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Guillaume Gras-Combe

Guillaume Gras-Combe
Clinique des Franciscaines, Nîmes, France · Neurosurgery

MD, MSc

About

21
Publications
2,758
Reads
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317
Citations
Additional affiliations
November 2011 - November 2012
Grenoble institute of neuroscience
Position
  • Bioelectrical imaging of induced modulation of cortico-subcortical networks by deep brain stimulation for obsessive compulsive disorders
Education
November 2007 - November 2013
Montpellier University Hospital
Field of study
  • Neurosurgery
September 2000 - September 2007
Paris Descartes, CPSC
Field of study
  • Medical School

Publications

Publications (21)
Article
Background: Herpes simplex encephalitis (HSE) and glioblastoma multiforme (GBM) co-occurrence has been described in few cases presenting immunocompromised status related to chemotherapy or chemoradiotherapy. Focal encephalitis over surgical edge of resection occurring shortly after GBM resection is rarely reported, and such infection has never bee...
Presentation
Full-text available
Clinical proteomics approaches rely mostly on the absolute quantification of specific targeted proteins and/or on global proteome quantification following a bottom-up approach [1, 2]. These quantitative data picture a global proteome in a steady-state. In this context, disease-relevant proteins or biomarkers are identified via detected differences...
Article
Hypothesis: Percutaneous pedicle screw fixations (PPSF) are increasingly used in spine surgery, minimizing morbidity through less muscle breakdown but at the cost of intraoperative fluoroscopic guidance that generates high radiation exposure. Few studies have been conducted to measure them accurately. Material and methods: The objective of our s...
Article
Full-text available
High-frequency deep brain stimulation of the subthalamic nucleus can be used to treat severe obsessive-compulsive disorders that are refractory to conventional treatments. The mechanisms of action of this approach possibly rely on the modulation of associative-limbic subcortical–cortical loops, but remain to be fully elucidated. Here in 12 patients...
Conference Paper
Full-text available
It has been shown that certain disease states can be characterized by disturbances in protein production, accumulation, or clearance. In the central nervous system (CNS), alterations in metabolism of proteins such as amyloid-beta (Aβ), alpha-synuclein, or Tau may be the cause of neurodegenerative diseases such as Alzheimer's disease (AD) (Bateman,...
Article
Full-text available
We report on a 72-year-old male patient who developed a nontraumatic spinal subdural hematoma (SSDH) during rivaroxaban therapy, a relatively new orally administered direct factor Xa inhibitor. The patient sustained a sudden onset of interscapular pain, followed by gait impairment and paraplegia. Magnetic resonance imaging (MRI) of the spine demons...
Article
Full-text available
Intravenous administration of stable isotope labeled amino acid (¹³C6-leucine) to humans recently made it possible to study the metabolism of specific biomarkers in cerebrospinal fluid (CSF) using targeted mass spectrometry (MS). This labeling approach could be of great interest for monitoring many leucine-containing peptides in parallel, using hig...
Article
Full-text available
Importance: There is an increasing interest in BRAF V600 mutations in melanomas and their associated sensitivity to vemurafenib, a BRAF inhibitor. However, physicians cannot find information in the literature about vemurafenib response for rare and/or atypical BRAF mutations. Observations: We describe the identification of a novel complex BRAF m...
Article
Full-text available
Preservation of the visual field in glioma surgery, especially avoidance of hemianopia, is crucial for patients' quality of life, particularly for driving. Recent studies used tractography or cortical occipital stimulation to try to avoid visual deficit. However, optic radiations have not been directly mapped intraoperatively. The authors present,...
Article
We report a 33-year-old man with a history of chronic cannabis use who sustained myocardial infarction followed by cerebral infarction after a recent significant increase in cannabis use. This is the first case of cannabis-associated stroke of probable cardioembolic origin.

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