Gregori Ghitti

Gregori Ghitti
OncoDNA

About

8
Publications
410
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28
Citations
Introduction
Senior computer scientist. Last 10 years, he is in the field of healthcare, specially in NGS Labs. He has managed the migration from Microarray to NGS high throughput. He has also implemented the LIMS/Workflows to manage the huge amount of data generated by these technologies. He invests hours researching and learning new technologies. Currently, he is the IT Director where he manages high tech develpments, with the goal to find the best treatment to help patient to fight the cancer.

Publications

Publications (8)
Article
Full-text available
The mechanistic target of the rapamycin (mTOR) pathway is frequently activated in human cancers. Our objective was to evaluate relationships between mTOR-pathway activity and functional mutations in the upstream genes PIK3CA and PTEN in solid-tumor biopsies from a broad selection of cancer types. Formalin-fixed paraffin-embedded (FFPE) tumor sample...
Article
Full-text available
Molecular profiling and functional assessment of signalling pathways of advanced solid tumours are becoming increasingly available. However, their clinical utility in guiding patients’ treatment remains unknown. Here, we assessed whether molecular profiling helps physicians in therapeutic decision making by analysing the molecular profiles of 1057...
Article
Full-text available
Molecular profiling and functional assessment of signalling pathways of advanced solid tumours are becoming increasingly available. However, their clinical utility in guiding patients’ treatment remains unknown. Here, we assessed whether molecular profiling helps physicians in therapeutic decision making by analysing the molecular profiles of 1057...
Article
Full-text available
Aim: To investigate if the genetic information provided by sequencing of both solid and liquid biopsies can shed light on tumor heterogeneity, and to understand the clinical usefulness of adding blood profiling to standard tissue analysis in cancer care. Methods: Data from 351 patients with stage IV solid tumors for whom molecular profiling of thei...
Article
e23097 Background: The mTOR pathway is often activated in human cancers. In this study, a total of 538 samples representing 40 different cancer types were analysed to evaluate the relationship between mTOR pathway activity and mutations in the upstream genes PIK3CA and PTEN. Methods: FFPE samples were analysed both by NGS (PIK3CA, PTEN, mTOR, TSC1,...
Article
e23099 Background: Advances in the molecular profiling of tumours, together with the expanding portfolio of targeted cancer therapies have established the terrain on which personalised cancer treatment can be conducted. This expanding area of precision medicine has the potential to be offered as a routine cancer-diagnostic service. Methods: We eval...

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