Gregor Thut

Gregor Thut
University of Glasgow | UofG · Institute of Neuroscience and Psychology

PhD

About

237
Publications
56,227
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19,863
Citations
Citations since 2017
70 Research Items
10406 Citations
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201720182019202020212022202305001,0001,500
201720182019202020212022202305001,0001,500

Publications

Publications (237)
Preprint
Full-text available
Statistical power in cognitive neuroimaging experiments is often very low. Low sample size can reduce the likelihood of detecting real effects (false negatives) and increase the risk of detecting non-existing effects by chance (false positives). Here we document our experience of leveraging a relatively unexplored method of collecting a large sampl...
Article
Graphene-colour synaesthetes experience an anomalous form of perception in which graphemes systematically induce specific colour concurrents in their mind's eye ("associator" type). Although graphene-colour synaesthesia has been well characterised behaviourally, its neural mechanisms remain largely unresolved. There are currently several competing...
Article
Full-text available
The combined use of transcranial magnetic stimulation (TMS), electroencephalogram (EEG), and behavioral performance allows investigation of causal relationships between neural markers and their functional relevance across a number of perceptual and cognitive processes. Here, we present a protocol for combining and applying these techniques on human...
Article
Full-text available
Alpha-band oscillatory activity over occipito-parietal areas is involved in shaping perceptual and cognitive processes, with a growing body of electroencephalographic (EEG) evidence indicating that pre-stimulus alpha-band amplitude relates to the subjective perceptual experience, but not to objective measures of visual task performance (discriminat...
Article
Pre‐stimulus EEG oscillations, especially in the alpha range (8‐13 Hz), can affect the sensitivity to temporal lags between modalities in multisensory perception. The effects of alpha power are often explained in terms of alpha’s inhibitory functions, whereas effects of alpha frequency have bolstered theories of discrete perceptual cycles, where th...
Article
Full-text available
Attempts to enhance human memory and learning ability have a long tradition in science. This topic has recently gained substantial attention because of the increasing percentage of older individuals worldwide and the predicted rise of age-associated cognitive decline in brain functions. Transcranial brain stimulation methods, such as transcranial m...
Article
Full-text available
Fluctuations in arousal, controlled by subcortical neuromodulatory systems, continuously shape cortical state, with profound consequences for information processing. Yet, how arousal signals influence cortical population activity in detail has so far only been characterized for a few selected brain regions. Traditional accounts conceptualize arousa...
Article
Full-text available
Transcranial alternating current stimulation (tACS) is a popular technique that has been used for manipulating brain oscillations and inferring causality regarding the brain-behaviour relationship. Although it is a promising tool, the variability of tACS results has raised questions regarding the robustness and reproducibility of its effects. Build...
Preprint
Full-text available
Fluctuations in arousal, controlled by subcortical neuromodulatory systems, continuously shape cortical state, with profound consequences for information processing. Yet, how arousal signals influence cortical population activity in detail has only been characterized for a few selected brain regions so far. Traditional accounts conceptualize arousa...
Article
Full-text available
Voluntary allocation of visual attention is controlled by top-down signals generated within the Frontal Eye Fields (FEFs) that can change the excitability of lower-level visual areas. However, the mechanism through which this control is achieved remains elusive. Here, we emulated the generation of an attentional signal using single-pulse transcrani...
Article
Full-text available
Pre-stimulus oscillatory neural activity has been linked to the level of awareness of sensory stimuli. More specifically, the power of low frequency oscillations (primarily in the alpha-band, i.e. 8-14 Hz) prior to stimulus-onset is inversely related to measures of subjective performance in visual tasks, such as confidence and visual awareness. Int...
Article
Full-text available
As the field of noninvasive brain stimulation (NIBS) expands there is a growing need for comprehensive guidelines on training practitioners in the safe and effective administration of NIBS techniques in their various research and clinical applications. This article provides recommendations on the structure and content of this training. Three differ...
Preprint
Full-text available
Pre-stimulus EEG oscillations, especially in the alpha range (8-13 Hz), can affect the integration of stimulus features into a coherent percept. The effects of alpha power are often explained in terms of alpha's inhibitory functions, whereas effects of alpha frequency have bolstered theories of discrete perceptual cycles, where the length of a cycl...
Chapter
Attention is one of the most important higher cognitive processes underlying the normal functioning of the human brain. It refers to a set of neural mechanisms that govern the selection and gating of sensory events, thoughts, and actions. Although psychologists have described this concept more than 100 years ago, until recently, underlying computat...
Article
Cognitive deficits are a fundamental feature of schizophrenia for which currently no effective treatments exist. This paper examines the possibility to use transcranial direct current stimulation (tDCS) to target cognitive deficits in schizophrenia as evidence from studies in healthy participants suggests that tDCS may improve cognitive functions a...
Article
The visual system has one of the most complex structures of all sensory systems and is perhaps the most important sense for everyday life. Its functional organization was extensively studied for decades in animal and humans, for example by correlating circumscribed anatomical lesions in patients with the resulting visual dysfunction. During the pas...
Article
Full-text available
At present, there is a lack of systematic investigation into intra- and inter-task consistency effects in older adults, when investigating lateralised spatial attention. In young adults, spatial attention typically manifests itself in a processing advantage for the left side of space (“pseudoneglect”), whereas older adults have been reported to dis...
Article
Full-text available
Rhythms are a fundamental and defining feature of neuronal activity in animals including humans. This rhythmic brain activity interacts in complex ways with rhythms in the internal and external environment through the phenomenon of 'neuronal entrainment', which is attracting increasing attention due to its suggested role in a multitude of sensory a...
Article
Concurrent transcranial magnetic stimulation and electroencephalography (TMS–EEG) has emerged as a powerful tool to non-invasively probe brain circuits in humans, allowing for the assessment of several cortical properties such as excitability and connectivity. Over the past decade, this technique has been applied to various clinical populations, en...
Article
Full-text available
How neural representations of low-level visual information are accessed by higher-order processes to inform decisions and give rise to conscious experience is a longstanding question. Research on perceptual decision making has revealed a late event-related EEG potential (the Centro-Parietal Positivity, CPP) to be a correlate of the accumulation of...
Article
Full-text available
Oscillatory neural activity is a fundamental characteristic of the mammalian brain spanning multiple levels of spatial and temporal scale. Current theories of neural oscillations and analysis techniques employed to investigate their functional significance are based on an often implicit assumption: In the absence of experimental manipulation, the s...
Article
Full-text available
Two largely independent research lines use rhythmic sensory stimulation to study visual processing. Despite the use of strikingly similar experimental paradigms, they differ crucially in their notion of the stimulus-driven periodic brain responses: one regards them mostly as synchronized (entrained) intrinsic brain rhythms; the other assumes they a...
Preprint
Full-text available
Oscillatory neural activity is a fundamental characteristic of the mammalian brain spanning multiple levels of spatial and temporal scale. Current theories of neural oscillations and analysis techniques employed to investigate their functional significance are based on an often implicit assumption: In the absence of experimental manipulation, the s...
Article
The year 2018 marks the 100th anniversary of the passing of the French composer Claude Debussy. Debussy's view of composing music could be compared to how some scientists view neural oscillations. He is reported to have said that music is not in the notes, but rather in the silences in between. Without regular periods of lull, it is not possible to...
Data
Fig. S1 plots the relationships between jackknife single‐trial estimates of EEG power and both spatial bias (PSE: 1A) and discrimination sensitivity measures (curve width: 1B) from the data points corresponding to the peak t‐values of the respective cluster‐analysis effects (PSE peak data point: 14 Hz, −1.78 s at electrode AF4; Curve width peak dat...
Article
Full-text available
Natural communication between interlocutors is enabled by the ability to predict upcoming speech in a given context. Previously we showed that these predictions rely on a fronto-motor top-down control of low-frequency oscillations in auditory-temporal brain areas that track intelligible speech. However, a comprehensive spatio-temporal characterisat...
Article
Full-text available
Integration of multimodal sensory information is fundamental to many aspects of human behavior, but the neural mechanisms underlying these processes remain mysterious. For example, during face-to-face communication, we know that the brain integrates dynamic auditory and visual inputs, but we do not yet understand where and how such integration mech...
Data
Local maps of redundancy and synergy in searching for mechanisms of AV speech interaction. This figure presents more detailed results from an analysis of interactions between auditory and visual speech signals as predictors of MEG signal in left superior temporal gyrus (pSTG) and left motor cortex. The selection of regions of interest was based on...
Data
Left pSTG and left motor cortex differentially predict visual speech. A potential benefit of speech-entrained brain activity is the facilitation of temporal prediction of upcoming speech. We therefore investigated to what extent the different integration mechanisms in pSTG and motor cortex (reflected by differences in redundancy versus synergy) lea...
Data
Synergy between brain regions predictive of visual speech. To better understand the integration mechanism of audiovisual speech processing observed in redundant and synergistic interaction between multisensory speech signals predictive of brain activity, we computed PID differently in which redundant and synergistic interaction between brain region...
Data
Attention to visual speech revealed by analysis of eye fixation. Participants were carefully instructed to fixate on the speaker’s mouth in all experimental conditions and we monitored participants’ eye movement using an eye tracker (see Materials and methods) to ensure that they fixate on the speaker’s lip movements. In order to investigate attent...
Data
Neural decomposition of natural audiovisual speech (‘All congruent’ condition). In order to understand multisensory representational interactions in the brain during processing of natural audiovisual speech, we first define characteristics of decomposed information in ‘All congruent’ condition. To observe overall patterns in each information map, w...
Data
Reference list for Supporting Information. (DOCX)
Preprint
Full-text available
How neural representations of low-level visual information are accessed by higher-order processes to inform decisions and give rise to conscious experience is a longstanding question. Research on perceptual decision making has revealed a late event-related EEG potential (the Centro-Parietal Positivity, CPP) to be a correlate of the accumulation of...
Article
Motion information can reach V5/MT through two parallel routes: one conveying information at early latencies through a direct subcortical route and the other reaching V5 later via recurrent projections through V1. Here, we tested the hypothesis that input via the faster direct pathway depends on motion characteristics. To this end, we presented mot...
Preprint
Full-text available
Two largely independent research lines use rhythmic sensory stimulation to study visual processing. Despite the use of strikingly similar experimental paradigms, they differ crucially in their notion of the stimulus-driven periodic brain responses: One regards them mostly as synchronised (entrained) intrinsic brain rhythms; the other assumes they a...
Article
Full-text available
Recent studies have probed the role of the parieto‐occipital alpha rhythm (8 – 12 Hz) in human visual perception through attempts to drive its neural generators. To that end, paradigms have used high‐intensity strictly‐periodic visual stimulation that created strong predictions about future stimulus occurrences and repeatedly demonstrated perceptua...
Preprint
Full-text available
Natural communication between interlocutors is enabled by the ability to predict upcoming speech in a given context. Previously we showed that these predictions rely on a fronto-motor top-down control of low-frequency oscillations in auditory-temporal brain areas that track intelligible speech. However, a comprehensive spatio-temporal characterisat...
Article
Full-text available
Prismatic adaption (PA) has been proposed as a tool to induce neural plasticity and is used to help neglect rehabilitation. It leads to a recalibration of visuomotor coordination during pointing as well as to aftereffects on a number of sensorimotor and attention tasks, but whether these effects originate at a motor or attentional level remains a m...
Article
Full-text available
Prestimulus oscillatory neural activity has been linked to perceptual outcomes during performance of psychophysical detection and discrimination tasks. Specifically, the power and phase of low frequency oscillations have been found to predict whether an upcoming weak visual target will be detected or not. However, the mechanisms by which baseline o...
Article
Full-text available
Several recent studies have reported non-linear effects of transcranial direct current stimulation (tDCS), which has been attributed to an interaction between the stimulation parameters (e.g. current strength, duration) and the neural state of the cortex being stimulated (e.g. indexed by baseline performance ability, age) (see Fertonani & Miniussi,...
Preprint
Full-text available
Many recent studies have probed the role of the parieto-occipital alpha rhythm (8 – 12 Hz) in human visual perception through attempts to drive its neural generators. To that end, paradigms have used high-intensity strictly-periodic visual stimulation that created strong predictions about future stimulus occurrences and repeatedly demonstrated perc...
Preprint
Full-text available
Information integration is fundamental to many aspects of human behavior, and yet its neural mechanism remains to be understood. For example, during face-to-face communication we know that the brain integrates the auditory and visual inputs but we do not yet understand where and how such integration mechanisms support speech comprehension. Here we...
Article
Full-text available
Human perception of perithreshold stimuli critically depends on oscillatory EEG-activity prior to stimulus-onset. However, it remains unclear exactly which aspects of perception are shaped by this pre-stimulus activity and what role stochastic (trial-by-trial) variability plays in driving these relationships. We employed a novel Jackknife approach...
Article
Previous research has highlighted posterior oscillations in the alpha-band to play a key role in goal-directed (top-down) visuospatial attention (Foxe&Snyder 2011). However, the oscillatory signatures of automatically driven (bottom-up) alerting and orienting of attention remain uncertain. Likewise, it is unclear to what extend these automatic proc...
Article
Full-text available
An author name was incorrectly spelled as Giovanni A. The correct spelling is Giovanni Assenza; the correct surname (family name) is Assenza; the correct name is Giovanni; thus when abbreviated it should be cited as Assenza G. The authors apologize for this error and state that this does not change the scientific conclusions of the article in any w...
Article
Full-text available
Actions are typically associated with sensory consequences. For example, knocking at a door results in predictable sounds. These self-initiated sensory stimuli are known to elicit smaller cortical responses compared to passively presented stimuli, e.g., early auditory evoked magnetic fields known as M100 and M200 components are attenuated. Current...
Article
Full-text available
Non-invasive brain stimulation (NIBS) has been under investigation as adjunct treatment of various neurological disorders with variable success. One challenge is the limited knowledge on what would be effective neuronal targets for an intervention, combined with limited knowledge on the neuronal mechanisms of NIBS. Motivated on the one hand by rece...
Article
Full-text available
Transcranial electrical stimulation (tES) is being investigated as an experimental and clinical interventional technique in human participants. While promising, important limitations have been identified, including weak effect sizes and high inter-and intra-individual variability of outcomes. Here, we compared two " inhibitory " tES-techniques with...
Article
Full-text available
In multisensory integration, processing in one sensory modality is enhanced by complementary information from other modalities. Intersensory timing is crucial in this process because only inputs reaching the brain within a restricted temporal window are perceptually bound. Previous research in the audiovisual field has investigated various features...
Article
Full-text available
A group-level visuospatial attention bias towards the left side of space (pseudoneglect) is consistently observed in young adults, which is likely to be a consequence of right parieto-occipital dominance for spatial attention. Conversely, healthy older adults demonstrate a rightward shift of this behavioural bias, hinting that an age-related reduct...
Article
Question Transcranial electrical stimulation is under investigation as an experimental and clinical interventional technique in both healthy participants and patients. While the technique is promising in many regards, important limitations have been identified, including weak effects as well as high inter- and intra-individual variability, hence th...
Article
Question Previous TMS studies have shown that attention-regulated changes in posterior brain rhythms are under FEF control (Capotosto, JNeurosci 2009) and that FEF-TMS affects the probability of perceiving phosphenes (Silvanto, JNeurophysiol 2006). However the oscillatory nature of the latter changes has never been examined. Here we specifically te...
Article
Question Oscillatory brain activity in specific frequency bands has been related to cognitive processes such as attention (Foxe and Snyder (2011) Front Psychology 2:154). While in the domain of endogenous top-down control of visuospatial attention, occipito-parietal oscillations in the alpha band have been causally implicated (Romei et al. (2010) J...
Article
Introduction TDCS studies have recently faced strong criticism for exhibiting both a large intra- and inter-subject response variability and a low reproducibility of effects. We here attempt to replicate one of our own recent studies. In this study, we found a rightward shift of spatial attention bias, relative to a leftward (“pseudoneglect”) bias...
Article
Introduction Iconic memory represents the registration of visual information in a high-capacity but fast decaying visuo-sensory buffer. It has recently been shown that the primary visual cortex contributes to this memory function. Objectives In this TMS study, we investigated visual priming effects when TMS is applied over the primary visual corte...
Article
Non-invasive transcranial brain stimulation (NTBS) techniques have a wide range of applications but also suffer from a number of limitations mainly related to poor specificity of intervention and variable effect size. These limitations motivated recent efforts to focus on the temporal dimension of NTBS with respect to the ongoing brain activity. Te...
Article
Full-text available
Post-movement beta synchronization (PMBS) modulations have been related to sensory reafferences after movement initiation and inhibitory processes after movement interruption. Although these processes have been separately studied in young and old adults, little is known about the age-related changes in PMBS during selective inhibitory control (i.e....
Article
Full-text available
Being able to predict self-generated sensory consequences is an important feature of normal brain functioning. In the auditory domain, self-generated sounds lead to smaller brain responses (e.g., auditory evoked responses) compared to externally generated sounds, which is usually referred to as the sensory attenuation effect. Here we investigated t...