Gozde Erturk Zararsız

Erciyes Üniversitesi · Department of Biostatistics and Medical Informatics

As the most readily adopted molecular screening test, low-pass WGS of maternal plasma cell-free DNA for aneuploidy detection generates a vast amount of genomic data. This large-scale method also allows for high-throughput virome screening. NIPT sequencing data, yielding 6.57 terabases of data from 187.8 billion reads, from 12,951 pregnant Turkish w...

Several studies have shown a high prevalence of dyslipidemia in children. Since childhood lipid concentrations continue into adulthood, recognition of lipid abnormalities in the early period is crucial to prevent the development of future coronary heart disease (CHD). Low density lipoprotein cholesterol (LDL-C) is one of the most used parameters in...

Background: Aging is a process that includes progressive physiological changes. Grip strength is an important indicator of current health in the elderly. Objective: The aim of the study was to examine the correlation between dominant-hand grip strength (HGS) and cognitive function, mid-upper arm circumference, muscle-bone mass, balance, mobility...

Background Due to overdispersion in the RNA-Seq data and its discrete structure, clustering samples based on gene expression profiles remains a challenging problem, and several cluster-ing approaches have been developed so far. However, there is no “gold standard” strategy for clustering RNA-Seq data, so alternative approaches are needed. Objectiv...

This is a single-center prospective, open-label, single arm interventional study to test the safety and efficacy of recently described ChipEXO™ for severe COVID-19 pneumonia. The ChipEXO™ is a natural product derived from convalescent human immune plasma of patients recovered from moderate COVID-19 infection. In September 2021, 13 patients with pen...

Gene expression studies have been studied using microarray data for many years, and numerous methods have been developed for these data. However, microarray technology is old technology and has some limitations. RNA-Seq is a new transcriptomics technique capable of coping with these limitations, using the capabilities of new generation sequencing t...

Gene-expression studies have been studied using microarray data for many years, and numerous methods have been developed for these data. However, microarray technology is old technology and has some limitations. RNA-sequencing (RNA-seq) is a new transcriptomics technique capable of coping with these limitations, using the capabilities of new genera...

With the recent advances in molecular biology techniques such as next-generation sequencing, mass-spectrometry, etc., a large omic data is produced. Using such data, the expression levels of thousands of molecular features (genes, proteins, metabolites, etc.) can be quantified and associated with diseases. The fact that multiple omics data contains...

Background Circulating tumor cells represent an opportunity for the assessment of early recurrent disease or for real-time tracing of cancer. Glucose Regulated Protein 78 ( GRP78 ) is known in the literature as a stress factor in endometrial cancer. We aimed to investigate the importance of the gene by targeting tumor traces circulating in the cell...

Background: Neonatal cholestasis is caused by a group of diseases that cause jaundice, which can be encountered in the neonatal period. Biliary atresia (BA) and idiopathic neonatal hepatitis (INH) are among neonatal cholestasis diseases. Aims: The aim of this study was to perform histopathological and ultra-structural examinations of liver biops...

Amaç: Bu çalışmada amaç; diyafram kalınlığının weaning üzerine etkilerini ultrasonografi (USG) ile değerlendirmektir. Gereç ve Yöntem: Prospektif olarak yapılan bu çalışmada; hastaların demografik özellikleri, yoğun bakıma yatış ve mekanik ventilasyon endikasyonları, ek hastalıkları, diyafram kalınlığı, Sıralı Organ Yetmezliği Değerlendirmesi (SOFA...

Familial Mediterranean fever (FMF) is a monogenic autoinflammatory disorder with recurrent fever, abdominal pain, serositis, articular manifestations, erysipelas-like erythema, and renal complications as its main features. Caused by the mutations in the MEditerranean FeVer (MEFV) gene, it mainly affects people of Mediterranean descent with a higher...

Background: This study aimed to investigate the effect of the Cystatin C based model on kidney function and the value of this model on predicting mortality in patients with the recent novel coronavirus disease (COVID-19). Methods: Demographic characteristics, clinical manifestations, and laboratory measurements were measured in critically ill patie...

Objective:To know cultural characteristics of infant sleep pattern and guide the families can be useful to prevent sleep problems. The aim of this study to determine the sleep habits during infancy and to evaluate the effectiveness of sleep training.Materials and Methods:This longitudinal study included 127 healthy infants. Infants were randomly as...

Background Low-density lipoprotein cholesterol (LDL-C) is an important biomarker for determining cardiovascular risk and regulating lipid lowering therapy. Therefore, the accurate estimation of LDL-C concentration is essential in cardiovascular disease diagnosis and prognosis. Sampson recently proposed a new formula for the estimation of LDL-C. How...

Purpose This study aimed to validate different low-density lipoprotein cholesterol (LDL-C) estimating equations in the Turkish population, composed of children and adolescents. Methods In this study at Sivas Cumhuriyet University Hospital in Sivas (Turkey), a total of 3,908 children under the age of 18 were included. LDL-C was directly measured by...

Purpose This study aimed to validate different low-density lipoprotein cholesterol (LDL-C) estimating equations in the Turkish population, composed of children and adolescents. Methods In this study at Sivas Cumhuriyet University Hospital in Sivas (Turkey), a total of 3,908 children under the age of 18 were included. LDL-C was directly measured by...

Background: Late-life depression is a geriatric syndrome which should be taken seriously. Many clinical scales have been developed for the screening of geriatric depression. Most of these have been validated at different times and in diverse populations. A five-question version of the Geriatric Depression Scale (GDS-5) was developed in 1997. This...

Background Low-density lipoprotein cholesterol (LDL-C) is an important biomarker for determining cardiovascular risk and regulating lipid lowering therapy. Therefore, the accurate estimation of LDL-C concentration is essential in cardiovascular disease diagnosis and prognosis. Sampson recently proposed a new formula for the estimation of LDL-C. How...

Background/aim: PSORTAKSIS is a psoriasis registry, is used for follow-up of patients in Kayseri City Education and Research Hospital, Dermatology Clinic since 2016 in Turkey. PSORTAKSIS includes demographic data, follow-up clinical findings, laboratory output, and treatment information of patients. Here, drug survivals of biologic therapeutics (B...

Background: Polypharmacy and adverse drug side effects are among the high-risk causes for falls in older adults. Objective: To assess the association between polypharmacy and the risk of recurrent falls and different pharmacological groups of drugs with falls. Setting: University hospital in community-dwelling older adults in Turkey. Method: Falls...

Practices for the evaluation and treatment for people with aphasia (PWA) is dominated by an impairment-based view of aphasia. The number of aphasia evaluation tools adapted or developed to reflect PWA's perspective in Turkish is limited. Aphasia Impact Questionnaire-21 (AIQ-21), a tool developed based on the social model of disability, measures the...

Oropharyngeal dysphagia has features of geriatric syndromes and is strongly associated with sarcopenia. In this cross-sectional study, we aimed to evaluate the association between dysphagia and sarcopenia, in a practical way, accompanied by comprehensive geriatric assessment. Dysphagia and sarcopenia were defined by the EAT-10 and SARC-F questionna...

Introduction Arteriovenous fistula (AVF) stenosis is one of the most important clinical problems in hemodialysis patients. The histopathological findings of neointimal hyperplasia and impaired angiogenesis have been well established in stenotic AVFs. Soluble vascular endothelial growth factor receptor‐1 (sVEGFR‐1) has been implicated in pathologica...

The aim of this study was to examine the association between sleep duration and frailty in community-dwelling Turkish older adults and to determine whether this association varies depending on gender. A cross-sectional study was conducted from August 2013 to December 2013 with 905 individuals, representative of the aged population ≥ 60 years in com...

Objective: The aim of this study was to invastigate the effect of body mass index (BMI) on semen parameters and reproductive hormone levels in infertile males. Material and methods: Overall, 858 infertile male patients, aged between 18 and 55 years, referred to our infertility clinic were included in the study. Patients without risk factors, bes...

Introduction: Aim of this study was identify the prevalence of frailty in patients with idiopathic Parkinson's disease (PD), to describe the relationship between severity of the disease and frailty, and to evaluate if timed up and go (TUG) is an eligible test for determination of frailty in idiopathic PD patients. Methods: We conducted a cross-s...

Background/aim To assess sarcopenia and dynapenia and their relationship with disease severity and disabilities in PD and to state body composition in PD. Methods We conducted a case–control, cross-sectional study that included 70 patients with idiopathic PD and 85 controls. Sarcopenia was defined according to the European Working Group on Sarcope...

Background and objective: In the last decade, RNA-sequencing technology has become method-of-choice and prefered to microarray technology for gene expression based classification and differential expression analysis since it produces less noisy data. Although there are many algorithms proposed for microarray data, the number of available algorithm...

Boron plays roles in the metabolism of calcium, vitamin D, steroid hormones, healthy bone development, and maintenance of cell membranes. The biological effects of boron are dose-dependent but follow a U-shaped pattern, rendering it important to define the active range. The studies of Bahadoran et al. on rats and Naghii et al. on humans showed that...

The effectiveness of using a face mask with a small diffuser for oxygen delivery (OxyMask) was compared to use of a high-flow nasal cannula (HFNC) in patients with moderate or severe bronchiolitis.The study population in this open, phase 4, randomized controlled trial consisted of 60 patients aged 1-24 months diagnosed with moderate or severe bronc...

RNA sequencing (RNA-Seq) is a powerful technique for thegene-expression profiling of organisms that uses the capabilities of next-generation sequencing technologies.Developing gene-expression-based classification algorithms is an emerging powerful method for diagnosis, disease classification and monitoring at molecular level, as well as providing p...

RNA sequencing (RNA-Seq) is a powerful technique for thegene-expression profiling of organisms that uses the capabilities of next-generation sequencing technologies.Developing gene-expression-based classification algorithms is an emerging powerful method for diagnosis, disease classification and monitoring at molecular level, as well as providing p...

RNA sequencing (RNA-Seq) is a powerful technique for the gene-expression profiling of organisms that uses the capabilities of next-generation sequencing technologies. Developing gene-expression-based classification algorithms is an emerging powerful method for diagnosis, disease classification and monitoring at molecular level, as well as providing...

All figures for simulation results. (ZIP)

MLSeq package source. (ZIP)

Simulation R codes. (ZIP)

Computational infrastructure. (DOCX)

Computational costs of classifiers. (DOCX)

Objective Parkinson's Disease Caregivers (PDC) play an important role, especially in the medium and advanced phase of the disease for patients’ daily life activities, treatment, and follow‐up. The aim of this study is to attract attention to the factors which place PDC at risk of psychological problems and to give consideration to these factors. M...

Objective: As in adults, hypertension is also an important risk factor for cardiovascular disease in children. We aimed to evaluate the effect of sleep duration on blood pressure in normal weight Turkish children aged between 11-17 years. Methods: This cross-sectional study was conducted in the primary and secondary schools of the two central an...

Introduction . Only a few studies have been conducted to determine the level of knowledge among caregivers about Parkinson’s disease (PD). The aim of the current study was to determine the knowledge of PD among caregivers at a movement disorder clinic in Turkey. Methods . We conducted a questionnaire based interview with the subjects in a tertiary...

Background RNA sequencing (RNA-Seq) is a powerful technique for transcriptome profiling of the organisms that uses the capabilities of next-generation sequencing (NGS) technologies. Recent advances in NGS let to measure the expression levels of tens to thousands of transcripts simultaneously. Using such information, developing expression-based clas...

Questionnarie: There is ten questions about PD, one about epidemiology, three on symptoms and seven on treatment. Correct answers are in bold letters.

Objective: To evaluate the relation between nephrin levels and preeclampsia severity by comparing serum and urine levels of nephrin in the severe and mild groups according to severity of associated intrauterine growth retardation (IUGR) development. Methods: A total of 150 patients who attended our ante-natal clinic (ANC) were included in this s...