Gokhan Unal

• PhD
• Marmara University

The majority of schizophrenia patients have cognitive deficits as a separate symptom cluster independent of positive or negative symptoms. Current medicines, unfortunately, cannot provide clear benefits for cognitive symptoms in patients. Recent findings showed decreased α7 nicotinic acetylcholine receptor (nAChR) expressions in subjects with schiz...

Objective: Schizophrenia is a chronic disorder with approximately 1% prevalence and related to disrupted neurodevelopment process. It has been known that N-methyl D-Aspartate (NMDA) receptor antagonists such as ketamine and MK-801 mimic schizophrenia-like behaviors in rodents and cellular changes in cell culture. There are certain preliminary repor...

Bimetallic nanoparticles (NP) have improved properties such as antimicrobial, anticancer and photocatalytic activity due to the synergistic effects of their components. Unmet needs of the current cancer treatments encourage researchers for the new treatment approaches especially natural products. In this study, we aimed to investigate the antiproli...

New hydrazone derivatives were synthesized from 4-chloro-2-(methylthio)pyrimidine-5-carbohy-drazide. IR,¹H-NMR,¹³C-NMR, mass spectral data and elemental analysis characterized synthesized compounds. All compounds were investigated for analgesic and anti-inflammatory activity with hot plate test and biochemical assay, respectively. The results of an...

Schizophrenia is a severe psychiatric disorder with about 1% prevalance. NMDA receptor antagonists such as Phencyclidine (PCP) and MK-801 are commonly used for modeling schizophrenia in rodents. In literature, despite of the concensus about subchronic PCP administration (commonly 7 days, bi-daily administration followed by a 1 week washout period),...

INTRODUCTION: Schizophrenia is one of the most severe psychiatric disorders with about 1% prevalence. It has been proved that glutamatergic N-methyl-d-aspartate (NMDA) receptor antagonists such as MK-801 and phencyclidine cause schizophrenia-like behaviours in rodents. Agmatine is an endogenous amine synthesized from decarboxylation of arginine and...

Objectives Nicotinic receptor systems are involved in a wide variety of behavioural functions, including cognitive function, and nicotinic medications, may provide beneficial treatment for cognitive dysfunctions such as schizophrenia. According to the results of postmortem studies of schizophrenic patients, alpha 7 nicotinic acethylcholine receptor...

Neuroinflammation in schizophrenia: a critical review and the future Schizophrenia is a serious mental illness that affects approximately 1% of the population worldwide, with positive, negative and cognitive dysfunctions and a significant deterioration in psychosocial functioning. Interactions between genetic predisposition and environmental stress...

Glycogen synthase kinase-3 (GSK-3), a member of the serine/threonine kinase family was first identified as an inhibitor of the metabolic enzyme glycogen synthase and is now accepted as a widely influential enzyme responsible for many intracellular regulatory mechanisms with over 50 known substrates characterized. There are two mammalian GSK-3 isofo...

The pKa constant of varenicline using a partial agonist of the nicotinic α4β2 acetylcholine receptor was determined potentiometrically. The pKa constant of varenicline was calculated as 9.22 (± 0.13) at I = 0.15 (NaCl), 25 ± 1 °C using the Irving–Rossotti method. The experimental results were compared with theoretical ones obtained via the SPARC pK...