Gordon K Murdoch

Gordon K Murdoch
Washington State University | WSU · Department of Animal Sciences

Doctor of Philosophy, Physiology

About

114
Publications
9,454
Reads
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1,538
Citations
Citations since 2016
38 Research Items
787 Citations
2016201720182019202020212022020406080100120140
2016201720182019202020212022020406080100120140
2016201720182019202020212022020406080100120140
2016201720182019202020212022020406080100120140
Additional affiliations
April 2019 - April 2019
University of Idaho
Position
  • Professor (Full)
January 2007 - present
University of Idaho
January 1997 - March 1998
University of Alberta
Position
  • Research Associate

Publications

Publications (114)
Article
Full-text available
Because of its high content of polyphenolic compounds, dietary inclusion of grape pomace (GP) in finishing cattle diet could possibly enhance product quality and the health value of beef lipids. Therefore, the aim of this study was to evaluate the effects of feeding a high amount of grape pomace in finishing cattle diets on carcass traits, product...
Article
As the population increases, it is necessary to improve the sustainability of beef production. Bos indicus (BI) cattle are better adapted to nutritional stress, consume less water, and are better able to withstand thermal stress when compared to Bos taurus (BT) cattle. Additionally, anabolic implants, which typically contain the steroid hormones tr...
Article
Myokine abundance and function have not been thoroughly evaluated in beef cattle. Many myokines have been shown to have a substantial impact on the health and well-being of mammals. While interleukin 6 (IL-6) is a known immune cytokine, it is also classified as a myokine and in mice is produced from muscle contraction post-exercise. IL-6 is linked...
Article
Background: Maternal exercise (ME) improves fetal and offspring muscle development, but mechanisms remain to be established. Since thyroid hormone (TH) is critical for cell differentiation during embryonic development, we hypothesized that ME elevates TH receptor (THR) signaling in embryos, which promotes embryonic myogenesis. Methods: Female mi...
Article
Full-text available
Variation in cut size and weight of fabricated subprimals is a challengeof increased beef carcass weights. Subsequently, variation in carcass size hasresulted in consistency challenges during retail display. Theobjective of this study was to assess the retail shelf-life of commerciallyavailable top rounds from varying carcass weights. In the curren...
Article
Accelerated skeletal maturity is prevalent in modern commercial heifers harvested under 30 months of age. It is hypothesized that selection for increased growth and earlier reproductive maturity over several decades, unintentionally co-selected for precocious skeletal ossification in heifers. This study examines the relationship of single nucleotid...
Article
Full-text available
Emerging research suggests that hormones found in anabolic implants interact with polyamine biosynthesis. The objective of this study was to determine the effects of steroidal hormones, polyamines and polyamine precursors on bovine satellite cell (BSC) differentiation and polyamine biosynthesis temporally. Primary BSCs were induced to differentiate...
Article
Because of its high content of polyphenolic compounds, dietary inclusion of grape pomace (GP) in ruminant diets can reduce reactive nitrogen (N) and methane emissions and enhance the shelf life and beneficial fatty acids content of meat. However, dietary inclusion of GP beyond a threshold that is still to be determined for feedlot cattle, can also...
Article
Full-text available
The ability of livestock to reproduce efficiently is critical to the sustainability of animal agriculture. Antral follicle count (AFC) and reproductive tract scores (RTS) can be used to estimate fertility in beef heifers, but the genetic mechanisms influencing variation in these measures are not well understood. Two genome-wide association studies...
Article
Full-text available
The mechanism through which anabolic implants improve skeletal muscle growth of beef animals is incompletely understood. Polyamines (PA) are bioactive amino acid derivatives that act as potent growth stimulants. The objective of this study was to determine effects of anabolic implants, PA and their precursors on bovine satellite cell (BSC) differen...
Article
Full-text available
Background The pia arachnoid complex (PAC) is a cerebrospinal fluid-filled tissue conglomerate that surrounds the brain and spinal cord. Pia mater adheres directly to the surface of the brain while the arachnoid mater adheres to the deep surface of the dura mater. Collagen fibers, known as subarachnoid trabeculae (SAT) fibers, and microvascular str...
Article
Full-text available
Beef carcass weights in the United States have continued to increase over the past 30 years. As reported by the United States Department of Agriculture, grid-based carcass weight discounts begin when carcasses exceed 408 kg. Despite weight discounts, beef carcass weights continue to increase. At the same time, an increased prevalence of discolorati...
Preprint
Full-text available
The pia arachnoid complex (PAC) is a cerebrospinal fluid-filled tissue conglomerate that surrounds the brain and spinal cord. Pia mater adheres directly to the surface of the brain while the arachnoid mater adheres to the inferior side of the dura mater. Collagen fibers, known as subarachnoid trabeculae (SAT) fibers, and microvascular structure lie...
Preprint
Full-text available
Background: The pia arachnoid complex (PAC) is a cerebrospinal fluid-filled tissue conglomerate that surrounds the brain and spinal cord. Pia mater adheres directly to the surface of the brain while the arachnoid mater adheres to the deep surface of the dura mater. Collagen fibers, known as subarachnoid trabeculae (SAT) fibers, and microvascular st...
Article
Full-text available
The objective of this study was to evaluate the effect of timing of electrical stimulation on free calcium concentration, calpain-2 activity, Warner-Bratzler shear force (WBSF), and consumer sensory analysis. Twenty-three beef steers were harvested and stimulated (S) using extra-low voltage or not stimulated (NS), at exsanguination and/or 1 h postm...
Article
Full-text available
The objective of this study was to evaluate the effectiveness of genetic panel marbling indexes [Igenity (IT) and PredicGEN (PG)] to predict marbling and tenderness of crossbred cattle. Steers (n = 23) were harvested at the University of Idaho Meat Science Laboratory, and blood samples were submitted to Neogen and Zoetis for genetic panel analysis....
Article
Full-text available
Genetic panel use as a selection tool has grown in popularity in the beef industry. The objective of the study was to determine whether beef cattle genetically selected for tenderness generated a tender product. Igenity® (IT) panel results were provided by a cattle producer for 52 steers, which were harvested at a commercial harvest facility. Bonel...
Article
Full-text available
Approximately 90% of beef cattle on feed in the U.S. receive at least one anabolic implant, which results in increased growth, efficiency, and economic return to producers. However, the complete molecular mechanism through which anabolic implants function to improve skeletal muscle growth remains unknown. This study had two objectives: (1) determin...
Article
Full-text available
Our objective was to determine the relationship between heifer carcass maturity and beef palatability of the longissimus lumborum (LM) and biceps femoris (BF). Left sides of A (n=30), B (n=30), and C (n=30) maturity heifer carcasses under 30 months of age by dentition were used. Carcasses were selected to ensure similar marbling scores across matur...
Article
Examining the effect of a physiological dose of the polyamine; spermine, on myogenic regulatory transcription factor expression. Spermine is a micronutrient derived from amino acids. It affects cell growth, proliferation, differentiation and gene regulation in many cell types. Polyamines have long been overlooked with respect to their biological ef...
Article
Full-text available
Extended aging increases browning and decreases redness in fresh beef. The goal of this study was to test an already proven combination of antioxidants (0.05% ascorbic acid + 0.1% rosemary extract) using a method that could be applied at the retail level to simply and effectively extend the shelf-life of extended aged beef. The specific objective w...
Poster
Over the last several decades, there has been an increase in the number of heifers categorized as B and C-maturity based upon skeletal maturity at harvest in animals that are actually under 30 months of age chronologically. While the losses associated with advanced maturity will be abated through the new USDA approved use of dentition to determine...
Article
Our objective was to determine the effects of feeding a high amount of grape pomace (GP) in finishing (FIN) cattle diets on product quality. A group of 24 cows (Jersey × Holstein crosses), were allotted to either a typical FIN diet (CON) or a FIN diet containing 58% GP (DM basis). The GP partially replaced some of the energy sources in the CON diet...
Article
The objective of this study was to determine the effects of pre-transport administration of Meloxicam (MEL) on protein metabolism in transported calves. Prior to transportation, Jersey bull calves (n = 20; 4 d old) were weighed, and body temperature was recorded before collection of blood samples. Calves were then administered either a whey protein...
Article
Objective: This study employs a recently developed experimental technique for comparison of the flow characteristics and the effectiveness of gas washout between pressure control ventilation (PCV) and high frequency percussive ventilation (HFPV) in high compliance and low compliance ex vivo porcine respiratory tracts. Approach: The ex vivo porcine...
Conference Paper
Evaluation of lung mechanics is the primary component for designing lung protective optimal ventilation strategies. This paper presents a machine learning approach for bedside assessment of respiratory resistance (R) and compliance (C). We develop machine learning algorithms to track flow rate and airway pressure and estimate R and C continuously a...
Conference Paper
Full-text available
Introduction: The pia arachnoid complex (PAC) is a cerebrospinal fluid-filled tissue that surrounds the brain and spinal cord. Within the PAC are arachnoid trabeculae (AT) fibers, AT sheets and blood vessels that help hold the delicate central nervous system tissue in place [1]. Due to their structural role, alterations to PAC mechanical properties...
Article
Objective: A comparison between flow and gas washout data for High Frequency Percussive Ventilation (HFPV) and pressure control ventilation (PCV) under similar conditions is currently not available. This bench study aims to compare and describe the flow and gas washout behavior of HFPV and PCV in a newly designed experimental setup and establish a...
Article
This study examined the effect of dietary rumen-protected histidine (HIS) supplementation in cattle on growth and carcass traits/product quality. Three levels of daily HIS (Balchem Corp.) were tested (control, low dose [DL], and high dose [DH]) over a 55-d finishing period in 48 crossbred steers implanted with Revalor-XS. Cattle were randomly alloc...
Article
Our objectives were to determine the effect of post rigor calcium chloride injection or freezing on 1) sarcoplasmic calcium concentration and calpain-2 activity of beef longissimus lumborum (LL) and semimembranosus (SM) steaks aged 1, 4, and 14days post-treatment and on 2) Warner-Bratzler shear force, water holding capacity, and consumer acceptabil...
Article
Longissimus thoracis (LD) samples from 500 cattle were screened for protein expression differences relative to carcass quality grade. The LD of the top 5% (low prime and high choice, HQ) and bottom 5% (low select, LQ) carcasses were analyzed using two-dimensional difference gel electrophoresis and western blot. Following initial screening, 11 candi...
Article
Full-text available
Nutrition represents one of the greatest environmental determinants of an individual’s health. While nutrient quantity and quality impart direct effects, the interaction of nutrition with genetic and epigenetic modifications is often overlooked despite being shown to influence biological variation in mammals. Dissecting complex traits, such as thos...
Article
Full-text available
Bovine spongiform encephalopathy (BSE) is a prion disease that is invariably fatal in cattle and has been implicated as a significant human health risk. As a transmissible disease of livestock, it has impacted food safety, production practices, global trade, and profitability. Genetic polymorphisms that alter the prion protein in humans and sheep a...
Article
Full-text available
The paired box-7 (pax7) transcription factor expressed in satellite cells (SCs) is an essential regulator of skeletal muscle growth and regeneration in vertebrates including fish. Characterization of rainbow trout (Oncorhynchus mykiss) pax7 gene/s may offer novel insights into skeletal myogenesis by SCs in this indeterminate growth species. Further...
Article
Full-text available
Conditions during fetal development influence health and disease in adulthood, especially during critical windows of organogenesis. Fetal exposure to the endocrine disrupting chemical, bisphenol A (BPA) affects the development of multiple organ systems in rodents and monkeys. However, effects of BPA exposure on cardiac development have not been ass...
Article
Investigating the genetic and physiological drivers of postweaning residual feed intake (RFI) and finishing phase feed efficiency (FE) may identify underlying mechanisms that are responsible for the variation in these complex FE traits. The objectives were 1) to evaluate the relationship of serum IGF-I concentration and muscle gene expression with...
Article
Full-text available
The potential benefits of selenium (Se) supplementation are currently under investigation for prevention of certain cancers and treatment of neurological disorders. However, little is known concerning the response of the brain to increased dietary Se under conditions of Se sufficiency, despite the majority of Se supplementation trials occurring in...
Conference Paper
Full-text available
http://www.fasebj.org/cgi/content/meeting_abstract/27/1_MeetingAbstracts/919.1
Conference Paper
Quiescent muscle satellite cells (SCs) express paired box transcription factor 7 (Pax 7) and Sprouty1 (Spry1), expression of these transcription factors decreases upon activation. In contrast, activated SCs increase expression of myogenic regulatory factors (MRFs) such as; myogenin and myogenic differentiation factor (MyoD) as they differentiate an...
Conference Paper
Satellite cells (SCs) exist amongst other cell types in a unique microenvironment within skeletal muscle. The interactions between SCs and non-myogenic cells within this niche are poorly characterized. However, most cells behave differently in co-culture (CC) compared to mono-culture (MC). Our results indicate that SCs co-cultured with preadipocyte...
Article
Full-text available
Myoblast differentiation is mediated by a cascade of changes in gene expression including transcription factors such as myogenin. Subsequent to myoblast differentiation, there is an increase in expression of the transmembrane protein NADPH oxidase (Nox). Nox is one of the primary factors for the generation of reactive oxygen species (ROS) in myogen...
Article
Abstract We tested whether boldness is associated with attenuation of the physiological stress response in behaviorally selected lines of zebrafish Danio rerio. We measured three component behaviors of boldness: cortisol levels under control and stressed conditions, growth rate, and expression of key genes linked to the hypothalamic-pituitary-inter...
Article
Energy expenditure is a physiological process that may be closely associated with residual feed intake (RFI). The maintenance energy (ME(M)) EPD was developed by the Red Angus Association of America (RAAA) and is used as an indicator of energy expenditure. The objectives of this study were to evaluate and quantify the following relationships using...
Article
Amphibian populations around the world are threatened by an emerging infectious pathogen, the chytrid fungus Batrachochytrium dendrobatidis (Bd). How can a fungal skin infection kill such a broad range of amphibian hosts? And do different host species have a similar response to Bd infection? Here, we use a genomics approach to understand the geneti...
Article
Adipocyte differentiation (AD) and AD-specific gene expression was studied in 3T3-L1 cells in response to oleic acid (OA) or linoleic acid (LA) alone and in combination with insulin. This system facilitated the study of key regulators of adipogenesis PPARγ and C/EBPα and other AD-specific genes, in the absence of dexamethasone (DEX) and isobutyl-1-...
Article
The calcineurin–NFAT (nuclear factor of activated T-cells) signalling pathway is involved in the regulation of activity-dependent skeletal muscle myosin heavy chain (MHC) isoform type expression. Emerging evidence indicates that nitric oxide (NO) may play a critical role in this regulatory pathway. Thus, the purpose of this study was to investigate...
Article
A total of 42 F-1 Red Angus progeny from sires divergent in maintenance energy (MEM) EPD were analyzed to determine whether selecting for sire MEM would alter end-product meat quality. Data from animals were grouped based on the divergence of the MEM EPD of their sire from the Red Angus Association-reported breed average and defined as either high...
Article
Full-text available
A total of 42 F(1) Red Angus progeny from sires divergent in maintenance energy (ME(M)) EPD were analyzed to determine whether selecting for sire ME(M) would alter end-product meat quality. Data from animals were grouped based on the divergence of the ME(M) EPD of their sire from the Red Angus Association-reported breed average and defined as eithe...
Article
Full-text available
Classical bovine spongiform encephalopathy (BSE) is an acquired prion disease that is invariably fatal in cattle and has been implicated as a significant human health risk. Sequence variations in the coding region of the prion gene (PRNP) have been associated with acquired transmissible spongiform encephalopathy (TSE) susceptibility in mammals; how...
Article
Full-text available
This study examined the effect of nitric oxide synthase (NOS) inhibition via N(ω)-nitro-l-arginine methyl ester (l-NAME) administration on low-frequency stimulation-induced satellite cell (SC) activation in rat skeletal muscle. l-NAME only delayed stimulation-induced increases in SC activity. Also, stimulation-induced increases in hepatocyte growth...
Article
Full-text available
Due to their excellent specificity for a single epitope, monoclonal antibodies (mAbs) present a means of influencing the function of cells at the molecular level. In particular they show great promise in the treatment of cancer because they can inhibit cancer cell proliferation, tumor angiogenesis, invasiveness and malignant spread of cancerous cel...
Conference Paper
Nutritional restriction and increased catabolism during lactation in primiparous sows has been associated with changes in follicle and oocyte quality and can be detrimental to embryonic survival and development in the subsequent litter. Delaying breeding of primiparous sows until the second oestrus after weaning resulted in increased embryonic surv...
Article
Full-text available
The weaning period is associated with an increased prevalence of gastrointestinal infection in many species. Glutamine (Gln) has been shown to improve intestinal barrier function and immune function in both in vivo and in vitro models. The objective of the present study was to determine the effect of dietary Gln supplementation on intestinal barrie...
Article
We have shown that creatine (Cr) loading of rat muscle attenuates fast-to-slow fiber type transformations in plantaris after wheel running and in tibiailis anterior (TA) after chronic low frequency stimulation (CLFS). A model of muscle endurance training, CLFS alone also induces decreases in fiber cross-sectional areas (CSA's). PURPOSE: To test the...
Article
Involvement of calcineurin/NFAT signaling in the regulation of skeletal muscle myosin heavy chain (MHC)-based fast-to-slower isoform adaptations (F-S) is recognized. Less is known about the role nitric oxide (NO) plays in this process. OBJECTIVE: To investigate the necessity of NO in activity-induced skeletal muscle F-S in vivo. METHODS: Endogenous...
Article
Full-text available
Four pancreatic cancer cell lines with the same point mutation at the 12 th codon (GGT > GAT) of the K-Ras oncogene were used in this study: Panc1 and Panc 8.13 are both homozygous for mutant K-Ras (mK-Ras), Panc 10.05 is heterozygous for the mutation, and BXPC3 possesses both wild-type K-Ras (wK-Ras) alleles. Cells were transfected with Lipofectam...
Data
Complete list of genes with significant differences in expression between naïve and Bd-exposed frogs. Table columns correspond to gene identifiers (NimbleGen, Joint Genome Institute, and Ensembl), number of probes in probe set, summary of tissues and time points for differential expression, log2 fold-changes for tissues and time points with signifi...
Article
Pre-ovulatory follicle development is a complex process involving extra-ovarian factors such as the gonadotrophins, and local growth factors produced by the oocyte, granulosa and theca cells. Although the role of the gonatrophins has been extensively studied during porcine pre-ovulatory follicle development, the intrafollicular cell-to-cell interac...
Article
Bisphenol A (BPA) is an endocrine disruptor that has been implicated in many developmental disorders and recently associated with cardiovascular disease and diabetes in adult humans. However, no reported studies have examined the effect of BPA on fetal cardiomyocyte development. Maternal mice were orally administered BPA of 0, 2, 20, 100 or 500 ng/...