Gokul Krishna

Gokul Krishna
The University of Arizona College of Medicine · Child Health

Doctor of Philosophy

About

39
Publications
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605
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Publications

Publications (39)
Article
Full-text available
Traumatic brain injury (TBI) is associated with diffuse axonal injury (DAI), a primary pathology linked to progressive neurodegeneration and neuroinflammation, including chronic astrogliosis, which influences long-term post-TBI recovery and morbidity. Sex-based differences in blood-brain barrier (BBB) permeability increases the risk of accelerated...
Preprint
Full-text available
Despite the number of studies supporting the neuroprotective role of creatine in pathophysiology caused by traumatic brain injuries, there is insufficient knowledge of how this ergogenic compound may potentially affect brain-injury complications in adolescence. Thus, we hypothesized that creatine supplementation after a TBI could prevent from delet...
Article
Full-text available
Background Aspects of glutamate neurotransmission implicated in normal and pathological conditions are predominantly evaluated using in vivo recording paradigms in rats anesthetized with isoflurane or urethane. Urethane and isoflurane anesthesia influence glutamate neurotransmission through different mechanisms; however, real-time outcome measures...
Article
Clinical evidence indicates that injury to the brain elicits systemic metabolic disturbances that contributes to the brain pathology. Since dietary fructose is metabolized in the liver, we explored mechanisms by which traumatic brain injury (TBI) and dietary fructose influence liver function and their possible repercussions to brain. Consumption of...
Article
Transforming Growth Factor-β (TGF-β) is a multifunctional cytokine expressed in virtually every cell type of the human body. It has various roles throughout the body and is heavily reliant on cellular and environmental context, with major roles in extracellular matrix (ECM) turnover and inflammation. TGF-β is upregulated after neurological insults...
Article
Marfan syndrome (MFS) is a connective tissue disorder (CTD) associated with mutations in fibrillin-1 (Fbn1), leading to systemic increases in transforming growth factor-β (TGF-β) availability and signaling that induces an accelerated vascular aging phenotype with known peripheral vascular dysfunction by 6-months (6M) of age in Fbn1 C1041G/+ (MFS) m...
Preprint
Full-text available
Aspects of glutamate neurotransmission implicated in normal and pathological conditions are often evaluated using in vivo recording paradigms in rats anesthetized with isoflurane or urethane. Urethane and isoflurane anesthesia influence glutamate neurotransmission through different mechanisms; however real-time outcome measures of potassium chlorid...
Preprint
Full-text available
Traumatic brain injury (TBI) manifests late-onset and persisting clinical symptoms with implications for sex differences and increased risk for the development of age-related neurodegenerative diseases. Few studies have evaluated chronic temporal profiles of neuronal and glial pathology that include sex as a biological variable. After experimental...
Article
Full-text available
Traumatic brain injury (TBI) is a leading cause of death and disability worldwide, with estimates indicating that ~50% of the world’s population will acquire a head injury at some point in their lifetime (Maas et al., 2017). Mild TBIs account for ~80% of all reported cases, with up to 43% of all TBI patients reporting symptoms beyond 2 weeks post-i...
Chapter
Diffuse traumatic brain injury (TBI) induces damage to the neuro-vascular-glial units with the hallmark pathology as diffuse axonal injury (DAI) throughout the brain in concert with persisting neuroinflammatory responses and molecular cascades that disrupt global circuit function without gross focal lesions. In response to axonal injury, neuroplast...
Article
Full-text available
Disruption of the blood–brain barrier and occurrence of coagulopathy after traumatic brain injury (TBI) have important implications for multiple secondary injury processes. Given the extent of post-traumatic changes in neuronal function, significant alterations in some targets, such thrombin (a protease that plays a physiological role in maintainin...
Article
Drosophilae are emerging as a valuable model to study traumatic brain injury (TBI)-induced secondary injury cascades that drive persisting neuroinflammation and neurodegenerative pathology that imposes significant risk for long-term neurological deficits. As in mammals, TBI in Drosophila triggers axonal injury, metabolic crisis, oxidative stress, a...
Chapter
The increase in exposure to environmental neurotoxicants has contributed to the development of neurological disorders around the world such that neurodegenerative disease and neurodevelopmental disorders are becoming more common. The gut–brain axis is recognized as a crucial signaling bidirectional loop for the interactions between gut bacteria and...
Article
Full-text available
Over 2.8 million traumatic brain injuries (TBIs) are reported in the United States annually, of which, over 75% are mild TBIs with diffuse axonal injury (DAI) as the primary pathology. TBI instigates a stress response that stimulates the hypothalamic-pituitary-adrenal (HPA) axis concurrently with DAI in brain regions responsible for feedback regula...
Article
Full-text available
Women approximate one-third of the annual 2.8 million people in the United States who sustain traumatic brain injury (TBI). Several clinical reports support or refute that menstrual cycle-dependent fluctuations in sex hormones are associated with severity of persisting post-TBI symptoms. Previously, we reported late-onset sensory hypersensitivity t...
Article
Full-text available
Mild traumatic brain injury (TBI) often results in pathophysiological damage that can manifest as both acute and chronic neurological deficits. In an attempt to repair and reconnect disrupted circuits to compensate for loss of afferent and efferent connections, maladaptive circuitry is created and contributes to neurological deficits, including pos...
Article
Full-text available
Scope Traumatic brain injury (TBI) compromises neuronal function required for hippocampal synaptic plasticity and cognitive function. Despite the high consumption of blueberries, information about its effects on brain plasticity and function under conditions of brain trauma is limited. We assessed the efficacy of dietary blueberry (BB) supplementat...
Article
Full-text available
Background: Parkinson's Disease (PD) is characterized by alterations in cerebellum and basal ganglia functioning with corresponding motor deficits and neuropsychiatric symptoms. Involvement of oxidative dysfunction has been implicated for the progression of PD, and environmental neurotoxin exposure could influence such behavior and psychiatric pat...
Article
Fetal and early childhood exposure to low levels of chemicals formed in foods during heating, especially acrylamide (ACR) is of increased concern due to developmental neurotoxicity. The neurodevelopment during perinatal period is critical and evidence suggests that the gut microbiota plays a major role in shaping brain development and behavior. Pre...
Article
Environmental insults including pesticide exposure and their entry into the immature brain are of increased concern due to their developmental neurotoxicity. Several lines of evidence suggest that maternal gut microbiota influences in utero fetal development via modulation of host's microbial composition with prebiotics. Hence we examined the hypot...
Article
Full-text available
Metabolic dysfunction accompanying traumatic brain injury (TBI) severely impairs the ability of injured neurons to comply with functional demands. This limits the success of rehabilitative strategies by compromising brain plasticity and function, and highlights the need for early interventions to promote energy homeostasis. We sought to examine whe...
Chapter
Dietary phytochemicals, in particular flavonoids, have been suggested to limit neurodegeneration in a variety of neurological diseases and ameliorate age-related cognitive impairments. Emerging evidence suggests that absorbed dietary flavonoids and their metabolites traverse across the blood–brain barrier and exert multiple neuropharmacological act...
Article
Full-text available
Accumulating evidence suggests that probiotic bacteria play a vital role in modulating various aspects integral to health and well-being of humans. In the present study, probiotic attributes, antioxidant, anti-inflammatory and neuromodulatory potential of Enterococcus faecium (EF) CFR 3003 were investigated by employing suitable model systems. EF e...
Article
Full-text available
Prebiotic oligosaccharides are demonstrated to confer a wide spectrum of physiological benefits during pregnancy. In view of this, focused attempts are being directed towards understanding their role as modulators of brain chemistry and behavior. Epidemiological studies have identified that exposure to neurotoxins during prenatal/early life can pro...
Article
Background Tomato seeds, a major by-product from food processing industry, constitute a rich source of bioactives and a large population consumes tomato (either in raw or cooked form). In the present study, initially we assessed the antioxidant activity of aqueous extract of tomato seeds (TSE) in selected chemical systems and further explored the n...
Article
Accumulating evidence suggests that the developing brain is more susceptible to a variety of chemicals. Recent studies have shown a link between the enteric microbiota and brain function. While supplementation of non-digestible oligosaccharides during pregnancy has been demonstrated to positively influence human health mediated through stimulation...
Article
Full-text available
Objectives: Bacopa monnieri (BM), an ayurvedic medicinal plant, has attracted considerable interest owing to its diverse neuropharmacological properties. Epidemiological studies have shown significant correlation between paraquat (PQ) exposure and increased risk for Parkinson's disease in humans. In this study, we examined the propensity of standa...
Article
Full-text available
Although tomato seeds (an industrial by-product) are known to contain several bioactive compounds, studies describing their health effects are limited. Previously, we evidenced that aqueous extract of tomato seeds (TSE) markedly attenuated rotenone (ROT)-induced oxidative stress and neurotoxicity in Drosophila system. This study investigated the ne...
Article
Full-text available
The study was intended to evaluate the anti-inflammatory activity of non-irradiated and gamma-irradiated (dose 5KGy and 10KGy) samples of Andrographis paniculata in carageenan induced rat paw oedema in Wistar rats at a dose level of 200mg / kg body weight administered orally. Significant anti-inflammatory activity was observed in aqueous extracts o...
Article
The effect of gamma irradiation on pharmacological activity of non-irradiated and gamma-irradiated (at doses of 5 KGy and 10 KGy) samples of Ashwagandha were examined. Investigations were performed to study the anti-stress activity by forced swim endurance test in Albino Swiss mice at a dose level of 100mg / kg b.w. administered orally. Significant...

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