Gonçalo Espregueira Themudo

Gonçalo Espregueira Themudo
University of Lisbon | UL · cE3C

PhD, Leiden University, 2010

About

39
Publications
10,457
Reads
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768
Citations
Additional affiliations
August 2019 - present
University of Porto
Position
  • Researcher
November 2017 - July 2019
Psykiatrisk Center Sct. Hans
Position
  • PostDoc Position
August 2014 - November 2017
University of Copenhagen
Position
  • PostDoc Position
Education
April 2005 - March 2010
Leiden University
Field of study
  • Biology
September 2002 - February 2005
University of Porto
Field of study
  • Applied Ecology
September 1997 - June 2001
University of Porto
Field of study
  • Biology

Publications

Publications (39)
Article
Full-text available
Schizophrenia is a heterogeneous disorder, exhibiting variability in presentation and outcomes that complicate treatment and recovery. To explore this heterogeneity, we leverage the comprehensive Danish health registries to conduct a prospective, longitudinal study from birth of 5432 individuals who would ultimately be diagnosed with schizophrenia,...
Article
Full-text available
Cardiac diseases and sudden cardiac death (SCD) are more prevalent in individuals diagnosed with schizophrenia compared to the general population, with especially coronary artery disease (CAD) as the major cardiovascular cause of death. Antipsychotic medications, genetics, and lifestyle factors may contribute to the increased SCD in individuals wit...
Article
Full-text available
The Mediterranean monk seal Monachus monachus is one of the most threatened marine mammals, with only 600–700 individuals restricted to three populations off the coast of Western Sahara and Madeira (North Atlantic) and between Greece and Turkey (eastern Mediterranean). Its original range was from the Black Sea (eastern Mediterranean) to Gambia (wes...
Article
Full-text available
The skin is a multi-layered organ, often displaying associated structures, that establishes a protective interface between the organism and the surrounding environment. In mammals, the skin provides a physical and immune barrier, while contributing to thermoregulation and water balance. Within cetaceans, the archetypal mammalian skin was drasticall...
Article
Full-text available
The European honeybee (Apis mellifera) is a key pollinator and has in the last decades suffered significant population decline. A combination of factors, including decrease in genetic diversity and introduction of Varroa mites, have been suggested to be responsible for these losses, but no definitive cause has yet been appointed. In Europe not only...
Article
Nuclear receptors (NRs) are key transcription factors that originated in the common ancestor of metazoans. The vast majority of NRs are triggered by binding to either endogenous (e.g. retinoic acid) or exogenous (e.g. xenobiotics) ligands, and their evolution and expansion is tightly linked to the function of endocrine systems. Importantly, they re...
Article
Full-text available
Schizophrenia patients have higher mortality rates and lower life expectancy than the general population. However, forensic investigations of their deaths often fail to determine the cause of death, hindering prevention. As schizophrenia is a highly heritable condition and given recent advances in our understanding of the genetics of schizophrenia,...
Article
The blue buck or blue antelope (Hippotragus leucophaeus) is an extinct antelope endemic to coastal South Africa. With a much wider distribution in the Pleistocene, it was already in decline before European settlement in the region (c. 400 years ago), and it went extinct in the late 18th century. Due to the short time span between its formal descrip...
Article
Full-text available
Ancestry inference for an individual can only be as good as the reference populations with allele frequency data on the SNPs being used. If the most relevant ancestral population(s) does not have data available for the SNPs studied, then analyses based on DNA evidence may indicate a quite distantly related population, albeit one among the more clos...
Article
The HID-Ion AmpliSeq Ancestry Panel from Life Techologies includes 123 SNPs from the Seldin panel and 55 SNPs from Kidd panel in a single multiplex assay that helps to determine the continental biogeographic ancestry of individuals. We tested the panel on 104 Greenlanders, divided into a training set of 89 individuals and a test set of 15 individua...
Article
Full-text available
As sequencing technologies become more affordable, it is now realistic to propose studying the evolutionary history of virtually any organism on a genomic scale. However, when dealing with non-model organisms it is not always easy to choose the best approach given a specific biological question, a limited budget, and challenging sample material. Fu...
Article
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Hemorrhagic pneumonia in mink (Neovison vison) is caused by Pseudomonas aeruginosa and is an acute and fatal disease in farmed mink. Earlier work has demonstrated that some outbreaks of hemorrhagic pneumonia are caused by pathogenic strains while most outbreaks are caused by local strains. The objective of this study was to determine the genetic an...
Article
Objective: Several classification systems have been launched to characterize Barrett's esophagus (BE) mucosa using magnification endoscopy with narrow band imaging (ME-NBI). The good accuracy and interobserver agreement described in the early reports were not reproduced subsequently. Recently, we reported somewhat higher accuracy of the classifica...
Article
Full-text available
Data from the Quality Assurance System in Danish Broiler Production (KIK system) were analyzed to identify within farm biosecurity- and management-related risk factors for Campylobacter infection in Danish broiler flocks. In the study, data from 2,835 flocks originating from 187 farms in the time period of December 2009 to November 2010 were includ...
Article
How frequently genes pass through a hybrid zone may be influenced by the environment. Accordingly, in long hybrid zones that span more than one environmental setting, different patterns may emerge. The varied conditions allow testing of hypotheses on dispersal as a function of the environment. We reconstruct the amount and direction of gene flow ac...
Article
Full-text available
SUMMARY Despite a number of risk-factor studies in different countries, the epidemiology of Campylobacter colonization in broilers, particularly spatial dependencies, is still not well understood. A series of analyses (visualization and exploratory) were therefore conducted in order to obtain a better understanding of the spatial and temporal distr...
Article
Eradication of Aleutian disease was initiated in Denmark in 1976. The prevalence of positive farms has since then been reduced from 100% to only being continuously present in the region of Vendsyssel, Northern Denmark since 2004. In this study, we attempted to identify risk factors for the infection in this region based on logistic regression of sp...
Article
Aleutian disease (Plasmacytosis) is caused by the Aleutian mink disease virus (AMDV), an autonomous parvovirus and affects many mustelid species, including the American mink (Neovisonvison). In Denmark, an eradication program reduced the prevalence of test-positive farms from 100% in 1976 to 15% in 1996. Nevertheless, the disease persists in the Ve...
Article
Full-text available
Crested newts of the Triturus karelinii group occur in a phylogeographically understudied region: the Near East. Controversy surrounds the systematic position of these newts within the complete crested newt assemblage (the Triturus cristatus superspecies). We explore the situation using mitochondrial sequence data (ND2 and ND4, approximately 1.7kb)...
Article
Newts of the genus Triturus are parapatrically distributed across Europe. Within this group, the crested newts (Triturus cristatus superspecies) radiated in a short temporal interval. Given the relatively short timespan in between branching events and to address the gene tree-species tree problem, we sequenced two mitochondrial and five nuclear gen...
Article
To increase the number of markers available for study of phylogeny and phylogeography in the newt genus Triturus, we developed and tested 59 primer pairs using three different techniques. Primers were obtained from published sources, by designing exon-primed intron-crossing primers and from randomly cloned anonymous nuclear DNA fragments. Successfu...
Article
Aim To identify the ecological factors associated with the range borders of two amphibian species, to investigate geographical variation in environmental parameters that determine species range limits, and to develop a testable hypothesis on the species’ biogeographical history.Location Portugal and Spain.Methods We documented the distribution of t...
Article
Full-text available
Newts of the genus Triturus (Amphibia, Caudata, Salamandridae) are distributed across Europe and adjacent Asia. In spite of its prominence as a model system for evolutionary research, the phylogeny of Triturus has remained incompletely solved. Our aim was to rectify this situation, to which we employed nuclear encoded proteins (40 loci) and mitocho...
Article
The newt species Triturus marmoratus and Triturus pygmaeus are both present in central Portugal where they have parapatric distributions. We used four genetic markers to determine which species was present in 31 populations. In the centre of the study area we found a T. marmoratus enclave. Despite small interpopulation distances, hybridization is l...
Article
Full-text available
The marbled newts Triturus marmoratus and T. pygmaeus are common and readily diagnosed species occurring in central Portugal, but difficult to survey in large and deep ponds. Conversely, embryos of both species are easy to locate but morphologically indistinguishable. We studied a panel of nuclear genetic loci by starch gel electrophoresis (the enz...
Article
Dissertação de Mestrado em Ecologia Aplicada, área de especialização em Genética Populacional, apresentada à Faculdade de Ciências da Universidade do Porto
Article
Full-text available
The interspecific relationships in the genus Triturus are incompletely known. In CHAPTER 2, we attempt to resolve them by using allozyme and mtDNA data. Despite the large number of markers used, relationships continue to elude us. The results suggest that speciation in the group occurred during a short time period (the end of the Middle Miocene). P...

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Projects

Projects (7)
Archived project
Characterize and model the spread of infectious diseases in production animals.
Project
Using genomic techniques in non-model organisms.