Gordon J Prescott

Gordon J Prescott
University of Central Lancashire | UCLAN · Lancashire Clinical Trials Unit

About

151
Publications
18,332
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7,447
Citations
Additional affiliations
September 2004 - present
University of Aberdeen
Position
  • Senior Lecturer in Medical Statistics

Publications

Publications (151)
Preprint
Introduction Long COVID (LC), the persistent symptoms ≥12 weeks following acute COVID-19, presents major threats to individual and public health across countries, affecting over 1.5 million people in the UK alone. Evidence-based interventions are urgently required and an integrated care pathway (ICP) approach in pragmatic trials, which include inve...
Article
Background Urinary incontinence affects around half of stroke survivors in the acute phase, and it often presents as a new problem after stroke or, if pre-existing, worsens significantly, adding to the disability and helplessness caused by neurological deficits. New management programmes after stroke are needed to address urinary incontinence early...
Article
Full-text available
Introduction Post-COVID-19 complications require simultaneous characterisation and management to plan policy and health system responses. We describe the 12-month experience of the first UK dedicated post-COVID-19 clinical service to include hospitalised and non-hospitalised patients. Methods In a single-centre, observational analysis, we report t...
Preprint
Full-text available
Background. Complications following SARS-CoV-2 infection require simultaneous characterisation and management to plan policy and health system responses. We describe the 12-month experience of the first UK dedicated Post-COVID clinical service to include both hospitalised and non-hospitalised patients. Methods. In a single-centre, observational ana...
Article
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Objective Cognitive–behavioural therapy (CBT) has been shown to be effective in the management of chronic widespread pain (CWP); we now test whether it can prevent onset among adults at high risk. Methods A population-based randomised controlled prevention trial, with recruitment through UK general practices. A mailed screening questionnaire ident...
Article
Background Multimorbidity (MM) is the co-existence of two or more health conditions. Whilst its prevalence is higher in older adults, in absolute numbers there are more multimorbid young people. Recently, the trends for increasing life expectancy observed in high income countries have stalled or reversed. The relationship between MM and premature m...
Article
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Objectives Multimorbidity is the coexistence of two or more health conditions in an individual. Multimorbidity in younger adults is increasingly recognised as an important challenge. We assessed the prevalence of secondary care multimorbidity in mid-life and its association with premature mortality over 15 years of follow-up, in the Aberdeen Childr...
Article
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Background Cognitive behaviour therapy (CBT) is effective in the management of fibromyalgia (and its characteristic feature chronic widespread pain (CWP). CBT is recommended in all recent major fibromyalgia management guidelines. From large-scale epidemiological studies, prediction models are available which identify groups at high-risk of developi...
Article
Background: Benzodiazepines are commonly prescribed drugs with approximately 10% of adults having used them in the past year. These drugs are clearly addictive, yet many patients are prescribed these for years, with long-term side effects. The present study aimed to investigate whether patients on repeat diazepam prescription had their prescriptio...
Article
Importance Early identification of individuals at elevated risk of developing chronic kidney disease (CKD) could improve clinical care through enhanced surveillance and better management of underlying health conditions. Objective To develop assessment tools to identify individuals at increased risk of CKD, defined by reduced estimated glomerular f...
Article
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Introduction Knowledge about the career decisions of doctors in relation to specialty (residency) training is essential in terms of UK workforce planning. However, little is known about which doctors elect to progress directly from Foundation Year 2 (F2) into core/specialty/general practice training and those who instead opt for an alternative next...
Article
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Objectives Many countries are driving forward policies to widen the socioeconomic profile of medical students and to train more medical students for certain specialties. However, little is known about how socioeconomic origin relates to specialty choice. Nor is there a good understanding of the relationship between academic performance and specialt...
Article
Background: Change in albuminuria as a surrogate endpoint for progression of chronic kidney disease is strongly supported by biological plausibility, but empirical evidence to support its validity in epidemiological studies is lacking. We aimed to assess the consistency of the association between change in albuminuria and risk of end-stage kidney...
Article
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Objective Multimorbidity (the coexistence of two or more health conditions) is increasingly prevalent. No long-term cohort study has examined the impact of contemporaneously measured birth social class along with educational attainment on adult self-reported multimorbidity. We investigated the impact of educational attainment on the relationship be...
Article
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Background: The UK faces geographical variation in the recruitment of doctors. Understanding where medical graduates choose to go for training is important because doctors are more likely to consider practicing in areas where they completed postgraduate training. The wider literature also suggests that there is a relationship between origin and ba...
Article
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IntroductionMultimorbidity, the co-existence of two or more health conditions, is a growing challenge. It may be measured using health service administrative data via the emerging consensus measure by Barnett. However, the original Barnett was developed using Scottish-specific primary care coding, which restricts its application in other health sys...
Article
Full-text available
Background Multimorbidity, the co-existence of two or more health conditions, is a growing challenge. It has been measured using health service administrative data via the emerging consensus measure by Barnett (containing 40 health conditions). However,this was developed using Scottish-specific primary care coding, which restricts its application i...
Article
Full-text available
Background: Multimorbidity, the coexistence of multiple health conditions, is a growing public health challenge. Research and intervention development are hampered by the lack of consensus regarding defining and measuring multimorbidity. The aim of this systematic review was to pool the findings of systematic reviews examining definitions and meas...
Article
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Introduction Knowledge about allocation of doctors into postgraduate training programmes is essential in terms of workforce planning, transparency and equity issues. However, this is a rarely examined topic. To address this gap in the literature, the current study examines the relationships between applicants’ sociodemographic characteristics and o...
Article
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Background Individuals on renal replacement therapy (RRT) have increased fracture risk, but risk in less advanced chronic kidney disease (CKD) is unclear. Objective To investigate CKD associations with hip fracture incidence and mortality. Design Record linkage cohort study Grampian Laboratory Outcomes Mortality and Morbidity Study II. Setting S...
Article
Background: Critical care services underpin the delivery of many types of secondary care, and there is increasing focus on how to best deliver such services. The aim of this study was to investigate the impact of establishing a medical high dependency unit, in a tertiary referral center, on the workload, case mix, and mortality of the intensive ca...
Article
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Introduction Attracting graduates was recommended as a means of diversifying the UK medical student population. Graduates now make up nearly a quarter of the total medical student population. Research to date has focused on comparing the sociodemographic characteristics of applicants to and/or students on traditional and graduate entry programmes (...
Data
Post-episode estimated glomerular filtration rate in the first year after discharge from the index admission episode.
Data
Relative risk of subsequent sustained 30% renal decline and new chronic kidney disease stage 4 after acute kidney injury using Fine and Gray model.
Data
Crude long-term renal outcomes up to 5 years after a hospital admission episode with or without acute kidney injury (AKI).
Data
Relative risk of renal progression after excluding those with post-episode proteinuria.
Data
Relative risk of subsequent sustained 30% renal decline and new chronic kidney disease stage 4 after acute kidney injury with additional adjustment for acute hospital diagnoses.
Article
Background Some evidence suggests that chronic kidney disease is a risk factor for lower-extremity peripheral artery disease. We aimed to quantify the independent and joint associations of two measures of chronic kidney disease (estimated glomerular filtration rate [eGFR] and albuminuria) with the incidence of peripheral artery disease. Methods In...
Article
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The extent to which renal progression after acute kidney injury (AKI) arises from an initial step drop in kidney function (incomplete recovery), or from a long-term trajectory of subsequent decline, is unclear. This makes it challenging to plan or time post-discharge follow-up. This study of 14651 hospital survivors in 2003 (1966 with AKI, 12685 no...
Article
Objectives: Xpert MTB/RIF (Cepheid) is a rapid molecular assay shown to be sensitive and specific for pulmonary tuberculosis (TB) diagnosis in highly endemic countries. We evaluated its diagnostic performance in a low TB prevalence setting, examined rifampicin resistance detection and quantitative capabilities predicting graded auramine microscopy...
Article
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Background Reducing readmissions is an international priority in healthcare. Acute kidney injury (AKI) is common, serious and also a global concern. This analysis evaluates AKI as a candidate risk factor for unplanned readmissions and determines the reasons for readmissions. Methods GLOMMS-II is a large population cohort from one health authority...
Data
Crude long-term RRT outcomes up to 10 y in eGFR subgroups.
Data
Patient characteristics by AKI severity in eGFR subgroups.
Data
Sensitivity analyses for mortality after AKI vs no AKI.
Data
Crude long-term RRT outcomes up to 10 y.
Article
Introduction Providing systemic screening to a growing diabetes population is a challenge for most screening programmes. We have previously developed software for the automated detection of diabetic retinopathy which is now routinely used within the Scottish Diabetic Retinopathy Screening programme. Purpose In this study we explored whether automa...
Article
Full-text available
Background: The long-term prognosis after acute kidney injury (AKI) is variable. It is unclear how the prognosis of AKI and its relationship to prognostic factors (baseline kidney function, AKI severity, prior AKI episodes, and recovery of kidney function) change as follow-up progresses. Study design: Observational cohort study. Setting & parti...
Article
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Objective To assess the long term effects of hypertensive disorders of pregnancy on renal function. Design Cohort study where exposure was gestational hypertension or preeclampsia in the first pregnancy. Normotensive women formed the comparison group. Setting Aberdeen, Scotland. Participants All women with date of birth on or before 30th June 19...
Article
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Background Early recognition of acute kidney injury (AKI) is important. It frequently develops first in the community. KDIGO-based AKI e-alert criteria may help clinicians recognize AKI in hospitals, but their suitability for application in the community is unknown. Methods In a large renal cohort (n = 50 835) in one UK health authority, we applie...
Article
Full-text available
Background Cognitive behavioural therapy (CBT) has been shown to improve outcomes for patients with fibromyalgia, and its cardinal feature chronic widespread pain (CWP). Prediction models have now been developed which identify groups who are at high-risk of developing CWP. It would be beneficial to be able to prevent the development of CWP in these...
Article
Full-text available
Background: In a randomised trial of treatments for chronic widespread pain (CWP), participants were asked their treatment preference prior to randomisation. This analysis examined whether treatment preference was associated with baseline factors and whether receiving preferred treatment affected outcomes. Methods: The MUSICIAN trial was a 2x2 rand...
Article
Background Acute kidney injury is serious and common, but the long-term prognosis after isolated episodes of the disorder is not well described. Therefore, giving individual patients an accurate prognosis, and planning future care, is difficult. We describe the prognosis of patients after admission to hospital with acute kidney injury. Methods Thi...
Poster
Full-text available
Aim Retinal screening for diabetic retinopathy, involving taking images of the retina, has been shown to be cost-effective. This project explored the feasibility of using automated analysis of sequential retinal images to identify specific features, which could be used to identify those people at risk of their disease progressing and require referr...
Article
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Background: A key skill for a practising clinician is being able to do research, understand the statistical analyses and interpret results in the medical literature. Basic statistics has become essential within medical education, but when, what and in which format is uncertain. Methods: To inform curriculum design/development we undertook a quan...
Article
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Background Acute kidney injury (AKI) is serious and widespread across healthcare (1 in 7 hospital admissions) but recognition is often delayed causing avoidable harm. Nationwide automated biochemistry alerts for AKI stages 1-3 have been introduced in England to improve recognition. We explored how these alerts compared with clinical diagnosis in d...
Article
Chronic kidney disease (CKD) is common and important due to poor outcomes. An ability to stratify CKD care based on outcome risk should improve care for all. Our objective was to develop and validate 5-year outcome prediction tools in a large population-based CKD cohort. Model performance was compared with the recently reported 'kidney failure risk...
Article
Full-text available
Early detection of acute kidney injury (AKI) is important for safe clinical practice. NHS England is implementing a nationwide automated AKI detection system based on changes in blood creatinine. Little has been reported on the similarities and differences of AKI patients detected by this algorithm and other definitions of AKI in the literature. We...
Article
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Objectives: The MUSICIAN study has previously shown short term benefit but only marginal cost-effectiveness for two non-pharmacological interventions for chronic widespread pain (CWP). We wished to determine their long-term effectiveness and cost-effectiveness. Methods: A 2x2 factorial randomised controlled trial based in primary care in the UK. Pe...
Article
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The Charlson index is a widely used measure of comorbidity. The objective was to compare Charlson index scores calculated using administrative data to those calculated using case-note review (CNR) in relation to all-cause mortality and initiation of renal replacement therapy (RRT) in the Grampian Laboratory Outcomes Mortality and Morbidity Study (G...
Article
Internationally, investment in the availability of routine health care data for improving health, health surveillance and health care is increasing. We assessed the validity of hospital episode data for identifying individuals with chronic kidney disease compared to biochemistry data in a large population-based cohort, the Grampian Laboratory Outco...
Conference Paper
Full-text available
Introduction and Aims: In hemodialysis (HD) patients low pre-HD serum sodium (SNa+) and high Na+ gradients have been associated with higher mortality. Increased pre-HD SNa+ variability has been linked to mortality, while stable SNa+ levels are associated with better survival. Here we investigated the joint relationship of SNa+ variability (expresse...
Poster
Full-text available
Introduction and Aims: In clinical practice it has been reported that hypomagnesaemia is associated to low mineral density. On the other hand in vitro studies have shown that magnesium (Mg) decreases calcification in vascular smooth muscle cells. But the effects of increasing Mg levels on bone homeostasis are poorly understood. Here we elucidate th...
Article
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In clinical practice, research, and increasingly health surveillance, planning and costing, there is a need for high quality information to determine comorbidity information about patients. Electronic, routinely collected healthcare data is capturing increasing amounts of clinical information as part of routine care. The aim of this study was to as...