Gonca Alak

Atatürk University · Department of Aquaculture, Faculty of Fisheries

Epilepsy, the most common neurological disorder worldwide, is characterized by sudden paroxysmal brain activity, which can be generalized or focal. Extensive research has explored various treatment strategies for this condition. Our study employed a pilocarpine (PL)-induced seizure model in zebrafish (Danio rerio) embryos and larvae to assess the e...

Information on the microplastic (MPs) migration, particularly phthalate acid esters (PAEs) in packaged seafood, is limited to a few studies. The aim of this study is to follow the possible migration potential and speed of phthalates in rainbow trout ( Oncorhynchus mykiss ) fillets stored in vacuum packaging depending on the storage temperature, as...

Phthalates or phthalate esters (PAEs) have become a serious concern due to their toxicity and risks of migration from contact materials to food matrices and the environment. The aim of this study is to monitor the possible migration potential of PAEs in pelagic fish stored in vacuum packaging depending on the storage time and to determine the polye...

Acrylamide (ACR) can have adverse environmental effects because of its multiple applications. Relevant scientific literatures of the existence of ACR residues in foods following processing steps have raised concern in the biochemistry, chemistry and safety of this vinyl substance. The interest has focused on the hepatotoxicity of ACR in animals and...

Physico-chemical properties of fish flesh are reliable predictors of fillet quality and nutritional value. In our study, the age-related variations of the chemical composition, pH, water activity (aw), water holding capacity (WHC), color and texture analysis, protein thermal stability, myofibrillar fragmentation index (MFI), glycogen content, prote...

In recent years, the presence and migration of PAEs in packaging materials and consumer products has become a serious concern. Based on this concern, the aim of our study is to determine the possible migration potential and speed of PAEs in benthic fish stored in vacuum packaging, as well as to monitor the storage time and type as well as polyethyl...

The toxicological effects of a synthesized pyrazoline derivative 4-(3-(4-bromophenyl))- 5-(3,4-dimethoxyphenyl)-4,5-dihydro-1H-pyrazol-1-yl) benzene sulfonamide, compound B8, on rainbow trout (Oncorhynchus mykiss) were evaluated by following the activity of the antioxidant enzymes and the hematological parameters. Fish were exposed to variant doses...

This study focuses on the comparative metabolic profiling and effects of two steroid types: natural and synthetic, specifically 17α-methyl testosterone (17α-MT) at varying concentrations (1.5, 2, and 3 mg/kg) in rainbow trout (Oncorhynchus mykiss). Over a 75-day feeding trial, growth metrics, such as feed efficiency, daily specific growth, live wei...

This study investigated the curative effect of black cumin oil (Nigella sativa, NS), which is a phytotherapeutic agent against to cypermethrin (CYP), which is known to have adverse effects on rainbow trout (Oncorhynchus mykiss)'s behavioral changes, oxidative stress-mediated neurotoxicity, hematotoxicity and hepatotoxicity parameters.At the end of...

Described as the ’main ecological factor’, temperature, strongly affects the physiological stress responses of fish. In order to evaluate the effects of temperature variations on fish culture and food value chain, the present study was designed as a climate change model. Furthermore, the present study provides a theoretical basis for a better under...

Aquatic environments are one of the final destinations for microplastics. In this review, a combination of systematic and narrative literature review was conducted to identify and summarise advances, gaps, and future directions in microplastic monitoring studies in the Turkish aquatic environment and in inhabiting aquatic organisms. A total of 62 p...

BACKGROUND Temperature, which affects numerous physiological processes, has been described as the ‘main ecological factor’ for fish. The aim of this modeling study is to explore the impact of climate‐induced temperature changes on fish fillet quality and shelf life. RESULTS Temperature stress in rainbow trout affected ash and moisture, and inhibit...

In recent years, with the encouragement of national and international authorities, researchers on plastic levels in aquaculture have begun to assess consumer health risks as well as ecological monitoring. Based on this guidance, the aim of this study is to determine the microplastic load of rainbow trout raised under routine breeding conditions wit...

Although the number of studies documenting the presence of Microplastics (MP) in fish is increasing, research studies focused on its detoxification are very limited. In this study, rainbow trout (Oncorhyncus mykiss) were randomly divided into two groups after being fed with MPs (15% polypropylene [PP] +15% polyethylene [PE]) for 2 months. MP excret...

Fish and other seafood are fundamental nutritional ingredients for a healthy life that are consumed globally. However, the high degree of spoilage of these products has led to the progress of a prevalent variety of preservation, processing, and analytical techniques in this sector. Food safety, authenticity, nutritional quality, and freshness are i...

Although nickel (Ni) is an important cofactor for various enzymes in biological systems, it can cause serious problems when insufficient or excessive in an organism. Therefore, it is very important to investigate Ni in biological systems, especially in cells with its related pathogenic mechanism. This study was carried out to demonstrate the effect...

Increasing nanoplastics (NPs) pollution may lead to unknown environmental risks when considered together with climate change, which has the potential to become an increasingly important environmental issue in the coming decades. In this context, the present study aimed to evaluate the stressor modelling of polystyrene nanoplastic (PS-NPs) combined...

The toxic effects of microplastic (MP) pollution, which is a growing threat to the aquatic ecosystem, are constantly recorded by scientific reports at the organism and cellular levels. Despite this, the action mechanism of MP toxicity remains ambiguous. This research was designed to investigate the interactions with multiple biomarkers in the tissu...

Industrial products containing PdCu@GO can gain access to the aquaculture environment, causing dangerous effects on living biota. In this study, the developmental toxicity of zebrafish treated with different concentrations (50, 100, 250, 500 and 1000 μg/L) of PdCu@GO was investigated. The findings showed that PdCu@GO administration decreased the ha...

BACKGROUND In this study, the effects of biofilm coatings obtained by immobilization of different borates – namely borax (BX), colemanite (COL), and ulexite (UX) – with chitosan (Ch) on the shelf life of rainbow trout fillets were investigated. The immobilization and characterization of borates in Ch were confirmed by scanning electron microscopy,...

Microplastic (MP) pollution has become a health concern subject in recent years. Althoughann increasing number of studies about the ingestion of microplastics by fish, research on the oxidative stress response to MPs in natural environments is quite limited. In this study, the identification and characterization of MPs in gill (G), muscle tissues (...

The mechanisms of various metal nanoparticles are still a matter of debate in aquatic toxicology. In order to close this gap, the number of studies on this subject is increasing. The aims of this study to explore the interactions of PdCu@f‐MWCNT NPs with zebrafish and get to know if it has an ecotoxicological risk. In this study, we synthesized, ch...

The presence of microplastics (MPs) in several components of different ecosystems has aroused great concern and led to numerous studies on MP pollution. Although there has been an increasing number of these studies in aquatic ecosystems, no data about the MP pollution in zebra mussel (Dreissena polymorpha, Pallas 1771) living in Beyhan dam lake (El...

The current study was designed to assess the possible neuroprotective effect of borax (BX) against the toxicity of aluminum hydroxide [AH, Al (OH)3] on brain of rainbow trout (Oncorhynchus mykiss) with multibiomarker approaches. For this purpose, the presence of the neuroprotective action by BX against the AH exposure was assessed by the activities...

Nowadays, the unique features of nanoparticles (NPs) have encouraged new applications in different areas including biology, medicine, agriculture, and electronics. Their quick joining into daily life not only enhances the uses of NPs in a wide range of modern technologies but also their release into the aquatic environment causes inevitable environ...

Having no adverse effects on the consumer's health, causing zero or minimal damage to the environment, and maintaining the nutritional quality of the product are too important criteria for food packaging materials. Edible biofilm packaging techniques are successful to meet many of these features. To strengthen this claim, rainbow trout ( Oncorhynch...

Aluminum (Al), which has wide usage areas, is released into aquatic environments by natural processes and anthropogenic sources including coal strip mining activities, water treatment facilities using aluminum hydroxide (AH) as a coagulant for suspended solid particles, industrial wastes and acid rainfall. With the acidification of surface waters,...

Heat treatment is an inevitable step in making meat and meat products ready for human consumption. Researches on ready‐to‐eat foods had shown that foods can also contain microplastics (MPs). The source of the presence of MPs in foods is: air, raw materials, food production stages, or plastics used in packaging. This study was carried out to evaluat...

Fe²⁺ in ferrocene facilities the oxidation. Based on this phenomenon, increased iron (Fe) level in freshwater ecosystems is thought as an important environmental problem in many geographic regions. In addition to increased mobilization of Fe from sediment due to changes in land use, mining, industrial activity, and elevated acid deposition are also...

The developing technological infrastructure has accelerated the evolution of nanoscience and encouraged the use of nanomaterials in very large areas. However, environmental liberation of nanomaterials can pose potential risks. Although different toxicity screening methodologies have been successfully used to assess the potential risks of these subs...

Due to global warming, drought, population growth and industrialisation, existing water resources are rapidly being depleted and polluted. Pollution caused by millions of plastic waste reaching water resources seriously threatens the aquatic environment. This manuscript reviews the current state of knowledge about microplastics in the aquatic ecosy...

The presence of microplastic (MP) in different fish species taken from stations in Erzurum, Erzincan and Bingöl was examined. The obtained data were classified and shared with the scientific world as the first record made in this region. In the obtained results, the most dominant color was black (39-58%) and the most prevalent forms were fragment a...

Graphene oxide (GO) and their natural/synthetic composites are encouraging tools for humanity. There is a need to address critical challenges and potential risk possibilities in GO-based architectures, which have a wide range of uses. In this study, ecotoxicological levels as well as GO-based nanoparticle synthesis, characterization, interaction me...

The effect of green synthesis approaches in NP synthesis and their possible toxicity in aquatic environments has been very limitedly studied. In this study, VA-Ag / AC NPs were synthesised using Viscum album plant as a reducing agent and Chenopodium album (CA) plant as an active carbon source. TEM (Transmission Electron Microscope) and XRD (X-ray c...

In this study, the neuroprotective action potential by ulexite (UX) (18.75 mg/l) against acetylferrocene (AFC) (3.82 mg/lt) induced neurotoxicity was aimed to investigate in brain tissues of Oncorhynchus mykiss. For this purpose, the effects on neurotoxicity markers, proinflammatory cytokines, antioxidant immune system, DNA and apoptosis mechanisms...

Genetic, neuropathological and biochemical investigations have revealed meaningful relationships between aluminum (Al) exposure and neurotoxic and hematotoxic damage. Hence, intensive efforts are being made to minimize the harmful effects of Al. Moreover, boron compounds are used in a broad mix of industries, from cosmetics and pharmaceuticals to a...

Silver nanoparticles (AgNPs) are prominent nanomaterials that are efficiently used in different industries including medical products, water treatment, and cosmetics. However, AgNPs are known to cause adverse effects on the ecosystem and human health. In this study, aqueous extract of Rumex patientia (RP) was used as a reducing and stabilizing agen...

Acrylamide(AA) is a compound with wide usage areas including paper, dyes, and plastics industries. Due to its broad spectrum and water solubility suggest that this vinyl compound may cause serious environmental problems. AA was shown to exhibit neurotoxic, immunotoxic, reproductive toxicant as well as carcinogenic potency on animals. Especially in...

There is very limited aquaculture research on candidate probiotics and their effects on fish physiology. In this study, acute applications of four different molecularly identified bacterial species - Brevibacillus brevis FD-1 (A), Pseudomonas fluorescens FDG-37 (B), Bacillus sphaericus FD-48 (C), and B. amyloliquefaciens TV-17C (D), with potential...

The prevalent exposition of metallic nanoparticles (MNPs) to the aquatic medium and their negative influence on human life is one of the major concerns global. Stress mechanization, as a non-specific and pervasive response, involves all physiological systems, particularly the closely interconnected neuroendocrine and immune systems. In this study,...

Background In recent years, therapeutic targets and the development of new drugs have shifted research towards inflammatory and oxidative stress pathways. Ferrocene (FcH) is a stable, small molecule that exhibits immunostimulatory and anti-tumor properties by a different mechanism and is effective at low doses in oral administration. However, it wa...

Pyridine is a basic heterocyclic organic compound. The pyridine ring is present in many important compounds, including agricultural chemicals, medicines and vitamins. Due to their widespread industrial use, bioaccumulation and non-target toxic effects are being considered as a great risk to human and environmental health. In this study, we aimed to...

Due to the disadvantages of conventional chemical methods, the green synthesis of metallic nanoparticles has attracted great attention in recent years. In the present study, for the synthesis of palladium nanoparticles, green synthesis nanoparticle protocol, which consists of plant extracts with reducing and capping agents, was used. RP-Pd/AC NPs w...

Seaweeds have been generally utilized as food and alternative medicine in different countries. They are specifically used as a raw material for wine, cheese, soup, tea, noodles, etc. In addition, seaweeds are potentially good resources of protein, vitamins, minerals, carbohydrates, essential fatty acids and dietary fiber. The quality and quantity o...

New strategies for fast, efficient and environmentally friendly approaches in nanoparticle (NP) synthesis have increased the interest in less toxic green synthesis products. In this study, VA-Pd / AC nanoparticles (NPs) were synthesized using palladium (Pd), activated carbon (AC) and Viscum album (VA) aqueous extract as stabilizer / reductant. Acti...

The researches on MPs in commercial marine fish are very limited although in marine environments microplastic (MPs) pollution is a global problem. In this study, the presence, composition, and characterization of MPs in different tissues (brain, gill, muscle, and gastrointestinal tract) of commercial fish species [red mullet (Mullus barbatus) and p...

It is known that microplastics (MPs) are increasingly detected in aquatic environments (sea and fresh water), and the presence of these pollutants have worrying potential effects on the biota. This study is the first research to measure and characterize MPs in freshwater ecosystems (inland waters) in Turkey. Accordingly, the identification and char...

This research was designed to determine the shelf life of products obtained by using humic acid as a feed additive in trout culture. Accordingly, brown trouts (Salmo trutta fario) were fed with different levels of humic acid added feed for 90 days. At the end of the feeding trial, the chemical composition, mineral substance, color and texture analy...

In this research, Brown trout (Salmo trutta fario L., 1758) with 100±15 g from the fish production center of Aquaculture department of Fisheries Faculty at Ataturk university was used. The effects of addition of prebiotic (0 % prebiotic as control and 0.1 % prebiotic) to the fish diets was determined from a-90 days of feeding trial (Experiment 1) w...

Bioremediation is widely used to remove water pollution as environmentally friendly smart solutions. In this study, Bacillus isolates were investigated in terms of the effectiveness of single and multiple cultures in eliminating aquatic pollution related to aquaculture activities. In the established experimental setups, the environments where Bacil...

There are many studies on microplastics (MPs) about the aquatic ecosystems and its components. However, there is limited study on the MPs abundance, identification and sources in processed seafood products which are manufactured for direct human consumption. In this study, rainbow trout (Oncorhynchus mykiss) fillets were packed with different packa...

Insecticides have potential to non-target organisms, disrupting the healthy functioning of the aquatic environment as they are the ultimate receptor of the aquatic ecosystem. Insecticides, which are widely used in agriculture, have high neurotoxicity on aquatic organisms. In this study, the acute alterations [catalase (CAT), arylesterase (ARE), mal...

In recent years, because of its significant biological roles, the usage of boron has been started in animal feeding. In this research, it was aimed to investigate the ulexite’s action mechanism on the zebrafish brain with an evaluation of the oxidative parameters. The adult zebrafish were exposed to four ulexite doses (5, 10, 20, and 40 mg/l) in a...

Fish and other fishery products are among the foods recommended for the prevention and treatment of diseases with their high nutritional properties. The demand for fish caviar has increased in recent years due to the increase in fish consumption and their high nutritional and commercial value. In order to meet this increasing demand, caviar substit...

In recent years, n‐butanol, a type of alcohol, has been widely used from the chemical industry to the food industry. In this study, toxic effects of n‐butanol's different concentrations (10, 50, 250, 500, 750, 1,000, and 1,250 mg/L) in Zebrafish Danio rerio embryos and larvae were investigated. For this purpose, Zebrafish embryos were exposed to n‐...

Pesticide toxicities are common in aquatic ecosystems and affects aquatic livings negative. Therefore, it is important to strengthen the antioxidant system in aquatic organisms and to protect the organisms against these toxic chemicals. In this study, the simulative toxicity was established to the fish then the healing process was followed. For thi...

Authors' Contribution DOO, SB, HIG and CY performed synthesis of the B4 compound. GA, AU, MK, VP, MA and TY tested B4 compound. AM and TY evaluated the data and wrote the manuscript. In this study, a mixture of a suitable chalcone and p-hydrazinobenzenesulfonamide hydrochloride in 1:1.1 mol ratio in ethanol (25 ml) in the presence of glacial acetic...

In this study, changes in the blood tissue of rainbow trout (Oncorhynchus mykiss, Walbaum, 1792) caused by Fipronil (FP) insecticide were investigated using different biomarkers (Hematology parameters, superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPX), malondialdehyde (MDA), paraoxonase (PON), arylesterase (ARE), myeleperoxid...

The ulexite (UX), a borate mineral, is used as boron source and commonly used in various industrial processes. The hematological and hepatic effects of UX were investigated by exposing adult zebrafish to UX (5, 10, 20 and 40 mg/L) over 96 hours. The blood and liver tissues were taken at the end of the trial period then micronucleus (MN) rates, oxid...

Insecticides that disrupt the healthy functioning of the ecosystem have toxic potential on non-target organisms. Fish, an important component of the aquatic ecosystem, are exposed to these pesticides in different ways. The stress response is regarded as an adaptive mechanism that allows the fish to cope with the perceived stressor to maintain its n...

Bu çalışmada, kahverengi alabalıklara (Salmo trutta fario) farklı öldürme teknikleri uygulanarak balıkların fizyolojik yanıtları bazı kan biyokimya enzimleri ile araştırılmıştır. Buzlu su, elektroşok, CO2, hipoksi ve kafasına vurma gibi farklı öldürme teknikleri, 75 balık kullanılarak denenmiş ve balıkların kan biyokimya parametrelerindeki değişim...

Recently, boron has been used in animal feeding due to its significant biological roles. In this study, the action mechanism of colemanite (COL), a commercially important borate mineral, was aimed to investigate via evaluating parameters related to oxidative alterations on the brain, liver and blood tissues of zebrafish. For this purpose, zebrafish...

In this study, the structural features (thickness and light transmittance) of edible films that obtained from quinoa starch were analyzed, and the films were applied to rainbow trout fillets. These fillets were classified under two different groups without quinoa starch film (control) and coated with quinoa starch film (QSBF).Thereafter, these fill...

In this study, the relationship between stunning techniques and protein oxidation which are accepted as the main cause of food spoilage was investigated. For this purpose, the antioxidant status, in vivo myofibrillary protein (MP) oxidation and sensitivity, and postmortem oxidation (inducted with hydroxyl radical system) of rainbow trout (Oncorhync...

The aim of this study was to determine the therapeutic potential of borax against copper in the kidney tissue of the rainbow trout fed with added borax (BX) (1.25, 2.5, and 5 mg/kg) and/or copper (Cu) (500,1000 mg/kg) contents. For this purpose, two treatment groups had designed, and glutathione peroxidase (GPx), superoxide dismutase (SOD), and cat...

In recent years, n-butanol has growing use in many areas, including the food industry. In this study, acute toxic effects of n-butanol to zebrafish (Danio rerio) larvae by applying different concentrations (10, 50, 250, 500, 750, 1000 and 1250 mg/L) to embryos were evaluated. For this purpose the data of oxidative stress, antioxidant - acetyl choli...

In this study, it is aimed to investigate the potential effects of the use of quinoa as a carrier polymer in the production of edible film and the importance of essential oils (with lemon and sage oil) with highly important biological activity as supportive in this coating material. The rainbow trout fillets were wrapped with the edible film which...