound subcutaneous, preperitoneal, omental and peri...
Article
Background: The use of apps for weight management has increased over recent years; however, there is a lack of evidence regarding the efficacy and safety of these apps. The EVALAPPS project will develop and validate an assessment instrument to specifically assess the safety and efficacy of weight management apps. Objective: The aim of this study w...
Article
Introduction There are more than 320,000 accessible health apps, with the most downloaded of those related to physical exercise and weight control. However the initiatives for their validation address only partial aspects of the evaluation. The EVALAPPS project aims to develop an assessment tool for overweight and obesity management apps, based on...
Preprint
BACKGROUND The use of Mobile Applications (apps) for managing overweightness/obesity has increased over recent years. However, there is a lack of evidence on the efficacy, effectiveness and safety of these apps. The EVALAPPS project will develop and validate an assessment tool for specifically assessing these dimensions in overweightness/obesity ma...
Article
Background The use of apps for weight management has increased over recent years; however, there is a lack of evidence regarding the efficacy and safety of these apps. The EVALAPPS project will develop and validate an assessment instrument to specifically assess the safety and efficacy of weight management apps. Objective The aim of this study was...
Article
Full-text available
Human neuroimaging studies have consistently reported changes in cerebellar function and integrity in association with obesity. To date, however, the nature of this link has not been studied directly. Emerging evidence suggests a role for the cerebellum in higher cognitive functions through reciprocal connections with the prefrontal cortex. The pur...
Article
Body fat distribution play a key role in metabolic syndrome pathogenesis. TC and DEXA imaging allow us to differentiate abdominal subcutaneous from visceral fat. Ultrasound (US) imaging, widely used in thyroid assessment, further allows us to differentiate other abdominal layers: superficial and profound subcutaneous, pre-peritoneal, omental and pe...
Preprint
Full-text available
BACKGROUND In recent years there has been a rise in the use of Mobile Applications (Apps) to prevent and treat adult overweight/obesity since they can facilitate the tracking of physical and dietary patterns, provide recommendations and advice, and include motivation strategies to achieve personalized goals. However, evidence available on the effic...
Article
Full-text available
Background: The use of apps to tackle overweight and obesity by tracking physical and dietary patterns and providing recommendations and motivation strategies to achieve personalized goals has increased over recent years. However, evidence of the efficacy, effectiveness, and safety of these apps is severely lacking. Objective: The aim of this st...
Article
Background: Glucagon-like peptide 1 receptor agonists differ in chemical structure, duration of action, and in their effects on clinical outcomes. The cardiovascular effects of once-weekly albiglutide in type 2 diabetes are unknown. We aimed to determine the safety and efficacy of albiglutide in preventing cardiovascular death, myocardial infarcti...
Article
Full-text available
Objective Growth hormone (GH) was shown to stimulate proliferation, migration and survival of neural cells in animal models. GH deficiency (GHD) was reported following traumatic brain lesions; however, there are not available data in spinal cord injury (SCI) patients. The aim of the study was to evaluate (1) the frequency of GHD in chronic SCI popu...
Article
Purpose: To describe real-world use of lanreotide combination therapy for acromegaly. Patients and methods: ACROCOMB is a retrospective observational Spanish study of patients with active acromegaly treated with lanreotide combination therapy between 2006 and 2011. 108 patients treated at 44 Spanish Endocrinology Departments were analyzed separa...
Conference Paper
Full-text available
Resumen Introducción: El tratamiento con múltiples dosis de insulina (MDI) es la opción terapéutica más utilizada en pacientes con diabetes tipo 1 (DM1). El ajuste de las dosis en función de la ingesta de hidratos de carbono (HC) es esencial para el tratamiento. Aunque los glucómetros con calculador de bolus, como FreeStyle InsuLinx ® (FSI, Abbott...
Article
Full-text available
Fibromyalgia Syndrome (FMS) is a frequent idiopathic condition in which patients experience intense pain in specific tender points, profound fatigue and sleep disturbances. Although pain had not account so far in growth hormone deficiency syndrome (GHD) description, symptoms of FMS are very similar; and there is strong evidence of decreased GH secr...
Conference Paper
Full-text available
Introduction: ACROCOMB is a retrospective Spanish Multicenter study, designed to evaluate the efficacy (extent of tumour control) and safety of lanreotide (LAN) treatment combined with pegvisomant (PEG) or cabergoline in acromegalic patients with monotherapy failure. Methods: patients with acromegaly treated with LAN+PEG (45% of ACROCOMB patients)...
Article
Full-text available
Functional defects in growth hormone (GH) secretion and its efficacy as a complementary treatment have been suggested for fibromyalgia. This study investigated the efficacy and safety of low-dose GH as an add-on therapy in patients with both severe FM and low insulin-like growth factor 1 levels. A total of 120 patients were enrolled in a multicente...
Article
Full-text available
The long-term effects of sibutramine treatment on the rates of cardiovascular events and cardiovascular death among subjects at high cardiovascular risk have not been established. We enrolled in our study 10,744 overweight or obese subjects, 55 years of age or older, with preexisting cardiovascular disease, type 2 diabetes mellitus, or both to asse...
Article
Fibromyalgia (FM) is characterized by widespread pain and fatigue and is considered a syndrome with different pathogenic mechanisms. Controversial data on GH axis disturbances have been published. Some preliminary trials have shown promising effects of GH therapy on tender points and quality of life in FM. The aim was to study the patterns of GH se...
Article
Chronic stress, understood as a disturbance of the body homeostasis, is partially driven by many hormonal pathways. Prolactine, TSH (Thyrotropin), vasopresin, FSH (Follicle-Stimulating Hormone), LH (Luteinizing Hormone), and GH (Growth Hormone) have been involved in many stress reactions. In acute stress, there are many evidences for the increased...
Article
Chronic stress, understood as a disturbance of the body homeostasis, is partially driven by many hormonal pathways. Prolactine, TSH (Thyrotropin), vasopresin, FSH (Follicle-Stimulating Hormone), LH (Luteinizing Hormone), and GH (Growth Hormone) have been involved in many stress reactions. In acute stress, there are many evidences for the increased...
Article
Fibromyalgia is a chronic, idiopathic condition in which patients experience pain, asthenia and fatigue. The pathogenesis of the condition is unknown, and numerous mechanisms have been postulated, including neural hypersensitivity and autoimmunity. Symptoms of fibromyalgia are broadly similar to those of growth hormone deficiency (GHD), and there i...
Article
Morbid obesity is usually refractory to conventional treatments. Consequently, weight that is lost by modifying diet and exercise and/or the use of drugs is usually later regained. Bariatric surgery constitutes a therapeutic option in obese patients with a high body mass index associated with comorbidities and achieves good results in both the shor...
Article
Morbid obesity is usually refractory to conventional treatments. Consequently, weight that is lost by modifying diet and exercise and/or the use of drugs is usually later regained. Bariatric surgery constitutes a therapeutic option in obese patients with a high body mass index associated with comorbidities and achieves good results in both the shor...
Article
Full-text available
There is evidence of functional growth hormone (GH) deficiency, expressed by means of low insulin-like growth factor 1 (IGF-1) serum levels, in a subset of fibromyalgia patients. The efficacy of GH versus placebo has been previously suggested in this population. We investigated the efficacy and safety of low dose GH as an adjunct to standard therap...
Article
Two young females with severe morbid obesity presented with Wernicke's syndrome after Roux-en-Y gastro-jejunum bypass had been performed. The first patient had recurrent vomiting and dyplopia two months post-surgery. Physical examination indicated bilateral ophthalmoparesia with conserved convergence and ataxia. The second patient had frequent vomi...
Article
Background: Von Hippel-Lindau disease is characterized by the variable presence of cerebellar and retinal haemangioblastomas, phaeocromocytomas and hypernephromas, begining at early stages of life. Von Hippel-Lindau gene has been located in the short arm of chromosome 3 (3p25.5) and has been involved in the regulation of DNA transcription acting as...
Article
Von Hippel-Lindau disease is characterized by the variable presence of cerebellar and retinal haemangioblastomas, phaeocromocytomas and hypernephromas, beginning at early stages of life. Von Hippel-Lindau gene has been located in the short arm of chromosome 3 (3p25.5) and has been involved in the regulation of DNA transcription acting as a suppress...
Article
Full-text available
The aim of this work was to assess the relationship between GH-binding protein (GHBP) and leptin. Both peptides are nutritionally regulated, but the recent implication of a role for leptin in the GH axis requires further study. To avoid the sexual dimorphism in leptin values, we performed leptin standardization according to gender (SD score-leptin)...
Article
Objective: The aim of this investigation was to assess the insulin cleavage capacity in obese humans. Increased insulin degradation by visceral adipose tissue has previously been demonstrated in obese rats and could be interpreted as a physiological response to hyperinsulinaemia. The recent characterization of leptin receptors in pancreatic beta c...
Article
The aim of this investigation was to assess the insulin cleavage capacity in obese humans. Increased insulin degradation by visceral adipose tissue has previously been demonstrated in obese rats and could be interpreted as a physiological response to hyperinsulinaemia. The recent characterization of leptin receptors in pancreatic β cells, liver and...

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Projects (4)