Gosia Furmanik

Evidera

Objective Vascular calcification is common among aging populations and mediated by vascular smooth muscle cells (VSMCs). The endoplasmic reticulum (ER) is involved in protein folding and ER stress has been implicated in bone mineralization. The role of ER stress in VSMC-mediated calcification is less clear. Approach and Results mRNA expression of...

Rationale: Vascular calcification, the formation of calcium phosphate crystals in the vessel wall, is mediated by vascular smooth muscle cells (VSMCs). However, the underlying molecular mechanisms remain elusive precluding mechanism-based therapies. Objective: Phenotypic switching denotes a loss of contractile proteins and an increase in migration...

Dysregulated mineral metabolism and factors in uraemic serum place chronic kidney disease (CKD) patients at high risk of ectopic calcification, particularly vascular calcification. CKD patients have impaired phosphate excretion accompanied by klotho deficiency and vitamin D deficiency. The parathyroid hormone and fibroblast growth factor 23 negativ...

Cardiovascular disease continues to be the leading cause of death in industrialised societies. The idea that the arterial smooth muscle cell (ASMC) plays a key role in regulating many vascular pathologies has been gaining importance, as has the realisation that not enough is known about the pathological cellular mechanisms regulating ASMC function...

Cardiovascular disease is the major cause of death worldwide. The success of medication and other preventive measures introduced in the last century have not yet halted the epidemic of cardiovascular disease. Although the molecular mechanisms of the pathophysiology of the heart and vessels have been extensively studied, the burden of ischemic cardi...

Aims Smokers are at increased risk of cardiovascular events. However, the exact mechanisms through which smoking influences cardiovascular disease resulting in accelerated atherosclerosis and vascular calcification are unknown. The aim of this study was to investigate effects of nicotine on initiation of vascular smooth muscle cell (VSMC) calcifica...

Aortic aneurysm is a vascular disease whereby the ECM (extracellular matrix) of a blood vessel degenerates, leading to dilation and eventually vessel wall rupture. Recently, it was shown that calcification of the vessel wall is involved in both the initiation and progression of aneurysms. Changes in aortic wall structure that lead to aneurysm forma...

Children on dialysis have a cardiovascular mortality risk equivalent to older adults in the general population, and rapidly develop medial vascular calcification, an age-associated pathology. We hypothesized that premature vascular ageing contributes to calcification in children with advanced chronic kidney disease (CKD). Vessels from children with...

Objective: Vascular calcification is the deposition of hydroxyapatite crystals in the blood vessel wall. Osteogenic differentiation of vascular smooth muscle cells (VSMCs) plays a key role in this process. Increased expression of alkaline phosphatase (ALP) occurs in some in vitro models of VSMC calcification and is thought to be crucial for minera...

Vascular calcification (VC) is the process of deposition of calcium phosphate crystals in the blood vessel wall, with a central role for vascular smooth muscle cells (VSMCs). VC is highly prevalent in chronic kidney disease (CKD) patients and thought, in part, to be induced by phosphate imbalance. The molecular mechanisms that regulate VC are not f...

Rationale: Matrix vesicles (MVs), secreted by vascular smooth muscle cells (VSMCs), form the first nidus for mineralization and fetuin-A, a potent circulating inhibitor of calcification, is specifically loaded into MVs. However, the processes of fetuin-A intracellular trafficking and MV biogenesis are poorly understood. Objective: The objective...

Vascular calcification (VC) is a health problem common in ageing populations, diabetes and chronic kidney disease. It leads to vascular stiffening and heart failure. VC is a regulated process mediated by vascular smooth muscle cells (VSMCs), with similarities to developmental osteogenesis. The exact molecular events responsible for triggering it ar...

Arterial stiffening caused by deposition of calcium phosphate salts in the vessel wall is common in patients with atherosclerosis, renal failure and diabetes and contributes to high cardiovascular morbidity and mortality in these groups. Medial calcification is mediated by vascular smooth muscle cells (VSMCs) which undergo phenotypic transitions an...

Vascular calcification is pathological deposition of hydroxyapatite in the blood vessel wall. It causes vascular stiffness and increases cardiovascular morbidity and mortality in ageing populations, especially in atherosclerosis, diabetes and chronic kidney disease. It is a regulated, cell-mediated process, which shares similarities with bone forma...

Vascular calcification is a pathological process of deposition of hydroxyapatite HAp in the blood vessel, which causes stiffness and increases cardiovascular morbidity and mortality in ageing populations and in conditions such as atherosclerosis, diabetes and chronic kidney disease. It is a regulated, cell-mediated process, similar to bone formatio...

Vascular calcification is a pathological process of deposition of calcium and phosphate crystals in the form of hydroxyapatite (HAp) in the blood vessel wall. Its presence in the vessel wall causes stiffness and leads to left ventricular hypertrophy and increases cardiovascular morbidity and mortality. It is a serious health problem common in agein...

Children on dialysis develop medial vascular calcification and have a cardiovascular mortality risk equivalent to the very elderly general population. Emerging evidence has shown that dysregulated mineral metabolism is associated with premature ageing and vascular calcification. However, the mechanisms driving premature ageing in response to dysreg...

Vascular calcification is a regulated pathological process similar to bone formation which is mediated by vascular smooth muscle cells (VSMCs) undergoing osteogenic transdifferentiation. Initiation of vascular calcification occurs in small membrane-bound matrix vesicles (MVs), secreted by VSMCs into the extracellular matrix however the mechanisms r...

Background Vascular calcification is a strong risk factor for cardiovascular morbidities and mortality of patients with chronic kidney disease where the blood levels of calcium (Ca) and phosphate (P) are significantly altered. Calcification is driven by the osteogenic transition of vascular smooth muscle cells (VSMCs) and is accompanied by accumula...