Gonzalo Mora

Gonzalo Mora
ITRAMED (Instituto de Traumatologia y Medicina Regenerativa Avanzada) · Medicina Regenerativa

MD, PhD, Orthopedic Surgeon, Researcher, Arthroscopic Surgeon

About

39
Publications
4,434
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970
Citations
Citations since 2016
7 Research Items
575 Citations
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2016201720182019202020212022020406080100120
2016201720182019202020212022020406080100120
2016201720182019202020212022020406080100120
Introduction
Gonzalo Mora currently works at the Medicina Regenerativa, ITRAMED (Instituto de Traumatologia y Medicina Regenerativa Avanzada). Gonzalo does research in Orthopedic Surgery, Traumatology and Sports Medicine. Another current project is 'InsightMedi App http://www.insightmedi.com'.

Publications

Publications (39)
Preprint
Full-text available
Background Mesenchymal stromal cells are a safe and promising option to treat knee osteoarthritis as previously demonstrated in different clinical trials. However, their efficacy, optimal dose and addition of adjuvants must be determined. Here, we evaluated the clinical effects of a dose of 100 × 10⁶ bone marrow mesenchymal stromal cells (BM-MSCs)...
Preprint
Full-text available
Background Mesenchymal stromal cells are a safe and promising option to treat knee osteoarthritis as previously demonstrated in different clinical trials. However, their efficacy, optimal dose and addition of adjuvants must be determined. Here, we evaluated the clinical effects of a dose of 100x10 6 bone marrow mesenchymal stromal cells (BM-MSCs) i...
Article
Full-text available
Background: Mesenchymal stromal cells (MSCs) are a promising option to treat knee osteoarthritis (OA). Their safety and usefulness have been reported in several short-term clinical trials but less information is available on the long-term effects of MSC in patients with osteoarthritis. We have evaluated patients included in our previous randomized...
Article
Full-text available
Background: Mesenchymal stromal cells (MSCs) are a promising option to treat knee osteoarthritis (OA). Their safety and usefulness have been reported in several short-term clinical trials but less information is available on the long-term effects of MSC in patients with osteoarthritis. We have evaluated patients included in our previous randomized...
Article
Full-text available
Background Mesenchymal stromal cells are a promising option to treat knee osteoarthritis. Their safety and usefulness must be confirmed and the optimal dose established. We tested increasing doses of bone marrow mesenchymal stromal cells (BM-MSCs) in combination with hyaluronic acid in a randomized clinical trial. MaterialsA phase I/II multicenter...
Article
Full-text available
Introduction: To compare the clinical, analytical and graft maturation effects of two different platelet-rich plasma (PRP) preparations applied during anterior cruciate ligament (ACL) reconstruction. Materials and methods: A total of 150 patients with ACL disruption were included in the study. Arthroscopic ACL reconstruction with patellar tendon...
Article
Background: The use of autologous chondrocytes in cartilage repair is limited because of loss of the cartilage phenotype during expansion. The mechanosensing capacity of chondrocytes suggests evaluating the use of soft substrates for in vitro expansion. Our aim was to test the expansion of chondrocytes on collagen hydrogels to improve their capaci...
Article
Full-text available
Patellar tendon rupture after total knee replacement is a rare and highly limiting injury with multifactorial aetiology. Many reconstruction techniques have been described with not very predictable results. The use of allografts has been accepted as a suitable solution. A series of seven patients with patellar tendon rupture treated with fresh-froz...
Article
Aim: The influence of culture substrate stiffness (in the kPa range) on chondrocyte behavior has been described. Here we describe the response to variations in substrate stiffness in a soft range (2-20 Pa), as it may play a role in understanding cartilage physiopathology. Methods: We developed a system for cell culture in substrates with differe...
Article
Polymer-ceramic composites obtained as the result of a mineralization process hold great promise for the future of tissue engineering. Simulated body fluids (SBFs) are widely used for the mineralization of polymer scaffolds. In this work an exhaustive study with the aim of optimizing the mineralization process on a poly(L-lactic acid) (PLLA) macrop...
Article
Full-text available
Purpose: Due to the attractive properties of poly(L-lactic acid) (PLLA) for tissue engineering, the aim was to determine the growth and differentiation capacity of mesenchymal stromal cells (MSCs) in PLLA scaffolds and their potential use in the treatment of cartilage diseases. Methods: MSCs were cultured in PLLA films and thin porous membranes...
Article
The aim of this work was to determine the pathways implicated in the mechanosensing of chondrocytes. Rat chondrocytes were cultured in collagen hydrogels of different stiffness (2-20 Pa) in normoxia and hypoxia, in monolayer and embedded inside hydrogels. First, chondrocyte were cultured on hydrogels in the presence of antibodies to block integrins...
Article
Full-text available
The aim of this study was to evaluate and compare the clinical and inflammatory parameters with the addition of platelet-derived growth factor (PDGF) in primary anterior cruciate ligament (ACL) reconstruction with bone-patellar tendon-bone allograft. We prospectively randomized 100 patients undergoing arthroscopic patellar tendon allograft ACL reco...
Conference Paper
Full-text available
When articular cartilage is injured, different techniques may be used to regenerate it. To evaluate their potential is important to characterize the mechanical properties of the regenerated cartilage and comparing them with the healthy one. Moreover, when cartilage is injured, a tensional redistribution is produced around this defect, increasing t...
Article
Purpose We conducted a prospective multicenter study with alternate selection methodology in order to evaluate postoperative blood loss further to primary knee replacement at the time of tourniquet release, with or without hemostasis, as well as possible local and systemic complications. Materials and methods We studied 194 patients (194 knees) di...
Article
Objetivo Realizar un estudio prospectivo multicéntrico de selección alternante para valorar las pérdidas hemáticas postoperatorias de la prótesis total de rodilla en relación con el momento de soltar la isquemia, realizando o no hemostasia, y las posibles complicaciones locales y generales. Material y método Se analizan 194 pacientes (194 rodillas...
Article
Full-text available
The purpose of this study was to analyze cartilage degeneration in knees after total medial meniscectomy, transplantation of fresh-frozen meniscus allograft, and Achilles tendon allograft. Experimental study. Methods: We have studied the articular cartilage in the medial compartment of the left knees in 32 sheep aged 5 to 6 months, with 8 animals i...
Article
Arthroscopy: The Journal of Arthroscopic and Related Surgery, Vol 17, No 9 (November-December), 2001: pp 985–987
Article
Full-text available
Objective: Bone integration and contamination were studied in three types of external fixation nail of the same geometry made of different materials (stainless steel, titanium, and silver-plated stainless steel). Experimental design: The study was made of 18 lambs weighing 30-45 kg, which were divided into 3 groups. Bone integration and microbacter...
Article
Full-text available
Under standard conditions the left tibia was osteotomised in nine sheep. The osteotomy was transverse in six, and oblique in three. The osteotomies were fixated using a strain-gauge-monitored unilateral external fixator. The fixation was rigid in three sheep with a transverse osteotomy (group 1) and also in three sheep with an oblique osteotomy (gr...
Article
Twenty-two patients with 25 neural injuries at the elbow joint were reviewed. Follow-up lasted 2 years after surgery. Mean age was 9.4 years. Findings at surgery revealed discontinuity of the affected nerve trunk in eight cases; 17 cases showed a constrictive lesion with the nerve trunk in continuity. Surgical technique involved repair by interfasc...
Article
An analysis was made of the evolution of load bearing by monolateral external fixation equipped with extensiometric gauges and the stiffness of the fracture callus. Three groups of fractures were studied: a) transverse and b) oblique with rigid fixation, and c) transverse with compression fixation. Each group consisted of three lambs. The forces tr...
Article
Bilateral angular deformity of the lower extremity in children is common, and it is often due to benign physiological conditions in which the deformity corrects with growth1,2. However, unilateral angular deformity is rare and usually involves an abnormal condition such as Blount disease, fibrous dysplasia, Ollier disease, dyschondrosteosis, neurof...
Article
Fifty patients affected by spondylolisthesis in the lumbar-sacral region, younger than 20 years old, that have been treated conservatively with an average follow-up time of 3 years, have been studied. These patients were classified according to the localization of the lesion (L4-L5 or L5-S1) and to the type of spondylolisthesis (grade I and II), wi...
Article
The experience obtained with the cervical fixation using the plate of Senegas, with the object to confirm its actual utility, has been valued. Taking into account the age, sex, aetiology, the indication, tha technique of osteosynthesis, length of time of the intervention, the time of consolidation and the possible complications, in a group of 20 pa...
Article
OBJECTIVE: To obtain the mechanical behaviour pattern of the lengthening process. DESIGN. IN VIVO: measurement of forces during bone lengthening in lambs. BACKGROUND: A series of parameters of a mechanical and biological nature have a bearing on all lengthening processes, and most of them are not fully understood. METHODS: A strain-gauge-monitored...
Article
Twenty nine patients with bone tumours, were embolized according to the following criterium and indications: the aetiology, localization of the tumour and characteristics of the tumour (great vascularization, important size and difficult surgical approach). The object of the embolization being therapeutical curation, pre-surgical or palliative. Of...
Article
Surgery of spinal deformities and vertebral tumors often requires extensive arthrodesis, with the difficulty of obtaining sufficient autogenous bone graft (particularly in children and cases of paralytic deformities) and the necessity of a second incision, thus lengthening the operation and eventual increase of the morbidity. We present 52 patients...
Article
The number of indications of the allografts is increasing in bone and joint pathology treatment. With this good alternative, it is possible to avoid the morbidity sometimes observed in patients in which autograft is used. We present 6 cases of fractures of the external tibial plateau type B3 (AO classification) treated using bone allograft (a piece...
Article
The authors present an unusual case of pure traumatic bilateral lumbosacral dislocation in a 5-year-old boy, the conservative treatment carried out, and the long-term result. To describe a rare traumatic lesion in children and evaluate the result obtained with conservative treatment. Watson-Jones was the first to describe this type of lesion. Since...
Article
This study analysed the influence of several factors affecting the consolidation time of 83 massive bone allografts in 79 patients with malignant bone tumours: osteosarcoma 57; Ewing's sarcoma 8; malignant fibrous histiocytoma 3; chondrosarcoma 4; fibrosarcoma 5; and giant cell tumours 2. The mean age of the patients was 19 years and the mean lengt...

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Projects (9)
Project
The relation between obesity and osteoarthritis development traditionally has been explained as the consequence of the excessive joint effort derived of the overweight. However, in the last two decades a metabolic relation trough diverse molecular mechanism has been suggested between metabolic syndrome and osteoarthritis development.