Gordon Broderick

Gordon Broderick
Rochester General Hospital · Center for Clinical Systems Biology

Ph.D.

About

198
Publications
13,421
Reads
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3,081
Citations
Additional affiliations
December 2017 - present
Rochester Institute of Technology
Position
  • Professor
November 2017 - present
Rochester Institute of Technology
Position
  • Professor
March 2017 - present
Rochester General Hospital
Position
  • Manager
Education
September 1991 - June 1994
Montreal Polytechnic (University of Montreal)
Field of study
  • Chemical Engineering
January 1988 - September 1989
McGill University
Field of study
  • Chemical Engineering
September 1980 - June 1984
McGill University
Field of study
  • Mechanical Engineering

Publications

Publications (198)
Article
Full-text available
Early patient discontinuation from adjuvant endocrine treatment (ET) is multifactorial and complex: Patients must adapt to various challenges and make the best decisions they can within changing contexts over time. Predictive models are needed that can account for the changing influence of multiple factors over time as well as decisional uncertaint...
Article
Full-text available
The co-occurrence of stress-induced posttraumatic stress disorder (PTSD) and obesity is common, particularly among military personnel but the link between these conditions is unclear. Individuals with comorbid PTSD and obesity manifest other physical and psychological problems, which significantly diminish their quality of life. Current understandi...
Article
Full-text available
Bronchoalveolar lavage of the epithelial lining fluid (BALF) can sample the profound changes in the airway lumen milieu prevalent in chronic obstructive pulmonary disease (COPD). We compared the BALF proteome of ex-smokers with moderate COPD who are not in exacerbation status to non-smoking healthy control subjects and applied proteome-scale transl...
Preprint
The brain and body consist of complex networks of interconnected feedback and feed forward loops. Because these networks are capable of supporting multiple homeostatic states, a stressor or combination of stressors may cause the network to become “stuck” in a persistent maladaptive state, for example, chronic pain and the potentiation of opioid dep...
Preprint
Rationale Bronchoalveolar lavage of the epithelial lining fluid can sample the profound changes in the airway lumen milieu prevalent in Chronic Obstructive Pulmonary Disease (COPD). Characterizing the proteins in bronchoalveolar lavage fluid in COPD with advanced proteomic methods will identify disease-related changes, provide insight into pathogen...
Article
The matrix (M) protein of vesicular stomatitis virus (VSV) has a complex role in infection and immune evasion, particularly with respect to suppression of Type I interferon (IFN). Viral strains bearing the wild-type (wt) M protein are able to suppress Type I IFN responses. We recently reported that the 22-25 strain of VSV encodes a wt M protein, ho...
Preprint
Modeling of systems for which data is limited often leads to underdetermined model identification problems, where multiple candidate models are equally adherent to data. In such situations additional optimality criteria are useful in model selection apart from the conventional minimization of error and model complexity. This work presents the attra...
Article
Aims There is an inadequate portfolio of treatments for Gulf War Illness (GWI), a complex disease involving multiple organ systems, and early-phase clinical trials are hampered by many logistical problems. To address these challenges, the Gulf War Illness Clinical Trials and Interventions Consortium (GWICTIC) was formed with the aims of (i) creatin...
Article
Full-text available
Acute otitis media (AOM) pathogenesis involves nasopharyngeal colonization by potential otopathogens and a viral co-infection. Stringently-defined otitis prone (sOP) children show characteristic patterns of immune dysfunction. We hypothesized that otitis proneness is largely a result of altered signaling between immune components that are otherwise...
Article
e18063 Background: Epithelial-to- mesenchymal transition (EMT) plays a key role not only in cancer invasiveness and progression but also in treatment resistance. Experimental models suggest that epithelial and mesenchymal phenotypes may represent steady states supported by the regulatory logic of intracellular signaling networks. Using known regula...
Article
Full-text available
Potentially linked to the basic physiology of stress response, Gulf War Illness (GWI) is a debilitating condition presenting with complex immune, endocrine and neurological symptoms. Here we interrogate the immune response to physiological stress by measuring 16 blood-borne immune markers at 8 time points before, during and after maximum exercise c...
Article
Full-text available
Introduction Gulf War Illness (GWI) currently has no known cure and affects soldiers deployed during the Persian Gulf War. It is thought to originate from exposure to neurotoxicants combined with battlefield stress, and previous research indicates that treatment first involves inhibition of interleukin-2 and tumor necrosis factor alpha, followed by...
Conference Paper
Full-text available
Gulf War Illness is a disease that affects about a third of the veterans that served in the 1990-91 Persian Gulf War. The symptoms are varied, the cause is unknown, and there is no known treatment. In this paper we compare the dynamic characteristics of cytokines feedback response to exercise in n=12 veterans diagnosed with Gulf War Illness (GWI) a...
Article
Full-text available
Neurotoxicology is hampered by the inability to predict regional and cellular targets of toxicant‐induced damage. Evaluating astrogliosis overcomes this problem because reactive astrocytes highlight the location of toxicant‐induced damage. While enhanced expression of glial fibrillary acidic protein is a hallmark of astrogliosis, few other biomarke...
Article
Purpose The complex and varied presentation of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) has made it difficult to diagnose, study, and treat. Its symptoms and likely etiology involve multiple components of endocrine and immune regulation, including the hypothalamic-pituitary-adrenal axis, the hypothalamic-pituitary-gonadal axis, a...
Data
Supplemental Figures S1–S3. Migration trajectories of benchmark systems under their respective MIS.
Data
Supplemental Tables S1–S3. Lists of regulatory interactions used in the HPA, T-helper, and LVR example networks.
Article
Purpose: Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a debilitating multisymptom illness impacting up to 1 million people in the United States. As the pathogenesis and etiology of this complex condition are unclear, prospective treatments are limited. Identifying US Food and Drug Administration-approved drugs that may be reposit...
Article
Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a debilitating disorder characterized by prolonged periods of fatigue, chronic pain, depression, and a complex constellation of other symptoms. Currently, ME/CFS has no known cause, nor are the mechanisms of illness well understood. Therefore, with few exceptions, attempts to treat ME/C...
Article
Full-text available
The in silico study and reverse engineering of regulatory networks has gained in recognition as an insightful tool for the qualitative study of biological mechanisms that underlie a broad range of complex illness. In the creation of reliable network models, the integration of prior mechanistic knowledge with experimentally observed behavior is hamp...
Preprint
Full-text available
Enabled by rapid advances in computational sciences, in silico logical modeling of complex and large biological networks is more and more feasible making it an increasingly popular approach among biologists. Automated high-throughput, drug target identification is one of the primary goals of this in silico network biology. Targets identified in thi...
Article
A model of pathogenesis of ME/CFS and GWI includes genetic predisposition and presence of a triggering event such as exposure (GWI) or infection (ME/CFS). Important mediators of disease include autonomic, endocrine, neuroendocrine, sleep, psychosocial, immune, viral reactivation or persistence, as well as other antigenic exposures (e.g. microbiome)...
Article
Full-text available
Gulf War Illness (GWI) is a chronic multisymptom illness characterized by fatigue, musculoskeletal pain, and gastrointestinal and cognitive dysfunction believed to stem from chemical exposures during the 1990-1991 Persian Gulf War. There are currently no treatments; however, previous studies have predicted a putative multi-intervention treatment co...
Article
Full-text available
Aberrant inflammatory signaling between neuronal and glial cells can develop into a persistent sickness behavior-related disorders, negatively impacting learning, memory, and neurogenesis. While there is an abundance of literature describing these interactions, there still lacks a comprehensive mathematical model describing the complex feed-forward...
Poster
Full-text available
Background: Gulf War Illness (GWI) is a multi-symptom disorder diagnosed by a phenotype which includes persistent headaches, chronic fatigue, memory loss, confusion, skin and gastrointestinal problems. These features are characteristic of persistent sickness behavior, which is known to result from underlying neuroinflammation. Chronic exposure to c...
Chapter
We propose that the complexity of regulatory interactions modulating brain neurochemistry and behavior is such that multiple stable responses may be supported, and that some of these alternate regulatory programs may play a role in perpetuating persistent psychological dysfunction. To explore this, we constructed a model network representing major...
Chapter
Complex disorders like Gulf War illness (GWI) often defy diagnosis on the basis of a single biomarker and may only be distinguishable by considering the co-expression of multiple markers measured in response to a challenge. We demonstrate the practical application of such an approach using an example where blood was collected from 26 GWI, 13 health...
Chapter
Natural killer (NK) cells are an essential component of innate immunity. These lymphocytes are also sensitive barometers of the effects of endogenous and exogenous stressors on the immune system. This chapter describes a chromium (⁵¹Cr)-release bioassay designed to measure to the target cell killing capacity of NK cells (NKCC). Key features of the...
Chapter
The brain maintains homeostasis in part through a network of feedback and feed-forward mechanisms, where neurochemicals and immune markers act as mediators. Using a previously constructed model of biobehavioral feedback, we found that in addition to healthy equilibrium another stable regulatory program supported chronic depression and anxiety. Expl...
Article
Full-text available
Background: Gulf War illness (GWI) is an archetypal, medically unexplained, chronic condition characterised by persistent sickness behaviour and neuroimmune and neuroinflammatory components. An estimated 25-32% of the over 900,000 veterans of the 1991 Gulf War fulfil the requirements of a GWI diagnosis. It has been hypothesised that the high physi...