Goutam Brahmachari

Goutam Brahmachari
Visva Bharati University · Department of Chemistry

M.Sc. (1st Classs 1st) PhD (Chem) DSc (Chem)
Teaching and Research at the university level. Open to potential collaborative works with novel organic molecules.

About

442
Publications
100,676
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4,324
Citations
Citations since 2017
214 Research Items
2943 Citations
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20172018201920202021202220230100200300400500
20172018201920202021202220230100200300400500
Introduction
Full Professor of Organic Chemistry Fellow, Royal Society of Chemistry (FRSC) INSA Teachers Awardee-2019, CRSI Bronze Medal-2021, Dr. Basudev Banerjee Memorial Award-2021 (Indian Chem Soc), Featured among the Top2% Scientists-2020, 2021, 2022 in the world (Organic Chemistry Category), AD Scientific- 2022, 2023 Elsevier Series Editor: Natural Product Drug Discovery Life Member: ISCA, IACS, CRSI Co-editor-in-chief: Current Green Chemistry Advisory Board: Tetrahedron Green Chemistry
Additional affiliations
December 1998 - November 2015
Visva Bharati University
Position
  • Full Professor of Organic Chemistry
December 1998 - present
Visva Bharati University
Position
  • Professor (Full)

Publications

Publications (442)
Article
This research deals with the interaction of a synthetic bio-relevant drug-molecule with fullerene like nanocages specifically C24 and B12N12 to explore their potential as carrier in drug delivery systems. The efficacy of C24 and B12N12 nanocages as an effective drug career has been investigated by computing electronic and geometrical properties alo...
Book
Biotechnology of Microbial Enzymes: Production, Biocatalysis, and Industrial Applications, Second Edition provides a complete survey of the latest innovations on microbial enzymes, highlighting biotechnological advances in their production and purification along with information on successful applications as biocatalysts in several chemical and ind...
Article
A straightforward and efficient electrochemical method for regioselective C(sp2)-H selenylation and sulfenylation of substituted 2-amino-1,4-naphthoquinones has been unearthed. This oxidative cross-coupling reaction avoids using transition metal catalysts, oxidants, and high temperatures. The other notable advantages of this protocol are the tolera...
Poster
Full-text available
Result_Doctor of Science (DSc)_Prof. Goutam Brahmachari
Article
This communication is devoted to the X-ray diffraction study of a single crystal of the compound N'-acetyl-4-formyl-N'-phenylbenzohydrazide. The compound crystallizes in the triclinic space group P . The crystal structure has been solved by direct methods and refined by full matrix least squares procedure to a final R value of 0.0855 for 1886 refle...
Article
A biologically promising new molecule, 3-(benzylthio)-4-hydroxy-2H-chromen-2-one has been synthesized following visible light-induced protocol in the presence of singlet molecular oxygen. Its detailed spectral properties and X-ray crystal structure are studied. The crystal structure is solved by direct method and refined to a final R value of 0.070...
Poster
Receiving Dr. Basudev Banerjee Memorial Award-2021 nominated by the Indian Chemical Society. (http://indianchemicalsociety.com/uploaded_files/List%20of%20the%20various%20Endowment%20Awards%20and%20the%20previous%20Awardees%20of%20the%20respective%20Awards.pdf)
Article
A photochemical method based on visible‐light (white LEDs/sunlight) irradiation has been developed for the regioselective and oxidative C(sp2)‐H selenylation and sulfenylation of substituted 2‐amino‐1,4‐naphthaquinones at an oxygen atmosphere. The photochemical process does not require any external photoredox catalysts. The other notable advantages...
Article
The present communication deals with the conformational, vibrational spectroscopic analysis and molecular docking study of an important biore-levant molecule namely 5-Chloro-2-hydroxy-N-isobutyl-3-oxo-2,3-dihydro-benzofuran-2-carboxamide. We have recorded FTIR spectrum of the target molecule in the spectral range of 4000-400 cm À1 and this has been...
Poster
Awarded 'CRSI BRONZE MEDAL-2021' by the Chemical Research Society of India (CRSI) in recognition of significant contribution to chemistry research https://crsi-india.org/bronze-medal-winners-for-the-period-2000-2021/
Poster
INSA Teachers Award -2019, a Nation Level Teachers Award, was awarded to Prof. Goutam Brahmachari by Indian National Science Academy (INSA) for his significant contribution to society in guiding, inspiring, and mentoring students to take up careers in Science and Technology. https://www.indiascienceandtechnology.gov.in/listingpage/saluting-teacher...
Poster
Full-text available
September 2022 data-update for "Updated science-wide author databases of standardized citation indicators" Published: 10 October 2022 Version 4 | DOI: 10.17632/btchxktzyw Contributor: John P.A. Ioannidis https://elsevier.digitalcommonsdata.com/datasets/btchxktzyw/4
Article
The 3-(cyclohexylthio)-4-hydroxy-6-methyl-2H-chromen-2-one (mf. C16H18O3S), a biologically relevant new version of organo-sulfur compounds, has been synthesized Its detailed spectral properties and X-ray crystal structure are studied. The crystal structure was solved by direct method and refined by full matrix least squares procedure to final R val...
Article
Full-text available
N'-Acetyl-N'-phenyl-2-naphthohydrazide, a biologically relevant organic molecule, was synthesized following a reported method and characterized based on its single X-ray crystallographic studies. The present manuscript deals with its detailed molecular interactions and X-ray crystal structure. Its space group is P-1 with the following unit cell par...
Chapter
Organophosphorus chemistry is a broad and exciting field, with potential opportunities for researchers involved in multi-disciplinary areas of scientific endeavour, including organic, medicinal, pharmaceutical, agricultural, and industrial chemistry. Organophosphorus compounds find extensive applications in all these fields owing to their inherent...
Article
Full-text available
A one-pot room-temperature-based three-component reaction strategy has been accomplished to access a new series of bio-relevant barbituric/2-thiobarbituric acid hydrazones from the reaction between barbituric/2-thiobarbituric acids, primary aromatic amines, and tert-butyl nitrite in an acetonitrile solvent, without the aid of any catalysts/additive...
Article
Benzo‐oxepines and dibenzo‐oxepines, a unique class of naturally occurring secondary metabolites, are distributed mainly in plants and fungi and have received much attention from phytochemists and biologists based on their fascinating structural features and health‐promoting functions. This review summarizes 100 oxepine derivatives comprising three...
Article
The design and development of eco-friendly procedures for synthesizing organic compounds is an essential key to synthetic chemistry and has gained significant interest. The catalysts increase the rate of chemical reactions with additional advantages such as reduced energy input, diminished environmental impact, and overall financial benefit. The co...
Article
Organophosphorus chemistry is an exciting field of research. Phosphorus-functionalized organic molecules find practical and useful applications in such diverse areas as medicinal, pharmaceutical, agrochemical, and materials chemistries, both on laboratory and industrial scales. Green-chemistry principles are motivating the design and development of...
Article
Full-text available
Synthetic and modified natural derivatives are reported as potential bioactive compounds and are being used therapeutically against various diseases in a widespread manner nowadays. Cancerous cells exhibit high levels of reactive oxygen species (ROS) internally, and thus successfully manage to sustain themselves and proliferate via antioxidative me...
Article
Background Type 1 Diabetes mellitus initiates by loss of pancreatic activity which affects other major organs leading to multi-organ failure. Lupeol, a novel phytochemical, is emerging as a potent bioactive molecule. However, the effect of lupeol on hyperglycaemia is not clearly understood. This study delivers an elaborate vision towards the detail...
Article
A dual synthetic strategy based on visible-light (white LEDs/direct sunlight) irradiation and electrosynthesis has been explored for the regioselective cross-dehydrogenative C(sp2)-H sulfenylation and selenylation of substituted benzo[a]phenazin-5-ols at oxygen atmosphere under mild reaction conditions. The photochemical process does not require an...
Article
We performed optimization of a bio-relevant molecule N-Allyl-2-hydroxy-5-methyl-3-oxo-2, 3-dihydrobenzofuran-2-carboxamide and its monohydrate cluster in the isolated form. Potential energy scanning for the target molecule was carried out. Consequently, three stable conformers were obtained. The effect of interfusion of a water molecule on energy...
Article
A bio relevant organo sulfur compound, 3-(sec-butylthio)-4-hydroxy-2H-chromen-2-one (mf. C13H14O3S) has been synthesized following a visible light-induced green protocol in the atmosphere of oxygen. Its detailed spectral properties and X-ray crystal structure were studied. Crystal structure was solved by direct method and refined by full matrix lea...
Article
As a dual approach, we herein disclose electrochemical and mechanochemical methods for the efficient and straightforward synthesis of a new series of functionalized dihydrofuro[3,2-c]chromenones using warfarin analogues. Both processes involve intramolecular direct Csp3–H cross-dehydrogenative oxygenation within the warfarin framework. The notable...
Article
Adenosine 5’-triphosphate (ATP) is the major energy currency of living cells and its efficient real-time monitoring in vivo has increased the demand for the development of fluorescent chemosensors. For the prompt detection of ATP in submolar range, we have developed an easily accessible colorimetric and fluorescence probe 4-(Di-p-tolylphosphoryl)-7...
Article
A metal-free sequential amidation and intramolecular direct Csp2−H amination of coumarin-3-carboxylic acids has been achieved under ambient conditions, resulting in a new series of biologically interesting chromenopyridopyrimidine-derived polyfunctional heterocycles. The DFT study offers mechanistic insights into this transformation. The salient fe...
Article
Full-text available
Glycogen phosphorylase kinase (PhK) converts by phosphorylation, the inactive glycogen phosphorylase (GPb) into active GPa in the glycogenolytic pathway. It is a complex enzyme comprising of the catalytic (γ) and three regulatory subunits (α, β, δ) forming a hexadecamer with stoichiometry (αβγδ)4. Several studies have indicated PhK as a promising t...
Article
A new synthetic strategy for accessing a diverse series of 2-hydroxyphenylated alpha-ketoamides has been achieved based on visible light (white LED/direct sunlight)-driven photocatalytic decarboxylative amidation of 4-hydroxycoumarins. Advantages of this new protocol include mild and energy-efficient reaction conditions, the use of dioxygen as a re...
Article
A naturally-occurring new nor-triterpenoid compound (pterocaronol; 1) has been isolated from the barks of Peltophorum pterocarpum (DC.) Backer ex K. Heyne (Fabaceae) based on its detailed spectral and single-crystal X-ray analyses. The compound crystallizes in the orthorhombic space group P 212121 with the following unit-cell parameters: a = 10.581...
Article
A biologically relevant novel molecule, isopropyl 5-chloro-2-hydroxy-3-oxo-2,3-dihydrobenzofuran-2-carboxylate (mf. C12H11ClO5) has been synthesized in the presence of molecule singlet oxygen induced by visible-light. Its detailed spectral properties and X-ray crystal structure are studied. The crystals are Triclinic, space group P-1, Z = 2. The cr...
Article
Full-text available
Twenty chromenes were synthesized with good to excellent yields (70-96%). From the series of chromenes herein tested, compounds 14, 12, 15, 16, 17, 18, and 20 were the most potent throughout the cancer human cell lines tested. In general, the para-position electron-withdrawing substituents on the phenyl ring are favored towards potency and selectiv...
Article
Full-text available
Herein we report crystallographic comparison of some geometrical and structural features for a series of biologically relevant bis-indole derivatives. Selected bond distances and bond angles of interest in a series of bis-indole derivatives have been discussed in detail. The biological activity of the substances has been correlated with based the s...
Article
Background Antiplatelet drugs represent the keystone in the treatment and prevention of diseases of ischemic origin, including coronary artery disease. The current palette of drugs represents efficient modalities in most cases, but their effect can be limited in certain situations or associated with specific side effects. In this study, representat...
Article
Full-text available
Quantum chemical calculations have been carried out to explore structural and spectroscopic properties of some derivatives of N-iso-butyl, S-2-nitro-1-phenylethyl dithiocarbamate molecule in neutral and cationic forms. Electron releasing groups (Me, OH and OMe) are considered to explore their effect on geometrical parameters, vibrational spect...
Article
The present communication deals with a straightforward, efficient and green synthesis of a series of racemic version of 3-(3-(2-hydroxyphenyl)-3-oxo-1-arylpropyl)-4-hydroxycoumarins as biologically interesting warfarin analogues upon decarboxylative hydrolysis of bis-coumarin derivatives in aqueous potassium hydroxide solution. The salient features...
Article
The indole derivative, 3,3′-((4-(trifluoromethyl)phenyl)methylene)bis(1-methyl-1H-indole), has been synthesized and characterized by elemental analyses, spectral studies (FT-IR, NMR, Mass) and its crystal structure is determined by X-ray structure analysis. Crystal structure was solved by direct method and refined by full-matrix least squares proce...
Article
A one-pot procedure for the synthesis of biologically relevant coumarin-hydrazones by a three-component reaction between 4-hydrocoumarins, primary aromatic amines and tert-butyl nitrite under ball-milling in the absence of any catalyst/additive and solvent has been developed. The mechanic force implements the Csp2-H functionalization of 4-hydroxyco...
Article
A catalyst-free practical version of Kabachnik-Fields strategy has been developed for the efficient and straightforward one-pot synthesis of diversely substituted α-aminoallylphosphonates, a limitedly reported class of biologically important α-aminophosphonates family. The protocol offers many advantages including avoidance of additive/catalyst, on...
Article
Ultrasonication, nowadays, is well-regarded as an effective green tool in implementing a plethora of organic transformations. The last decade has seen quite useful applications of ultrasound irradiation in synthetic organic chemistry. Ultrasound has already come out as a unique technique in green chemistry practice, for its inherent properties of m...
Article
This work describes the synthesis, conformational, thermodynamics and vibrational spectroscopic studies of N-n-butyl, S-2-nitro-1-(p-tolyl)ethyl dithiocarbamate, a bio-relevant sulfur molecule. A total of seven low lying energy structures of N-n-butyl, S-2-nitro-1-(p-tolyl)ethyl dithiocarbamate are theoretically predicted. The quantum chemical calc...
Article
Herein, we have evaluated the in vivo therapeutic efficacy and systemic toxicity profile of a synthetic anticancer compound [3,3′-((4-(trifluoromethyl)phenyl)methylene)bis(2-hydroxynaphthalene-1,4-dione)]. A multifunctional mesoporous silica nanoparticle (MSN) constructed drug delivery network was also fabricated which specifically showed targeting...
Article
An ultrasound assisted efficient, expeditious and environmentally benign new methodology for direct access to broad ranges of structurally interesting and pharmacologically significant spiropyrido[2,1‐b][1,3]oxazino compounds based on three component reactions approach via domino 1,4‐dipolar cycloaddition from easily available starting materials in...
Chapter
As a part of green chemistry advancements, particularly in the field of synthetic organic chemistry, the concept of self-catalytic synthesis has recently emerged. Accordingly, the last decade has seen an ongoing development in designing organic synthetic protocols without the aid of any added catalysts. Catalyst-free synthetic processes have manifo...
Chapter
4H-Pyrans and 4H-pyran-annulated heterocyclic scaffolds represent a “privileged” structural motif well-distributed in biologically active natural products and also in promising synthetic compounds in the field of medicinal, agrochemical, cosmetics, and pigment industries. It is worthy to mention that currently, a number of drug molecules bearing 4H...
Chapter
This chapter aims to offer an overview of Volume 2 of the present book and summarizes the contents and subject matter of each chapter with an intention to highlight certain glimpses of the coverage to the readers before they go in-depth.
Article
Full-text available
The present manuscript reports the synthesis, structural confirmation, thermodynamics and vibrational spec-troscopic studies of an important biorelevant molecule, named N-iso-butyl, S-2-nitro-1-phenylethyl dithiocar-bamate in the gas phase. We have found a total of five low lying energy structures of N-iso-butyl, S-2-nitro-1-phenylethyl dithiocarba...
Chapter
This chapter is aimed to offer an overview of the present book and summarizes the contents and subject matter of each chapter intending to highlight certain glimpses of the coverage to the readers before they go in-depth.
Chapter
Epothilones, a novel class of myxobacterial 16-membered natural macrolides, have proven to be highly productive lead structures for anticancer drug discovery. Epothilones exert their inhibitory activity against human cancer cell growth through the stabilization of cellular microtubules. A handful of semisynthetic and synthetic epothilone analogs ha...
Article
The cyclohexene derivative 5'-amino-4,4''-dichloro-2'-nitro-2',3'-dihydro-[1,1':3',1''-terphenyl]-4',4',6'(1'H)-tricarbonitrile-dimethyl sulfoxide has been synthesised via one-pot pseudo five component reaction and its crystal structure is determined by X-ray analysis. The crystal is triclinic and its space group is P1¯ with unit cell parameters a...
Article
The communication deals with the eco-friendly synthesis and X-ray crystal structure of an organic carbonitrile, namely 6-amino-3-phenyl-4-(pyridin-4-yl)-2,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile. The title compound was synthesized in 89% yield by following a simple, straightforward and highly efficient multicomponent one-pot protocol under th...
Article
The indole derivative [3,3':3',3''-terindolin]-2'-one bis(dimethyl sulfoxide), C24H17N3O ⋅ 2(C2H6OS) has been synthesized using green protocol in 89% yield, and its crystal structure is determined by X-ray structure analysis. The crystals are monoclinic, space group P21/n, Z = 4. Bicyclic indole moieties form dihedral angle of 60.32° with each othe...
Article
The compounds, 2-amino-2',5-dioxo-5,6,7,8-tetrahydrospiro[chromene-4,3'-indoline]-3-carbonitrile (4a), 2-amino-1'-methyl-2',5-dioxo-5,6,7,8-tetrahydrospiro[chromene-4,3'-indoline]-3-carbonitrile (4b), and 2-amino-1',7,7-trimethyl-2',5-dioxo-5,6,7,8-tetrahydrospiro[chromene-4,3'-indoline]-3-carbonitrile (4c) were synthesized and characterized by ele...
Article
The present manuscript reports the synthesis, structural confirmation, thermodynamics and vibrational spectroscopic study of an important biorelevant molecule, named N-iso-butyl, S-2-nitro-1-phenylethyl dithiocarbamate in the gas phase. We have found a total of five low lying energy structures of N-iso-butyl, S-2-nitro-1-phenylethyl dithiocarbamate...
Article
The present manuscript reports the synthesis, structural confirmation, thermodynamics and vibrational spectroscopic study of an important biorelevant molecule, named N-iso-butyl, S-2-nitro-1-phenylethyl dithiocarbamate in the gas phase. We have found a total of five low lying energy structures of N-iso-butyl, S-2-nitro-1-phenylethyl dithiocarbamate...
Article
Full-text available
Theoretical calculations of geometrical structure and vibrational wavenumbers, nuclear magnetic behavior and natural bond orbital (NBO) analysis were carried out using density functional (DFT/B3LYP) method with 6-311++G(d, p) as basis set for diethyl (2-amino-3-cyano-4H-chromen-4-yl)phosphonate (DACHP; 1), diethyl (2-amino-6-chloro-3-cyano-4H-chrom...
Article
The present work deals with a comparative experimental and theoretical study on a synthetic analog of biologically relevant 4H-pyran motif. We have performed spectral and structural properties of 6-amino-3-phenyl-4-(pyridin-4-yl)-2,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile. This compound was synthesized in 89% yield by following a simple, strai...
Article
A catalyst‐ and additive‐free practical and green synthetic strategy for decarboxylative C‐4 phosphorylation of coumarin‐3‐carboxylic acids, for the first time, has been accomplished to access a series of substituted 4‐(diarylphosphoryl)chroman‐2‐ones at ambient conditions. The developed protocol is successfully applied to large‐scale synthesis.
Article
Full-text available
The present work deals with the synthesis as well as molecular modeling and vibrational spectroscopic analysis of two biorelevant molecules, namely N-n-butyl, S-2-nitro-1-phenylethyl dithiocarbamate and N-n-butyl, S-2-nitro-1-(4-flurophenyl)ethyldithiocarbamate in gas phase. The optimization of the molecular structures of these compounds was perfor...
Article
Development of a visible light-induced and singlet oxygen-mediated green protocol has been accomplished for the first time for the photochemical transformation of 4-hydroxy-alpha-benzopyrones to new series of biorelevant 2-hydroxy-3-oxo-2,3-dihydrobenzofuran-2-carboxamides and 2-hydroxy-3-oxo-2,3-dihydrobenzofuran-2-carboxylates using rose bengal a...
Article
A water-mediated and catalyst-free practical method for the synthesis of a new series of pharmaceutically interesting functionalized 5-(2-arylimidazo[1,2-a]pyridin-3-yl)pyrimidine-2,4(1H,3H)-diones has been accomplished based on a one-pot multicomponent reaction between arylglyoxal monohydrates, 2-aminopyridines/2-aminopyrimidine and barbituric/N,N...
Article
In the present study, we have performed a comparative analysis on two hexahydroacridine-1,8(2H,5H)-dione derivatives namely, 3,3,6,6-tetramethyl-9-(4-nitrophenyl)-3,4,5,6,7,9-hexahydro-1H-xanthene-1,8(2H)-dione (TNHXD) and 9-(benzo[d][1,3]dioxol-5-yl)-3,3,6,6-tetramethyl-3,4,5,6,7,9-hexahydro-1H-xanthene-1,8(2H)-dione (BDTHXD). The equilibrium geom...
Chapter
Organophosphorus chemistry is a very broad and exciting field, with potential opportunities to researchers involved in multi-disciplinary areas of scientific endeavour including organic, medicinal, pharmaceutical, agricultural and industrial chemistry. Organophosphorus compounds find extensive applications in all these fields owing to their inheren...
Article
Nano sized silica supported DABCO based amphoteric ionic liquid coated combined catalytic system Nano-SiO2@[DABCO(CH2CH2CO2H)]⁺[Br]⁻ has been synthesised in a very simple and convenient way. This newly synthesised SCILL has been characterised via FT-IR, SEM, HRTEM and EDAX spectra. The high efficiency of this catalyst was unquestionably recognised...
Article
Design and synthesis of a new series of pharmaceutically interesting curcumin‐derived 4H‐pyrans have been accomplished via a one‐pot tandem reaction between curcumin, aromatic aldehydes, and malononitrile under the influence of sodium formate as a mild base in ethanol at ambient conditions. Operational simplicity, mild reaction conditions, use of a...
Article
Full-text available
Recently, substituted 1, 8-dioxodecahydroacridine derivatives have been investigated and found to possess a wide variety of biological and pharmacological activities. Two of these biologically relevant N-heterocyclic scaffolds 2-(9-(4-methoxyphenyl)-3,3,6,6-tetramethyl-1,8-dioxo-1,2,3,4,5,6,7,8-oc-tahydroacridin-10(9H)-yl)succinic acid (MTDOSA) and...
Article
Full-text available
Renal cell carcinoma (RCC) is the most common kidney cancer leading to 140,000 deaths per year. Among all RCCs 80% evolve from the epithelial proximal tubular cells within the kidney. There is a high tendency of developing chemoresistance and resistance to radiation therapy in most RCC patients. Therefore, kidney resection is considered as the most...
Chapter
Abstract This chapter is aimed to offer an overview of the present book, and summarizes the contents and subject matter of each chapter with an intention to highlight on certain glimpses of the coverage to the readers before they go in-depth. Keywords: Inflammation; Natural products with anti-inflammatory potential; Natural sources and isolation;...
Book
Discovery and Development of Anti-inflammatory Agents from Natural Products, the latest volume in the Natural Product Drug Discovery series, presents cutting-edge research advances in the field of bioactive natural products and natural drug formulations, with this volume focusing on molecules of natural origin and their synthetic analogues that hav...
Chapter
Abstract 6-Gingerol, the primary bioactive phenylpropanoid chemical constituent of the rhizome of ginger (Zingiber officinale Roscoe; family: Zingiberaceae), is known to possess multifaceted pharmacological activities including potent beneficial effects against inflammation. The present book chapter focuses on the possible biosynthetic pathways, an...
Article
Full-text available
A catalyst‐ and additive‐free simple and straightforward method for regioselective direct sp2 C–H acetoxylation reaction of aldehyde hydrazones has been achieved at ambient temperature employing PIDA as an acetoxy source. The scope of the reaction has been successfully verified with a wide range of biologically important aldehyde hydrazones with di...
Article
Highlights •Ultrasound-assisted and trisodium citrate dihydrate-catalyzed one-pot MCR. •Green synthesis of substituted chromeno[3',4':5,6]pyrano[2,3-d]pyrimidines. •Use of ambient conditions, and low-cost and eco-friendly catalyst and solvent. •Large-scale application, no column chromatography and operationally simple. •Practically no waste (wa...
Article
Full-text available
Sopherone A (1) and B (2), two new biologically relevant dibenzo-α-pyrones, were isolated from the stems of Cassia sophera Linn. (Caesalpiniaceae). Their structures were elucidated by detailed analysis of their spectroscopic data, including 1D and 2D NMR
Article
An alternative green protocol for the synthesis of a series of biologically relevant biscoumarin derivatives, 3,3′‐(arylmethylene)bis(4‐hydroxy‐2H‐chromen‐2‐one) (3), has been developed from a one‐pot pseudo‐three component reaction between 4‐hydroxycoumarin (1) and diverse aromatic aldehydes (2) using ceric ammonium nitrate (CAN) as a cheap, eco‐f...
Book
Total Synthesis of Bioactive Natural Products provides step-by-step guidelines for effectively synthesizing the most promising bioactive agents from a broad range of natural products. Beginning with a concise background that outlines the benefits and challenges faced in effective synthesis, the book goes on to provide individual outlines for approx...
Article
Cancer is a multi-origin collection of diseases attributed by abnormal and uncontrolled cell growth spread from origin to other parts of body eventually leading to death. After decades of research, anti-cancer drug therapy is still very much limited to inhibiting growth and controlling spared of tumor cells. Finding novel molecular targets and drug...
Article
Full-text available
Abstract BACKGROUND: Among varieties of commercially available alums, potassium alum (KAl(SO4)2.12H2O), usually called simply as ‘alum’, is very much common both for household and medicinal uses. Alum is reported to act as an efficient acid-catalyst in implementing a handful of organic transformations. This benign and commercially available cheap...
Article
Development of an ultrasound-promoted green protocol to access pharmaceutically relevant functionalized coumarin-uracil molecular hybrids, 6-amino-5-((4-hydroxy-2-oxo-2H-chromen-3-yl)(aryl)methyl)pyrimidine-2,4(1H,3H)-diones (4/4′), has been accomplished based on a three-component tandem reaction between 4-hydroxycoumarin (1), substituted aromatic...
Article
A simple, straightforward, and eco‐friendly protocol for one‐pot synthesis of a new series of diversely functionalized spiro[indoline‐3,5′‐pyrido[2,3‐d]pyrimidines] (4)/spiro[acenaphthylene‐1,5′‐pyrido[2,3‐d]‐pyrimidines] (5/5′) has been developed based on a three‐component reaction between isatins (1)/ acenaphthylene‐1,2‐dione (1′), malononitrile...
Article
A diverse range of functionalized N‐alkyl/substituted alkyl, S‐2‐nitro‐1‐arylethyl dithiocarbamates (4) has been synthesized following a modified protocol based on a three‐component tandem reaction between amines (1), carbon disulfide (2), and substituted β‐nitrostyrenes (3) at ambient temperature. Large scale synthetic application and an investiga...

Questions

Questions (6)
Question
CALL for PAPERS!!
A Thematic Special Issue titled as "Green Chemistry Practice for Sustainable Future" has been designed for the Elsevier Scopus-Indexed well-established Journal (Rasayan Journal of Chemistry) under my guest editor-ship! Call for articles has now been launched from the journal editor-in-chief. Pl. visit the link for details: 
Being guest editor of this specially designed hot issue, I do welcome your supports and submissions. Thanks and regards, Goutam Brahmachari (Guest editor). For any inquiry, pl. feel free to write at brahmg2001@gmail.com / goutam.brahmachari@visva-bharati.ac.in
Question
Esteemed Colleagues:  I want to extend collaboration in assessing anticoagulant profiles of some natural and synthetic molecules. If anybody likes to discuss the issue with me, please e-mail me at goutam.brahmachari@visva-bharati.ac.in
Question
Please contact me 
Feel free to contact!
Book Title: Antidiabetic Natural Products: Recent Advances
Key areas: Designing topics as per target sites for natural antidiabetic agents, such as glycolysis and krebs cycle, gluconeogenesis, hexose monophosphate shunt, glycogen synthesis and glycogenolysis, digestion and absorption of carbohydrate, glucose transporters (GLUT), insulin mimetic, downstream signal of insulin cAMP, compounds acting on glucose absorption; aldose reductase inhibitors as new antidiabetic drugs, pharmacokinetics
Possible publisher: Front-line internationally reputed publisher like Elsevier (priority)/Wiley-VCH (priority)/CRC Press/Springer
Question
Please find details in the attached file. Please contact me at my e-mail address for any query: brahmg2001@yahoo.co.in; brahmg2001@gmail.com; goutam.brahmachari@visva-bharati.ac.in
Feel free to contact! 
Possible publisher of the book 'Neuroprotective Natural Products: Impacts and Prospects' will be the top-level international publishing houses like Elsevier/ Wiley-VCH/CRC Press etc. 
Question
Esteemed Colleagues:
You are welcome to contribute to the HOT issue of Current Organocatalysis being guest edited by me. Please visit the following links for more information.
You can feel free to inquire at me via brahmg2001@yahoo.co.in / brahmg2001@gmail.com
Looking forward to your participation! Goutam Brahmachari