Gregory A. Johnson
, College Station

Cell Biology, Chemical Biology, Photochemistry

Ph.D. Biochemistry & Biophysics



My research involves enhancing the specificity and activity of photosensitizers (PS) using antimicrobial peptides (AMPs) and cell-penetrating peptides (CPPs) as targeting agents. My focus is on the mechanisms of bacterial inactivation achieved by the PS-AMP conjugate eosin-(KLAKLAK)2. We have found that conjugating a soluble PS (eosinY) to a selective AMP provides effective photokilling of bacteria without damaging human cell lines or red blood cells, unlike other hydrophobic PS used clinically.

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