Guillaume Rossignol

• Doctor of Medicine
• Medical Doctor at CHU de Lyon - Hôpital Femme-Mère-Enfant

Background/Objectives: In paediatric liver transplantation, donor–recipient compatibility depends on graft size. We explored whether the graft weight can be predicted using the donor’s biometric parameters. Methods: We used seven easily available biometric variables in 142 anonymised paediatric and adult donors, with data collected between 2016 and...

Objective To analyse outcomes after adult right ex-situ split graft liver transplantations (RSLT) and compare with available outcome benchmarks from whole liver transplantation (WLT). Summary Background Data Ex-situ SLT may be a valuable strategy to tackle the increasing graft shortage. Recently established outcome benchmarks in WLT offer a novel...

Optimizing graft preservation is key for ex-situ split grafts in pediatric liver transplantation (PSLT). Hypothermic Oxygenated Perfusion (HOPE) improves ischemia-reperfusion injury (IRI) and post-operative outcomes in adult LT. This study compares the use of HOPE in ex-situ partial grafts to static cold storage ex-situ partial grafts (SCS-Split) a...

Bile acids (BA) are key for liver regeneration and injury. This study aims at analyzing the changes in the BA pool induced by ischemia-reperfusion (IRI) and investigates the impact of hypothermic oxygenated perfusion (HOPE) on the BA pool compared to static cold storage (SCS). In a porcine model of IRI, liver grafts underwent 30 min of asystolic wa...

Background: Hypothermic oxygenated perfusion (HOPE) improves outcomes of marginal liver grafts. However, to date, no preservation solution exists for both static cold storage (SCS) and HOPE. Methods: After 30 min of asystolic warm ischemia, porcine livers underwent 6 h of SCS followed by 2 h of HOPE. Liver grafts were either preserved with a sin...

Background The gold standard in pediatric split liver transplantation (SLT) is living donation (LD) providing high-quality grafts with short static cold storage (SCS). Aims This study investigates the protective effect of hypothermic oxygenated perfusion (HOPE) on ex-situ partial grafts from deceased donors in comparison to standard ex-situ Static...

Background A comprehensive outcome analysis of ex situ right split liver graft transplantation (RSLT) is currently lacking. Aims Benchmarking outcomes of RSLT against best achievable results from whole LT offers a novel comparative approach. Methods This retrospective study includes all consecutive ex-situ RSLT for adult recipients performed from...

In this report, we discuss several technical and anatomical details of ex‐situ H67 reduction of liver grafts during hypothermic oxygenated perfusion to prevent large‐for‐size syndrome in the case of anthropometric graft‐recipient mismatch.

Liver graft-recipient matching remains challenging and both morphological and hemodynamic characteristics have been shown to be relevant indicators of post-transplant outcomes. However, no combined analysis is available to date. To study the impact of both morphological and hemodynamic characteristics of liver grafts on transplantation outcomes, we...

Background: Graft-recipient size matching is a major challenge in pediatric liver transplantation, especially for adolescent recipients. Indeed, adolescents have the lowest transplantation rate among pediatric recipients, despite prioritization policies and the use of split grafts. In case of an important graft-recipient size mismatch, ex situ gra...

Given the increasing graft shortage, the transplant community is forced to use so called marginal liver grafts with a higher susceptibility to ischemia-reperfusion injury. This exposes the recipient to a higher risk of graft failure and post-transplant complications. While static cold storage remains the gold standard in low-risk transplant scenari...

Résumé La pénurie de greffons hépatiques, disponibles pour la greffe, justifie une utilisation croissante de greffons dits marginaux. Ces derniers sont plus sensibles aux lésions d’ischémie-reperfusion, ce qui expose le receveur à un risque majoré de dysfonction du greffon et, donc, à une morbidité post-transplantation plus importante. Alors que la...

Background: In-situ normothermic regional perfusion (NRP) and ex-situ normothermic machine perfusion (NMP) aim to improve outcomes of liver transplantation (LT) using controlled donation after circulatory death (cDCD). NRP and NMP have not yet been compared directly. Methods: In this international observational study, outcomes of LT performed be...

Partial liver grafts from ex‐situ splitting are considered as marginal due to prolonged static cold storage. The use of ex‐situ Hypothermic Oxygenated Perfusion (HOPE) may offer a strategy to improve preservation of ex‐situ split grafts. In this single‐center pilot study, we prospectively performed ex‐situ liver splitting during HOPE (HOPE‐Split) f...

Background: Ex vivo split liver transplantation in pediatric recipients has shown inferior results compared with whole grafts. One factor among others contributing to split grafts being considered as marginal is the prolonged static cold storage time related to ex vivo liver splitting. End ischemic hypothermic oxygenated perfusion is a validated s...

We read with great interest the study by Ruiz et al and we would like to discuss three issues raised by their results.(1) First, as highlighted by the authors , their specific NRP protocol with pre‐mortem cannulation in an interventional radiology facility leads to less technical failures (1%) compared to post‐mortem cannulation (5,6%) but is not a...

Normothermic regional perfusion (NRP) in controlled donation after circulatory death (cDCD) is a promising procurement strategy. However, a detailed analysis of graft utilization rates is lacking. This retrospective study included all cDCD donors proposed to a single center for NRP procurement of at least one abdominal organ from 2015 to 2020. Util...

Contexte La circulation régionale normothermique (CRN) et la machine de perfusion normothermique ex vivo (MPN) ont pour but d’améliorer les résultats de la transplantation hépatique (TH) de greffons issus de donneurs décédés par arrêt circulatoire (DDAC). Cependant, ces 2 techniques n’ont jamais été comparées. Méthodes Cette étude multicentrique i...

Patients with nonresectable liver metastases from colorectal cancer have few therapeutic options and a dismal prognosis. Although liver transplantation for this indication has historically a poor reputation, recent advances in the field of chemotherapy and immunosuppression have paved the way to revisit the concept. New data have shown promising re...

Background The safety of the laparoscopic treatment of intestinal malrotation remains controversial. This study compared the outcomes of laparoscopic and open surgical treatment of intestinal malrotation. Methods A multicentric retrospective study included pediatric cases of intestinal malrotation operated on between 2005 and 2016. Results This s...

Background: The aim of our study was to report our experience in extended Hirschsprung's disease (HD) in children operated on by laparoscopy. Patients and methods: Retrospective data collection from a single center from 1991 to 2013 concerned extended forms of HD operated on by laparoscopic Duhamel procedure and included extension of aganglionos...

Introduction: The absence of a testis occurs for various reasons in children, but testicular prosthesis implantation in children is uncommon. The optimal time for prosthesis placement is still unclear, and its complication rate has been poorly studied in children. Objective: The aim of this study was to determine the risk factors of complication...