Guido Santos

Guido Santos
Universitätsklinikum Erlangen · Hautklinik

PhD Biomedical Sciences

About

29
Publications
7,339
Reads
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158
Citations
Introduction
I am currently working at the Hautklinik in the Universitätsklinikum Erlangen. I do research in Computing in Mathematics, Natural Science, Engineering and Medicine, Molecular Biology and Systems Biology. My current project is lung infection.
Additional affiliations
January 2012 - present
Universidad de La Laguna

Publications

Publications (29)
Article
Full-text available
In this paper, we combine kinetic modelling and patient gene expression data analysis to elucidate biological mechanisms by which melanoma becomes resistant to the immune system and to immunotherapy. To this end, we systematically perturbed the parameters in a kinetic model and performed a mathematical analysis of their impact, thereby obtaining si...
Article
Full-text available
A connection between lipid rafts and Alzheimer’s disease has been studied during the last decades. Mathematical modeling approaches have recently been used to correlate the effects of lipid composition changes in the physicochemical properties of raft-like membranes. Here we propose an agent based model to assess the effect of lipid changes in lipi...
Article
Full-text available
Lymphocyte invasion by HIV-1 is a complex, highly regulated process involving many different types of molecules that is prompted by the virus's association with viral receptors located at the cell-surface membrane that culminates in the formation of a fusion pore through which the virus enters the cell. A great deal of work has been done to identif...
Article
Full-text available
A mathematical model which predicts the intraerythrocytic stages of Plasmodium falciparum infection was developed using data from malaria-infected mice. Variables selected accounted for levels of healthy red blood cells, merozoite (Plasmodium asexual phase) infected red blood cells, gametocyte (Plasmodium sexual phase) infected red blood cells and...
Article
Full-text available
Based on experimental data from E. coli cultures, we have devised a mathematical model in the GMA-power law formalism that describes the central and L-carnitine metabolism in and between two steady states, non-osmotic and hyperosmotic (0.3 M NaCl). A key feature of this model is the introduction of type of kinetic order, the osmotic stress kinetic...
Article
Full-text available
Dendritic cells (DCs) can be used for therapeutic vaccination against cancer. The success of this therapy depends on efficient tumor-antigen presentation to cytotoxic T lymphocytes (CTLs) and the induction of durable CTL responses by the DCs. Therefore, simulation of such a biological system by computational modeling is appealing because it can imp...
Chapter
Mathematical modeling is a method that provides quantitative understanding of complex systems, especially when evolution in time is critical. Bacterial infections fall inside the category of complex time evolving systems which makes mathematical modeling a promising approach to solve the problems that a controlled experiment or external observation...
Article
Mathematical modeling of cell differentiated in colonic crypts can contribute to a better understanding of basic mechanisms underlying colonic tissue organization, but also its deregulation during carcinogenesis and tumor progression. Here, we combined bifurcation analysis to assess the effect that time delay has in the complex interplay of stem ce...
Article
Full-text available
Pneumococcal infection is the most frequent cause of pneumonia, and one of the most prevalent diseases worldwide. The population groups at high risk of death from bacterial pneumonia are infants, elderly and immunosuppressed people. These groups are more vulnerable because they have immature or impaired immune systems, the efficacy of their respons...
Article
Full-text available
Even today two bacterial lung infections, namely pneumonia and tuberculosis, are among the ten most frequent causes of death worldwide. These infections still lack effective treatments in many developing countries and in immunocompromised populations like infants, elderly people and transplanted patients. The interaction between bacteria and the ho...
Conference Paper
Full-text available
En este trabajo se presenta un juego serio para enseñar cómo se comportan las células en tumores cancerígenos y cómo funcionan los diferentes tratamientos para combatirlas. Para el diseño del funcionamiento del juego, se ha creado un modelo de comportamiento de las células y se ha adaptado dicho comportamiento a un juego, con el objetivo de que los...
Conference Paper
INTRODUCCIÓN La coevaluación (evaluación entre pares), es una estrategia formativa que fomenta el papel activo del estudiante en el proceso de aprendizaje. El alumnado tiene la oportunidad de revisar el trabajo de sus compañeros/as de clase frente a su propia evaluación lo que tiene reflejo en su propio proceso de aprendizaje, provocando la reorien...
Data
SIMENZKIN is a data table file (Excel and ods) programmed to simulate enzymatic metabolic reactions using the Michaelis-Menten formalism. Is optimized for being used in a practical module for a enzymology class together with the problem attached.
Data
SIMENZKIN is a data table file (Excel and ods) programmed to simulate enzymatic metabolic reactions using the Michaelis-Menten formalism. Is optimized for being used in a practical module for a enzymology class together with the problem attached.
Article
Full-text available
In this communication, we introduce a general framework and discussion on the role of models and the modeling process in the field of biosciences. The objective is to sum up the common procedures during the formalization and analysis of a biological problem from the perspective of Systems Biology, which approaches the study of biological systems as...
Article
Mathematical modelling of intra-host malaria is a relatively recent topic. Although the first mathematical model related to malaria was proposed by Sir Ronald Ross in 1915, the first attempt to model the parasite–host interactions was as recent as 1989. Since then, a moderate but steadily growing number of articles dealing with this topic have been...
Data
Full-text available
Phenol is an important commodity for the chemical industry, used for many processes and deemed to be a major pol-lutant due its xenobiotic nature and high toxicity. For the purpose of phenol bioremediation a biotechnological set up consisting of a continuous packed column bioreactor with Candida tropicalis adhered onto activated carbon beads has be...

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Projects

Projects (5)
Project
Science popularisation podcast
Project
Research, innovation, biosciences. Learning and teaching skills.
Project
Mathematical modelling of pneumonia pathophysiology