Godfried Dougnon

Niigata University · Brain Research Institute

Although the amyloid beta (Abeta) hypothesis (1) has long been central to Alzheimer's disease (AD) research, effective therapeutic strategies remain elusive (2,3). Here we re-evaluate the functions of amyloid precursor protein (APP) and reveal its critical function in protecting against nuclear impairment-induced cell death and inflammation (4,5)....

Traditional medicine (TM) is a significant resource for primary healthcare management all over the world, and principally in Africa. Quality improvement activities that promote evidence-based practices and the integration of traditional medicine into primary healthcare systems can help improve the quality of patient care. In the Republic of Benin (...

Autism spectrum disorders (ASD) and attention-deficit/hyperactivity disorder (ADHD) are two debilitating neurodevelopmental disorders. The former is associated with social impairments whereas the latter is associated with inattentiveness, hyperactivity, and impulsivity. There is recent evidence that both disorders are somehow related and that genes...

Essential oils are often utilized for therapeutic purposes and are composed of complex structural molecules, including sesquiterpenes, with high molecular weight and potential for stereochemistry. A detailed study on the properties of selected sesquiterpenes was conducted as part of a broader investigation on the effects of sesquiterpenes on the ce...

The chemical composition of the essential oils extracted from the leaves of Melia azedarach L. collected monthly from July 2019 to June 2020 was examined via gas chromatography (GC) and gas chromatography–mass spectrometry (GC–MS) techniques. Analysis of the essential oils identified about 17 compounds representing more than 85% of the oil. Oil yie...

Chromolaena odorata (L.) R.M.King & H.Rob. essential oil (COEO) was investigated for its sedative activity in mice. The results showed that COEO significantly reduced mice locomotor activity and the most efficient concentrations were 0.04 and 0.00004 mg/cage (volume of the cage 61.2L). Analysis of chemical composition of the oil indicated that cary...

The essential oil obtained from Dysphania ambrosioides leaves (DAEO) has antifungal, antioxidant, and antimicrobial properties. This study investigated DAEO’s chemical composition and its sleep-promoting effects via administration by inhalation in ddY mice. Ascaridole (35.5%) and p-cymene (47.2%) were the major components. To obtain insight into DA...

The anxiolytic and antidepressant-like activities of the naturally occurring monoterpene 1,8-cineole and its structural isomer 1,4-cineole were evaluated in mice via inhalation administration at doses ranging from 4 × 10−6 to 4 × 10−1 mg per 400 μL of triethyl citrate. Mice were tested for anxiety-like behaviours by using the light–dark box test (L...

Lantana camara Linn. (Verbenaceae) is used traditionally for its numerous medicinal properties such as antimalarial, antibacterial, anticancer and anti-inflammatory. In the present study, we investigated the chemical composition of essential oil from the leaves of L. camara (LCEO) occurring in the Republic of Benin (West Africa) in comparison with...

This study provides a list of popular medicinal plants found in southern Benin (West Africa) with their mode of use, diseases treated, and thin-layer and high-performance liquid chromatography profiles. The list includes 10 of the most widely used plant species from Dantokpa Market (biggest market located in Cotonou) and Abomey-Calavi in the Republ...

Infectious diseases such as diarrhea are generally very dangerous in human pathology especially when they are spread by ingestion of water or food contaminated with stool or by direct contact with infected stool. Bacterial resistance to antibiotics is increasing and becoming a major public health problem. This study aims to evaluate the antibacteri...

High blood pressure also called the "silent killer" is a major risk factor for cardiovascular diseases, and according to statistics, one in two adults will suffer of hypertension by 2025. Although the African people have used traditional herbs to heal themselves, very little information exists on species that show antihypertensive properties. This...

Vegetables are very important sources of protein and minerals. Some of them even have medicinal properties recog-nized traditionally. Despite the large number of studies carried out on various vegetables and vegetable crops, very few have scientifically explored the usefulness of S. macrocarpon. This study identified the main groups of chemicals an...