Guillaume Dumas

Guillaume Dumas
Université de Montréal | UdeM · Department of Psychiatry

M.Eng., Ph.D., HDR

About

156
Publications
56,443
Reads
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3,195
Citations
Introduction
My interdisciplinary project focuses on the embodied and reciprocal nature of human cognition that encompasses biological, behavioral, and social levels of analysis. It seeks new conceptual and methodological approaches towards a better understanding of the multiscale coordination dynamics in health and disease.
Additional affiliations
September 2020 - May 2022
Université de Montréal
Position
  • Professor (Assistant)
September 2020 - September 2020
CHU Sainte-Justine
Position
  • Managing Director
September 2020 - September 2020
Mila - Quebec Artificial Intelligence institute
Position
  • Researcher

Publications

Publications (156)
Article
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Social neuroscience has called for new experimental paradigms aimed toward real-time interactions. A distinctive feature of interactions is mutual information exchange: One member of a pair changes in response to the other while simultaneously producing actions that alter the other. Combining mathematical and neurophysiological methods, we introduc...
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Recent debates regarding the primacy of social interaction versus individual cognition appear to be caused by the lack of an integrative account of the multiple scales at play. We suggest that reconciling individual autonomy and dyadic interactive viewpoints requires the taking into account of different time scales (e.g. development, learning) and...
Article
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Much evidence suggests that dynamic laws of neurobehavioral coordination are sui generis: they deal with collective properties that are repeatable from one system to another and emerge from microscopic dynamics but may not (even in principle) be deducible from them. Nevertheless, it is useful to try to understand the relationship between different...
Article
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Recent work from our interdisciplinary research group has revealed the emergence of inter-brain synchronization across multiple frequency bands during social interaction.11. Dumas G, Nadel J, Soussignan R, Martinerie J, Garnero L. Inter-brain synchronization during social interaction. PLoS One 2010; 5:278 - 288 View all references Our findings resu...
Article
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During social interaction, both participants are continuously active, each modifying their own actions in response to the continuously changing actions of the partner. This continuous mutual adaptation results in interactional synchrony to which both members contribute. Freely exchanging the role of imitator and model is a well-framed example of in...
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This review article gives a high-level overview of the approaches across different scales of organization and levels of abstraction. The studies covered in this paper include fundamental models in computational neuroscience, nonlinear dynamics, data-driven methods, as well as emergent practices. While not all of these models span the intersection o...
Preprint
The transition to technologically-assisted communication has permeated all facets of human social life; yet, its impact on the social brain is still unknown and the effects may be most notable during key developmental transitions. Applying a two-brain perspective, the current pre-registered study measured mother-child brain-to-brain synchrony using...
Article
The use of digital technologies is constantly growing around the world. The wider-spread adoption of digital technologies and solutions in the daily clinical practice in psychiatry seems to be a question of when, not if. We propose a synthesis of the scientific literature on digital technologies in psychiatry and discuss the main aspects of its pos...
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The substantial phenotypic heterogeneity in autism limits our understanding of its genetic etiology. To address this gap, here we investigated genetic differences between autistic individuals ( n max = 12,893) based on core and associated features of autism, co-occurring developmental disabilities and sex. We conducted a comprehensive factor analys...
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This article introduces a three-axis framework indicating how AI can be informed by biological examples of social learning mechanisms. We argue that the complex human cognitive architecture owes a large portion of its expressive power to its ability to engage in social and cultural learning. However, the field of AI has mostly embraced a solipsisti...
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Background: Understanding the development of the neuronal circuitry underlying autism spectrum disorder (ASD) is critical to shed light into its etiology and for the development of treatment options. Resting state EEG provides a window into spontaneous local and long-range neuronal synchronization and has been investigated in many ASD studies, but...
Preprint
Successful communication is key to health in older age. This is true in the narrow sense of being able to gain critical information e.g., from health care providers, but also more broadly in being able to maintain social ties and pursue meaningful activities, which, in turn, are central to maintaining health and well-being. Compared to younger adul...
Preprint
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The use of EEG to simultaneously record multiple brains (i.e., hyperscanning) during social interactions has led to the discovery of inter-brain coupling (IBC). IBC is defined as the neural synchronization between people and is considered to be a marker of social interaction. IBC has previously been observed across different frequency bands, includ...
Article
Objective: Autism spectrum disorder (ASD) is a lifelong neurodevelopmental condition that is associated with significant difficulties in adaptive behavior and variation in clinical outcomes across the life span. Some individuals with ASD improve, whereas others may not change significantly, or regress. Hence, the development of "personalized medic...
Article
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This paper presents a version of neurophenomenology based on generative modelling techniques developed in computational neuroscience and biology. Our approach can be described as computational phenomenology because it applies methods originally developed in computational modelling to provide a formal model of the descriptions of lived experience in...
Preprint
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Machine learning models often fail to generalize well under distributional shifts. Understanding and overcoming these failures have led to a research field of Out-of-Distribution (OOD) generalization. Despite being extensively studied for static computer vision tasks, OOD generalization has been underexplored for time series tasks. To shine light o...
Article
We aimed to describe epilepsy and EEG patterns related to vigilance states and age, in chromosome15-long-arm-duplication-syndrome (dup15q) children with epilepsy, in both duplication types: interstitial (intdup15) and isodicentric (idic15). Methods: Clinical data and 70 EEGs of 12 patients (5 intdup15, 7 idic15), followed from 4.5m.oto 17y4m (media...
Preprint
Several neuronal mechanisms have been proposed to account for the formation of cognitive abilities through postnatal interactions with the physical and socio-cultural environment. Here, we introduce a three-level computational model of information processing and acquisition of cognitive abilities. We propose minimal architectural requirements to bu...
Preprint
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We are making the case that empirical results from social psychology and social neuroscience along with the framework of dynamics can be of inspiration to the development of more intelligent artificial agents. We specifically argue that the complex human cognitive architecture owes a large portion of its expressive power to its ability to engage in...
Preprint
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The principled design and discovery of biologically- and physically-informed models of neuronal dynamics has been advancing since the mid-twentieth century. Recent developments in artificial intelligence (AI) have accelerated this progress. This review article gives a high-level overview of the approaches across different scales of organization and...
Article
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Background The neurocognitive mechanisms underlying autism spectrum disorder (ASD) remain unclear. Progress has been largely hampered by small sample sizes, variable age ranges and resulting inconsistent findings. There is a pressing need for large definitive studies to delineate the nature and extent of key case/control differences to direct resea...
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Rabies is a zoonotic disease caused by rabies virus (RABV). As rabies advances, patients develop a variety of severe neurological symptoms that inevitably lead to coma and death. Unlike other neurotropic viruses that can induce symptoms of a similar range, RABV-infected post-mortem brains do not show significant signs of inflammation nor the struct...
Article
Maternal body odors serve as important safety-promoting and social recognition signals, but their role in human brain maturation is largely unknown. Utilizing ecological paradigms and dual- electroencephalography recording, we examined the effects of maternal chemosignals on brain-to-brain synchrony during infant-mother and infant-stranger interact...
Preprint
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Background. Sensory processing atypicalities are part of the core symptoms of autism spectrum disorder (ASD) and could result from an excitation/inhibition imbalance. Yet, the convergence level of phenotypic sensory processing atypicalities with genetic alterations in GABA-ergic and glutamatergic pathways remains poorly understood. This study aimed...
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Over the past decade, biomarker discovery has become a key goal in psychiatry to aid in the more reliable diagnosis and prognosis of heterogeneous psychiatric conditions and the development of tailored therapies. Nevertheless, the prevailing statistical approach is still the mean group comparison between “cases” and “controls,” which tends to ignor...
Article
Objective: Autism spectrum disorder (ASD) is accompanied by highly individualized neuroanatomical deviations that potentially map onto distinct genotypes and clinical phenotypes. This study aimed to link differences in brain anatomy to specific biological pathways to pave the way toward targeted therapeutic interventions. Methods: The authors ex...
Preprint
BACKGROUND Social media provide a window onto the circulation of ideas in everyday folk psychiatry, revealing the themes issues discussed both by the general public and by various scientific communities. OBJECTIVE This study aims to explore the trends in health information about Autism Spectrum Disorders (ASD) exchanged within popular and scientif...
Article
Background: Social media provide a window onto the circulation of ideas in everyday folk psychiatry, revealing the themes and issues discussed both by the public and by various scientific communities. Objective: This study explores the trends in health information about autism spectrum disorder within popular and scientific communities through t...
Article
This article proposes to investigate how Sleep disorders have been conceptualized within the DSM-5 through symptom network analysis of the diagnostic criteria of the “Sleep-Wake Disorders” section in the DSM-5. We hypothesize that the analysis of the most central symptoms will allow us to better analyze the position of Sleep disorders in Mental dis...
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Recent years have seen a dramatic increase in studies measuring brain activity, physiological responses, and/or movement data from multiple individuals during social interaction. For example, so-called “hyperscanning” research has demonstrated that brain activity may become synchronized across people as a function of a range of factors. Such findin...
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The third edition of the International Classification of Sleep Disorders (ICSD-3) is the authoritative clinical text for the diagnosis of sleep disorders. An important issue of sleep nosology is to better understand the relationship between symptoms found in conventional diagnostic manuals and to compare classifications. Nevertheless, to our knowle...
Article
Many natural systems, especially biological ones, exhibit complex multivariate nonlinear dynamical behaviors that can be hard to capture by linear autoregressive models. On the other hand, generic nonlinear models such as deep recurrent neural networks often require large amounts of training data, not always available in domains such as brain imagi...
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Social-communication (SC) and restricted repetitive behaviors (RRB) are autism diagnostic symptom domains. SC and RRB severity can markedly differ within and between individuals and may be underpinned by different neural circuitry and genetic mechanisms. Modeling SC-RRB balance could help identify how neural circuitry and genetic mechanisms map ont...
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Recent accounts of social cognition focus on how we do things together, suggesting that becoming aligned relies on a reciprocal exchange of information. The next step is to develop richer computational methods that quantify the degree of coupling and describe the nature of the information exchange. We put forward a definition of coupling, comparing...
Article
Brainhack is an innovative meeting format that promotes scientific collaboration and education in an open, inclusive environment. This NeuroView describes the myriad benefits for participants and the research community and how Brainhacks complement conventional formats to augment scientific progress.
Article
Full-text available
There is growing awareness across the neuroscience community that the replicability of findings on the relationship between brain activity and cognitive phenomena can be improved by conducting studies with high statistical power that adhere to well-defined and standardized analysis pipelines. Inspired by efforts from the psychological sciences, and...
Article
Full-text available
Background: Marked sex differences in autism prevalence accentuate the need to understand the role of biological sex-related factors in autism. Efforts to unravel sex differences in the brain organization of autism have, however, been challenged by the limited availability of female data. Methods: We addressed this gap by using a large sample of...
Article
Objective We aimed to describe epilepsy and EEG patterns related to vigilance states and age, in chromosome15-long-arm-duplication-syndrome (dup15q) children with epilepsy, in both duplication types: interstitial (intdup15) and isodicentric (idic15). Methods Clinical data and 70 EEGs of 12 patients (5 intdup15, 7 idic15), followed from 4.5m.o to 1...
Article
Recent advances in brain sciences have enabled the co-recording of multiple interacting brains (i.e., hyperscanning [ 1. ]). This technique has led to the discovery of inter-brain synchrony (IBS) between people involved in social and interactive scenarios. In a recent article, Novembre and Iannetti argued that studies using hyperscanning to underst...
Preprint
Full-text available
This paper presents a version of neurophenomenology based on generative modelling techniques developed in computational neuroscience and biology. We call this approach computational phenomenology because it applies methods originally developed in computational modelling to phenomenology. The first section presents a brief review of the project to n...
Preprint
Full-text available
Brainhack is an innovative meeting format that promotes scientific collaboration and education in an open and inclusive environment. Departing from the formats of typical scientific workshops, these events are based on grassroots projects and training, and foster open and reproducible scientific practices. We describe here the multifaceted, lasting...
Article
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The human brain has undergone massive expansion across primate evolution through life amidst multi-layered social attachments; within families, among friends, and between clan members and this enabled humans to coordinate their brains with those of others toward the execution of complex social goals. We examined how human attachments facilitate eff...
Article
The main objective of this theoretical review is to systematically analyze the type of ICSD-3 diagnostic criteria by labeling each of them in order to propose an overview of the way in which the diagnostic criteria are organized. Labelling of diagnostic criteria using a rigorous iterative process of “aggregation” and “generalization” was conducted...
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The human brain differs from that of other primates, but the genetic basis of these differences remains unclear. We investigated the evolutionary pressures acting on almost all human protein-coding genes (N=11,667; 1:1 orthologs in primates) based on their divergence from those of early hominins, such as Neanderthals, and non-human primates. We con...
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In 2011, personalized medicine was defined as “the tailoring of medical treatment to the individual characteristics of each patient". Since then, the term has been used widely in the field of Sleep Medicine, especially in the context of OSA syndrome. However, the term personalized medicine is related to a wider range of concepts that can overlap fo...
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The human pineal gland regulates day‐night dynamics of multiple physiological processes, especially through the secretion of melatonin. Using mass spectrometry‐based proteomics and dedicated analysis tools, we identify proteins in the human pineal gland and analyze systematically their variation throughout the day, and, compare these changes in the...
Article
Résumé Le champ de la psychiatrie computationnelle prend de l’ampleur depuis quelques années. Dans cet article, nous proposons de distinguer trois champs de la psychiatrie computationnelle. Le premier champ correspond à la Digital Psychiatry, ou psychiatrie utilisant les outils numériques, qui peut être définie comme un champ de la psychiatrie qui...
Article
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13,15 ✉ 16p11.2 and 22q11.2 Copy Number Variants (CNVs) confer high risk for Autism Spectrum Disorder (ASD), schizophrenia (SZ), and Attention-Deficit-Hyperactivity-Disorder (ADHD), but their impact on functional connectivity (FC) remains unclear. Here we report an analysis of resting-state FC using magnetic resonance imaging data from 101 CNV carr...
Preprint
Full-text available
There is growing awareness across the neuroscience community that the replicability of findings on the relationship between brain activity and cognitive phenomena can be improved by conducting studies with high statistical power that adhere to well-defined and standardised analysis pipelines. Inspired by efforts from the psychological sciences, and...
Article
Full-text available
The human dynamic clamp (HDC) is a human–machine interface designed on the basis of coordination dynamics for studying realistic social interaction under controlled and reproducible conditions. Here, we propose to probe the validity of the HDC as a psychometric instrument for quantifying social abilities in children with autism spectrum disorder (A...
Article
Full-text available
13,15 ✉ 16p11.2 and 22q11.2 Copy Number Variants (CNVs) confer high risk for Autism Spectrum Disorder (ASD), schizophrenia (SZ), and Attention-Deficit-Hyperactivity-Disorder (ADHD), but their impact on functional connectivity (FC) remains unclear. Here we report an analysis of resting-state FC using magnetic resonance imaging data from 101 CNV carr...
Article
Full-text available
The bulk of social neuroscience takes a 'stimulus-brain' approach, typically comparing brain responses to different types of social stimuli, but most of the time in the absence of direct social interaction. Over the last two decades, a growing number of researchers have adopted a 'brain-to-brain' approach, exploring similarities between brain patte...
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Understanding heterogeneity is an important goal on the path to precision medicine for autism spectrum disorders (ASD). We examined how cortical thickness (CT) in ASD can be parameterized as an individualized metric of atypicality relative to typically-developing (TD) age-related norms. Across a large sample (n = 870 per group) and wide age range (...
Article
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Background: Heterogeneity in the phenotypic presentation of autism spectrum disorder (ASD) is apparent in the profile and the severity of sensory features. Here, we applied factor mixture modelling (FMM) to test a multidimensional factor model of sensory processing in ASD. We aimed to identify homogeneous sensory subgroups in ASD that differ intri...
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We simultaneously revisited the ADI-R and ADOS with a comprehensive data-analytics strategy. Here, the combination of pattern analysis algorithms and an extensive data resources (n=266 patients aged 7 to 49 years) allowed identifying coherent clinical constellations in and across ADI-R and ADOS assessments widespread in clinical practice. Our clust...