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Guilherme Malafaia

Guilherme Malafaia
Goiano Federal Institute - Campus Urutaí (Brazil)

Doctor
Permanent Professor, Department of Biological Sciences, Goiano Federal Institute - Campus Urutaí (Brazil)

About

312
Publications
55,009
Reads
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2,970
Citations
Citations since 2017
206 Research Items
2684 Citations
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Introduction
Dr. Malafaia (Guilherme) He is a Professor in the Department of Biological Sciences at Federal Institute of Education, Science and Technology Goiano (Brazil). He received a bachelor’s degree from Federal University of Ouro Preto, a MS from Federal University of Goiás, PhD and Postdoc from Federal University of Goiás, all related to Environmental and Biological Sciences. He is directing the Biological Research Laboratory with a focus on the ecotoxicological assessment of emerging pollutants.
Additional affiliations
August 2021 - present
Instituto Federal Goiano
Position
  • Professor

Publications

Publications (312)
Preprint
Full-text available
The Spike protein (S protein) is a critical component in the infection of the new coronavirus (SARS-CoV-2). The objective of this work was to evaluate whether peptides from S protein could cause negative impact in the aquatic animals. The aquatic toxicity of SARS-CoV-2 spike protein peptides derivatives has been evaluated in tadpoles (n = 50 tadpol...
Article
Although environmental toxicity of high concentrations of nanoparticles (NP) is well reported in the literature, information about their effects on biological systems at environmentally relevant concentrations remains scarce. We investigated whether low ZnO-NP concentrations influence the dynamics of cell division processes, cause nuclear abnormali...
Article
Although microplastics’ (MPs) toxicity has been reported in several aquatic and terrestrial organisms, the knowledge about how these pollutants can affect insects at the early developmental stage remains incipient. Thus, the aim of this study was to use Culex quinquefasciatus larvae as a model system to test the hypothesis that, besides accumulatin...
Article
The toxicity of zinc oxide (ZnO NPs) and polystyrene nanoplastics (PS NaPs) has been tested in different animal models; however, knowledge about their impact on mice remains incipient. The aim of the current study is to evaluate the effects of these nanomaterials on Swiss mice after their individual exposure to a binary combination of them. The goa...
Preprint
Full-text available
Establishing new experimental animal models to assess the safety and immune response to the antigen used in the development of COVID-19 vaccine is an imperative issue. Based on the advantages of using zebrafish as a model in research, herein we suggest doing this to test the safety of the putative vaccine candidates and to study immune response aga...
Article
Audiovisual superstimuli at night parties have been concerning parents and public health authorities, mainly when it comes to the risk of drug abuse and violence. However, the effects of such stimuli on the mental health of night-party goers are little known. Thus, the aim of the present study was to evaluate whether Swiss mice exposure to night-pa...
Article
The toxicological safety of products developed as alternative for conventional plastics (i.e., petroleum derivatives) inevitably demands conducting (eco)toxicological studies. Thus, the aim of the current study was to evaluate the biochemical toxicity of polyethylene microplastics (PE MPs) (representative of conventional MPs) and polylactic acid bi...
Article
Although the toxicity of carbon-based nanomaterials has already been demonstrated in several studies, their transfer in the food chain and impact on the upper trophic level remain unexplored. Thus, based on the experimental food chain “Eisenia fetida → Danio rerio → Oreochromis niloticus”, the current study tested the hypothesis that carbon nanofib...
Article
The increased contamination of surface water with plastic waste is proportional to the increased consumption of products that use them as raw material. However, the impact of these residues on aquatic biota remains limited, mainly when it comes to nanoplastics (NPs). Thus, the aim of the current study is to test the hypothesis that the exposure of...
Article
Although nanoplastics (NPs) are known to be toxic to several groups of animals, the effects of such a toxicity on freshwater benthic macroinvertebrate communities remain unknown. Thus, the aim of the current study is to test the hypothesis that polystyrene nanoplastics (PS NPs) (34 μg/L - 48 h of exposure) lead to biochemical damage in Aphylla will...
Article
Despite the damaging effects of pesticides glyphosate (Gly), atrazine (Atra) and fipronil (Fip) on different organisms, the mutagenic, genotoxic and morphotoxic potential of testudine erythrocytes in freshwater remains unknown. Thus, the aim of the present study is to assess the toxicological potential of these compounds in Podocnemis expansa (Amaz...
Article
In this study, the hypothesis that polyethylene microplastics (MPs) can accumulate in animals, reach the upper trophic level and trigger behavioral changes was tested. Physalaemus cuvieri tadpoles were exposed to MPs (for 7 days) and fed on tambatinga fish for the same period. Subsequently, these fish were given as food to Swiss mice. The MP amount...
Article
The potential transfer of microplastics (MPs) between vertebrates belonging to the same taxonomic group, and the impact of such a transfer on higher trophic levels remains little explored. An experimental food chain with two fish species was installed to test the hypothesis that polyethylene MPs (PE MPs) can accumulate in animals and cause behavior...
Article
Full-text available
Microplastics (MPs) are critical emerging pollutants found in the environment worldwide; however, its toxicity in aquatic in amphibians, is poorly known. Thus, the aim of the present study is to assess the toxicological potential of polyethylene microplastics (PE MPs) in Physalaemus cuvieri tadpoles. According to the results, tadpoles' exposure to...
Article
The scientific knowledge about toxicological impacts of polyethylene microplastics (PE MPs) on different organisms has significantly improved in recent years. However, the effects of these pollutants on animal species such as amphibians remain poorly known. Thus, the aim of the current study is to investigate whether the short exposure (7 days) of...
Article
The toxicity of zinc oxide nanoparticles (ZnO NPs) has been addressed in several studies; however, their effect on the mammalian group, even at environmentally relevant concentrations, remains poorly understood. The aims of the present study are to expose female Swiss mice to ZnO NP concentrations commonly faced by mammals who enter aquatic systems...
Article
Although tannery effluent (TE) toxicity has already been demonstrated in different vertebrate models, our knowledge about their effects on birds remains significantly incipient. Thus, the aim of the current study was to evaluate the impact of ephemeral exposure of Gallus gallus domesticus eggs to environmental predictive TE dilutions (1.4% and 6.5%...
Article
Different studies have reported the ecotoxicological effects of polyethylene microplastics (PE MPs) on aquatic organisms; however, little is known about their toxicity in the early life stages of aquatic vertebrates living in freshwater ecosystems. Thus, the aim of the current study is to evaluate the toxicity of PE MPs throughout the development o...
Article
The ecotoxicity of untreated tannery effluent (UTE) in several animal models has been reported; however, its effects on fish behavior, and neurotoxicity, remain unknown. Thus, the hypothesis that the chronic exposure to UTE can induce behavioral changes in adult zebrafish (Danio rerio) representatives, even when it is highly diluted in water, was t...
Article
Understanding how human activities affect animal biodiversity is essential to investigations about the biological effects of several pollutants and contaminants dispersed in the environment. This is the case of zinc oxide nanoparticles (ZnO NPs), which are emerging pollutants whose effect on reptiles' health is completely unknown. Thus, the objecti...
Article
Tannery industries generate large amounts of tannery effluents (TE), which have been considered highly toxic to various groups of animals. However, the identification and characterization of the impact of this mix of pollutants on birds is still highly incipient. So, our goal was to evaluate the possible biological changes of Coturnix coturnix japo...
Article
The toxicity of zinc oxide nanoparticles (ZnO NPs) has been investigated in different animal models. However, concentrations tested in most studies are often much higher than the ones potentially identified in the environment. Therefore, such toxicity limits the application of these studies to evaluate ecotoxicological risks posed by these nanopoll...
Article
Full-text available
The advent of biotechnology provided the synthesis of nanoproducts with diverse applications in the field of medicine, agriculture, food, among others. However, the toxicity of many nanoparticles (NP) currently used, which can penetrate natural systems and impact organisms, is not known. Thus, in this study, we evaluated whether the short exposure...
Article
Full-text available
Considerando que no Brasil não há mecanismos de controle sobre os critérios técnicos de qualidade das páginas da internet que divulgam informações sobre saúde e/ou doenças, é importante que estudos sejam desenvolvidos, visando avaliar a qualidade técnica dessas páginas. Nesse sentido, o presente estudo objetivou avaliar a qualidade das informações...
Article
Full-text available
Antineoplastic drugs (AD) have been increasingly used, but the disposal of their wastes in the environment via hospital effluent and domestic sewage has emerged as an environmental issue. The current risks posed to these animals and effects of pollutants on the reptiles’ population level remain unknown due to lack of studies on the topic. The aim o...
Article
The transformation of skin in-natura into leather in tannery industries generates large volumes of organic matter that attract small mammals. i.e., rodents living close to these facilities. Animals foraging in the backyards of such industries get exposed to the effluent produced by them; however, attention has not been given to the impacts of such...
Article
Full-text available
The increasing consumption of medications by humans has negative effects such as the increased disposal of these compounds in the environment. Little is known about how the disposal of a “drug mix” (DM) in aquatic ecosystems can affect their biota. Thus, we evaluated whether the exposure of Lithobates casteibeianus tadpoles to a DM composed of diff...
Article
Full-text available
Smoked cigarette butt (SCB) discharged in the environment became an issue of unknown consequences for plants. Thus, we aim at assessing the impact of water containing SBC leachate on the meristem cells of Allium cepa roots. We defined the following experimental groups: negative control (water), positive control (cyclophosphamide); water with SCB le...
Article
Full-text available
Although the toxic effects of tannery effluent (TE) on tanning-industry workers have been reported in many studies, its effects on females’ reproductive system are unknown. We aimed at evaluating the effects of direct contact with TE on the “emotional” status, estrous cycle (during 15 consecutive exposure days), and ovarian follicular dynamics of f...
Article
Full-text available
Although the efficiency of haloxyfop-p-methyl ester (HPME) as selective herbicide is acknowledged, its impact on non-target organisms is poorly known. It is not known whether the short exposure of mammals to low HPME concentrations (consistent with a realistic contamination scenario) poses risks to these animals. Thus, the aim of the current study...
Article
Full-text available
Although the toxicity of the pesticide sulfentrazone in some aquatic organisms is known, its effects on edaphic organisms such as earthworms remain completely unknown. Thus, we aimed at evaluating the behavior and immune response of Eisenia fetida exposed to sulfentrazone at environmentally relevant concentrations (EC). E. fetida representatives ex...
Article
Cyclophosphamide (Cyc) and 5-fluorouracil (5-FU) are two of the most used antineoplastic drugs (AD) in the world. However, their discharge in the environment became a yet-unknown environmental issue that has impact on some groups of animals, such as amphibians. We assessed tadpoles (Lithobates catesbeianus) exposed to environmental concentrations (...
Article
Abamectin (ABA) toxicity in fish, amphibian and mammals was already proven, but its effect on birds is almost unknown. Thus, the aim of our study is to assess the impact of exposure to water with ABA for 40 days at predicted environmentally relevant concentrations on the behavior of female Japanese quails (Coturnix coturnix japonica). The three fol...
Article
The toxicity of ZnO nanoparticles (NPs) has been the subject of several investigations; however, concentrations much higher than the ones potentially found in the environment are often tested. In addition, groups of animals such as birds have not been used as model in studies in this field, fact that creates an important ecotoxicological gap in the...
Article
Previous studies have individually confirmed the toxic effects from different pollutants on mammals. However, effects resulting from the exposure of these animals to multi-pollutant mixes have not been studied so far. Thus, the aim of the current study is to assess the effect from the chronic exposure (105days) of C57Bl/6J mice to a mix of pollutan...
Article
Full-text available
There is a problem in the original publication of this paper (Figure 2 Graphs are in Portuguese). Shown in this paper is the correct version.
Article
Full-text available
Khaya ivorensis A. Chev. (African mahogany) is one of the most economically important forest species, since it is used in the international furniture market. However, little is known about its culture and nutritional requirements. This study aimed to assess the development of K. ivorensis plants subjected to different base saturations, as well as t...
Article
Full-text available
It is known that pesticides such as abamectin (ABA) present cytotoxic effects on target organisms; however, the effects from ABA on non-target organisms such as amphibians are poorly understood. The aim of the current study is to investigate whether the exposure of Lithobates catesbeianus tadpoles to different abamectin concentrations [12.5, 25, an...
Article
Full-text available
The aim of the current study is to assess possible erythrocyte mutagenic effects on Lithobates catesbeianus tadpoles exposed to water contaminated with 2,4-D. In order to do so, tadpoles were exposed to a predictive and environmentally relevant herbicide concentration (1.97 mg/L), which is likely to be found in lentic environments formed by superfi...
Article
Full-text available
O presente estudo objetivou identificar o conhecimento de discentes do ensino médio sobre plantas exóticas no Cerrado, considerando essa temática muito pouco estudada. Participaram do estudo 170 estudantes de diferentes cursos técnicos de nível médio, sendo utilizado, para coleta de dados um questionário investigativo e para análise dos resultados...
Article
Full-text available
Resumo: Foram analisadas 100 avaliações escritas (AE) relacionadas ao ensino de conceitos de Biologia, elaboradas e aplicadas por professores atuantes em uma Licenciatura em Ciências Biológicas de uma instituição pública de ensino superior, da região Centro-Oeste, no Brasil, no período de 2011 a 2014. Para validação, e posterior análise quali-quant...
Article
Full-text available
O uso e abuso de drogas causam prejuízos à sociedade e a abordagem educativa pode ser um fator de prevenção. Uma vez que o tema drogas é abordado em Biologia, no Ensino Médio, os livros didáticos são úteis na contribuição à prevenção ao uso de drogas. Assim, nosso objetivo foi avaliar as informações sobre drogas dos livros didáticos de Biologia. Fo...
Article
Full-text available
Considerando que o mapeamento de recursos naturais podem subsidiar o estabelecimento de políticas de governo para o meio ambiente, de forma a contribuir com a utilização adequada dos recursos naturais, bem como possibilitar a melhoria na qualidade de vida, este estudo visou construir mapas de distribuição dos elementos Fe, As, Pb, Mn, Ba, Zn e Ni n...
Article
Full-text available
Com o aumento da atividade urbana e industrial, é notório a problematização em torno da geração de resíduos derivados destas atividades. Dentre os tipos de resíduos gerados, destacam-se os lodos de curtume. No tratamento de resíduos como lodo de curtume a vermicompostagem se destaca como prática de baixo custo e é uma tecnologia na qual se utilizam...
Article
O objetivo deste estudo foi analisar, a partir da concepção de adolescentes, o desenvolvimento da educação sexual, por parte de professores e pais de estudantes de uma escola do Sudeste goiano. Para isto, foi realizada uma pesquisa qualitativa com utilização de um questionário investigativo. Participaram da pesquisa 86 adolescentes, matriculados no...
Article
Full-text available
A pressão de seleção promovida por fungicidas na agricultura estimula mecanismos de variabilidade dos patógenos a desenvolver populações insensíveis a moléculas químicas. Objetivo deste trabalho foi caracterizar a sensibilidade de isolados de C. gloeosporioides a fungicidas in vitro. Oito isolados de C. gloeosporioides (COLL) pertencentes a Coleção...
Article
Full-text available
The aim of this work was to relate the susceptibility of fruits, roots and stems of vegetables infected by P. capsici to the firmness of the pulp. The treatments were represented by 18 genotypes (carrot, papaya, chayote, apple, sweet pepper, kaki, sweet potato, gherkim, melon, tomato, gilo, potato; two genotypes of cucumber and three genotypes of p...
Article
In this study we modified the predatory stress paradigms to determine if a simple and new predatory stress paradigm could produce anxiety-like behaviour in female Swiss mice, exposed to male Wistar rat. We hypothesized that the stressor employed would induce anxiety in the short-term in mice. In addition, we assessed the behavioral effects of the p...
Article
Full-text available
Este estudo teve como objetivo analisar o perfil de professores orientadores do Programa Institucional de Bolsas de Iniciação Científica (PIBIC) do Instituto Federal Goiano – Câmpus Urutaí, entre os anos de 2011 e 2014. Para isso, coletou-se dados dos orientadores através da Plataforma Lattes do CNPq. Foram coletadas informações sobre titulação, ár...
Article
Full-text available
Recent studies have shown that cigarette consumption affects much more than human health. Smoked cigarette butt (SCB) disposal into the environment can bring little-known negative biological consequences to mammals, since it contains many organic and inorganic toxic chemical constituents. Thus, we aim at assessing whether the ingestion of water wit...
Article
Full-text available
The Amazon Basin is a center of diversity of Gossypium barbadense and the strategy for conservation of this genetic resource depends on the knowledge of the diversity maintained in Amazonas State. During two expeditions, in 2012 and 2014, plants were collected in ten municipalities in the state of Amazonas, in the central Brazilian Amazon region. T...
Article
Although the potential neurotoxic effects from the exposure to zinc oxide nanoparticles (ZnO NPs) on humans and on experimental models have been reported in previous studies, the effects from the exposure to environmentally relevant concentrations of them remain unclear. Thus, the aim of the present study is to investigate the effects from the expo...
Article
Full-text available
Tannery is a highly polluting activity due to the waste generated by bovine skin processing. Although there are several studies highlighting the health issues faced by workers exposed to tannery effluent, there are no records of experiments testing the neurobehavioral effects resulting from direct contact with this pollutant. Thus, the aim of the c...
Article
Full-text available
A evolução humana nos levou a viver em sociedade como um todo, levando em consideração as diferenças e as igualdades. Porém, no que se diz respeito a isso, se torna mais distante a continuidade da mesma, dando ênfase a visão egocêntrica, em que se vive por si, por suas vontades e anseios. Nesse contexto, o PIBID/Bio, durante várias reuniões e discu...
Article
Full-text available
Recentemente tem-se investigado sobre métodos de ensino e aprendizagem, que despertem a participação, motivação e compreensão dos conteúdos trabalhos em sala de aula. Nessa perspectiva, uma das grandes dificuldades encontradas pelos professores de Ciências e/ou Biologia tem sido, na maioria das vezes o modo de apresentar os conteúdos nas aulas, uma...
Article
Full-text available
Although tannery effluents are known for being highly toxic to organisms, reports about the effects of the intake of these xenobiotics on experimental mammal models are recent. Studies about the damages the chronic intake of these effluents can cause in the liver of outbred mice remain an unexplored field. Thus, the aim of the present study is to a...
Article
Full-text available
Although previous studies have already confirmed the toxicological potential of abamectin (ABA) in different experimental models (from invertebrates to vertebrates), almost nothing is known about the impacts the exposure to this pesticide can cause on birds. Thus, the aim of our study is to investigate the cytotoxic effects on the erythrocytes of f...
Article
Although the toxic potential of tannery effluents (TE) is acknowledged, the impacts these residues have on mammals who intake water contaminated with this pollutant are not completely known. Thus, in order to broaden the knowledge about how these contaminants affect the biota, the aim of the current study is to assess different behavioral categorie...