Gopi Aryal

Gopi Aryal
Patan Academy of Health Sciences · Department of Pathology

MD, PhD

About

40
Publications
14,374
Reads
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288
Citations
Additional affiliations
September 2014 - April 2016
Kidney Foundation of Nepal
Position
  • Renal Pathologist
March 2009 - March 2016
KIST Medical College
Position
  • Professor

Publications

Publications (40)
Article
Full-text available
Adenoid cystic carcinoma (ACC) is a rare slow-growing but aggressive malignant tumor arising from the epithelial cells of mucous-secreting glands. Primary intracranial ACC is one of the rarest entity. We report a case of a 61 years old male presenting with difficulty in swallowing, slurring of speech, generalized body weakness. Patient had residual...
Article
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BACKGROUND In 1954, Castleman Disease (CD), was first described and is also known as angiofollicular lymph node hyperplasia or giant lymph node hyperplasia . Among many sites where lesion occurs, commonest is in the thorax (60%), abdomen (11%), neck (14%), and axilla (4%) MATERIALS AND METHOD We analyzed five cases of Castleman disease we received...
Article
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BACKGROUND Cervical cancer is most common in Nepalese women. Human papilloma virus (HPV) plays a main role in pathogenesis of cervical cancer. Human papilloma virus serotype 16 is the most common type followed by HPV 18. Liquid based smear cytology (LBC) is a simple, safe, non-invasive and cost effective method for the detection of squamous intraep...
Article
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Intussusception is defined as telescoping of one segment of bowel into another one. It is an uncommon cause of intestinal obstruction in adults with a reported incidence of 1 in 1300 abdominal cases presenting as obstruction. Intussusception as a cause of intestinal obstruction in adults is rare. There is invariably an underlying pathology which le...
Article
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Herniation of bladder mucosa through the bladder wall muscle layer is known as bladder diverticulum. The incidence of bladder diverticulum is 1.7. About 0.8 to 10% of the urinary bladder diverticulum develops carcinoma. Transitional cell carcinoma is the most common. Painless hematuria is the most common clinical presentation. Different imaging mod...
Article
Prostate cancer metastasis to the ureter is extremely rare because only 45 such cases have been reported worldwide in the last century. It accounts for 30% of ureteral metastasis. Neuroendocrine differentiation is approximately 1% of the entire primary prostate adenocarcinoma pathology. Metastatic prostate cancer may pose as upper tract urothelial...
Article
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Colorectal cancer (CRC) is the third and second most frequent cancer in men and women respectively. Although histologically similar, CRCs are diverse with respect to the underlying molecular mechanism which could be explored for planning treatment strategies. Chromosomal instability, microsatellite instability, and errors in the DNA repair mechanis...
Article
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Diverse pathogenetic mechanisms and clinical manifestation of renal diseases may produce the same renal morphologic pattern or variety of renal morphologic pattern can lead to the same clinical syndrome. The primary role of the renal biopsy is to provide a diagnosis and information about disease activity and chronicity. The systematic approach to n...
Article
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Cysts occupying the third ventricle are rare lesions and may appear as an unusual cause of hydrocephalic crisis. A 40-year old woman with headache and one episode of fainting attack was diagnosed with a cystic lesion in the third ventricle after brain MRI study. She was operated with the pre-operative diagnosis of a colloid cyst. A yellowish, thick...
Article
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p>Cancers of the uterine cervix, breast, lung and stomach are four of the most common cancers in Nepal. Lack of knowledge and awareness about cancer, its risk factors and negligence of the early warning signs play crucial role in raising the incidence of the cancer. Curative therapies are most successful when cancer is diagnosed and treated at an e...
Chapter
Animal venoms are truly mortal cocktails of various toxins with the mere purpose of evolution for the survival of the organism it endogenously possesses. Due to the significant and unavoidable venomous animal-human interactions, human envenomation is an important public health concern. Animal venom toxins are capable of affecting human physiology r...
Article
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p> Background: Triple-negative breast cancers lack expression of estrogen receptor, progesterone receptor, and human epidermal growth factor receptor -2. These tumors have been known to be clinically aggressive. We evaluate GATA-3, pAKT and Ki-67 expression in 35 triple negative breast carcinomas. Materials and Methods: A total of 35 triple negati...
Chapter
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Diabetes mellitus is now a day every second person's problem and is diagnosed by persistent hyperglycemia which in turn activates various metabolic pathways that results into diabetic complications. Synthetic drugs for diabetes treatment have some limitations such as high economic burden, secondary failures and various side effects. This scenario b...
Article
Background: Chronic kidney disease (CKD) is a global burden and now recognized as a major public health problem worldwide. Patients with CKD have alteration in thyroid hormone metabolism. This study aims to evaluate the status of thyroid hormone profile in different stages of CKD. Methods: The cross-sectional study included 103 CKD patients atte...
Article
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It is high time now to discover novel drugs due to the increasing rate of drug resistance by the pathogen organisms and target cells as well as the dependence or tolerance of the body towards the drug. As it is obvious that significant numbers of the modern day pharmaceuticals are derived from natural products, it is equally astonishing to accept t...
Chapter
Animal venoms are truly mortal cocktails of various toxins with the mere purpose of evolution for the survival of the organism it endogenously possesses. Due to the significant and unavoidable venomous animal human interactions, human envenomation is an important public health concern. Animal venom toxins are capable of affecting human physiology r...
Article
Full-text available
Immunohistochemistry (IHC) or immunocytochemistry is a method of localizing specific antigen in tissue or cells based on antigen antibody reaction. IHC is the way of validating morphological findings. It helps in tumor diagnosis and classification, identify prognostic and predictive markers. IHC has a long history that dates back more than 70 years...
Chapter
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Venom-specific IgE (sIgE) usually increases within days or weeks after a sting. Following this initial phase specific IgE declines slowly with a large individual variation. The test should be repeated after a few weeks in patients with no detectable specific IgE to the presumptive relevant venom. In vitro radioallergosorbent test (RAST) and various...
Article
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Primary extra-osseous osteogenic sarcomas have been reported in many tissues of the body but their occurrence in the breast is rare. The tumor has poor prognosis with high risk of recurrence and hematogenous spread, most commonly to the lungs. We report a case of primary osteosarcoma of the breast occurring in a 58-year old woman. Histo-pathologica...
Article
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Hymenoptera stings are a health concern. Apidae (bees), Vespidae (hornets, yellow jackets and wasps) and Formicidae (ants) are medically-important stinging insects under the order Hymenoptera. Clinical features from simple skin manifestations to severe and fatal organ injury are due to the hypersensitivity reactions and/ or the toxic effects of the...
Article
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Background: Derangements of mineral metabolism occur during early stages of chronic kidney disease (CKD). Mineral metabolism has emerged as important predictors of morbidity and mortality in dialysis patients. This study aims to evaluate the values of calcium and phosphorous in reference to practice guidelines issued by National Kidney Foundation D...
Article
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Idiopathic Myelofibrosis is an infrequent chronic myeloproliferative disorder characterized by varying degrees of bone marrow fibrosis and extra medullary hematopoiesis, with the fibrosis being a reactive phenomenon to a neoplastic proliferation of a pluripotent hematopoietic stem cell. Idiopathic Myelofibrosis is heterogeneous in presentation and...
Article
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Journal of Pathology of Nepal (2012) Vol. 2, IDOI: http://dx.doi.org/10.3126/jpn.v2i4.6873
Article
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Background: The incidence of esophageal adenocarcinoma is increasing in trends. Squamous cell carcinoma is associated with tobacco and alcohol consumption. Adenocarcinoma is often associated with a history of gastroesophageal reflux disease and Barrett's esophagus. The aim of this study was to find out the histological pattern of esophageal cancer...
Article
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Hornet stings are medically important stings which can cause allergic manifestations and, in severe cases, may lead to the unusual complication of acute renal failure (ARF) and other systemic complications. ARF results from toxic or ischaemic acute tubular necrosis in a setting of haemolysis or rhabdomyolysis or both and acute allergic interstitial...
Article
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Background: Renal allograft biopsy remains the gold standard for the diagnosis of graft dysfunction. Protocol renal allograft biopsies have provided insights into pathogenesis of early and late allograft injury and guided clinical management. The aim of this study was to find out the causes of early and late graft dysfunction in renal allograft bio...
Article
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Background: Typhoid fever continues to be a worldwide health problem, especially in developing countries. Effective epidemiological surveillance is needed to monitor the presence and spread of disease. Materials and Methods: Variable number tandem repeats (VNTR) was performed for Salmonella enterica serovar typhi by multiplex-PCR in 28 Nepalese iso...
Article
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Background: There is no documented data regarding the histopathological spectrum of the central nervous system (CNS) tumors in Nepal. The aim of this study was to establish the relative frequency of biopsy proven tumors of the CNS from a single university hospital in Nepal. Materials and Methods: In the period between1998-2000, we retrospectively a...
Article
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End Stage Renal Disease affects many people in the world. There are three methods of renal replacement therapy available to patients: Continuous ambulatory peritoneal dialysis, haemodialysis and transplantation. Transplantation is the most viable and cost effective form of renal replacement therapy that is available for these patients. There are 3...
Article
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Background: To treat symptomatic benign prostatic hyperplasia α 1-adrenoceptor antagonists with little antagonism at α 1b-adrenoceptor were used to avoid orthostatic hypotension. In benign prostatic hyperplasia tissues α 1D-adrenoceptor are thought to predominate, but in the Japanese experience, either α 1A-or α 1D-adrenoceptor antagonists can alle...
Article
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Background: Chronic kidney disease is usually associated with anemia and the level of anemia correlates with the severity of renal failure. This study was carried out to evaluate the profile of anemia and to find the correlation between the severity of anemia and serum creatinine levels in predialysis and postdialysis Chronic kidney disease patient...
Article
We analyzed 137 cases of renal biopsies at the Department of Pathology from 2001 to 2007. The average age was 30.6 years (range, 13-72) for males and 32.9 years (range, 11-75) for females. The male to female ratio was 1.6: 1. The most common clinical syndromes for performing renal biopsy were nephrotic syndrome (81.6%) followed by asymptomatic urin...
Article
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Many histologic changes have been described in the esophageal squamous mucosa in patients with gastroesophageal reflux disease (GERD), including dilated intercellular spaces, balloon cells, intrapapillary vessel dilation, elongated papillae, basal cell hyperplasia, acanthosis, intraepithelial eosinophils, Langerhans cells, and p53 protein overexpre...
Article
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The incidence of peripheral pulmonary adeno-carcinoma has increased in recent years. Clara cell has been known as target for carcinogens and source of pulmonary tumors. One of the presumed roles of the bronchiolar Clara cell is the secretion of pulmonary surfactant into the bron-chiolar lumen. To establish the secretory morphology of Clara cell, a...

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