G.N. Bongo

G.N. Bongo
University of Kinshasa | UNIKIN · Department of Biology

MSc, Applied Microbiology

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191
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Publications (191)
Chapter
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Ageing is characterized by the maintaining deterioration of homeostatic processes over time, leading to functional decline and increased risk of disease and death. Several distinct mechanisms underlying ageing have been reported and mounting shreds of evidence have shown that histone methylation, an epigenetic marker, regulates gene expression duri...
Article
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The aim of the present work was to review data on the antiviral activities of some fruit plant species and their macronutrient composition. This was done with the aim of promoting these plants for the management of viral diseases, particularly covid-19. Several fruit plant species are mentioned in the literature for their antiviral properties. Thes...
Article
This research is based on a retrospective analysis of medical records filed in the archives of the emergency departments of Kalembe-lembe Hospital in the provincial city of Kinshasa in the Democratic Republic of Congo. The study involved 324 records of patients aged 0-71 months admitted to the emergency departments and hospitalized for acute diarrh...
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During pregnancy, women sometimes choose certain practices based upon the experience of their family and/or their vicinity to anticipate complications that may occur during childbirth. The main objective of this study is to understand the motivations and perceptions of pregnant women on lay knowledge in the prevention of complications related to ch...
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From centuries of evolution, knowledge and technological progress for man-kind to one day rediscover nature. Currently, the control of bacterial infections is becoming complex due to the concern of antibiotic resistance, which has been a significant global health problem. The aim was to determine and compare phytochemical constituents and in the in...
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Nowadays, invasive alien species are causing more and more environmental problems in several water bodies around the world, in Africa and in the Democratic Republic of the Congo. In October 2020, a floristic inventory was carried out around three islands of the Congo River (Molondo, Mipongo and Japon) at the Pool Malebo in Kinshasa. The study focus...
Article
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The world is facing an unprecedented health crisis caused by the COVID-19 pandemic. The DR Congo with its 90 million inhabitants and more than 500,000 refugees from neighboring countries recorded the first confirmed case in Kinshasa on March 10, 2020. Currently, the country is counting 16,039 cases of infection, 566 cases of death and 13,536 cases...
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According to official sources, the coronavirus pandemic that emerged in China in December 2019 has already infected more than 17 million and killed more than 666,850 people. Less impacted than the rest of the world, the Africa continent has nearly 890,000 confirmed cases as of July 30, 2020. According to the African Bank of Development, nearly 50 m...
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Marcel SONY LabouTansi, the author of the novel "The Shameful State", denounces the dictatorial system often practiced by most African leaders in the management of the "res publica". He paints the barbarity of man in relation to his fellow man. It also presents the duality between the traditional society characterized by democracy, peace ... and th...
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Aim: The present study aims at identifying potential inhibitors from a set of ten compounds from Ocimum basilicum against the SARS-CoV-2 main protease, the chymotrypsin-like protease (3CLpro). Materials and Methods: Computational studies by molecular docking (Autodock tool) were used to obtain the scoring function of ten phytochemicals in interacti...
Chapter
Ocimum bacilicum L. is an aromatic herb commonly known as sweet basil or sweet tulsi. It is rich in secondary metabolites like phenols, alkaloids, terpenoids, aldehydes, flavonoids, steroids, glycosides, essential oils, saponins, and tannins. The presence of these compounds makes sweet basil one of the most commonly used plants in aromatherapy, per...
Article
Aim: In the most severe case of the COVID-19, there is an excessive production of proinflammatory cytokines, being the main cause of mortality and morbidity. The present study aims at assessing the potential inhibitor effect of six phytochemicals with anti-inflammatory activity derived from Passiflora edulis, against the SARS-CoV-2 main protease. M...
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The Democratic Republic of the Congo is one of the major biodiversity hotspot in the world. Wild edible plants (WEPs) are widely consumed as part of daily diet by the local people and are part of their traditional culture and food habit. The T. triangulare species is a non-conventional vegetable crop of the Talinaceae family. It is well adapted to...
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Lassa fever is a viral hemorrhagic fever caused by the Lassa virus LASV, which was first isolated in the rodent Mastomys natalensis in 1974 in Kenema, Sierra Leone. As little is known about the abundance and the presence of LASV in rodents living in the Bo area, we carried out a small mammal longitudinal population survey. A standardized trapping s...
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Lassa fever is a viral hemorrhagic fever caused by the Lassa virus LASV, which was first isolated in the rodent Mastomys natalensis in 1974 in Kenema, Sierra Leone. As little is known about the abundance and the presence of LASV in rodents living in the Bo area, we carried out a small mammal longitudinal population survey. A standardized trapping s...
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Biosafety, as a set of measures to prevent laboratory acquired infections, has been recommended for more than fifty years. Indeed, since that time, evidence of contamination of laboratory workers has been provided in several articles. Are these measures known and applied in laboratories in Kinshasa, this was the question to what this study tried to...
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Aims: This study addressed the identification of bioactive compounds, the determination of mineral content and the evaluation of the antibacterial, antioxidant and anti-sickling activities of aqueous extract from stem bark of Harungana madagascariensis. Methodology: Phytochemical screening was evaluated by chromatographic methods (TLC and HPLC), th...
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Aims: COVID-19 pandemic affects hundreds of thousands of people worldwide. Since there is no effective treatment, the need of finding alternative methods, which can help to curb this pandemic is urgent. This study aims to collect the information on the virucidal and toxicity properties of Allium species. This genus is known to be source of nutraceu...
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Aim: The aim of this work was to review literature data reported on some species of the Ocimum genus regarding their phytochemistry and antiviral potential in order to show how Ocimum species might be used in the management of COVID-19. Methodology: Various databases like PubMed, PubMed Central., Science Direct, SCIELO, DOAJ, Science alert, Semanti...
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Aim: The aim of this work was to review literature data reported on some species of the Ocimum genus regarding their phytochemistry and antiviral potential in order to show how Ocimum species might be used in the management of COVID-19. Mini-review Article Tshilanda et al.; IJPR, 5(4): 42-54, 2020; Article no.IJPR.60559 43 Methodology: Various data...
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Aim: The main aim of the present study is to validate the bioactivity of O. basilicum, a medicinal plant traditionally used to treat helminthiasis in DRC. Place and Duration of Study: Department of Chemistry, Science Faculty, University of Kinshasa,between June 2018 and March 2019. Methodology: Different parts (stems, leaves and flowers) of O. bas...
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Rainforests constitute the great green heart of Africa and thus they present a unique combination of ecological, climatic and human interactions. The degradation of various forest ecosystems in mainly tropical regions and more particularly in sub-Saharan Africa has been a constant reality since the emergence of man. Faced to this almost alarming pi...
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Phyllanthus niruri L. is a medicinal plant from tropical regions with great pharmacognosic virtues scientifically proven. It is a rare herbaceous wild species in the dry season. Its use for the pharmaceutical industry requires a regular supply and it is independent of climatic hazards. The main aim to find optimal seed storage conditions with refer...
Preprint
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SARS-CoV-2 is the causative agent of the COVID-19 disease. Pathophysiologically, high levels of proin ammatory cytokines in the serum of SARS-CoV-2 patients are reported, which is so-called the cytokine storm. In this study, molecular docking calculations of six bioactive compounds from Passi ora edulis with anti-in ammatory activity in interaction...
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Aim: Till now, no specific treatment is available for COVID-19. This work is carried out with the aim of verifying in the literature the antiviral properties of aromatic plants and essential oils that can justify their use against the causative agent of COVID-19, SARS-CoV-2. Methodology: The literature review was based mainly on the usual databases...
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Aims: The incidence of infectious diseases is still a vital concern in developing countries. Recently, hygienists have focused on the risk of transmitted diseases through currency notes. This study aims at the determination of potential pathogenic microorganisms found on the Congolese Francs currency notes circulating in Kinshasa, Democratic Republ...
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The World Health Organization reported that at least 80% of populations rely on traditional medicine and medicinal plants for their primary health care. Due to their phytochemical compounds, the plants of the Aloe genus are reported to have high potential antiCovid-19 (and antioxidant properties. The aim of this study is to evaluate the in vitro an...
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The current relevance of Non-Timber Forest Products (NTFPs) as well as plant genetic resources (PGRs) for foresters and indigenous populations has prompted numerous initiatives in the last decade. In order to assess the environmental impact of the Plant Genetic Resources (PGRs) used as packaging, a survey was carried out on 64 respondents between A...
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Background and Aim: Condiment plants are not only a source of food, flavors or food additives but also antivirals. The aim of the present work consisted in compiling ethno-botanical, phytochemical, toxicological and biological activities literature data reported on some species of the Solanum genus, precisely their antiviral potential. Methodology:...
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Background and Aim : Condiment plants are not only a source of food, flavors or food additives but also antivirals. The aim of the present work consisted in compiling ethno-botanical, phytochemical, toxicological and biological activities literature data reported on some species of the Solanum genus, precisely their antiviral potential. Methodolog...
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SARS-CoV-2isthepathogenagentofthenewcoronavirusdiseasethatappearedattheendof2019inChina. Thereis,currently,noeffectivetreatmentagainstCOVID-19.Wereportinthisstudyamoleculardockingstudy oftenAloeveramoleculeswiththemainprotease(3CLpro)responsibleforthereplicationofcoronaviruses.The outcome of their molecular simulation and ADMET properties reveal th...
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Water pollution is currently at the top of the environmental agenda. In this study, the main objectives were (i) to assess the physicochemical and bacteriological quality of well and borehole water found in the vicinity of the University of Kinshasa and (ii) to assess the sensitivity of Escherichia coli and Enterococci strains isolated from various...
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Background: Plants of the Zingiberaceae family namely Curcuma longa, Aframomum melegueta and Zingiber officinale are known for their many biological activities such as the antiviral activity. Aim: To provide an updated knowledge on the phytochemistry, toxicology and antiviral activity of some medically interesting Zingiberaceae species. Study Desig...
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Background: Plants of the Zingiberaceae family namely Curcuma longa, Aframomum melegueta and Zingiber officinale are known for their many biological activities such as the antiviral activity. Aim: To provide an updated knowledge on the phytochemistry, toxicology and antiviral activity of some medically interesting Zingiberaceae species. Mini-review...
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Background: ART is one of the important pillars of the fight against AIDS. It restores immunity and reduces the risk of death. Its success lies in its strict compliance while its non-compliance exposes to the risk of resistance and therapeutic failure. The objective of this study was to determine the factors associated with the non-compliance to AR...
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In this work, a semi-empirical approach correlating the values of methanogenic toxicity of 22 aromatic compounds was used. The IC 50 exp, along with the various molecular properties of these compounds were determined using the DFT B3LYP/6-31G (d,p) method. While a conceptual approach of the DFT was made in order to determine those which are respons...
Article
SARS-CoV-2 is the pathogen agent of the new corona virus disease that appeared at the end of 2019 in China. There is, currently, no effective treatment against COVID-19. We report in this study a molecular docking study of ten Aloe vera molecules with the main protease (3CLpro) responsible for the replication of coronaviruses. The outcome of their...
Article
Full-text available
The aim of this study was to identify medicinal plants used in the traditional treatment of sickle cell disease (SCD) in Yakoma Territory. On the basis of the respondents' free consent, an ethnobotanical survey was carried out using a questionnaire among the Ngbandi traditional healers. The survey showed that 18 plant species are traditionally used...
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Aims: A novel β-coronavirus (2019-nCoV) has become a pandemic affecting hundreds of thousands of people worldwide. Since there is no effective treatment, the need of finding alternative methods which can help to curb this pandemic is urgent. This study aims to review the literature on the virucidal and cytotoxic properties of Aloe vera, one of the...
Article
Full-text available
A novel β-coronavirus (2019-nCoV) has become a pandemic affecting hundreds of thousands of people worldwide. Since there is no effective treatment, the need of finding alternative methods which can help to curb this pandemic is urgent. The aim of this study is to review the literature on the virucidal and cytotoxic properties of Aloe vera, one o...
Article
Full-text available
The pregnant woman feeding is very important for the optimal embryonic development of the zygote. The present study suggests a formulation of food supplement in soup form. We were able to make a soup which is composed of vegetables and animal products. This product like food supplement can cover the pregnancy nutrients needs. In fact, the nutrients...
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A cross sectional study was carried out on intestinal ascariasis, which is a helminth of fecal peril that colonizes the digestive tract with the possibility of complications in organs such as the intestines, liver, lungs and even the brain. The study was carried out at the General Reference Hospital of Kinshasa where medical records were used to co...
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In Africa, the importance of NTFPs in the livelihood security is well recognized and these products represent vital sources of income for poor population. However, the sales chain of Marantaceae leaves is informal in Gbado-Lite and there is no information available on this sector for the promotion of the sale of NTFPs at the local level to reduce p...
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L'anémie est l'un des problèmes de Santé Publique en régions d'endémie palustre. La présente étude avait pour objectif d'étudier le profil épidémiologique, bioclinique et évolutif de l'anémie chez les enfants de 0 à 5 ans à l'Hôpital Général de Référence (HGR) de Gbado-Lite en République Démocratique du Congo. La présente étude est rétrospective et...
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Sickle cell disease (SCD) is a hemoglobinopathy characterized by the presence in the blood of erythrocytes containing hemoglobin S. Surprisingly, the geographic distribution of SCD is superposed with that of the malaria which is also a haemolytic disease (like SCD) controlled by the great apes through their diet essentially vegetarian. Recent findi...
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Among various crops distributed in the world, insects remain a vital and privileged food as well they constitute an essential source of proteins, fats, minerals and vitamins. Caterpillars are among the most consumed and appreciated insects by African communities and particularly by Congolese. A socioeconomic survey was conducted among caterpillar s...
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Aim: To identify invasive aquatic alien plant species found in the Pool Malebo and some rivers in Kinshasa city, their behavior as well as their socio-economic impacts. Study Design: The study used a combination of purposive sampling and simple random sampling in order to select different sites where samples were collected. Place and Duration of St...