Glorisa Canino

Glorisa Canino
University of Puerto Rico at Rio Piedras | UPR-RP · Behavioral Sciences Research Institute

Ph.D

About

411
Publications
75,226
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28,999
Citations
Citations since 2016
100 Research Items
8418 Citations
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Introduction
Skills and Expertise

Publications

Publications (411)
Article
Full-text available
Background Adverse childhood experiences (ACEs) may sensitize individuals to view situations in adulthood as more stressful, which may contribute to poor health outcomes. In populations facing disadvantage, ACEs may lead to the accumulation of stressors (stress proliferation or mediation hypothesis) throughout the life course. ACEs could also heigh...
Article
Full-text available
Variability in response to short-acting β2-agonists (e.g., albuterol) among patients with asthma from diverse racial/ethnic groups may contribute to asthma disparities. We sought to identify genetic variants associated with bronchodilator response (BDR) to identify potential mechanisms of drug response and risk factors for worse asthma outcomes. Ge...
Article
Full-text available
Background: Asthma exacerbations are a serious public health concern due to high healthcare resource utilization, work/school productivity loss, impact on quality of life, and risk of mortality. The genetic basis of asthma exacerbations has been studied in several populations, but no prior study has performed a multi-ancestry meta-analysis of geno...
Article
Increasing violence-related distress over time was associated with worse lung function and worse asthma-related quality of life in youth with asthma despite treatment with low-dose inhaled corticosteroids. Exposure to violence has been associated with lower lung function in cross-sectional studies. We examined whether increasing violence-related di...
Article
Background: The mechanisms underlying the known link between overweight/obesity and childhood asthma are unclear. We aimed to identify differentially expressed genes and pathways associated with obesity-related asthma through a transcriptomic analysis of nasal airway epithelium. Methods: We compared the whole transcriptome in nasal airway epithe...
Article
Background Poor diet quality may contribute to the disproportionate asthma burden in Puerto Rican youth. Objective To examine whether an unhealthy diet at one or two study visits conducted over ∼5 years is associated with asthma, severe asthma exacerbations, and worse lung function in Puerto Rican youth. Methods Prospective study of 406 Puerto Ri...
Article
Policy Points In low-income communities in the South Bronx and Puerto Rico, Puerto Rican youth are exposed to many of the same risk and protective factors for developing depression, anxiety, or psychological distress; yet it is unclear how the ethnic minority context of the South Bronx and ethnic majority context of Puerto Rico influence risk. Resu...
Article
Full-text available
Background Barriers to mental health care access among Latinx children contribute to mental health disparities. It is unclear whether traditional spiritual guides in Latinx communities may function more as gateway providers or in some instances as deterrents to mental health treatment. This study assesses whether family involvement in Espiritismo a...
Article
Background: Whether persistent overweight or obesity impacts lung function or asthma morbidity in youth is unclear. Objective: To examine overweight or obesity that persists between school age and adolescence and change in lung function and total IgE, and severe asthma exacerbations in Puerto Rican youth. Methods: Prospective study of 340 Puerto Ri...
Article
Full-text available
Resting functional MRI studies of the infant brain are increasingly becoming an important tool in developmental neuroscience. Whereas the test-retest reliability of functional connectivity (FC) measures derived from resting fMRI data have been characterized in the adult and child brain, similar assessments have not been conducted in infants. In thi...
Article
Background Age- and sex-related differences in asthma may be due to changes in sex hormone levels. Objective To examine whether change in free testosterone or free testosterone to estradiol ratio is associated with changes in lung function and eosinophils in Puerto Rican youth. Methods We tested for association between change in sex hormone level...
Article
Background Exposure to violence (ETV) or chronic stress may influence asthma through unclear mechanisms. Methods Epigenome‐wide association study (EWAS) of ETV or chronic stress measures and DNA methylation in nasal epithelium from 487 Puerto Ricans aged 9–20 years who participated in the Epigenetic Variation and Childhood Asthma in Puerto Ricans...
Article
Background: Children with adverse childhood experiences (ACEs) are more likely to develop Attention-Deficit/Hyperactivity Disorder (ADHD). The reverse relationship - ADHD predicting subsequent ACEs - is vastly understudied, although it may be of great relevance to underserved populations highly exposed to ACEs. Methods: Participants were 5- to 1...
Preprint
Background Exposure to violence (ETV) or stress may cause asthma through unclear mechanisms. Methods Epigenome-wide association study (EWAS) of DNA methylation in nasal epithelium and four ETV or chronic stress measures in 487 Puerto Ricans aged 9-20 years who participated in the Epigenetic Variation and Childhood Asthma in Puerto Ricans study [EV...
Article
Full-text available
PurposeStudies document the substantial underutilization of mental health services by US Latinos in young adulthood. Rates of service use are higher in childhood, raising questions about whether mental health service use during childhood may facilitate access to services later in life. This article examines the extent to which utilization of mental...
Article
Severe asthma exacerbations are a major cause of school absences and healthcare costs in children, particularly those in high-risk racial/ethnic groups. To identify susceptibility genes for severe asthma exacerbations in Latino children and adolescents, we conducted a meta-analysis of genome-wide association studies (GWAS) in 4010 Latino youth with...
Article
Full-text available
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Article
Background Maternal depression has been linked to health care use for asthma in cross-sectional or short-term follow-up studies of school-aged children. Objective To examine whether increased or persistent maternal depressive symptoms over approximately 5 years are associated with severe asthma exacerbations or worse lung function in youth. Metho...
Article
Background: Few studies have examined concurrent exposure to household endotoxin and traffic-related air pollution (TRAP) in relation to childhood asthma, yet both factors are associated with asthma outcomes. Objective: We examined whether proximity to a major roadway (a TRAP proxy) modifies the estimated effects of indoor endotoxin on asthma ou...
Article
Background: Little is known about genetic determinants of severe asthma exacerbations. Objectives: We aimed to identify genetic variants associated with asthma hospitalizations. Methods: Genome-wide association study of asthma hospitalizations in 34,167 white British adults with asthma, of whom 1,658 (cases) had at least one asthma-related hos...
Article
Background Latinos are heavily affected with childhood asthma. Little is known about epigenetic mechanisms of asthma in Latino youth. Methods We conducted a meta-analysis of two epigenome-wide association studies (EWAS) of asthma, using DNA from white blood cells (WBCs) from 1,136 Latino children and youth aged 6 to 20 years. Genes near the top Cp...
Article
Child maltreatment and elevated sensation seeking are associated with a wide range of negative outcomes. Longitudinal data from a study of Puerto Ricans living in two sociocultural contexts were used to determine whether child maltreatment subtypes, sex, or sociocultural context relate to trajectories of sensation seeking. Participants were 2,489 i...
Preprint
Full-text available
Resting functional MRI studies of the infant brain are increasingly becoming an important tool in developmental neuroscience. Whereas the test-retest reliability of functional connectivity (FC) measures derived from resting fMRI data have been characterized in the adult and child brain, similar assessments have not been conducted in infants. In thi...
Article
Background Nasal (airway) epithelial methylation profiles have been associated with asthma, but the effects of such profiles on expression of distant cis-genes are largely unknown. Research question To identify genes whose expression is associated with proximal and distal CpG probes (within 1 Mb), and to assess whether and how such genes are diffe...
Article
Background Little is known about risk factors for atopic and non‐atopic asthma among children in Puerto Rico. We aimed to identify modifiable risk factors for atopic and non‐atopic asthma in this vulnerable population. Methods Case‐control study of children with (n=305) and without (n=327) asthma in San Juan (PR). Asthma was defined as physician‐d...
Article
Background Exposure to childhood adversities (CA) is associated with sleep disturbances; however, evidence has largely been drawn from cross-sectional data and has not addressed the relationship across developmental stages. Also, most studies have primarily focused on non-Hispanic White cohorts with a dearth of longitudinal evidence about racial/et...
Article
Full-text available
Objectives An Antisocial Behavior index (ASB-I) for children (ages 5 to 15) was previously developed by obtaining clinician ratings of the seriousness or severity of various behaviors with the goal of improving assessment of antisocial behaviors (ASB) longitudinally. We extend the instrument for use in late adolescence/young adulthood, as socially...
Article
Background Allergic diseases often occur in combination (multimorbidity). Human blood transcriptome studies have not addressed multimorbidity. Large‐scale gene expression data were combined to retrieve biomarkers and signaling pathways to disentangle allergic multimorbidity phenotypes. Methods Integrated transcriptomic analysis was conducted in 1,...
Article
Objective: Evidence stemming largely from retrospective studies suggests that childhood adversity (CA) is associated with earlier age at menarche, a marker of pubertal timing, among girls. Little is known about associations with pubertal tempo among boys or racial/ethnic minorities. We examined the association between CA and timing and tempo of pu...
Article
Exposure to violence (ETV) and chronic stress may cause or worsen asthma. 1 Among Puerto Rican school-aged children, we previously reported that lifetime ETV at individual or community level is associated with increased risk of asthma. 2 In a separate analysis (not accounting for ETV), we showed that high levels of chronic stress are associated wit...
Preprint
Nasal airway epithelial methylation profiles have been associated with asthma, but the effects of such profiles on expression of distant cis-genes are largely unknown. We identified 16,867 significant methylation-gene expression pairs in nasal epithelium from Puerto Rican children and adolescents (with and without asthma) in an expression quantitat...
Article
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In a transcription-wide association study of nasal epithelium, we identify novel and previously reported susceptibility genes for atopic asthma in children and show that gene co-expression networks differ markedly between children with and without atopic asthma.
Article
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Background: Epigenetic signatures in the nasal epithelium, which is a primary interface with the environment and an accessible proxy for the bronchial epithelium, might provide insights into mechanisms of allergic disease. Objective: We aimed to identify and interpret methylation signatures in nasal epithelial brushes associated with rhinitis an...
Article
Background: Long-term effects of sulfur dioxide (SO2 ) exposure on children, a vulnerable population, are largely unknown. Further, how long-term SO2 affects Puerto Rican children living in the island of Puerto Rico, a group with high asthma prevalence, is unclear. We evaluated the effects of annual average 1-hour daily maximum SO2 average on asth...
Article
Objective: Childhood parental incarceration has been linked to increased rates of delinquency and arrest during adolescence and young adulthood; however, previous research has focused on White and/or Black samples rather than Latinx youth. We examined relationships between childhood parental incarceration and later delinquency and arrest among Pue...
Article
Sensation seeking has been proposed as a risk factor for gambling and gambling problems; however, existing evidence for a relationship between sensation seeking and gambling behaviors is inconclusive and data are lacking for emerging adults and racial and ethnic minorities. In this longitudinal study, we explored the association between development...
Article
Few longitudinal studies have explored to date whether minority status in disadvantaged neighborhoods conveys risk for negative mental health outcomes, and the mechanisms possibly leading to such risk. We investigated how minority status influences four developmental mental health outcomes in an ethnically homogeneous sample of Puerto Rican youth....
Article
Background: Asthma is a common respiratory disorder with a highly heterogeneous nature that remains poorly understood. The objective was to identify regions of common genetic variation contributing to lung function in individuals diagnosed with asthma, utilizing whole-genome sequencing (WGS) data. Methods: WGS data were generated for 1,053 indiv...
Article
Full-text available
Purpose An emerging body of work suggests a link between childhood maltreatment and attention-deficit hyperactivity disorder (ADHD). However, research examining the role of maltreatment in the early course of the disorder lacks robust evidence from longitudinal studies. Our aim was to examine concurrent and prospective associations between maltreat...
Conference Paper
Full-text available
Rationale: Epigenetic changes in allergic diseases have recently attracted considerable interest because they might mediate genetic and environmental effects and lead to allergic diseases. Epigenetic mechanisms in nasal epithelium, the primary interface with the environment, which is a good and accessible proxy for the bronchial epithelium, might p...
Article
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The development of high-throughput biotechnologies allows the collection of omics data to study the biological mechanisms underlying complex diseases at different levels, such as genomics, epigenomics, and transcriptomics. However, each technology is designed to collect a specific type of omics data. Thus, the association between a disease and one...
Article
Suicidal behavior increases substantially during early adolescence, a critical understudied developmental period. This study reports on the prevalence of suicidal ideation, suicide attempts, and course of suicidal ideation among Puerto Rican early adolescents, a high-risk group for suicidal behavior in adulthood. Gender differences and the prospect...
Article
Full-text available
Early allergic sensitisation (atopy) is the first step in the development of allergic diseases such as atopic asthma later in life. Genes and pathways associated with atopy and atopic asthma in children and adolescents have not been well characterised. A transcriptome-wide association study of atopy and atopic asthma in white blood cells or whole b...
Article
Full-text available
Purpose The manuscript compares the rates of psychiatric disorder among island Puerto Ricans, the US population and US Puerto Ricans in order to examine whether social support explains differences in psychiatric disorder among these three groups. Methods Unadjusted and adjusted rates for sociodemographic factors and social support of main psychiat...
Article
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Background: Little is known about atopic dermatitis (AD) among children in Puerto Rico. Objective: To examine risk factors and identify approaches to better diagnose AD in Puerto Rican children. Methods: Case-control study of AD among 540 children aged 6-14 years in San Juan, Puerto Rico. AD was defined as: 1) physician-diagnosed AD, 2) RAST-A...
Article
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Background: Epigenetic mechanisms could alter the airway epithelial barrier and ultimately lead to atopic diseases such as asthma. We aimed to identify DNA methylation profiles that are associated with-and could accurately classify-atopy and atopic asthma in school-aged children. Methods: We did a genome-wide study of DNA methylation in nasal ep...
Article
Purpose: To examine the longitudinal relationship between depression, delinquency, and trajectories of delinquency among Hispanic children and adolescents. Methods: Propensity score matching is used to match depressed and non-depressed youth and a combination of group-based trajectory and multinomial logistic regression techniques are used. Res...
Article
Background Parenting behaviors have been shown to moderate the association between sensation seeking and antisocial behaviors. Methods Data were obtained from the Boricua Youth Study, a longitudinal study of 2,491 Puerto Rican youth living in the South Bronx, New York, and the metropolitan area of San Juan, Puerto Rico. First, we examined the pros...
Article
Objective Asthma and psychosocial stressors are common among Puerto Rican adults living in the United States. We estimated the prevalence of current asthma, and examined potential psychosocial risk factors and current asthma, among adults in Puerto Rico. Methods Cross-sectional study of 3,049 Puerto Ricans aged 18–64 years living in Puerto Rico be...
Article
Full-text available
Background: For decades, economists and sociologists have documented intergenerational transmission of socioeconomic disadvantage, demonstrating that economic, political, and social factors contribute to 'inherited hardship'. Drawing on biological factors, the developmental origins of adult health and disease model posits that fetal exposure to ma...
Article
Changes in dietary patterns may partly explain the epidemic of asthma in industrialized countries. The objective of this study was to examine the relationship between dietary patterns and lung function and asthma exacerbations in Puerto Rican children. This is a case-control study of 678 Puerto Rican children (ages 6-14 years) in San Juan (Puerto R...
Article
Full-text available
Objective The current study examined (a) the mediating role of parenting behaviors in the relationship between parental risks and youth antisocial behaviors (YASB), and (b) the role of youth cultural stress in a racial/ethnic minority group (i.e., Puerto Rican [PR] youth). Method This longitudinal study consisted of 3 annual interviews of PR youth...
Article
Aim: International collaboration is needed to enable large-scale pharmacogenomics studies in childhood asthma. Here, we describe the design of the Pharmacogenomics in Childhood Asthma (PiCA) consortium. Materials & methods: Investigators of each study participating in PiCA provided data on the study characteristics by answering an online questio...
Article
Full-text available
Rationale: Childhood asthma is a complex disease. In this study, we aim to identify genes associated with childhood asthma through a multi-omics "vertical" approach that integrates multiple analytical steps using linear and logistic regression models. Methods: In a case-control study of childhood asthma in Puerto Ricans (n=1127), we use adjusted...
Article
Full-text available
Puerto Ricans are disproportionately affected with asthma in the USA. In this study, we aim to identify genetic variants that confer susceptibility to asthma in Puerto Ricans. We conducted a meta-analysis of genome-wide association studies (GWAS) of asthma in Puerto Ricans, including participants from: the Genetics of Asthma in Latino Americans (GA...
Article
Background: Childhood asthma is likely the result of gene-by-environment (G × E) interactions. Dust mite is a known risk factor for asthma morbidity. Yet, there have been no genome-wide G × E studies of dust mite allergen on asthma-related phenotypes. Objective: We sought to identify genetic variants whose effects on lung function in children wi...
Article
Full-text available
Background: Total immunoglobulin E (IgE) is a therapeutic target in allergic diseases. DNA methylation in white blood cells (WBCs) was associated with total IgE in an epigenome-wide association study (EWAS) of Caucasians. Whether DNA methylation of eosinophils explains those findings is insufficiently understood. Methods: We tested for associati...
Article
Background: Parental warmth (PW) has a strong influence on child development and may precede the onset of psychiatric disorders in children. PW is interconnected with other family processes (e.g., coercive discipline) that may also influence the development of psychiatric disorders in children. We prospectively examined the association between PW...