Gregor Liegl

Gregor Liegl
Charité Universitätsmedizin Berlin | Charité · Medical Department, Division of Psychosomatic Medicine

Mag. Dr.

About

81
Publications
9,954
Reads
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641
Citations
Additional affiliations
April 2018 - present
Charité Universitätsmedizin Berlin
Position
  • Researcher
October 2014 - March 2018
Charité Universitätsmedizin Berlin
Position
  • PhD Student
May 2014 - September 2014
Landesklinikum Sankt Pölten
Position
  • Clinical Psychologist in Training

Publications

Publications (81)
Article
Full-text available
Background: Physical function (PF) is a core patient-reported outcome domain in clinical trials in rheumatic diseases. Frequently used PF measures have ceiling effects, leading to large sample size requirements and low sensitivity to change. In most of these instruments, the response category that indicates the highest PF level is the statement tha...
Article
Objectives: To translate the PROMIS Physical Function (PF) item bank version 1.2 into German and to investigate psychometric properties of resulting full bank and seven derived short forms. Design: Cross-sectional psychometric study. Setting: Inpatient and outpatient clinics of the Department of Psychosomatic Medicine at Charité-Universitätsme...
Article
Full-text available
Objective The computer-adaptive test (CAT) of the European Organisation for Research and Treatment of Cancer (EORTC), the EORTC CAT Core, assesses the same 15 domains as the EORTC QLQ-C30 health-related quality of life questionnaire but with increased precision, efficiency, measurement range and flexibility. CAT parameters for estimating scores hav...
Article
Full-text available
Objective: The PROMIS® physical function (PF) item bank has been developed to standardize patient-reported PF across medical fields. However, evidence of scoring equivalence across cardiology and rheumatology patients is still missing. Therefore, this study aims to investigate both 1) the extent of disease-related differential item functioning (DI...
Article
Full-text available
Objectives This study aimed to determine the relationship between frequently used patient-reported outcome (PRO) measures and a multi-task performance outcome (PerfO) measure of general physical function (PF) and to examine the association of these measures with depressive mood, pain, and age. Methods Frequently used PRO measures of general PF (Pa...
Article
Full-text available
Background General population normative values for the widely used health-related quality of life (HRQoL) measure, European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire – Core 30 (EORTC QLQ-C30), are available for a range of countries. These are mostly countries in northern Europe. However, there is still a lack o...
Article
Full-text available
Purpose General population normative data for the European Organisation for Research and Treatment of Cancer (EORTC) QLQ-C30 questionnaire facilitates interpretation of data assessed from cancer patients. This study aims to present normative data of the general Spanish population. Methods/patients Data were obtained from a prior larger study colle...
Preprint
Full-text available
PurposeGeneral population normative data for the European Organization for Research and Treatment of Cancer (EORTC) QLQ-C30 questionnaire facilitates interpretation of data assessed from cancer patients. This study aimed to present normative data of the Spanish general population.Methods/Patients Data were obtained from a prior larger study collect...
Article
Full-text available
Background: Stress is a major risk factor for the impairment of psychological well-being. The present study aimed to evaluate the empirical evidence of the Transactional Stress Model proposed by Lazarus and Folkman in patients with psychosomatic health conditions. Methods: A structural equation model was applied in two separate subsamples of inp...
Article
Recent developments in the dimensional assessment of personality functioning have made the implementation of latent measurement models increasingly attractive. In this study, we applied item response theory (IRT) to a well-established personality functioning instrument (the OPD Structure Questionnaire) to identify a unidimensional latent trait and...
Conference Paper
Aims: The aim of this project was to examine whether existing patient-reported instruments are suitable for measuring quality-related aspects of renal replacement therapy (RRT) in Germany or whether a new instrument for RRT quality assessment needs to be developed. Methods: Four bibliographic databases (MEDLINE, Embase, CINAHL, and the Cochrane Lib...
Conference Paper
Aims: The Institute for Quality Assurance and Transparency in the Healthcare Sector (IQTIG) has been commissioned to develop patient-reported instruments for measuring quality of care in dialysis centres and renal transplant clinics in Germany. Next to processes of care, different physical and psychosocial patient-reported outcome (PRO) domains hav...
Article
Full-text available
Objective The European Organisation for Research and Treatment of Cancer (EORTC) core questionnaire, QLQ-C30, is a frequently used patient-reported outcome (PRO) instrument to assess health-related quality of life of patients with cancer. To enhance the understanding and interpretation of PRO data, it is important to obtain norm data from the gener...
Article
Full-text available
Background The European Organisation for Research and Treatment of Cancer (EORTC) QLQ-C30 is a widely used cancer-specific questionnaire assessing 15 domains of health-related quality of life (HRQoL). Our aim was to facilitate the interpretation of scores on this questionnaire by providing Austrian normative data based on a general population sampl...
Article
Full-text available
Purpose: The number of non-responders to treatment among patients with chronic pain (CP) is high, although intensive multimodal treatment is broadly accessible. One reason is the large variability in manifestations of CP. To facilitate the development of tailored treatment approaches, phenotypes of CP must be identified. In this study, we aim to i...
Presentation
Objective: To develop and evaluate an AAQ-based CAT. Patients: Patients (n=1136) with hip/knee osteoarthritis from Denmark, France, The Netherlands, Norway, Spain, and the UK. Methods: Participants responded to all 17 items of the AAQ. Unidimensionality and country-related differential item functioning (DIF) were investigated. To establish item par...
Conference Paper
Aims: The Animated Activity Questionnaire (AAQ) is a computer-based tool for the (almost) non-verbal assessment of activity limitations, combining the advantages of self report questionnaires and performance based tests. Each of the AAQ items consists of multiple videos of an animated person performing a basic daily activity (e.g., climbing stairs)...
Article
Full-text available
Objective The European Organisation for Research and Treatment of Cancer (EORTC) QLQ-C30 health-related quality of life questionnaire is one of the most widely used cancer-specific health-related quality of life questionnaires worldwide. General population norm data can facilitate the interpretation of QLQ-C30 data obtained from cancer patients. Th...
Thesis
Full-text available
Background: Item response theory (IRT) methods are increasingly used to standardize the assessment of patient- reported outcomes. By estimating an IRT model with a large number of items measuring the same trait, a construct-based item bank can be established. In theory, any subset of relevant items for a specific population can be selected from an...
Article
Health-related quality of life (HRQoL) acquires increased importance as a target parameter for different stakeholders in healthcare, e. g. to assess treatment outcome in chronically ill patients. In this educational article, we explain the levels of the health-related quality of life construct and associated main dimensions including physical, ment...
Article
Objectives: To develop the first item bank to measure Stress Resilience (SR) in clinical populations. Study design and setting: Qualitative item development resulted in an initial pool of 131 items covering a broad theoretical SR concept. These items were tested in n=521 patients at a psychosomatic outpatient clinic. Exploratory and Confirmatory...
Conference Paper
ZIELSTELLUNG Die Patient-Reported Outcomes Measurement Information System (PROMIS®) Initiative hat Itembanken zur standardisierten Erfassung verschiedener Konstrukte der gesundheitsbezogenen Lebensqualität auf Basis der Item-Response Theorie (IRT) entwickelt (Cella et al., 2010). Die statistische Beziehung zwischen den einzelnen Items und dem gemes...
Article
Zusammenfassung Einleitung Das Screening struktureller Einschränkungen der Persönlichkeit gilt zunehmend als wichtig für die Planung der stationären Behandlung, da hierdurch frühzeitig spezifische Behandlungspfade festgelegt werden können. Kürzlich wurde zu diesem Zweck der 12-Item Screening-Fragebogen zur OPD-Strukturachse (OPD-SFK) entwickelt und...
Conference Paper
The PROMIS® Physical Function (PF) item bank has been calibrated as a unidimensional scale, enabling computerized adaptive testing (CAT). Consequently, several PF subdomains (e.g., upper extremity, mobility) are represented by a composite score. However, different diseases may be associated with condition-specific PF profiles, potentially leading t...
Poster
Full-text available
Aims: Information about personality pathology is highly relevant for treatment of mental disorders. Although there is no consensus about a general personality pathology (PP) construct, a growing number of researchers and clinicians support a dimensional approach. For example, the operationalized psychodynamic diagnostic (OPD) research group propose...
Conference Paper
Full-text available
Aims: The new computer-adaptive test (CAT) version of the European Organisation for Research and Treatment of Cancer (EORTC) quality of life questionnaire, the QLQ-CAT, was developed to assess health-related quality of life in cancer patients with increased precision and flexibility compared to the static QLQ-C30. Using item-response theory methods...
Presentation
Several PROMIS Physical Function measures, including a generic short form (SF-20a) and the PROMIS Mobility bank, are highly significant predictors of general physical performance in different clinical settings. An exception was the PROMIS Upper Extremity bank that appeared to be strongly associated with overall physical performance in rheumatology...
Article
Fragestellung: Bestimmung der Häufigkeit von somatoformen Syndromen und komorbiden Syndromen (Depression, Angst) in der allgemeinmedizinischen Praxis. Methode: PHQ-D und ärztliche Einschätzung wurden eingesetzt, um die Häufigkeit somatoformer Syndrome konsekutiver Patienten einer allgemeinärztlichen Praxis in Österreich innerhalb von acht Wochen z...
Poster
The objective of this study was to estimate the frequency of somatic syndromes and comorbid syndromes (depression, anxiety) in primary care.
Presentation
Full-text available
Körperliche Funktion ist ein zentraler Endpunkt in klinischen Studien, der meist mittels Patient-Reported Outcomes (PRO: Selbstbeurteilung durch Patienten) oder Performance Outcomes (PerfO: Bewältigung körperlicher Aufgaben) erfasst wird. Bisherige Studien fanden eine eher niedrige Übereinstimmung zwischen diesen beiden Erhebungsmethoden. Als mögli...
Article
Full-text available
Introduction There is no consensus about what constitutes the most appropriate patient-reported outcome measurement (PROM) instrument for measuring physical function in patients with rheumatic hand conditions. Existing instruments lack psychometric testing and vary in feasibility and their psychometric qualities. We aim to develop a PROM instrument...
Presentation
Full-text available
Objective: To investigate whether an extended response scale increases the range of measurement in static PROMIS® Physical Function (PF) measures. Methods: In the course of PROMIS wave 1 data collection, a 5-item PF short form was presented in three different item formats. Two of these formats are used in the PROMIS PF item bank, both utilizing a r...
Conference Paper
Objective: To investigate the influence of executing physical activities on patients’ responses to related self-rated physical function items. Methods: German patients from diverse clinical settings responded to the German version of the 121-item PROMIS® Physical Function item bank. Following this self-assessment, the participants executed 10 physi...
Conference Paper
Objective: To determine the association between generic self-reported and performance-based measures of physical function (PF), and to investigate whether these methods of assessment are affected by pain, depression, and illness perception. Methods: Seventy-eight German adults from various inpatient settings (rheumatology: n=26; cardiology: n=25; p...
Conference Paper
Full-text available
Aims: To date, there is no consensus about the personality pathology construct, i.e. whether it is dimensional or categorical, and, how many factors best reflect the construct. The operationalized psychodynamic diagnostic (OPD) system proposes a theory-based eight-factor model with 21-subfactors. Previous analyses could not show a stable factor so...
Article
To investigate differential item functioning (DIF) of PROMIS Depression items between US and German samples we compared data from the US PROMIS calibration sample (n = 780), a German general population survey (n = 2,500) and a German clinical sample (n = 621). DIF was assessed in an ordinal logistic regression framework, with 0.02 as criterion for...
Article
Full-text available
Background Due to several possible clinical and radiological pitfalls in response assessment, Tumorboard decision (TB) in patients with glioblastoma can sometimes be challenging. Early detection of recurrence in glioblastoma multiforme (GBM) is a crucial key factor for a prompt and effective second line therapy. Standard MRI sequences are the main...
Article
Eine empirische Studie zum Bedarf an ambulanter Psychotherapie in Österreich und der tatsächlichen Bedarfsabdeckung wird vorgestellt. Im Rahmen der Untersuchung wurde der ambulante Psychotherapiebedarf mittels Schätzmodellen anhand der Gesamtbevölkerung sowie der Prävalenz psychischer Erkrankungen erhoben. Das Behandlungskontingent wurde mittels de...
Presentation
Full-text available
This presentation focuses on the influences of sleep deprivation on pain perception
Article
Full-text available
Background Conversion Disorders (CD) are prevalent functional disorders. Although the pathogenesis is still not completely understood, an interaction of genetic, neurobiological, and psychosocial factors is quite likely. The aim of this study is to provide a systematic overview on imaging studies on CDs and investigate neuronal areas involved in Mo...
Article
Up to 30% of the population in Western countries suffer from chronic pain. The treatment of chronic pain causes medical and socioeconomic problems. Guided self-help (GSH) might be an effective supplementary treatment, however, the size of this effect is unclear. This meta-analysis quantifies the effect of GSH on chronic pain. A systematic literatur...
Article
The inclusion of the patient perspective is an important aspect in patient-oriented health care and complements medical diagnostics and clinical findings. Through the assessment of health-related quality of life physical, psychological, and social dimensions of patients are revealed. Various generic as well as disease-specific instruments to measur...
Article
Full-text available
Somatoform disorders(SD)are common medical disorders with prevalence rates between3.5%and 18.4%,depending on country and medical setting. SD as outlined in the ICD-10 exhibits various biological, social, and psychological pathogenic factors. Little is known about the neural correlates of SD. The aims of this meta-analysis are to identify neuronal a...
Presentation
Full-text available
Ein entscheidender Schritt in der Entwicklung von Selbstbeurteilungsfragebögen ist die Bestimmung des Frageformats, das neben inhaltlichen Aspekten auch die Formulierung der Items sowie die Anzahl der Antwortoptionen umfasst. Der vorliegende Beitrag beschäftigt sich mit dem Einfluss des Frageformats auf die Breite des Messbereichs in Fragebögen zur...
Poster
Full-text available
Therapeutengestützte Selbsthilfe stellt eine effektive Option für die Behandlung des Reizdarmsyndroms dar. Allerdings finden sich große Effektivitätsunterschiede zwischen einzelnen Studien, deren Ursachen in der vorliegenden Untersuchung nicht geklärt werden konnten. Aufgrund der relativ einfachen Umsetzbarkeit erscheint die Implementierung therape...
Poster
Full-text available
Einleitung Reizdarm-Syndrom (RDS) und Fibromyalgie-Syndrom (FMS) sind häufige funktionelle Störungen. Klinisch zeigen sich sowohl Überlappungen, als auch Unterschiede. Diese Meta-Analyse überprüft, ob sich diese klinischen Eindrücke auch neurobiologisch manifestieren. Methoden Mittels systematischer Literaturrecherche wurden bildgebende Studien (PE...
Article
Objective: To investigate the validity of a common depression metric in independent samples. Study Design and Setting: We applied a common metrics approach based on Item-Response Theory for measuring depression to four German-speaking samples that completed the PHQ-9. We compared the PHQ item parameters reported for this common metric to reestimat...
Presentation
Full-text available
In diesem Vortrag werden die Ausgaben für psychische Gesundheit in Österreich präsentiert.
Presentation
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In diesem Vortrag werden die Auswirkung von Schlafdeprivation auf das Schmerzempfinden gesunder Probanden besprochen.
Presentation
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In dieser Präsentation wird die Neurobiologie der somatoformen Schmerzstörung anhand einer Meta-Analyse bildgebender Studien diskutiert.
Article
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Objectives: Health costs, which are increasing at a yearly rate of 4 %, represent 11% and thus a large share of Austria's gross domestic product (GDP). High expenditures derive frommental health care costs, including medication. In this article we investigate whether the costs and usage of psychopharmaceutic products in Austria are rising. Method:W...
Article
Full-text available
Zusammenfassung: Selbsterfahrung als Ausbildungsbestandteil der Psychotherapie – Qualitätsmerkmal oder Mythos? Zentrale Ergebnisse des Forschungsprojektes „Die Rolle der Selbsterfahrung in der Psychotherapieausbildung“ Selbsterfahrung gilt als unverzichtbare Säule der Psychotherapieausbildung (vgl. Burns 2005) und ist als Ausbildungselement in eini...
Conference Paper
Aim: An essential step in the development of patient-reported outcomes (PROs) is the determination of the specific item format, including item content and wording. Using the example of measuring physical function (PF), respective item content can focus on either a person’s capability or on a person’s performance, while respective item wording may e...
Conference Paper
AIMS: There is still little experience with the practical application of common metrics combining different Patient-Reported Outcomes (PROs) on a common scale. Using the example of the well-established depression scale of the Patient Health Questionnaire (PHQ-9), the present study was aimed at examining the performance of a recently published depre...
Article
Although irritable bowel syndrome (IBS) is highly prevalent and is accompanied by high costs for respective healthcare systems, the data on treatment effectiveness are limited. Current treatment methods have limitations in terms of side effects and availability. Guided self-help (GSH) might be an easily accessible and cost-effective treatment alter...
Article
Background: There is strong evidence indicating an interaction between sleep and pain. However, the size of this effect, as well as the clinical relevance, is unclear. Therefore, this meta-analysis was conducted to quantify the effect of sleep deprivation on pain perception. Methods: A systematic literature search was conducted using the electro...
Article
Full-text available
Zusammenfassung: Fragestellung: Die Studie untersucht, wie belastend die Behandlung von Patienten mit somatoformen Störungen (SD) ist und welchen Einfluss eine psychosomatische Weiterbildung hat. Methode: Mittels Online-Fragebogen wurden Allgemeinmediziner befragt, wie häufig Patienten mit SD in der eigenen Praxis sind und wie belastend die Behandl...
Article
Full-text available
Abstract How burdensome is the treatment of patients with somatoform disorders? This study examines the influence of self-perceived emotional stress during the treatment of patients with somatoform disorders. It asks whether emotional stress can be influenced by psychosomatic education. Via online questionnaire general practitioners were asked abou...