Guillaume St-Jean

Guillaume St-Jean
Université de Montréal | UdeM · Department of Pathology and Microbiology

About

11
Publications
721
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70
Citations
Citations since 2017
11 Research Items
70 Citations
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2017201820192020202120222023051015202530
2017201820192020202120222023051015202530

Publications

Publications (11)
Article
Full-text available
Hippo signaling plays an essential role in the development of numerous tissues. Although it was previously shown that the transcriptional effectors of Hippo signaling Yes-associated protein (YAP) and transcriptional coactivator with PDZ-binding motif (TAZ) can fine-tune the regulation of sex differentiation genes in the testes, the role of Hippo si...
Article
Context: The establishment of pregnancy in cows requires uterine activity regulation of the main Hippo signalling effector yes-associated protein 1 (YAP). It remains unknown (1) how YAP activity at the corpus luteum (CL) correlates with early pregnancy-related events in ruminants; and (2) if YAP activity in the uterus and CL can be affected by met...
Article
Full-text available
Recent conditional knockout of core components of the Hippo signaling pathway in the adrenal gland of mice has demonstrated that this pathway must be tightly regulated to ensure proper development and maintenance of the adrenal cortex. We report herein that the most upstream kinases of the pathway, the mammalian STE20-like protein kinases 1 and 2 (...
Article
Objective: The purpose of this study was to identify the most common causes of equine abortion in Canada, and to compare findings to similar reports from other countries. Animal: Equine. Procedure: Necropsy reports from 901 equine abortion cases were acquired from provincial veterinary diagnostic laboratories across Canada. The final diagnosis...
Article
Background: Osteoarthritis (OA) is a major cause of equine lameness. Cannabinoid receptors (CB) are now considered to be promising therapeutic targets in human rheumatology for pain and inflammation, however little is known about the equine endocannabinoid system. Objectives: The primary goal was to assess the presence and expression pattern of...
Article
Full-text available
Spermatogenesis requires that a careful balance be maintained between the self-renewal of spermatogonial stem cells (SSCs) and their commitment to the developmental pathway through which they will differentiate into spermatozoa. Recently, a series of studies employing various in vivo and in vitro models have suggested a role of the wingless-related...
Article
It has recently been shown that the loss of the Hippo signaling effectors Yes-associated protein (YAP) and transcriptional coactivator with PDZ-binding motif (TAZ) in adrenocortical steroidogenic cells impairs the postnatal maintenance of the adrenal gland. To further explore the role of Hippo signaling in mouse adrenocortical cells, we conditional...
Article
WNT signaling plays essential roles in the development and function of the female reproductive tract. Although crosstalk with the Hippo pathway is a key regulator of WNT signaling, whether Hippo itself plays a role in female reproductive biology remains largely unknown. In this report, we show that conditional deletion of the key Hippo kinases Lats...
Article
Full-text available
Both Wnt4 and Wnt5a have well-established roles in the embryonic development of the female reproductive tract, as well as in implantation, decidualization and ovarian function in adult mice. Although these roles appear to overlap, whether Wnt5a and Wnt4 are functionally redundant in these tissues has not been determined. Here, we addressed this by...
Article
Full-text available
Introduction Mycobacterium xenopi is a rare opportunistic pathogen mainly causing infections in immunocompromised human patients or those with underlying chronic structural lung disease. Cases of disease in veterinary medicine remain scarce. Few animal species, including birds, are suspected of being vectors of the disease and there has not yet bee...
Article
Yes-associated protein (YAP) and transcriptional co-activator with PDZ-binding motif (TAZ) are functionally redundant transcriptional regulators that are downstream effectors of the Hippo signaling pathway. They act as major regulators of stem cell maintenance, cell growth and differentiation. To characterize their roles in the adrenal cortex, we g...

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