Grazia D'Onofrio

Grazia D'Onofrio
IRCCS Ospedale Casa Sollievo della Sofferenza | Opera di Padre Pio · Clinical Psychology Service - Health Department

PhD

About

141
Publications
39,317
Reads
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3,962
Citations
Citations since 2017
74 Research Items
2919 Citations
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Introduction
Grazia D'Onofrio currently works at the Clinical Psychology Srvice, Fondazione IRCCS Casa Sollievo della Sofferenza. Grazia does research in Biological Psychology, Clinical Psychology and Neuropsychology.
Additional affiliations
March 2007 - present
IRCCS Ospedale Casa Sollievo della Sofferenza
Position
  • Dementia and Genetic determinants
Education
October 2016 - November 2020
Scuola Superiore Sant'Anna
Field of study
  • Biorobotics
December 2004 - July 2009
Istituto Romano di Psicoterapia Psicodinamica Integrata
Field of study
  • Psychoterapy Specialization
October 1998 - March 2004
Università degli Studi di Urbino "Carlo Bo"
Field of study
  • Clinical Psychology

Publications

Publications (141)
Chapter
Assistive social robots are becoming increasingly important in our daily life. In this context, humans expect to be able to interact with them using the same mental rules applied to human-human communication, including the use of non-verbal channels. Therefore, over the last years, research efforts have been devoted to develop behavioral models for...
Article
Full-text available
Assistive devices could promote independent living and support the active and healthy aging of an older population; however, several factors can badly influence the long-term use of new technologies. In this context, this paper presents a two-step methodology called “pre-validation” that aims to identify the factors that can bias the use of new ser...
Article
Full-text available
As a consequence of the COVID-19 emergency, frail citizens felt isolated because of social isolation, suspended and/or strongly reduced home assistance, and limited access to hospitals. In this sense, assistive technology could play a pivotal role in empowering frail older adults reducing their isolation, as well as in reinforcing the work of forma...
Chapter
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Background: Autism spectrum disorder (ASD) is a category of neurodevelopmental disorder characterized by persistent deficits in social communication and social interaction across multiple contexts as well as restricted, repetitive patterns of behaviour, interests, or activities. Social robots offer clinicians new ways to interact and work with peop...
Article
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Socially Assistive Robots (SARs) are designed to support us in our daily life as a companion, and assistance but also to support the caregivers’ work. SARs should show personalized and human-like behavior to improve their acceptance and, consequently, their use. Additionally, they should be trustworthy by caregivers and professionals to be used as...
Chapter
Technology plays an important role into the life of older people. With the increase of age, they are experiencing physical and cognitive frailties and they require assistance for the management of their daily activities. In this sense, digital technologies could offer a holistic ecosystem which could empower their daily life 24 h decreasing the car...
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Our study aims to investigate the relationship between medial temporal lobe atrophy (MTA) score, assessed by computed tomography (CT) scans, and functional impairment, cognitive deficit, and psycho-behavioral disorder severity. Overall, 239 (M = 92, F = 147; mean age of 79.3 ± 6.8 years) patients were evaluated with cognitive, neuropsychiatric, aff...
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Background: The study aim was to review the evidence and effectiveness of psychological interventions applied during Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) pandemic. Methods: A literature search was run from April 2020 to April 2021. The inclusion criteria were: (1) RCTs or observational studies; (2) professional health car...
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Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has led to an increasing demand for online psychological intervention. The aim of this study is to evaluate the efficacy of received support in internet-based psychological intervention group (I-IG) patients, compared with a wait-list control group (CG). The Impact of Event Scale—Revised,...
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Background: The emotional experiences of healthcare workers during the first wave of COVID-19 warrant further investigation especially regarding gender differences. The purpose of this study was to determine the relationship between gender role, job role and risk and protective factors for the development of Post Traumatic Stress Disorder (PTSD). M...
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Background: Emotion recognition skills are predicted to be fundamental features in social robots. Since facial detection and recognition algorithms are compute-intensive operations, it needs to identify methods that can parallelize the algorithmic operations for large-scale information exchange in real time. The study aims were to identify if trad...
Article
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Background Information and communication technology solutions have the potential to support active and healthy aging and improve monitoring and treatment outcomes. To make such solutions acceptable, all stakeholders must be involved in the requirements elicitation process. Due to the COVID-19 situation, alternative approaches to commonly used face-...
Article
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Background: The Pilots for Healthy and Active Ageing (PHArA-ON) project aimsto ensure reality smart and active living for Europe's ageing population by creating a set of integrated and highly customizable interoperable open platforms with advanced services, devices, and technologies and tools. The aim of the present study was to determine the need...
Book
Full-text available
Sarcopenia is an important recently defined disease affecting people aged ≥65 years all over the world. Improving the assessment of loss of muscle mass is becoming mandatory. In this regard, various new technologies have been advanced. Although the gold standard is represented by magnetic resonance imaging (MRI) or magnetic resonance spectroscopy (...
Article
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Social companion robots are getting more attention to assist elderly people to stay independent at home and to decrease their social isolation. When developing solutions, one remaining challenge is to design the right applications that are usable by elderly people. For this purpose, co-creation methodologies involving multiple stakeholders and a mu...
Article
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Introduction. Telepresence provides clinicians the ability to monitor patients as well to communicate with all the members of the healthcare staff. Covid-19 Units cope with high complexity in providing care and an integration amount the care team and the patients’ relatives should be carried out to obtained successful outcomes and preventing compli...
Conference Paper
COVID-19 pandemic represents a massive global emergency which can put a strain on our ability to cope with stressful and traumatic events. Healthcare professionals are exposed to various stressors which could affect their psychological well-being. The aim of this study is to evaluate the psychological impact of COVID-19 on healthcare workers, ident...
Article
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Background: Alzheimer's disease (AD) may be a vascular disorder with neurodegenerative consequences opening possibility of preventing AD by targeting vascular risk factors including homocysteine. Objective: The study aims were to assess homocysteine distribution in different forms and severity of cognitive impairment (CogI) [mild cognitive impai...
Article
Natural products and their structural analogues have historically made a major contribution to pharmacotherapy, especially for cancer and infectious diseases. Nevertheless, natural products also present challenges for drug discovery, such as technical barriers to screening, isolation, characterization and optimization, which contributed to a declin...
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Crocus sativus L. (saffron) appears to own neuroprotective effects on cognitive impairment in patients with Alzheimer’s disease (AD). The purpose of this work is to review evidence and mechanisms of saffron-induced therapeutic outcomes and measureable cognitive benefits in AD. The literature was reviewed, and preclinical and clinical studies were...
Chapter
The main topic is the promotion of active and healthy ageing (AHA) through the use of appropriate nutrients or diets. AHA is one of the societal challenges we will be facing in the upcoming decades with an impact on society and economy. Nutrients and nutraceuticals may be used to improve health, supporting the functions of the body, improving the c...
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To increase the usage of assistive robots into daily life it is important to include end-users in early development stages. This paper propose an iterative co-creative method to refine the design of an assistive robot called ASTRO. Three co-creation sessions were organized involving a total of 102 individuals. This paper presents the feedback colle...
Chapter
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Aging is a complex and dynamic process. Senses become less sophisticated and negative life events increase. These factors combined with medical conditions contribute to develop a degenerative functional autonomy of the elderly. This clinical condition is known as frailty. However, there is a difference in the way people live their silver years in t...
Article
Objectives Few studies have analyzed factors associated with delirium subtypes. In this study, we investigate factors associated with subtypes of delirium only in patients with dementia to provide insights on the possible prevention and treatments. Design This is a cross-sectional study nested in the “Delirium Day” study, a nationwide Italian poin...
Article
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Background: Serotoninergic pathways underlying delusion symptoms in Alzheimer's disease (AD) have not been fully clarified. 5-Hydroxytryptamine transporter gene-linked polymorphic region (5-HTTLPR) is a variable number tandem repeats in the promoter region of serotonin transporter encoding-gene affecting transcription. Methods: We investigated t...
Article
Alzheimer's disease (AD) is a progressive neurodegenerative pathology affecting milions of people worldwide associated with deposition of senile plaques. While the genetic and environmental risk factors associated with the onset and consolidation of late onset AD are heterogeneous and sporadic, growing evidence also suggests a potential link betwee...
Conference Paper
Aging society is characterized by a high prevalence of sarcopenia, which is considered one of the most common health problems of the elderly population. Sarcopenia is due to the age-related loss of muscle mass and muscle strength. Recent literature findings highlight that the Tinetti Balance Assessment (TBA) scale is used to assess the sarcopenia i...
Article
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Being a transcription factor, NF-κB regulates gene expressions involving cell survival and proliferation, drug resistance, metastasis, and angiogenesis. The activation of NF-κB plays a central role in the development of inflammation and cancer. Thus, the down-regulation of NF-κB may be an exciting target in prevention and treatment of cancer. NF-κB...
Article
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Background/aim Technological solutions can support the elderly, improve their quality of life and reduce isolation and loneliness. The Euro-Japan ACCRA (Agile Co-Creation for Robots and Aging) project has the objective of building a reference co-creation methodology for the development of robotic solutions for ageing. The aim of this study is to pr...
Article
Phosphodiesterases (PDEs) consisted of 11 subtypes (PDE1 to PDE11) and over 40 isoforms that regulate levels of cyclic guanosine monophosphate (cGMP) and cyclic adenosine monophosphate (cAMP), the second messengers in cell functions. PDE inhibitors (PDEIs) have been attractive therapeutic targets due to their involvement in diverse medical conditio...
Article
Background: More than 70% of elderly people age 80 and older are experiencing problems in personal mobility. Assistive robotics can represent a concrete support providing also a support for caregivers, clinicians, and nurses by reducing their burden. Methods: A total of 20 older people and 34 caregivers (formal and informal) were interviewed in It...
Article
The current study focuses on the short-term effect of MARIO, a social robot, on quality of life, depression, and perceived social support in persons with dementia (PWD) and evaluates their acceptability of MARIO. Ten PWD in one nursing home took part in a 4-week pilot study, where each participant had up to 12 sessions with MARIO. Sessions comprise...
Article
Background & aims: The literature regarding enteral nutrition and mortality in older frail people is limited and still conflicting. Moreover, the potential role of comprehensive geriatric assessment is poorly explored. We therefore aimed to investigate whether the Multidimensional Prognostic Index (MPI), an established tool that assesses measures...
Article
Full-text available
Background: Insomnia seems to be related to disability, risk of injury, metabolic syndrome, risk for cardiovascular diseases, cognitive impairment, depression and impaired quality of life. Objectives: The goals in this paper was (1) to keep track of technological concepts and approaches to improve insomnia in elderly people, and (2) to define the e...
Article
Background: In the EU funded MARIO project, specific technological tools are adopted for the people living with dementia (PLWD). In the final stage of the project, a validation of the MARIO companion robot was performed from August to October 2017. Objective: The aims of the present study are: 1) to illustrate the key results and evidence obtain...
Chapter
ViTA (Virtual Training for Aging) is an experimental system that aims to strengthen the memory of the people who suffer the first symptoms of dementia and feel the risk of losing their ability to recall significant events in their lives due to the progression of the disease. ViTA exploits concepts of the reminiscence and behavioral therapies to imp...
Chapter
In the EU funded MARIO project, specific technological tools are adopted for the patient with dementia (PWD). At this stage of the project, the experimentation phase is under way, and the first two trials were completed as shown below: the first trial was performed in November 2016, and second trial was performed in April 2017. The current implemen...
Chapter
The mission of ACCRA (Agile Co-Creation for Robots and Aging) is to enable the development of advanced ICT Robotics based solutions for extending active and healthy aging in daily life by defining, developing and demonstrating an agile co-creation development process. ACCRA project consists of three robotic applications which aim to promote the ind...
Chapter
In the EU funded MARIO project, specific technological tools are adopted for the patient with dementia (PWD). In the final stage of the project, two trials were completed as shown below: first trial was performed in September 2017, and second trial was performed in October 2017. The implemented and assessed applications (apps) are My Music app, My...
Chapter
Robots can be key players in the healthcare digital revolution that is underway. More specifically, assistive robots are going to profoundly affect the way healthcare is delivered. In the research and commercial field, robotic technologies have been used for physical and cognitive rehabilitation, surgery, telemedicine, drug delivery, and patient ma...
Book
Aging well and actively is the real objective of human being. This book is an up-to-date and realistic view on physiopathological mechanisms of aging and age-related diseases. The book includes topical contributions from multiple disciplines to support the fundamental goals of extending active life and enhancing its quality.
Article
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Background/aim: The aim of the study was to evaluate the prognostic power of late-life depression (LLD) compared with amnestic mild cognitive impairment (aMCI) for the onset of Alzheimer's disease (AD) within 4 years of follow-up. Methods: We estimated the incidence of AD in 60 patients presenting with aMCI, 115 patients suffering of LLD treated...
Article
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Introduction Worldwide population is getting older. The older persons want to stay independent and wish to increase their engagement in social activities to tackle loneliness, depression, and isolation. Starting from these assumptions, we developed the ACCRA project (Agile Co-Creation for Robots and Aging) with the aim to enable the development of...
Article
This study aimed to identify and describe the fundamental characteristics of spoken dialogue systems and their role for supporting human-robot interaction and enabling the communication between socially assistive robots and patients with dementia. Firstly, this work provides an overview of spoken dialogue systems, by considering the underlying tech...
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Full-text available
Abnormalities of water homeostasis can be early expressions of neuronal dysfunction, brain atrophy, chronic cerebrovasculopathy and neurodegenerative disease. The aim of this study was to analyze the serum osmolality of subjects with cognitive impairment. One thousand and ninety-one consecutive patients attending the Alzheimer’s Evaluation Unit wer...
Article
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Healthy and impaired cognitive aging may be associated to different prevalences of single-nucleotide polymorphisms (SNPs). In a multicenter case-control association study, we studied the SNPs rs11136000 (clusterin, CLU), rs541458 (phosphatidylinositol binding clatrin assembly protein, PICALM), and rs1554948 (transcription factor A, and tyrosine kin...
Article
Alzheimer's disease (AD) and vascular dementia (VaD) lead to progressive decline in executive function. We estimated the prevalence of executive dysfunction in AD and VaD patients, investigating cognitive, functional, and clinical correlates and also using a multidimensional approach based on a standardized comprehensive geriatric assessment (CGA)....
Conference Paper
In the frame of the European Community funded MARIO, caregivers of 139 dementia patients were recruited in National University of Ireland (NUIG), in Geriatrics Unit of IRCCS “Casa Sollievo della Sofferenza”-Italy (IRCCS) and in Alzheimer Association Bari-Italy (AAB) for a multicenter survey on to determine the needs and preferences of caregivers fo...
Article
Full-text available
Background: Among various solutions to aid the aging population, the research community is focusing on assistive robotics that may help to delay admission to care facilities by fostering independence of older people in their homes. This paper presents the Robot-Era project and experimentation aimed at investigating 1) the psychological attitude of...
Article
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Background: In older patients depression and atherosclerosis can occur. The aim of the present study was to determine whether late-life depression (LLD) is associated with presence of carotid atherosclerosis, and to assess the direct proportionality between carotid atherosclerosis and depression severity.
Article
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Physical frailty and cognitive frailty are two important targets of secondary intervention in aging research to narrow the gap between life and health span. The objective of the present narrative review was to examine clinical and epidemiological studies investigating the recently proposed construct of cognitive frailty and its subtypes, with a foc...
Article
Full-text available
Background: Although it is well known that Alzheimer's disease (AD) is associated with the progressive accumulation of amyloid β-peptide (Aβ) in the human brain, its pathogenic role has yet to be completely clarified. Aβ moves from the blood-brain barrier to the plasma and an increased Aβ production in brain could be associated with higher Aβ conc...
Article
Introduction: Late-life psychiatric and neurological disorders (LLPND) are interesting models to understand the potential role of pharmacogenetics in drug management, since several pharmacological approaches for treating LLPND have proven to be ineffective or deleterious, thus resulting in therapeutic failures (TF) and adverse drug reactions (ADR)...
Article
Neurodegenerative diseases (NNDs) such as Alzheimer's and Parkinson's diseases are the most common age-related pathologies that affect millions of people all over the world. To date, effective therapy for NNDs is not available and current approaches to disease management include neuroprotection strategy with a hope of maintaining and enhancing the...
Chapter
Full-text available
Skeletal muscle is not only an endocrine organ but also one of core components of mus-closkeletal system. Sarcopenia refers to a decline in the skeletal muscle mass and function. The former involves the size and number of changes in two types of myofibers, lower satellite cell density, and regeneration ability. The latter shows a loss of muscle str...
Conference Paper
Cognitive Stimulation aims to improve cognitive skills and quality of life for people with dementia by helping to reduce the functional disability resulting from damage to the brain. Recent studies suggest that this kind of treatment is effective, but it is not yet possible to demonstrate that leads to changes in behavior or in the patient’s lifest...
Article
Full-text available
The aim of the present study was to assess systematically gender differences in susceptibility to frailty and cognitive performance decline, and the underlying mechanisms. A systematic assessment was performed of the identified reviews of cohort, mechanistic and epidemiological studies. The selection criteria of the present study included: i) Sexua...
Conference Paper
The mission of ACCRA (Agile Co-Creation for Robots and Aging) is to enable the development of advanced ICT Robotics based solutions for extending active and healthy aging in daily life by defining, developing and demonstrating an agile co-creation development process. ACCRA project consists of three robotic applications which aim to promote the ind...
Chapter
Alzheimer disease (AD) is a complex and progressive neurodegenerative disease. AD is one of the greatest challenges to modern medicine because multiple pathogenetic factors are associated with this disease. The current pharmacologic treatment offers limited symptomatic benefits. Due to the multifactorial etiology, dedicated search for new molecules...
Article
Full-text available
Background: Maintaining independent mobility is fundamental to independent living and to the quality of life of older people. Robotic and sensor technologies may offer a lot of potential and can make a significant difference in the lives of older people and to their primary caregivers. Aim: To provide a presentation of the methods that are used...
Conference Paper
In the frame of the European Community funded MARIO, caregivers of 139 dementia patients were recruited in National University of Ireland (NUIG), in Geriatrics Unit of IRCCS “Casa Sollievo della Sofferenza”-Italy (IRCCS) and in Alzheimer Association Bari-Italy (AAB) for a multicenter survey on to determine the needs and preferences of caregivers fo...
Conference Paper
Diabetes represents one of most serious public health disease. The aim of the Metabolink project was to develop a smart solution for elderly people with diabetes and obesity, in order to promote a healthier style of life, improve diabetic control trying to reduce overall cost for the community. It consists of an app for smartphone linked to a syste...
Article
Background: Significant innovations have been introduced in recent years in the application of information and communication technologies (ICTs) to support healthcare for patients with dementia. Objective: In the present systematic review, our goal is to keep track of ICT concepts and approaches to support the range of activities of daily living...
Chapter
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Background: It is known that caring in AlzUeimer's disease (AD) patients amplifies caregiver burden significantly. The aim of this study was to evaluate the efficacy of the Comprehensive
Article
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Klotho protein, encoded by the Klotho gene (KL) at locus 13q12, is an antiaging hormone-like protein playing a pivotal role in cell metabolism homeostasis and associated to longevity and age-related diseases. In particular, altered cell metabolism in central nervous system may influence the behavior of serotoninergic neurons. The role of KL in the...