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Guilherme C Ferraz

Guilherme C Ferraz
São Paulo State University (UNESP)

DVM, PhD
Associate Professor on Equine Exercise Physiology and Veterinary Pharmacology and Therapeutics – LAFEQ/DMFA/FCAV/UNESP.

About

110
Publications
27,602
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Introduction
Currently is Associate Professor of Equine Exercise Physiology in the Department of Animal Morphology and Physiology, Sao Paulo State University - FCAV/UNESP. Dr. Guilherme has a bachelor degree in Veterinary Science from Sao Paulo State University – Jaboticabal, Brazil. His has a Master and Ph.D. in Veterinary Medical Clinics from the Program of Graduate Course in Veterinary Medicine at UNESP/Jaboticabal, with an emphasis in equine and dog exercise physiology and science underlying performance in equestrian sports.
Additional affiliations
August 2010 - May 2016
São Paulo State University
Position
  • Professor (Assistant), Laboratory of Equine Exercise Physiology and Pharmacology (LAFEQ)
Description
  • search area: Equine Exercise Physiology

Publications

Publications (110)
Article
Full-text available
Recent studies performed in humans and rats have reported that exercise can alter the intestinal microbiota. Athletic horses perform intense exercise regularly, but studies characterizing horse microbiome during aerobic conditioning programs are still limited. Evidence has indicated that this microbial community is involved in the metabolic homeost...
Article
We compare the expression levels of the lactate transporter complex consisting of the lactate transporter, monocarboxylate transporter 1 (MCT1), and its ancillary protein, cluster of differentiation 147 (CD147), in the membranes of red blood cells (RBCs) from two breeds of jumping horses and associate the expression levels of these proteins with th...
Article
Full-text available
This research focuses on the adjustments in systolic and diastolic functions that are not fully understood in dogs submitted to athletic training. Beagle dogs carried out an endurance training program (ETP) prescribed from the external training load, corresponding to 70–80% of the lactate threshold (VLT) velocity. Eighteen dogs were randomly assign...
Article
Cost of transport (COT) and monocarboxylate transporters (MCTs) could affect the ability to perform fast actions during a jumping discipline. This study aimed to compare the COT and evaluate the MCT1, MCT4, and their auxiliary protein CD147 content in the gluteus medius and RBCs of Brazilian sport horses (BH), a breed developed for jumping competit...
Article
Full-text available
In horses, there is an increasing interest in developing long-lasting drug formulations, with bi-opolymers as viable carrier alternatives in addition to their use as scaffolds, suture threads, screws, pins, and plates for orthopedic surgeries. This communication focuses on the prolonged biocom-patibility and biodegradation of PLA, prepared by hot p...
Preprint
In horses, there is an increasing interest in developing long-lasting drug formulations, with bi-opolymers as viable carrier alternatives in addition to their use as scaffolds, suture threads, screws, pins, and plates for orthopedic surgeries. This communication focuses on the prolonged biocompatibility and biodegradation of PLA, prepared by hot pr...
Article
Full-text available
Background The detection of signatures of selection in genomic regions provides insights into the evolutionary process, enabling discoveries regarding complex phenotypic traits. In this research, we focused on identifying genomic regions affected by different selection pressures, mainly highlighting the recent positive selection, as well as underst...
Article
Poly(lactic acid) (PLA) and poly(ɛ-caprolactone) (PCL) are two important aliphatic esters known for their biodegradability and bioresorbability properties; the former is stiffer and brittle while the smaller modulus of the latter allows a suitable elongation. The new biomaterials being developed from the blend of these two polymers (PLA and PCL) is...
Preprint
Full-text available
Background: The Mangalarga Marchador horse (MM) is one of the breeds shaped over generations by local adaptations and specific preferences of Brazilian breeders to morphology, functionality, and locomotion. The animals genetically have “batida” or “picada” natural gait trait, which is a trademark of the breed. The movement biomechanics of this bree...
Article
Full-text available
The dogs’ responses to training exercise are seldom monitored using physiological variables, and cardiac autonomic regulation (CAR) is a relevant determinant of endurance-training adaptation. There are studies in the literature establishing that regular exercise could interfere with CAR in dogs, measured by heart rate and vagal-derived indexes of h...
Article
This paper focuses on the biocompatibility and biodegradation of PLA and a recently developed PLA/PCL blend containing an in vitro nontoxic compatibilizer based on a low-molecular-weight triblock copolymer derived from ε-caprolactone and tetrahydrofuran. The polymers were implanted subcutaneously in the lateral surface of the neck of horses. Physic...
Article
Full-text available
The horses’ responses to exercise are commonly monitored using physiological variables, nonetheless physical and mental states can also be expressed through body language. The aims of this study were: (i) to identify how facial expressions and other behavioural variables change in ranch horses after a routine workday, and (ii) to investigate if the...
Article
The ECA23:22999655C>A DMRT3 variant has been described as a causative region for the four-beat gait in horses, however it remains uncertain for the two distinct gait types observed in the Brazilian Mangalarga Marchador (MM) breed. This study aimed to perform a single-step GWAS, prospecting the genetic architecture of the marcha batida (MB) and marc...
Article
Full-text available
Objectives: To investigate effects of postural changes and bladder distention on intrabladder pressure whilst estimating intra-abdominal pressure in horses. Design: Two-year cohort study. Patients admitted for elective surgical procedures unrelated to gastrointestinal or genitourinary tract. Setting: School of Agricultural and Veterinarian Sci...
Conference Paper
Full-text available
In this study, two methodologies-integrated Haplotype Score (iHS) and Runs of Homozygosity (ROH)-were used to capture, and validate as much as possible the evolutionary scenario for recent positive selection in Mangalarga Marchador (MM) horses. In order to achieve this objective, 240 animals were genotyped using two platforms-Axiom ® Equine Genotyp...
Article
We compare the expression levels of the lactate transporter complex consisting of the lactate transporter, monocarboxylate transporter 1 (MCT1), and its ancillary protein, cluster of differentiation 147 (CD147), in the membranes of red blood cells (RBCs) from two breeds of jumping horses and associate the expression levels of these proteins with th...
Article
Full-text available
OBJECTIVE To determine whether the lactate threshold of dogs could be determined by a visual method and to assess the extent of agreement and bias among treadmill velocities for the lactate threshold as determined by visual (LTv) and polynomial (LTp) methods, glucose threshold as determined by visual (GTv) and polynomial (GTp) methods, and heart ra...
Article
This study aimed to investigate the use of maximum eye surface temperature (ESTmax), recorded by infrared thermography, as an indicator of physical fitness in ranch horses. Data collection was carried out with 16 horses by recording six physical fitness biomarkers (ESTmax, respiratory rate, creatine kinase activity [CK], and concentrations of total...
Conference Paper
Considering the effect of the DMRT3 gene on the gait pattern of the Icelandic, Finnhorse and Standardbred horses, the present investigation was designed to evaluate the influence of the DMRT3 genotype on the kinematic variables of the marcha picada (MP) gait of Mangalarga Marchador (MM) horses. Eighteen horses were divided into two genotype groups:...
Article
Full-text available
Few data exist on the physiological consequences of an incremental exercise test (IET) and training in dogs. Here we evaluated the effect of an endurance-training program (ETP) on the kinetics of the serum biomarkers: creatine kinase (CK), aspartate aminotransferase (AST), myoglobin, cardiac troponin I (cTnI), and creatine kinase isoenzyme MB (CK-M...
Conference Paper
O complexo transportador de monocarboxilato formado pela isofoma 1 (MCT1) e a proteína auxiliar CD147 atua no tamponamento do pH e na dinâmica do lactato. O objetivo deste trabalho foi quantificar a expressão deste complexo nas hemácias de cavalos Mangalarga (ML), Jumento Pêga (JP), Jumento Nacional (JN) e seus híbridos. Foram coletadas amostras sa...
Article
Full-text available
Cardiac biomarkers are potentially useful to identify primary or secondary cardiac muscle damage in horses and higher values of cardiac troponin have also been seen after high intensity exercise. The objective of this study was to investigate the effect of cavalcade of different distances on the serum concentrations of cardiac troponin I (cTnI) and...
Article
This study aimed to characterize the maximum heart rate (HR) and the intensity of official marcha contests (OMC) and to compare the cost of transport (COT) and metabolic power (Pmet) of Mangalarga Marchador (MM) horses of marcha batida (MB) and marcha picada (MP) gaits. Twenty-two MM horses participated in this study. The experiment was conducted i...
Article
Full-text available
This study provides information about the effect of chronic ingestion of a decoction of Bauhinia forficata on the behavior of rats. The aim of this study was to investigate the exploratory activity, anxiety level, and blood glucose of healthy rats submitted to prolonged treatment with a decoction of B.forficata. Twenty male rats, aged two months an...
Article
Monocarboxylate transporter isoform 1 (MCT1) and its ancillary protein, CD147 function to transport H+ and lactate ions, retarding systemic acidosis and fatigue. The PDK4 gene is involved in the ATP production and the DMRT3 gene is involved in the locomotor system. This study investigated polymorphisms of MCT1, CD147, PDK4, and DMRT3 in Arabian and...
Article
Full-text available
Some horse breeds are highly selected for athletic activities. The athletic potential of each animal can be measured by its performance in sports. High athletic performance depends on the animal capacity to produce energy through aerobic and anaerobic metabolic pathways, among other factors. Transmembrane proteins called monocarboxylate transporter...
Article
Full-text available
This study aimed to characterize the maximum heart rate (HRMAX) and the intensity of official marcha contests (OMC) and to compare the cost of transport (COT) and metabolic power (Pmet) of Mangalarga Marchador (MM) horses of marcha batida (MB) and marcha picada (MP) gaits. Twenty-two MM horses participated in this study. The experiment was conducte...
Data
Concentrate and digestible energy supplied and the body weights variables data. (XLSX)
Article
Full-text available
Show jumping is a century-old Olympic sport performed worldwide. However, despite the prominence of this sport, there is currently no satisfactory evaluation of the physical fitness of its horses. Our study compared two standardised exercise tests (specific and nonspecific for show jumpers) to determine the importance of a show jumping specific eva...
Conference Paper
Full-text available
The aim of this study was to assess the use of infrared thermography as an indicator of physical effort in horses. The respiratory rate (RR) and infrared thermography images (IRT) of the eye, ear and mouth were measured in sixteen crossbreed horses used for livestock ranch work. The assessments were carried out always between 17 and 18 h and under...
Conference Paper
Full-text available
The determination of lactate and glucose threshold in dogs submitted to incremental exercise test (IET) is scarce. This study aimed (1) to determine the lactate and glucose thresholds (2) to investigate the acid-base responses of untrained dogs submitted to incremental exercise test. Fourteen Beagle dogs, 1–2 years old, healthy and untrained were u...
Article
Full-text available
Little information is available comparing the i-STAT and the YSI 2300 Stat Plus devices to determine the lactate concentration [Lac] in dogs undergoing intense exercise. The reproducibility of the YSI 2300 for quantifying the [Lac] in canine blood [Lac]b and plasma [Lac]p samples has been observed. In addition, the i-STAT handheld device was used t...
Article
The DMRT3 gene is described as the main gene involved in the determination of gait phenotypes in horses and the allele A of the 22999655C>A SNP has been reported as a causal variant of this trait. In the Mangalarga Marchador breed (MM), which exhibits two gait patterns with well-defined characteristics, genotypes AA and CA are associated with march...
Article
Full-text available
The use of molecular markers has brought great progress to genetic breeding programs of commercial species aimed at production, such as cattle, pigs and poultry, especially with the increase of the accuracy of prediction of breeding values, allowing early selection of better animals. This occurred either through the use of a few markers linked to L...
Article
Full-text available
Lyme borreliosis is a disease transmitted by ticks to mammals, especially in horses and humans. Caused by a spirochete Borrelia burgdorferi, it can result in lameness, arthritis, carditis, dermatitis and neurological signs. Anaphylactoid reactions are severe responses caused by direct action of substances (drugs, toxins), which can pose risks to li...
Article
Full-text available
Avaliações da aptidão física de cavalos Puro Sangue Inglês (PSI) têm sido correlacionadas com o ganho financeiro, mas a influência da distância percorrida durante o treinamento, tanto sobre índices de condicionamento físico como na produtividade financeira tem sido pouco relatada. Monitoraram-se, por meio de global positioning system (GPS) acoplado...
Article
Full-text available
The use of human equipment in veterinary medicine is very common; therefore, it is essential that it is tested and validated. In this study, a comparison was made between blood levels of glucose, lactate, triglycerides, and cholesterol obtained by the portable device Accutrend® Plus and those found in laboratory methods considered standard for the...
Article
Full-text available
This study aims at standardizing the pre-incubation and incubation pH and temperature used in the metachromatic staining method of myofibrillar ATPase activity of myosin (mATPase) used for asses and mules. Twenty four donkeys and 10 mules, seven females and three males, were used in the study. From each animal, fragments from the Gluteus medius mus...
Article
The Brazilian sport horse (BH) was specifically developed for jumping competition. Monocarboxylate transporters are key regulators of cell pH and therefore facilitate co-transport of protons and lactate. Lactate transport in red blood cells (RBCs) is bimodal (high [HT] and low transport [LT]) and is related to CD147 levels. This study aimed to quan...
Conference Paper
IntroductionAcid-base disturbances are frequently assessed using traditional variables PCO2, pH, and bicarbonate. This study aimed to compare the changes in acid-base balance in horses performing a CEI endurance race (160 km) using traditional and quantitative methodologies.Methods Blood samples were drawn before racing, at the vet-gate (66 km), im...
Article
Full-text available
IntroductionHeart rate (HR) and blood lactate (LAC) are biomarkers whose responses to exercise are related to physical fitness. This study evaluated the cost of transport (CT) by assessing the cardiovascular and metabolic efficiency of jumping horses using an incremental jumping test.Methods Sixteen Brazilian Sport horses of two fitness levels were...
Conference Paper
IntroductionRepeated monitoring of faecal pH may be useful in detecting the effects of exercise and conditioning on the fermentative activity within the large intestine. This study investigated the effect of a maximal incremental exercise test (MIET) and aerobic conditioning on the faecal pH of untrained horses.Methods Fourteen equines were randoml...
Conference Paper
IntroductionThe Brazilian Mangalarga Marchador breed is valued for its gait. However few studies have assessed the use of nutritional additives on this breed's performance. This study was designed to test the hypothesis that chelated trivalent chromium and L-carnitine feed supplementation may reduce subcutaneous fat deposition after training.Method...
Conference Paper
IntroductionDuring anaerobic glycolysis for energy production, lactate and H+ ions accumulate in muscle fibers and pass into the bloodstream. Monocarboxylate transporter type 1 and its ancillary protein CD147 transport H+ and lactate ions from the plasma into red blood cells, thereby maintaining acid/base homeostasis and retarding systemic acidosis...
Conference Paper
IntroductionThe evaluation of acid-base balance of horses is important because it detects alterations that affect their performance and health. There are studies relating these changes with endurance type effort, but few regarding sprint exercise. The purpose of this study was to determine whether the fitness level of Quarter Horses performing barr...
Article
Full-text available
The aim of this study was to determine the no-observable-adverse-effect concentration (NOAEC) for trichlorfon, an antiparasitic agent used in aquaculture, in Piractus mesopotamicus (pacu) using acetylcholinesterase (AChE) activity as an end point. Fish were exposed 24 h/d for 15 d to different concentrations of trichlorfon in tanks of water for whi...
Article
Full-text available
The anaerobic threshold is a physiologic event studied in various species. There are various methods for its assessment, recognized in the human and equine exercise physiology literature, several of these involving the relationship between blood lactate concentration (LAC) and exercise load, measured in a standardized exercise test. The aim of this...
Article
Full-text available
To determine the behavioral and antinociceptive effects of narcotic and non-narcotic analgesics administered by intravenous injection in horses, 10 thoroughbred mares weighing between 450 and 550 kg and ranging in age from 8 to 13 years old were analyzed. The effects of alfentanil, butorphanol, flunixin, and saline solution on the general activity...
Conference Paper
Full-text available
Introduction. Endurance horses are more susceptible to acid-base disturbances. Although most studies on equestrian horses are conducted in countries with temperate climates, the upcoming Rio 2016 Olympic Games increase the need for studies in tropical climates. Objective. To evaluate acid-base imbalances in horses during an endurance race in Brazil...
Conference Paper
Introduction. There are no published studies that have characterized the different types of muscle fibers responsible for the work of traction, cargo transport and locomotion in mules. Objective. To typify the skeletal muscle fibers of the Gluteus medius of mules and to determine possible gender-specific differences. Methods. A percutaneous muscle...
Conference Paper
Introduction. There are no published studies that have characterized the different types of muscle fibers responsible for the work of traction, cargo transport and locomotion in mules. Objective. To typify the skeletal muscle fibers of the Gluteus medius of mules and to determine possible gender-specific differences. Methods. A percutaneous muscle...