Goran Stimac

Goran Stimac
University Clinical Hospital Center "Sestre Milosrdnice" · Urology

MD, PhD, Urologist, Senior research associate, Urologic Oncology and Urolithiasis Subspec.

About

128
Publications
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375
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January 2001 - December 2015
University Clinical Hospital Center "Sestre Milosrdnice"
Position
  • Sestre Milosrdnice University Hospital Center

Publications

Publications (128)
Article
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SUMMARY – Fifty years ago, Robson introduced radical nephrectomy (RN) setting the gold standard for treating kidney tumors. Experience has shown that partial nephrectomy (PN) can be equally effective with the advantages of preserving kidney function and avoiding unnecessary nephrectomies for benign tumors. The purpose of this report is to demonstra...
Conference Paper
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Liječenje lokaliziranog raka prostate radikalnom prostatektomijom doživjelo je posljednjih dvadesetak godina dramatičan porast. Unatoč napretku u kirurškoj tehnici i smanjenju ranih i kasnih postoperativnih komplikacija i dalje je prisutan dio bolesnika u kojih perzistira stresna inkontinencija urina. Većina pacijenata podvrgnutih radikalnoj prost...
Conference Paper
Full-text available
Prostate-specific antigen (PSA) is the most useful serum marker for the early detection of prostate cancer (PC), but it is not cancer-specific and various processes, such as benign prostatic hyperplasia or prostatitis, also effect PSA levels. Particularly acute prostatitis shows elevated PSA levels. In practice, we are often confronted with the ass...
Article
Full-text available
Although prostatitis can contribute to the lack of prostate specific antigen (tPSA) specificity, there is disagreement concerning the effect of histological inflammation on free PSA (fPSA). We investigated the correlation between aggressiveness of histological inflammation and tPSA, fPSA and f/tPSA in patients without detectable prostate cancer (PC...
Article
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Fusion anomalies of the kidney are rarely encountered and the association of malignant tumors with such conditions is exceedingly rare. Association of tumors with horseshoe kidney is also uncommon, with fewer than 200 cases having been reported in the literature, and the association of tumors with crossed-fused ectopia is even rarer, with only four...
Article
p>The aim of this review is to provide a brief overview of some current approaches regarding diagnostics, pathologic features, treatment, and genetics of prostate carcinoma (PCa). Prostate carcinoma is the most common visceral tumor and the second most common cancer-related cause of death in males. Clinical outcomes for patients with localized pros...
Article
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Prostate cancer (PCa) is the most commonly diagnosed neoplasm among men. Since it often resembles benign prostate hyperplasia (BPH), biomarkers with a higher differential value than PSA are required. Epigenetic biomarkers in liquid biopsies, especially miRNA, could address this challenge. The absolute expression of miR-375-3p, miR-182-5p, miR-21-5p...
Article
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Interleukin-6 receptor antagonist tocilizumab is a biologic drug used for treating patients with active rheumatoid arthritis (RA) who failed to respond to synthetic or other biologic disease-modifying antirheumatic drugs or where they were contraindicated. Interleukin-6 receptor blockade results in a decrease of disease activity but has some potent...
Article
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Although collecting duct carcinoma is a subtype of renal cell carcinoma, several studies implicate association with urothelial carcinoma. The coexistence of collecting duct carcinoma and another renal neoplasm is rare. endemic nephropathy is a renal disease causing chronic renal failure. it is highly associated with urothelial neoplasm and occurs i...
Article
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The history of Croatian urology clearly shows its affiliation to the medical and civilizational circle of the Western world. The Department of Urology at the Sestre milosrdnice University Hospital Center is the oldest urology institution in the Republic of Croatia. The Department was established in 1894, when the new Sestre milosrdnice Hospital was...
Article
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One of the main reasons for the introduction of a new grading system was Gleason sum 7, which differed significantly in the prognosis of the disease depending on the primary Gleason. The aim of this study was to compare grade group 2 and grade group 3, and the impact of cancer percentages in final pathology reports after radical prostatectomy on th...
Article
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Stress urinary incontinence (SUI) continues to present a major complication after radical prostatectomy. Suburethral slings represent one of the less invasive options for postprostatectomy SUI, and a more recent addition is a transobturator sling, the AdVance®. We report our results with the AdVance® sling for the management of postoperative SUI. T...
Article
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Smjernice se odnose na klasifi kaciju, dijagnostiku i liječenje sindroma prostatitisa. Njihov su cilj standardizacija, izjednačavanje i optimalizacija dijagnostike, liječenja i praćenja bolesnika s prostatitisom koji će dovesti do poboljšanja kvalitete zdravstvene zaštite ovih bolesnika te promovirati racionalnu potrošnju antibiotika. Namijenjene s...
Conference Paper
Full-text available
UVOD i CILJEVI: Liječenje lokaliziranog raka prostate radikalnom prostatektomijom (RP) doživjelo je posljednjih dvadesetak godina dramatičan porast. Većina pacijenata postiže zadovoljavajuću kontinenciju unutar godine dana nakon zahvata. Unatoč napretku u kirurškoj tehnici i dalje je prisutan dio bolesnika u kojih perzistira stresna urinarna inkont...
Conference Paper
Full-text available
Još do prvog predstavljanja 70-ih godina prošlog stoljeća perkutana nefrolitotripsija (PCNL) najvažnija je minimalno invazivna metoda u liječenju bubrežne litijaze. Unatoč razvoju retrogradne intrarenalne kirurgije PCNL je još uvijek najprihvatljivija metoda primarnog operativnog liječenja kompleksne (recidivne/odljevne/koraljne) litijaze. Na Klini...
Conference Paper
Full-text available
Liječenje lokaliziranog raka prostate radikalnom prostatektomijom doživjelo je posljednjih dvadesetak godina dramatičan porast. Većina pacijenata podvrgnutih radikalnoj prostatektomiji postiže zadovoljavajuću kontinenciju unutar godine dana nakon zahvata. Unatoč napretku u kirurškoj tehnici i smanjenju ranih i kasnih postoperativnih komplikacija i...
Article
Full-text available
INTRODUCTION & OBJECTIVES: Bellini duct carcinoma represents one of the most aggressive carcinomas in urology. High percentage of metastatic disease at time of diagnosis and very poor outcomes have been reported in several studies. Primary treatment remains, as with all kidney cancers, surgical but adjuvant therapy is needed more often than in kidn...
Conference Paper
Full-text available
Karcinom prostate je jedan od vodećih zdravstvenih problema muškaraca druge i tre¬će životne dobi. Na njega otpada značajan udio od ukupnog broja svih malignih bolesti u muškaraca starijih od 50 godina, a incidencija se povećava svakim desetljećem, te je on na Zapadu najčešća maligna bolest muške populacije i drugi uzrok smrti. Nagli porast inciden...
Article
Full-text available
Tociiizumab (TCZ), humanizirano monoklonalno protutijelo na IL-6 receptor je indiciran u bolesnil€ s RA, u kojihje izostio uspjehl ijetenja lijekovimak oji modficiraju titek upalnei ematske bolesti( engl.skrD. N{ARDS). Najieite ntlspojaveT CZ su povileni rizik od iJrfekcta,n aroiito balterijskih i hiperkolesterolernijaA.p scesm . psoasajed jed(o sl...
Conference Paper
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OBJECTIVES: Tumors arising within urinary bladder diverticula are rare. Explanation of carcinogenic transformation is based on urinary stasis within poorly contractile diverticula and chronic inflammation. Additionally, bladder diverticula neoplasms have a poorer prognosis than tumors arising within the urinary bladder lumen. Early transmural infil...
Article
Full-text available
Objectives: To report a rare case of squamous cell carcinoma arising in a urinary bladder diverticulum and present recent literature overview on treatment options. Clinical Presentation and Intervention: A 56-year-old man presented with intermittent hematuria. Ultrasound examination indicated primary carcinoma in the urinary bladder diverticulum. D...
Article
Full-text available
Objective Sarcomatoid variant of urothelial carcinoma is a rare neoplasm of the urinary bladder, defined as a biphasic tumor consisting of malignant epithelial and mesenchymal components, with an incidence ranging 0.2-4.3%. Method Twenty-seven cases of sarcomatoid variant of urothelial carcinomas (~0.5% of all urothelial carcinomas) were retrieved...
Conference Paper
Full-text available
Interdisciplinarna sekcija za kontrolu rezistencije na antibiotike (ISKRA) MZSS RH inicirala je 2010. g. razvoj nacionalnih smjernica za liječenje prostatitisa. Cilj je ovih smjernica standardizacija, izjednačavanje i optimalizacija dijagnostike, liječenja i praćenja bolesnika s prostatitisom koja će dovesti do poboljšanja kvalitete njihove zdravst...
Conference Paper
Full-text available
Operativno liječenje odljevne/koraljne litijaze izazov je za svakoga urologa praktičara. Dugotrajni morbiditet, smanjenje kvalitete života te u konačnici zatajenje bubrežne funkcije posljedice su neliječene i neadekvatno liječene bolesti. Iskustvo i tehnološki napredak (PCNL, mini PCNL, RIRS, ESWL) pokazali su da minimalno invazivni i multimodalni...
Data
Full-text available
PurposeWe are often confronted with patients in the "gray zone" (prostate-specific antigen [PSA]<10 ng/mL) whose biopsies reveal no malignancy but only inflammation. We investigated the relationship between histological inflammation and total PSA (tPSA), free PSA (fPSA), and percentage of free PSA (f/tPSA) levels in patients without prostate cancer...
Article
Full-text available
The aim is to report a rare case of squamous cell carcinoma arising in a urinary bladder diverticulum and present recent literature overview of treatment options. A 56-year-old man presented with intermittent hematuria. Ultrasound examination indicated primary carcinoma in the urinary bladder diverticulum. Diagnosis was confirmed with cystoscopy an...
Article
Full-text available
INTRODUCTION & OBJECTIVES: Testicular lymphoma may be a manifestation of primary extranodal disease, the first manifestation of clinically hidden nodal disease or a later manifestation of disseminated nodal lymphoma. Of all testicular tumors, the primary testicular non-Hodgkin lymphoma makes up 5% of testicular tumors and 1-2% of all non Hodgkin’s...
Conference Paper
Full-text available
Ministarstvo zdravlja Republike Hrvatske imenovalo je članove Radne grupe za izradu smjernica za liječenje prostatitisa. Smjernice su prvenstveno namijenjene liječnicima opće prakse te specijalistima koji rade u primarnoj zdravstvenoj zaštiti i bolnicama, a odnose se na klasifikaciju, dijagnozu i liječenje sindroma prostatitisa. Cilj je smjernica s...
Article
Full-text available
Foreign bodies inside the urinary tract are a relatively rare condition in our practice. There are several reports published and in most cases the reason for self insertion of an object is autoerotic stimulation or psychiatric illness. Self treatment by homemade instruments is a rarely seen scenario. A 62 year old man reported to our clinic complai...
Article
Full-text available
Purpose We are often confronted with patients in the "gray zone" (prostate-specific antigen [PSA]<10 ng/mL) whose biopsies reveal no malignancy but only inflammation. We investigated the relationship between histological inflammation and total PSA (tPSA), free PSA (fPSA), and percentage of free PSA (f/tPSA) levels in patients without prostate cance...
Conference Paper
Full-text available
Novija istraživanja sugeriraju da bi kronična upala, te uz nju vezana proliferativna upalna atrofija (PIA) mogla biti uključena u patogenezu karcino¬ma prostate. S druge strane, subklinička upala u prostati svojim učinkom na PSA biokemijski imitira karcinom pa se značajan udio muškaraca podvrgava nepotrebnim ponavljanim biopsijama. Nije jasno treba...
Conference Paper
Full-text available
Pedeset godina nakon Robsonove radikalne nefrektomije: Koje su granice parcijalne nefrektomije? SAŽETAK: Prije 50 godina Robson je učinio prvu radikalnu nefrektomiju (RN) koja je dugo bila "zlatni standard" u kirurškom liječenju solidnih tumora bubrega. U posljednjem desetljeću iskustvo ili golemi tehnološki napredak pokazali su da elektivna par...
Conference Paper
Full-text available
Prostate-specific antigen (PSA) is the most useful marker for the early detection and follow up of patients with prostate cancer. However, PSA is not a cancer-specific marker and elevated PSA levels due to benign conditions most directly underscore the difficulty in making a decision about the need for prostate biopsy. Today, an important question...
Conference Paper
Full-text available
Article
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Erectile dysfunction (ED) has been defined as the persistent inability to attain and maintain an erection suf-ficient to permit satisfactory sexual performance. Although ED is a benign disorder, it affects physical and psychosocial health and has a significant impact on the quality of life of sufferers and their partners. Recent epidemiological dat...
Article
Full-text available
Prostate-specific antigen (PSA) is the most useful marker for the early detection and follow up of patients with prostate cancer. However, PSA is not a cancer-specific marker and elevated PSA levels due to benign conditions most directly underscore the difficulty in making a decision about the need for prostate biopsy. Today, an important question...
Article
Full-text available
Prostate-specific antigen (PSA) is the most useful marker for the early detection and follow up of patients with prostate cancer. However, PSA is not a cancer-specific marker and elevated PSA levels due to benign conditions most directly underscore the difficulty in making a decision about the need for prostate biopsy. Today, an important question...
Article
Full-text available
Sažetak Erektilna je disfunkcija (ED) nemogućnost posti-zanja i održavanja erekcije dostatne za zadovoljavajući odno-šaj. Zbog starenja populacije i komorbiditeta ED postaje sve važniji zdravstveni problem, koji smanjuje kvalitetu života i na-rušava odnose među partnerima. Smatra se da od ED-a boluje više od polovice muškaraca u dobi od 40 do 70 go...
Conference Paper
Full-text available
Prostatitis is a prevalent, confusing and frustrating presentation for both patients and clinicians. It is an inflammatory condition of the prostate that presents with urethral symptoms, prostatic symptoms and sexual dysfunction. It is diagnosed by clinical symptoms and signs, the microscopy of expressed prostatic secretion (EPS) and culture of EPS...
Article
Full-text available
S indrom prostatitisa čest je klinički entitet i naziv je za niz poremećaja funkcije prostate.1,2 O sindromu prostatitisa govorimo stoga što etiologija bolesti nije u potpunosti razjašnjena, a dijagnostički i terapijski kriteriji nisu jasno određeni.3-5 Sindrom prostatitisa najčešći je urološki problem u muškaraca mlađih od 50 godina i treći najčeš...
Article
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Erektilna disfunkcija (ED) je nemogućnost postizanja i održavanja erekcije dostatne za zadovoljavajući spolni odnos. Rastući je zdravstveni problem, koji negativno utječe na zdravlje pojedinca i kvalitetu njegova života, te narušava odnose među partnerima. Smatra se da od ED-a stalno ili povremeno boluje više od polovice muškaraca u dobi do 70 godi...
Conference Paper
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Article
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Connexins (Cxs) are a family of transmembrane proteins that build cell-to-cell channels in gap junctions. Gap junctions composed of Cxs have an essential role in intercellular communication, adhesion and cell differentiation. Several studies investigated the role of connexin43 (Cx43) in different carcinomas; however, none investigated its prognosti...
Article
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A 65-year-old man was referred to our department with clinical signs of septic shock and necrotizing soft tissue infection of the scrotal, perianal and right inguinal region. Initial presentation was a typical Fournier's gangrene. Because of the life-threatening condition, the initial treatment was extensive removal of necrotic tissue. Antibiotic t...
Conference Paper
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Introduction & Objectives: In recent publications there is emerging evidence that inflammation may contribute to prostatic carcinogenesis. It is hypothesised that oxydative stress triggers the appearance of proliferative inflammatory atrophy (PIA) lesions which can degenerate into carcinoma. The aim of the study was to assess the risk of detecting...
Conference Paper
Full-text available
In recent publications there is emerging evidence that inflamma¬tion may contribute to prostatic carcinogenesis. It is hypothesised that oxydative stress triggers the appearance of proliferative inflammatory atrophy (PIA) lesions which can degenerate into carcinoma. The results from recent studies connecting PIA with cancer have been contraversial....
Article
Full-text available
Syndecans are a four-member family of transmembrane heparan sulphate proteoglycans that have different functions in cell signalling, adhesion, cytoskeleton organization, migration, proliferation, and angiogenesis. Several studies investigated the role of syndecan-2 (SDC2) in different carcinomas; however, only one being focused on SDC2 in prostate...
Conference Paper
Full-text available
Karcinom prostate je jedan od vodećih zdravstvenih problema muškaraca druge i tre¬će životne dobi. Na njega otpada značajan udio od ukupnog broja svih malignih bolesti u muškaraca starijih od 50 godina, a incidencija se povećava svakim desetljećem, te je on na Zapadu najčešća maligna bolest muške populacije i drugi uzrok smrti. Nagli porast inciden...
Article
Full-text available
A rare case of posttraumatic high-flow priapism is presented. A 20-year-old man underwent diagnostic procedure with color Doppler sonography and angiography. On color Doppler sonography and selective and supraselective angiographic images, arteriocavernosal fistula and pseudoaneurysm were detected in the proximal part of the right cavernous body. C...
Article
Full-text available
A rare case of posttraumatic high-flow priapism is presented. A 20-year-old man underwent diagnostic procedure with color Doppler sonography and angiography. On color Doppler sonography and selective and supraselective angiographic images, arteriocavernosal fistula and pseudoaneurysm were detected in the proximal part of the right cavernous body. C...