Godswill Nduka Anyasor

Godswill Nduka Anyasor
Babcock University · Department of Biochemistry

Doctor of Philosophy

About

45
Publications
38,047
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924
Citations
Citations since 2017
13 Research Items
654 Citations
2017201820192020202120222023020406080100120140
2017201820192020202120222023020406080100120140
2017201820192020202120222023020406080100120140
2017201820192020202120222023020406080100120140
Introduction
I am interested in drug discovery processes using in vitro, in vivo and in silico approaches
Skills and Expertise

Publications

Publications (45)
Article
Full-text available
This study evaluated the hepatoprotective effect of oral administration of aqueous fraction of methanolic extract of Costus afer leaves (CALAF) during induction of hepatocellular carcinoma (HCC) with diethylnitrosamine (DEN) in rats. The methanolic leaf extract was fractionated into hexane, ethyl acetate, butanol, and aqueous fractions. The in vitr...
Article
Justicia secunda Vahl is an exotic plant that is used to treat medical problems. We investigated the hepatoprotective and hematological effects of aqueous extracts of J. secunda leaves on carbon tetrachloride induced toxicity in rats. Leaf extracts were prepared using hot and cold extraction methods to obtain a hot extract of J. secunda leaves (JSH...
Article
Full-text available
Background Justicia secunda Vahl. is a medicinal plant used in ethnomedical practice as therapy to manage inflammation. Therefore, this study was designed to evaluate the anti-inflammatory activity of methanol extract of J. secunda leaves (MEJSL) using in vitro and in vivo inflammation models. Methods Seventy-percent MEJSL was prepared following s...
Article
Piper guineense Schumach. & Thonn. seeds are employed in ethnomedicine practice as therapy against inflammatory disorders. This study was designed to determine the most active anti-inflammatory fraction of P. guineense seed using in vitro and in vivo models. Pulverized P. guineense seeds were partitioned into hexane and aqueous fractions using solv...
Article
Garcinia kola Heckel (Clusiaceae) has been widely used in ethnomedicine practice as a therapy against numerous disorders. Therefore, this study was designed to evaluate the protective effects of orally administered G. kola stem bark ethanolic extract (EEGK) and triterpenoid fraction (TFGK) against sodium arsenite-induced hepatotoxicity and nephroto...
Article
Myristica fragrans Houtt. seed commonly known as “nutmeg” is used in ethnomedical of practice as phytotherapy in the management of degenerative diseases. This study was designed to investigate the effects aqueous and dichloromethane extracts of M. fragrans seeds on calcium ion-induced rat liver mitochondrial membrane permeability transition (MMPT)...
Article
Alstonia boonie de Wild is an ethnomedical plant used as therapy against inflammatory disorders. This study evaluated the most active anti-inflammatory and anti-oxidant fraction of A. boonei leaves using in vitro and in vivo models. Quantitative phytochemical analysis, anti-protein denaturation and hypotonicity-induced hemolysis of human red blood...
Article
Full-text available
This study investigates the anti-inflammatory properties of Hydrocotyle bonariensis Comm. Ex Lam, a medicinal plant used by indigenous traditional healers to manage chronic inflammatory diseases especially rheumatism and arthritis. The hexane extract of H. bonariensis leaves was evaluated for the presence and concentration of phytochemicals. It was...
Article
The chemical constituents in Myristica fragrans seeds were analyzed using proximate analysis, atomic absorption spectroscopic (AAS), phytochemical and gas chromatographic-mass spectrometric (GC-MS) methods. Results showed the percentage proximate composition of M. fragrans seeds as: crude ash < crude protein < crude fibre < moisture < crude fat < n...
Article
Thaumatoccocus daniellii Benn (Benth.) is an organic food wrapper that influences the color and flavour of most foods processed and packaged with it. Hence, this study was designed to evaluate the phytochemical constituent and antioxidant activity of T. daniellii leave. Quantitative phytochemical analysis was carried out using standard procedures w...
Article
Full-text available
Aim: This study was designed to investigate the bioactive compounds in Costus afer Ker Gawl, an indigenous African medicinal plant whose leaf and stem extracts are used in the treatment of chronic inflammatory diseases, especially rheumatism and arthritis. Materials and methods: The bioactive compounds present in the n-butanol fractions of C. af...
Article
Costus afer Ker Gawl. (Costaceae) is an ethnomedical plant used as therapy against inflammatory disorders. The objective of this study was to evaluate the hematological and lipid profile analysis of hexane fraction of C. afer leaves (CAHLF) in arthritic rats. Male albino rats were randomly distributed into seven groups of six rats each. Rats were i...
Article
Full-text available
Objective: To evaluate the anti-inflammatory activity of a tropical African medicinal plant, Costus afer (C. afer) Ker Gawl. in vitro and identify the chemical constituents in the most active fraction. Methods: Hexane, ethyl acetate, n-butanol and aqueous fractions obtained through successive solvent partitioning of 70% methanolic leaf or stem extr...
Article
In view of the high demands for alternative medicines in developing countries and the dearth of valid scientific data on herbal formulations. This study was designed to identify and characterize the bioactive compounds present in hexane fraction of Costus afer ker Gawl stem, an indigenous medicinal African plant used as therapy in the treatment of...
Article
Ethnopharmacological relevance: Costus afer Ker Gawl is an indigenous tropical African medicinal plant used as therapy in the treatment of inflammatory ailments such as rheumatoid arthritis. This study was designed to evaluate the anti-inflammatory and antioxidant activities of the hexane fraction of C. afer leaves (CAHLF). Materials and methods:...
Article
Full-text available
Aim: This study was designed to determine the proximate composition and mineral content of Costus afer leaf and stem, as well as to identify the most active antioxidant fraction. Materials and methods: The proximate composition and mineral analysis of C. afer leaf and stem were performed using the standard methods described by Pearson and Associ...
Article
This study investigated the cytotoxic effect of varying doses of antimalarial coartemether (2.0, 4.0, 8.0 and 10.0 mg kg -1) in the presence of ferrous sulphate (2800 mg kg -1) for 3 days on normal rat liver mitochondrial membrane permeability transition pore opening and F 1F 0 ATPase activity. Swelling was estimated spectrophotometrically under su...
Article
This study investigated the effect of coartemether on antioxidant and hepatotoxic biomarkers in Plasmodium berghei infected mice. Erythrocyte, hepatic and renal superoxide dismutase (2.71 ± 0.51; 1.96 ± 0.87; 2.84 ± 0.22 Units/mg protein respectively) and catalase (4.10 ± 0.10; 8.25 ± 1.24; 6.28 ± 0.11 Units/mg protein respectively) activities were...
Article
Full-text available
The effect of extracting solvents (absolute methanol, ethanol, acetone and ethyl acetate) on the phenolic, flavonoid contents and antioxidant activities of the bark of Azadirachta indica, leaves of Acalypha wilkesiana, and Solanum scabrum were studied. The total phenolic content (TPC) was determined using folin-ciocalteu method while total flavonoi...
Article
Objectives: To investigate the lipid profile and oxidative stress status in vegetarians and non-vegetarians. Methodology: Fifty healthy volunteered adults, 25 vegetarians and 25 non-vegetarians (meat eaters) ages 20-50 Years from Babcock University community were recruited for this study. Venous blood sample was collected pre meal and two hours pos...
Article
The present study investigated the protective state of endogenous antioxidants against free radicals generated in human plasmodium malaria. Two hundred structured questionnaires were administered to the participants and blood samples were collected to assess the activities of superoxide dismutase (SOD), catalase (CAT), glutathione S-transferase (GS...
Article
Full-text available
Medicinal plants contain bioactive compounds capable of preventing and fighting oxidative related diseases. These compounds must be screened and assayed before effective drugs are developed. Thus, phytochemical constituents and antioxidant activities of aqueous and methanol stem extracts of Costus afer Ker-Gawl were evaluated. C. afer contained fla...
Article
Full-text available
This study evaluated and compared in vitro antioxidant activity, phytochemical constituent and proximate analysis of aqueous and methanolic leaf extracts of Vernonia amygdalina and Talinum triangulare to determine their acceptability in folkloric medicine. The total phenolic content of aqueous and methanolic extracts of V. amygdalina (0.822±0.050 a...
Article
Full-text available
Modern poultry production is based on manipulation of genetics and environmental factors that affect intensively farmed poultry. This includes feeding well balanced and hygienically produced feeds to highly productive lines of birds. Feed formulation involves combining different ingredients in proportions necessary to provide the animal with proper...
Article
Full-text available
Mosquitoes exploit almost all types of aquatic habitats for breeding. Prevailing physicochemical parameters in these habitats are important factors for survival and development of mosquito. Here, six water samples from Atlantic Ocean, River, well, distilled (control), rain and borehole water were used to culture Anopheline eggs collected from pure...
Article
Medicinal plants contain bioactive compounds capable of preventing and fighting oxidative related diseases. These compounds must be screened and assayed before effective drugs are developed. Thus, phytochemical constituents and antioxidant activities of aqueous and methanol stem extracts of Costus afer Ker-Gawl were evaluated. C. afer contained fla...
Article
Evidences have shown that diet-type is associated with the level of oxidative stress; however, reporton the impact of professional status on oxidative stress level is scanty. The present study assessed the impactof profession and diet-type on human oxidative stress status using self-administered structured questionnaires.A total of three hundred qu...
Article
The prevalence of STI pathogens in HIV- infected and non infected women attending HIV and STIclinic of the Olabisi Onabanjo University Teaching Hospital (OOUTH), Sagamu, Ogun state, Nigeria wascompared for possible implications in the acquisition and transmission of HIV. The study involved thecollection of urine and vagina swabs using sterile unive...
Article
Full-text available
The incidence of malaria is dramatically increasing, especially because parasites responsible for the majority of fatal malaria infections have now become resistant to commonly used antimalarial drugs such as chloroquine, mefloquine, and quinine. To combat this menace, the World Health Organization (WHO) introduced a new antimalarial drug called ar...
Article
Full-text available
Peanut ( Arachis hypogaea L. ) oil from seeds of six varieties; boro red, boro light, mokwa, ela, campala and guta as well as oil from three geographical zones in Nigeria; northern, eastern and western were investigated. Gas chromatography analysis showed high concentrations of oleic and linoleic acids in the oil samples. Capric (0.0%) and Lauric (...
Article
Full-text available
Extracts from the leaf of Tithonia diversifolia used in folk medicine for treatment of various ailments were tested for antimalaria and mosquito repellency properties in experimental animals and human volunteers, under the laboratory conditions. Comparison of the effectiveness of Chloroquine with the aqueous and methanolic extracts from the plant (...

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Projects (4)
Project
To determine the potency of concerned plants in the induction of mitochondrial membrane permeability transition pore; a phenomenon that result into cell death.