Gloria González FortesUniversity of Ferrara | UNIFE · Department of Life Sciences and Biotechnologies
Gloria González Fortes
Biology
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Introduction
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September 2017 - present
September 2015 - August 2017
May 2015 - July 2015
Publications
Publications (68)
[This corrects the article DOI: 10.1371/journal.pone.0249537.].
Domestic cattle were brought to Spain by early settlers and agricultural societies. Due to missing Neolithic sites in the Spanish region of Galicia, very little is known about this process in this region. We sampled 18 cattle subfossils from different ages and different mountain caves in Galicia, of which 11 were subject to sequencing of the mitoch...
Domestic cattle were brought to Spain by early settlers and agricultural societies. Due to missing Neolithic sites in the Spanish region of Galicia, very little is known about this process in this region. We sampled 18 cattle subfossils from different ages and different mountain caves in Galicia, of which 11 were subject to sequencing of the mitoch...
En este artículo se aborda el proceso de elaboración de la escultura hiperrealista de Elba, la pastora mesolítica de O Courel, cuyos restos fueron encontrados en la cueva de Chan do Lindeiro (Pedrafita do Cebreiro, Lugo). En él se definen los procesos técnicos que se han realizado durante la ejecución de la pieza escultórica, siguiendo el mismo ord...
To reconstruct aspects of human demographic history, linguistics and genetics complementeach other, reciprocally suggesting testable hypotheses on population relationships and interactions.
Relying on a linguistic comparative method based on syntactic data, here we focus on the
non-straightforward relation of genes and languages among Finno-Ugric (...
To reconstruct aspects of human demographic history, linguistics and genetics complement each other, reciprocally suggesting testable hypotheses on population relationships and interactions. Relying on a linguistic comparative method exclusively based on syntactic data, here we focus on the complex relation of genes and languages among Finno-Ugric...
Technological innovations such as next generation sequencing and DNA hybridisation enrichment have resulted in multi-fold increases in both the quantity of ancient DNA sequence data and the time depth for DNA retrieval. To date, over 30 ancient genomes have been sequenced, moving from 0.7x coverage (mammoth) in 2008 to more than 50x coverage (Neand...
Genetic studies that include ancient samples are often hampered by the low amount of endogenous DNA that ancient samples often contain, relative to co-extracted “contaminant” DNA from other organisms. One approach to mitigate this challenge is to perform hybridization-based capture of target genomic regions using DNA or RNA baits. Such baits are de...
Being at the western fringe of Europe, Iberia had a peculiar prehistory and a complex pattern of Neolithization. A few studies, all based on modern populations, reported the presence of DNA of likely African origin in this region, generally concluding it was the result of recent gene flow, probably during the Islamic period. Here, we provide eviden...
For many archaeological and paleontological samples, the relative content of endogenous compared to contaminant DNA is low. In such cases, enriching sequencing libraries for endogenous DNA, prior to sequencing can make the final research project more cost-effective. Here, we present an in-solution enrichment protocol based on homemade baits that ca...
Although many large mammal species went extinct at the end of the Pleistocene epoch, their DNA may persist due to past episodes of interspecies admixture. However, direct empirical evidence of the persistence of ancient alleles remains scarce. Here, we present multifold coverage genomic data from four Late Pleistocene cave bears (Ursus spelaeus com...
When studying an extinct species such as the cave bear (Ursus spelaeus ROSENMÜLLER 1794), it is possible to apply a variety of molecular biology techniques such as the study of stable isotopes or mitochondrial DNA (mDNA) to infer patterns of behaviour or physiology that would otherwise remain concealed. Throughout Europe and along time, differences...
European farmers' first strides from the south
The early spread of farmers across Europe has previously been thought to be part of a single migration event. David Reich and colleagues analyse genome-wide data from 225 individuals who lived in southeastern Europe and the surrounding regions between 12000 and 500 BC. They analyse this in combination...
The transition from hunting and gathering to farming involved profound cultural and technological changes. In Western and Central Europe, these changes occurred rapidly and synchronously after the arrival of early farmers of Anatolian origin [1; 2 ; 3], who largely replaced the local Mesolithic hunter-gatherers [1; 4; 5 ; 6]. Further east, in the B...
Data S1. Dataset of Ancient Samples Used for Population Genetic Analyses, Related to Figures 1, 2, and S3 and STAR Methods
Data S2. Results of the Outgroup f3 Statistics for the Romanian Genomes, Related to Figures 2 and S3 and STAR Methods
The transition from hunting and gathering to farming involved profound cultural and technological changes. In Western and Central Europe, these changes occurred rapidly and synchronously after the arrival of early farmers of Anatolian origin [1, 2, 3], who largely replaced the local Mesolithic hunter-gatherers [1, 4, 5, 6]. Further east, in the Bal...
Farming was first introduced to southeastern Europe in the mid-7th millennium BCE - brought by migrants from Anatolia who settled in the region before spreading throughout Europe. However, the dynamics of the interaction between the first farmers and the indigenous hunter-gatherers remain poorly understood because of the near absence of ancient DNA...
The transition from hunting and gathering to farming involved profound cultural and technological changes. In Western and Central Europe, these changes occurred rapidly and synchronously after the arrival of early farmers of Anatolian origin [1–3], who largely replaced the local Mesolithic hunter-gatherers [1, 4–6]. Further east, in the Baltic regi...
Little is known about the genetic prehistory of Sardinia because of the scarcity of pre-Neolithic human remains. From a genetic perspective, modern Sardinians are known as genetic outliers in Europe, showing unusually high levels of internal diversity and a close relationship to early European Neolithic farmers. However, how far this peculiar genet...
In this paper we present 73 short mitochondrial DNA (mtDNA) sequences obtained from 30 brown bear (Ursus arctos) and 56 cave bear (Ursus spelaeus) samples in several cave sites of Northwestern Iberian Peninsula (Galicia and Asturias), of Holocene and Pleistocene ages. The technique used was PCR amplification of small mtDNA fragments and the subsequ...
En este trabajo se presentan los primeros resultados de un estudio de paleogenética realizado en los restos óseos de Elba, la mujer mesolítica de Chan do Lindeiro (Pedrafita do Cebreiro, Lugo). El estudio se realizó a nivel de ADN mitocondrial completo y de marcadores nucleares relacionados con rasgos fenotípicos, como pigmentación y tolerancia a l...
Resumen En este trabajo se presentan los primeros resultados de un estudio de paleogenética realizado en los restos óseos de Elba, la mujer mesolítica de Chan do Lindeiro (Pedrafita do Cebreiro, Lugo). El estudio se realizó a nivel de ADN mitocondrial completo y de marcadores nucleares relacionados con rasgos fenotípicos, como pigmentación y tolera...
The ability to access genomic information from ancient samples has provided many important biological insights. Generating such palaeogenomic data requires specialised methodologies, and a variety of procedures for all stages of sample preparation have been proposed. However, the specific effects and biases introduced by alternative laboratory proc...
The ability to access genomic information from ancient samples has provided many important biological insights. Generating such palaeogenomic data requires specialised methodologies, and a variety of procedures for all stages of sample preparation have been proposed. However, the specific effects and biases introduced by alternative laboratory proc...
We report genome-wide ancient DNA from 44 ancient Near Easterners ranging in time between ~12,000 and 1,400 BCE, from Natufian hunter–gatherers to Bronze Age farmers. We show that the earliest populations of the Near East derived around half their ancestry from a ‘Basal Eurasian’ lineage that had little if any Neanderthal admixture and that separat...
Ancient DNA studies have revolutionised the study of extinct species and populations, providing insights on phylogeny, phylogeography, admixture and demographic history. However, inferences on behaviour and sociality have been far less frequent. Here, we investigate the complete mitochondrial genomes of extinct Late Pleistocene cave bears and middl...
We report genome-wide ancient DNA from 44 ancient Near Easterners ranging in time between ~12,000-1,400 BCE, from Natufian hunter-gatherers to Bronze Age farmers. We show that the earliest populations of the Near East derived around half their ancestry from a ‘Basal Eurasian’ lineage that had little if any Neanderthal admixture and that separated f...
Ancient DNA studies have revolutionised the study of extinct species and populations, providing insights on phylogeny, phylogeography, admixture and demographic history. However, inferences on behaviour and sociality have been far less frequent. Here, we investigate the complete mitochondrial genomes of extinct Late Pleistocene cave bears and middl...
Ancient DNA studies have revolutionised the study of extinct species and populations, providing insights on phylogeny, phylogeography, admixture and demographic history. However, inferences on behaviour and sociality have been far less frequent. Here, we investigate the complete mitochondrial genomes of extinct Late Pleistocene cave bears and middl...
We extend the scope of European palaeogenomics by sequencing the genomes of Late Upper Palaeolithic (13,300 years old, 1.4-fold coverage) and Mesolithic (9,700 years old, 15.4-fold) males from western Georgia in the Caucasus and a Late Upper Palaeolithic (13,700 years old, 9.5-fold) male from Switzerland. While we detect Late Palaeolithic–Mesolithi...
Se presentan los resultados de 12 nuevas dataciones radiométricas 14C de restos de oso pardo (Ursus arctos L.) procedentes de cuevas de la mitad occidental de la Cordillera Cantábrica (Galicia-Asturias-Cantabria). Estas dataciones, además de otras previamente publicadas, datan la presencia de la especie en cuevas de esta zona desde hace más de 40.0...
Ancient mitochondrial DNA has been used in a wide variety of palaeontological
and archaeological studies, ranging from population dynamics of extinct species
to patterns of domestication. Most of these studies have traditionally been
based on the analysis of short fragments from the mitochondrial control region,
analysed using PCR coupled with Sang...
Leopard complex spotting is inherited by the incompletely dominant locus, LP, which also causes congenital stationary night blindness in homozygous horses. We investigated an associated single nucleotide polymorphism in the TRPM1 gene in 96 archaeological bones from 31 localities from Late Pleistocene (approx. 17 000 YBP) to medieval times. The fir...
In this paper we present 13 new radiocarbon datings of brown bear (Ursus arctos L.) remains from caves of the western half of the Cantabrian Mountains (Galicia, Asturias, Cantabria). This dates, as well as other previously reported, range from more than 40,000 years BP to 2,442 ± 61 years cal BP, belonging mostly to the early Holocene. From a whole...
In 2012, a skeleton was excavated at the presumed site of the Grey Friars friary in Leicester, the last-known resting place of King Richard III. Archaeological, osteological and radiocarbon dating data were consistent with these being his remains. Here we report DNA analyses of both the skeletal remains and living relatives of Richard III. We find...
Technological innovations such as next generation sequencing and DNA hybridisation enrichment have resulted in multi-fold increases in both the quantity of ancient DNA sequence data and the time depth for DNA retrieval. To date, over 30 ancient genomes have been sequenced, moving from 0.7× coverage (mammoth) in 2008 to more than 50× coverage (Neand...
The Great Hungarian Plain was a crossroads of cultural transformations that have shaped European prehistory. Here we analyse a 5,000-year transect of human genomes, sampled from petrous bones giving consistently excellent endogenous DNA yields, from 13 Hungarian Neolithic, Copper, Bronze and Iron Age burials including two to high (~22 x) and seven...
In this paper we review the chronological and spatial distribution of Pleistocene deposits containing remains of cave and brown bear in the Iberian Peninsula as well as the Holocene deposits with traces of brown bear. The data comes from our own research and from paleontological and archaeological literature.
Leopard complex spotting is a group of white spotting patterns in horses caused by an incompletely dominant gene (LP) where homozygotes (LP/LP) are also affected with congenital stationary night blindness. Previous studies implicated Transient Receptor Potential Cation Channel, Subfamily M, Member 1 (TRPM1) as the best candidate gene for both CSNB...
The great majority of phenotypic characteristics are complex traits, complicating the identification of the genes underlying their expression. However, both methodological and theoretical progress in genome-wide association studies have resulted in a much better understanding of the underlying genetics of many phenotypic traits, including externall...
This paper addresses a metric, isotopic and genetic study of cave bears (Ursus spelaeus) from four deposits of Galicia (NW Iberian Peninsula) in relation to other European sites, in order to find possible differences that may have arisen due to its westernmost position in the area of distribution of this species. No special differences are observed...
This article describes some biogeochemical techniques increasingly used in the study of prehistoric skeletal remains based on data contained in organic molecules preserved in the bones (mainly collagen and DNA). The stable isotope study of bone collagen allows reconstructions of the diets of individuals and also infer paleoenvironmental parameters....
A consensus microsatellite-based linkage map of the turbot (Scophthalmus maximus) was constructed from two unrelated families. The mapping panel was derived from a gynogenetic family of 96 haploid embryos and a biparental diploid family of 85 full-sib progeny with known linkage phase. A total of 242 microsatellites were mapped in 26 linkage groups,...
Among the variety of cultured marine species, the turbot Scophthalmus maximus is a fish of growing importance in European aquaculture. In this paper, an advanced application of AFLPs to estimate the genetic diversity of haploid gynogenetic families with the aim of obtaining a preliminary genetic map is presented. Ten EcoRI/TaqI primer combinations...
To review the general consideration about the different compositional structure of warm and cold-blooded vertebrates genomes, we used of the increasing number of genetic sequences, including coding (exons) and non-coding (introns) regions, that have been deposited on the databases throughout last years. The nucleotide distributions of the third cod...
Several sociological, health and conservation arguments request a correct labelling of seafood products. Nowadays, molecular genetics is a useful tool for food chain traceability, particularly in regards to species identification. Among the variety of PCR-based molecular markers, AFLPs (Amplified Fragment Length Polymorphisms) have recently been us...
Scophthalmus maximus is an important commercially aquaculture fish species. We tackle the search for new microsatellites using two different approaches: an enriched partial genomic library and a screening of all turbot DNA sequences deposited in GenBank. Out of 15 genomic library derived loci, five gave working primer pairs, with expected heterozyg...
As a consequence of analyzing isotopically the skeletal remains of a brown bear (Ursus arctos L.) with osteoarthritis and osteoporosis, a great variability of results has been obtained. These data compared to a healthy individual, could be the result of differences in bone remodeling due to these diseases, although the bones used for analysis did n...