Greta Barbulescu

Victor Babeș University of Medicine and Pharmacy Timișoara | UMFT · Clinic of Cardiology ASCAR

Cardiovascular diseases are the leading cause of global mortality. Over the past two decades, researchers have tried to provide novel solutions for end-stage heart failure to address cardiac transplantation hurdles such as donor organ shortage, chronic rejection, and life-long immunosuppression. Cardiac decellularized extracellular matrix (dECM) ha...

Whole organ decellularization techniques have facilitated the fabrication of extracellular matrices (ECMs) for engineering new organs. Unfortunately, there is no objective gold standard evaluation of the scaffold without applying a destructive method such as histological analysis or DNA removal quantification of the dry tissue. Our proposal is a so...

Heart transplantation remains the only curative treatment for end-stage heart failure. This life-saving option continues to be limited by the low number of organ donors, graft rejection and adverse effects of immunosuppressants. Engineering bioartificial hearts from acellular native-derived scaffolds and stem cells has gained attention because of i...

In this paper we propose the design and implementation of a modified Langendorff experimental device, pressure controlled, used to decellularize the heart with a sodium dodecyl sulfate (SDS) surfactant solution to obtain cardiac biomatrix. The experimental device consists of two constructive parts: a hydraulic part that provides through a peristalt...

In this paper we propose the design and implementation of an electrophysiological experimental device capable of acquiring in real time three cardiovascular parameters: an electrocardiographic derivation (DII), the phonocardiogram and the peripheral photoplestismogram pulse wave at the level of a finger from the upper limb. These parameters allow u...