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Pathologic inflammation in response to injury, infection, or oxidative stress is a proposed mechanism relating cognitive decline to dementia. The kynurenine pathway and thioredoxin-interacting protein (TXNIP) activity regulate inflammation and neurotoxicity in Alzheimer disease (AD). We examined cognitive deficits, kynurenine pathway mediators, TXN...
Fig. S1. S100A10 mRNA is over‐expressed in pancreatic TCGA tumors and CCLE cell lines. Fig. S2. S100A10 mRNA is overexpressed in pancreatic tumors compared to normal pancreatic tissue. Fig. S3. Representative images of S100A10 staining in normal ducts and cancerous lesions. Fig. S4. The three cut‐offs of S100A10 mRNA. Fig. S5. Correlation of S1...
Pancreatic cancer is arguably the deadliest cancer type. The efficacy of current therapies is often hindered by the inability to predict patient outcome. As such, the development of tools for early detection and risk prediction is key for improving outcome and quality of life. Here, we introduce the plasminogen receptor S100A10 as a novel predictiv...
Pancreatic cancer is arguably the deadliest cancer type. Patients are diagnosed at advanced stages at which point therapeutic intervention is rarely successful. To date, current treatments have not been clinically efficacious. The 5-year survival of pancreatic cancer patients remains dismal (4%) without treatment and only increases to 20% after che...