Güngör Kanbak

Eskisehir Osmangazi University | ESOGU · Department of Medical Biochemistry

Acute high-dose alcohol consumption can lead to oxidative stress, which can cause harm to organs. In this study we aim to determine whether administering boric acid (BA) can protect certain organs (liver, kidney, and brain) from the damaging effects of alcohol by reducing oxidative stress. We used 50 and 100 mg/kg of BA. Thirty-two Sprague Dawley (...

In this study, the effects of the pretreatment of Curcumin and LoxBlock-1 on liver, pancreas, and cardiac dysfunction following Ischemia-Reperfusion-induced (IR) Acute Kidney Injury (AKI) were investigated through the mechanisms of oxidative stress and ferroptosis. Total antioxidant status (TAS), total oxidant status (TOS) and oxidative stress inde...

Acute kidney injury is still a worldwide clinic problem that affects kidney function and associated with high mortality risk. Unfortunately, approximately 1.7 million people are thought to die from acute kidney injury each year. Boron element is defined as an “essential trace element” for plants and thought to have a widespread role in living organ...

The gut microbiota influences brain development and functioning through the gut-brain axis. This is first study regulate maternal gut microbiota and fetal neurodevelopment processes by using probiotics such as Bifidobacterium bifidum (BIF) and Lactobacillus salivarius (LAC) in the prenatal period. In this study, Wistar Albino female rats were divid...

Crohn’s disease (CD) and ulcerative colitis (UC) are two chronic relapsing inflammatory bowel diseases (IBD). Although there are several treatment options available to improve the symptoms of IBD patients, there is no effective treatment that provides a definitive solution. In the present study, we aim to investigate the antioxidative/anti-inflamma...

Interest in phytochemical therapy methods in the treatment of diabetes is increasing day by day. Although the antidiabetic and antioxidant effects of Cistus laurifolius L. (CL) have been mentioned, the systemic effects remain unknown. The present study aims at evaluating the antidiabetic effects of the CL aqueous extract via metformin on streptozot...

We investigated the presence of myocardial apoptosis on isoproterenol (ISO)-induced myocardial injury (MI) after long-term high dose alcohol consumption and examined the antiapoptotic role of calpain inhibitor 1. Male Wistar Albino rats (n = 108) were divided into six groups: Control, alcohol (ethanol was given during 30 days for chronic alcohol co...

OBJECTIVES:Amyloid-beta(1-42) accumulation in thebrain is an important sign of Alzheimer’s disease and has been shown to induce apoptosis and impair cellular integrity. In this study, it was aimed to reveal the protective effects of boric acid (BA) and curcumin, which have antioxidant and anti-inflammatory properties, on amyloid-beta(1-42)-induced...

Boric acid and omega-3 are used as essential elements for both animal and human health. Many researchers have shown these beneficial effects on cardiac and inflammatory markers. This study aims to evaluate cardiac protective effect of boric acid and omega-3 against MI (myocardial infarction), probably due to the suppression of pro-inflammatory cyto...

Aging is a natural process in which morphological and functional abnormalities in living organisms increase irreversibly. Nicotinamide (NAM) acts both as a precursor of many metabolites and as a cofactor of many enzymes involved in cell energy metabolism, homeostasis of redox balance, and regulation of signaling pathways. In this study, we investig...

In this study, we were aimed to investigate the neuroprotective effects of bexarotene and nicotinamide in synaptosomes incubated with amyloid-beta (Aβ). Our study consists of 2 parts, in vivo and in vitro. In the in vivo section, twenty-four Wistar albino male rats were divided into 4 groups (control, dimethyl sulfoxide (DMSO), nicotinamide and bex...

Background Hexagonal boron nitride nanoparticles (hBN NPs) are encouraging nanomaterials with unique chemical properties in medicine and biomedical fields. Until now, the optimal hBN NP’s dosage and biochemical mechanism that can be used for in vivo systems has not been fully revealed. The main aim of this article is to reveal characteristics, seru...

The aim of our study is to investigate the dose-dependent biological system effect of hexagonal boron nitride (hBN) nanoparticles, which is directly produced nanoscale, in vivo. Wistar albino rats (n = 80) weighing 200–250 g were divided into eight groups (n = 10). The acute effects of hBN NPs (i.v) on the rats were investigated by measuring the bi...

Gliomas are one of the most aggressive brain tumors with a poor prognosis in the central nervous system. Bexarotene is a third-generation retinoid X receptor agonist that is promising in the treatment of both cancer and neurodegenerative diseases. In this study, we aimed to investigate the cytotoxic and anti-proliferative effects of bexarotene in C...

Cyproheptadine is first-generation antihistamine drug, that is, H1 receptor antagonist, with a drug being anesthetic, anti-serotonergic and anti-cholinergic and started to be used clinically in the 1960s. As firstly utilized as an anti-allergic drug, usage of cyproheptadine was expanded to other cases including serotonin syndrome, appetite increasi...

Glioma is the most common brain tumor. C6 rat glioblastoma cells provide the possibility to the scientist to study brain cancer. Concanavalin A (Con A) has a lot of antitumoral effects, especially over oxidative stress. In the present study, it was aimed to decide the impacts of various doses of Con A on C6 glioblastoma cells regarding cytotoxicity...

Objectives: Renal ischemia/reperfusion injury is observed in many cases such as kidney transplantation, partial nephrectomy and renal artery angioplasty, and it has been suggested to be associated with prolonged hospitalization and increased mortality. This study designed for investigating the post-ischemic effects of conivaptan and boric acid on r...

Zinc takes part in several of cellular signaling pathways, containing defense against free radicals, apoptosis, and inflammation. However, interaction between zinc and prostate cancer progression is poorly understood. Therefore, zinc treatment in DU-145 human prostate cancer cells was investigated. First, zinc sulfate (ZnSO4) concentrations with an...

Aims Ischemia/reperfusion (I/R) is one of the most important causes of acute kidney injury (AKI), a clinical syndrome with kidney dysfunction and high mortality rates. New diagnostic biomarkers need to be defined to better illuminate the pathophysiology of AKI. For the first time, we aim to investigate the protective effects of Curcumin which is kn...

Ischemia/reperfusion (I/R) injury is associated with a strong inflammatory and oxidative stress response to hypoxia and reperfusion that impair organ function. We aimed to investigate the role of oxidative stress, renal inflammation, and apoptosis in the injury of the kidney tissue after ischemic reperfusion, and the protective effect of dose-depen...

Aim: The aim of the present study was to investigate the effect of apoptosis on rat skeletal muscle caused by chronic alcohol and statin consumption with modified liquid diet and to elucidate protective effects of betaine supplementation. Methods: TNF-α (tumor necrosis factor), NF-kB (Nuclear Factor kappa B), cytochrome c and caspase-3 levels wi...

Background Paracetamol is one of the widely used antipyretic and analgesic drug around the world. Many researchers showed that paracetamol caused to hepatotoxicity or nephrotoxicity. Objective In the present study, we aimed to determine whether betaine has protective effects on hepatotoxicity and nephrotoxicity in neonate rats, following to long t...

Boric acid is known to regulate the proliferation of cancer cells. Prostate cancer is among the types of cancer with high mortality in men. There are a few numbers of studies investigating the effects of boric acid on prostate cancer cells. The objective of the present study was to assess the effects of boric acid at concentrations higher than that...

The purpose of the this study was to defined protective effects of silymarin on the experimental colitis induced by intra-colonic application of 2,4,6-trinitrobenzene sulfonic acid (TNBS). The twenty eight Sprague-Dawley rats were randomly seperated into four groups, each group containing seven rats represent as follows: group 1 determined as contr...

Of all cancer types, prostate cancer is the second most common one with an age-standardized incidence rate of 29.3 per 100,000 men worldwide. Nitric oxide (NO) is both a radical and versatile messenger molecule involved in many physiological activities. NO was documented to be highly secreted and utilized by cancer cells. Nω-nitro-l-arginine methyl...

Understanding the abnormal biochemical and psychological mechanisms underlying autism spectrum disorders, identifying the impacts caused by environmental factors, and exciting studies for researchers and clinicians are important because research on our understanding of the main causes of autism is expected to lead to new approaches to diagnosis, tr...

The neurotoxic effects of aluminum are generally associated with reduced antioxidant capacity, increased oxidative stress and apoptosis, which lead to the induction of neurodegenerative processes. Curcumin has a lipophilic polyphenol character and effects of antioxidant and anti-apoptotic. The present study was undertaken to examine possible alumin...

Prostate cancer is the main cause of cancer-related mortality in men around the world and an important health problem. DU-145 human prostate cancer cells provide an opportunity to investigate prostate cancer. Betaine has a number of anticancer effects, such as inactivation of carcinogens, inhibition of cancer cell proliferation, angiogenesis, and m...

Aim: Oxidative stress(OS) and lipid peroxidation(LP) occur in a cell due to irreversible damage resulting from incidents such as traumatic brain injury(TBI). The aim of our study was to investigate the possible neuroprotective effect of boric acid (BA) by examining the changes in catalase (CAT) activity and levels of CAT and malondialdehyde (MDA)...

Introduction: Due to irreversible damage following head trauma, many overlapping pathophysiological events occur including excitotoxicity, acidotoxicity, ionic imbalance, edema, oxidative stress inflammation and apoptosis. Material and methods: In this this study, after the rats were separated in to groups theserats were fed throughout fourteen...

AIM: To investigate the possible neuroprotective effect of boric acid (BA) by examining the changes in catalase (CAT) activity and levels of CAT and malondialdehyde (MDA) in brain tissues from rats with closed head trauma. MATERIAL and METHODS: This experimental study consisted of three groups of rats: control (n=8), traumatic brain injury (TBI) (n...

Prostate cancer is the second most common cancer in men and has approximately six times more incidence in western countries with millions of new cases diagnosed annually. Many studies have shown that the use of complementary and alternative medicines is common among patients with prostate cancer, and the use of vitamins, supplements and specific fo...

OBJECTIVES:Diabetes mellitus is considered to be one of the five major causes of death around the world and is considered a global public health problem due to its multi-factorial characteristics affecting basic biochemical processes in the body. Metformin (MET) is currently the most widely used first-line antihyperglycemic agent for diabetes melli...

OBJECTIVES:Recent studies have shown the effects of distant tissue on renal ischemia/reperfusion (I/R) damage in some organs such as the brain, liver, pancreas and spleen. The aim of this study was to examine the therapeutic effect of Boric Acid (BA) due to the properties of different doses against distant tissue splenic injury, which is caused by...

OBJECTIVES:In this study, it was aimed to investigate the effect of diabetic injury on renal function, hepatic enzyme levels and lipid profile. At the same time, the therapeutic properties of commonly used metformin (MET) in diabetes treatment and Cistus laurifolius (CL) plant extracts against diabetic damage were investigated for the first time MA...

OBJECTIVES:Renal ischemia/reperfusion (I/R) may cause distant tissue damage. Boric acid (BA) with antioxidant properties is suggested to be a protective agent against I/R injury. The aim of this study was to investigate the neuroprotective effects of boric acid on brain against renal I/R induced oxidative damage. MATERIALS and METHODS:35 rats were...

OBJECTIVES:Ischemia/reperfusion(I/R) has an important place in various heart diseases. In this study, it was aimed to investigate the effects of boric acid(BA), which is known contribution to antioxidant defense system on heart tıssue damage caused by renal ıschemıa/reperfusıon. MATERIALS and METHODS:In our study, 35 Spraque Dawley rats were random...

The purpose of this studywas to demonstrate the effects of dosing-dependent boric acid (BA) administration on the renal I/R effect on remote tissue pancreas function. For this purpose, 35 Spraque Dawley albino rats were divided into five groups as 7 animals in each group: sham, I/R, I/R + 50 mg kg of BA, I/R + 100 mg/kg of BA and I/R + 200 mg/kg of...

The present study aims to evaluate the acute antidiabetic effects of the aqueous extract of the Cistus laurifolius (CL) via Metformin (MET) on streptozotocin (STZ) induced diabetic rats. In this study, 40 male Wistar albino rats were used in 5 groups (1-Control, 2-diabetic (STZ) control, 3-250 mg/kg body weight (BW) CL + STZ, 4-100 mg/kg BW MET+STZ...

Renal ischemia/reperfusion injury may occur due to hypotension, hypovolemic shock, vascular occlusion and renal transplantation. The severity of the damage increases with the duration of ischemia. Renal ischemia/reperfusion injury can also cause distant tissue damage, especially in the kidney. Boric acid with antioxidant properties is suggested to...

z Majör depresif bozukluk, kişinin sosyal işlevlerini ve günlük yaşama dair etkinliklerini rahatsız edecek dereceye ulaşmış üzüntü, melankoli veya keder durumudur. İlaç ile tedavisi ise özellikle kişilerin tedaviye olumlu yanıt vermesi noktasında yetersiz ve iyileşme sürecinden uzakta kalmaktadır. Son zamanlarda yapılan çalışmalar insanlarda meydan...

Ischemia / reperfusion injury (I/R) is caused by a temporary transient impairment of blood flow in a particular organ. I/R is usually associated with a strong inflammatory and oxidative stress response to hypoxia and reperfusion that impairs organ function. Renal damage caused by renal IR contributes to high morbidity and mortality. Boric acid is f...

Fluoride toxicity primarily contributes to the production of reactive oxygen and nitrogen derivatives, triggering cell death pathways by causing lipid peroxidation and DNA damage. Boric acid (BA) contributes to preservation of membrane integrity and function and maintenance of redox balance due to its high affinity to some metabolites in the organi...

Renal Ischemia-Reperfusion elicits tissue damage in a number of organs: heart, lung, and liver. Among the major regulatory organs in our body are the liver and the kidney. Any liver or kidney damage can affect the other. Renal Ischemia-reperfusion injury (RIRI) defines tissue ischemia, which is a source of insufficient oxygen, followed by reperfusi...

Abstract Objective: Fluoride toxicity primarily contributes to the production of reactive oxygen and nitrogen derivatives, trigger the cell death pathways by causing lipid peroxidation and DNA damage. Boric acid (BA) contributes to preservation of membrane integrity and function and maintenance of redox balance due to its high affinity to some meta...

Organic and inorganic wastes increase fluoride concentration in drinking water. Therefore, fluoride-contaminated water is the main resource of chronic fluorosis in livings. Recently, many studies have been carried out on cellular damage and neurotoxicity caused by fluoride exposure. In this study, we researched the neuroprotective effects of coenzy...

Objective: Isoproterenol (iso)-induced myocardial infarction is a widely used experimental model to study the beneficial effects of many drugs. Morinda citrifolia (noni) has traditionally been used for treating many diseases. Low-dose aspirin may have been protected heart tissueThis study aimed to investigate the possible protective effects of noni...

Mercury (Hg) is a bioaccumulative toxic metal that poses a high risk for human and environmental health through natural and anthropogenic emissions. Hg is an environmental toxic substance that causes neurological and developmental problems in biological systems. Although the molecular mechanisms mediating Hg-induced neurotoxicity are not fully unde...

As a broad spectrum expressing neurodevelopmental conditions caused by prenatal alcohol exposure, fetal alcohol spectrum disorders involve alcohol-related neurodevelopmental disorders, fetal alcohol syndrome (FAS) and alcohol-related birth defects. The developing fetus may exhibit developmental abnormalities if exposed to ethanol, which is a well-k...

Oxidative stress occurs in a cell due to irreversible damage resulting from some pathophysiological incidents such as a traumatic brain injury (TBI). Free oxygen radicals, which cause the formation of oxidative stress and lipid peroxidation, also leads to neurotoxicity. Protective role of boric acid on the brain in several animal models except TBI...

S137/P-68, Abant, Turkey

Free oxygen radicals which are toxic to the central nervous system are called as neurotoxic agents. Oxidative stress is seen as a result of several pathophysiological events including subarachnoid hemorrhage, edema, ischemia, hypertension, inflammatory reaction and trauma, leading to the production of lipid peroxidation products. In the present stu...

Purpose: Alcohol consumption in pregnancy may cause fetal alcohol syndrome (FAS) in the infant. This study aims to investigate prenatal alcohol exposure related neuroapoptosis on the cerebral cortex tissues of newborn rats and possible neuroprotective effects of betaine, folic acid, and combined therapy. Methods: Pregnant rats were divided into...

Objective: Aspirin intake of specific daily doses are advised by doctors to postmenapausal women and men above 40 years of age to prevent heart attack and even cancer in recent times. In vitro cytototoxic effects of different doses of ethanol (50 mm, 100 mM ve 200 mM) alone and together with 100 μg/mL aspirin, and possible protective role of 1 mM b...

model of acute myocardial infarction

Purpose: We aim to study the effect of neurodegeneration on the brain of rat pups caused by prenatal and postnatal ethanol exposure with modified liquid diet to elucidate protective effects of betaine and omega-3 supplementation. When ethanol is consumed during prenatal and postnatal periods, it may result in fetal alcohol syndrome (FAS) in the of...

In this article we report the healing effects of a Phellinus linteus fruiting body hot water extract (PLE) in streptozotocin (STZ)–induced diabetic rats. PLE was given before and after STZ. The preprotective, protective, and postprotective effects of PLE on STZ-induced oxidative stress were studied using biochemical (caspase 3 activity, cytosolic-t...

To the best of our knowledge, this is the first study concerning the effect of boric acid (BA) administration on fetal alcohol syndrome (FAS). In this study, the aim was to investigate prenatal alcohol-induced oxidative stress on the cerebral cortex of newborn rat pups and assess the protective and beneficial effects of BA supplementation on rats w...

Excessive alcohol consumption and alcoholism cause medical problems with high mortality and morbidity rates. In this study we aimed to decrease the alcohol related tissue damage by inhibiting calpain activation which plays an important role in apoptosis and necrosis, in rats with cardiomyopathy induced by acute alcohol consumption. Male Sprague-Daw...

Aim: Prevention of secondary injury developing as a result of spinal cord injury will reduce significantly neurological deficits which may occur after trauma. These are focused in experimental studies and many agents are being tested. In our study, we have invesitigated the effects of kefir, which is a a probiotic, associated with life prolongation...

In this study, our aim was to investigate whether cellular alterations occurred in liver and lung tissue in presence of chronic alcohol ingestion and Pseudomonas aeruginosa pneumonia related to oxidative stress and in situ cell death. Male wistar rats were divided into five groups: the sham group fed by normal solid diet, two control groups; one fe...

Context: Excess use of alcohol is known to be associated with liver diseases such as fatty liver, alcoholic hepatitis, and cirrhosis. Various practices may be applied to prevent or treat the damage caused by chronic alcoholism. Coprinus comatus (O.F. Müll.) Pers. (Agaricaceae) is a macrofungus that has been reported to aid the recovery of murine l...

Abstract In the present study, the curative effects of crude polysaccharides (PSs) from mushrooms on the symptoms of alcoholic liver injury were investigated. PSs from Agaricus bisporus, Agaricus brasiliensis, and Phellinus linteus fruiting bodies were administered by gavage at levels of 100 mg per kg body weight per day for 7 d after the onset of...

Aim: In this study, probable effects of gallic acid were investigated in experimentally induced renal I/R injury in rats. Material and methods: For this purpose, each group consisted of 7 Spraque dawley male albino rats. Groups were defi ned as follows; Group I: control group; Group II: I/R group; Group III, IV and V: I/R+Gallic acid (50, 100 and 2...