Giusy Rita Maria La Rosa

• University of Catania

Background Tobacco use is a global issue, and non-combustible nicotine products (NCNPs) like electronic nicotine delivery systems, nicotine pouches, snus, and nicotine replacement therapies offer potential risk/harm reduction for smokers unable or unwilling to quit. Although NCNPs are less harmful than tobacco smoking, their impact on oral health r...

E-cigarettes (ECs) are a well-established consumer product. To study their respiratory health effects, there is the issue of heterogenous patterns of use: concurrently with cigarette smoking (dual use), exclusive use after smoking cessation (exclusive use), or use initiated without any prior or current use of cigarettes (naïve use). Our primary goa...

Digital and mobile health technologies offer promising solutions for smoking detection and cessation. This scoping review examines the current state of research and development in this field, encompassing smartphone applications, wearable devices, and sensor-based systems. We analyzed 49 studies published between 2019 and 2023 from PubMed and ACM D...

Nicotine consumption in many countries is shifting away from combustible cigarettes and toward electronic cigarettes (ECs). Understanding the overall population-level impact requires weighing their possible benefits (e.g., for smoking cessation/switching) vs harms (e.g., long-term health risks). However, current evidence on health risks is limited...

Apical periodontitis (AP) is the local inflammation of periapical tissues originating from the dental pulp disease. Cumulative evidence suggests a link between oral and gastro-intestinal systems in both health and disease. In this context, the relationship between AP and inflammatory bowel diseases (IBDs) has not yet been elucidated. The aims of th...

The aim of this study was to assess the cyclic fatigue resistance of a single-file system (i.e., Hyflex EDM OneFile), during continuous rotation and reflex dynamic motion with and without irrigation. Cyclic fatigue tests were conducted on 48 new Hyflex EDM One files using two different motions, with and without irrigation. The files were randomly a...

To evaluate the reliability of integrated electronic apex locators (EALs) compared to other methods (traditional apical locators, radiographic determination) in determining the working length (WL) and to summarize the current evidence on their clinical performance. This systematic review followed the Preferred Reporting Items for Systematic Reviews...

Objectives: Apical extrusion of debris can affect the success of endodontic treatments, and the specific performance of certain retreatment systems has not been studied yet. Therefore, the aim of this in vitro study was to quantitatively assess the amount of apically extruded debris produced during retreatment procedures using three rotary NiTi ret...

To determine the shaping ability, the amount of accumulated hard tissue debris (AHTD) and untouched area is generated by different kinematics through micro-CT. Thirty-two mesial roots of mandibular molars with Vertucci type IV were pre-scanned through micro-CT evaluation and randomized to one of the four experimental groups according to the kinemat...

This scoping review aims to summarize current research to assess the impact of heating on the chemo-physical properties of bioceramic sealers. Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) Extension for Scoping Reviews guidelines, a comprehensive literature search was conducted in April 2024 across PubMed...

BACKGROUND Electronic nicotine delivery systems (ENDS) – e-cigarettes or vapes – have been shown to substantially reduce or eliminate many toxins compared to cigarette smoke and simultaneously ENDS use produces its own unique toxins. Yet the patterns of use among people who use ENDS are not homogeneous. Some people who use ENDS also smoke cigarette...

Background Electronic nicotine delivery systems (ENDS)—e-cigarettes or vapes—have been shown to substantially reduce or eliminate many toxins compared with cigarette smoke, but simultaneously ENDS use also produces their own unique toxins. Yet the patterns of use among people who use ENDS are not homogeneous. Some people who use ENDS also smoke cig...

Background Tobacco smoking exacerbates diabetes-related complications; its prevalence is notwithstanding substantial. Persons with diabetes face a number of barriers and challenges to quitting such as multiple lifestyle restrictions; tailored interventions are required for smoking cessation. Objective To identify research on behavioral interventio...

Background Weight gain following smoking cessation is a well-documented concern, often attributed to the absence of nicotine’s metabolic influence. The adoption of Electronic Nicotine Delivery Systems (ENDS) has been used to achieve smoking cessation, with claims of aiding weight control. However, existing reviews present conflicting conclusions on...

Objectives This study aimed to compare the impact of pre- and postoperative etoricoxib administration versus only postoperative on third molar extraction sequelae and oral health quality of life. Materials and methods This prospective quasi experimental study involved 56 patients, divided into a study group receiving preemptive etoricoxib 120 mg b...

Objective The limitations of spontaneous bone healing underscore the necessity for exploring alternative strategies to enhance bone regeneration in maxillary radicular cyst cases. This retrospective study aimed to assess the impact of a bone substitute material (i.e., Bio-Oss) on bone volume regeneration following maxillary radicular cyst enucleati...

Objective: The aim of this scoping review was to explore and synthesise the current evidence on the antimicrobial activity of antibacterial suture materials used in oral surgery. Methods: The review was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) Extension for Scoping Reviews. A bibliographic...

This experimental anatomic study aimed to investigate the correlations between the mesio-vestibular canal (MB1) and the second mesio-vestibular canal (MB2) of the mesio-vestibular root of the upper sexts using cone-beam computed tomography (CBCT) imaging. A total of 24 extracted maxillary first molars were collected and subjected to CBCT imaging. T...

Objectives Abstaining from tobacco smoking may not only improve general health, but also reduce teeth staining and restore teeth whiteness. Compared with conventional cigarettes, E-cigarettes (ECs) and heated tobacco products (HTPs) may offer substantial reduction in exposure to pigmented tar-like compounds of cigarette smoke. It is possible that i...

Objective This is the first study evaluating the impact of different pecking motion depths on dynamic cyclic fatigue resistance of different endodontic instruments. Methods Four nickel-titanium systems (Hyflex EDM OneFile 25/. ∼; Rotate 25/0.6; Mtwo 25/0.6; Reciproc Blue R25) were tested. Forty instruments from each group were subjected to 4 diffe...

BACKGROUND Weight gain following smoking cessation is a well-documented concern, often attributed to the absence of nicotine’s metabolic influence. The adoption of Electronic Nicotine Delivery Systems (ENDS) has been used to achieve smoking cessation, with claims of aiding weight control. However, existing reviews present conflicting conclusions on...

Objectives The aim of this study is to determine the cyclic fatigue resistance of Mtwo Minimal in static and dynamic tests, with different amplitudes of pecking movements, at intracanal temperature. Materials and Methods Two hundred new 25‐mm Mtwo Minimal rotary files (#10/0.035, #17.5/0.045, #25/0.05, #40/0.03, #45/0.03) were tested in static and...

Background E-cigarettes (electronic nicotine delivery system, ENDS) have been presented as a harm reduction strategy for people who smoke tobacco cigarettes but who cannot achieve abstinence, or for those who wish to continue to enjoy nicotine and the habit of smoking. What are the health effects of the substitution of ENDS for tobacco cigarettes?...

The aim of the study was to evaluate the impact of kinematics and irrigation protocols on the extrusion of apical debris during removal of different obturation techniques. A total of 144 single-rooted teeth were instrumented and obturated with Thermafil+AH Plus, Thermafil+AH Plus Bioceramic and single gutta-percha cone+AH Plus Bioceramic. Samples w...

The aim of this study was to compare the cyclic fatigue resistance of nickel-titanium instruments inside single and double-curved canals at different temperatures. 160 HyFlex EDM #20.05 (HEDM), VDW.ROTATE #20.05 and #25.06, Mtwo #25.06 were randomised (n = 10) for the dynamic cyclic fatigue tests according to the curvature (i.e. single and double)...

This scoping review aimed to synthesize and explore the current boundaries and limitations of laboratory research on the effectiveness of continuous chelation irrigation protocol in endodontics. This scoping review was reported according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) Extension for Scoping Reviews...

Objective The purpose of this research note is to share a technique for the identification of spin bias that we developed as part of a living systematic review on the cardiovascular testing of e-cigarette substitution for cigarette smoking. While some researchers have remarked on the subjective nature of ascertaining spin bias, our technique object...

To compare the shaping ability of Procodile and R6 Reziflow instruments used in reciprocating motion in severely curved root canals, assessed with micro‐computed tomography (μCT). Fourteen extracted human mandibular first molars were randomly assigned to two instrumentation techniques ( n = 14 mesial root canals): Procodile or R6 Reziflow. For both...

Objectives The aim of this scoping review was to determine the effectiveness of the platelet-rich fibrin in the control of pain associated with alveolar osteitis. Materials and methods Reporting was based on Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) Extension for Scoping Reviews. A literature search was conducted...

To compare the amount of extruded debris caused by different motions using a single-file system. Fifty mandibular first molar teeth were randomized into 5 groups (n = 10) according to the motion tested: Optimize Torque Reverse (OTR), TF Adaptive Motion (TFA), continuous rotation (CR), reciprocation motion (+ 150°, -30°) (REC), and Jeni motion (Jeni...

Some persons who smoke have substituted e-cigarettes for tobacco cigarettes, either completely or partially. What effect does this have on cardiovascular functioning? We conducted a living systematic review on human clinical studies measuring the cardiovascular effects of e-cigarette substitution for smoking. The Scopus, PubMed, and CENTRAL Cochran...

Nickel-titanium (NiTi) usage is associated in endodontics with some complications including canal transportation. Centering ability of a NiTi file is the ability to stay centered in the root canal system during instrumentation. Any undesirable deviation from the natural canal path is indicated as canal transportation. A possible strategy to improve...

Background: To assess the cutting efficiency of two heat-treated endodontic files with a brushing motion in oval-shaped canals. Methods: A total of 10 intact lower molars with a single oval distal canal were selected and randomly divided into two groups according to the system used for shaping: 2Shape and Hyflex CM. The instrumentation was performe...

To synthesise the current knowledge on the effects of probiotics in apical periodontitis progression by a scoping review of animal and human studies. Reporting was based on Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) Extension for Scoping Reviews. The literature search and screening was performed on PubMed and Scopus...

Tribology is the discipline concerning the application of friction, lubrication, and wear concepts of interacting surfaces in relative motion. A growing interest has developed in tribology application in medical biomaterials, such as resin composites used in restorative dentistry. Yet, the keywords “tribology” and “biotribology” are little applied...

The aim of this case series is to contribute to the better knowledge and management of the complex anatomical configurations of maxillary premolars with four canals. The paper explains the endodontic treatment of five maxillary premolars with four canals, with three buccal and one palatal orifices, in different patients. The cases report several ap...

Objectives To evaluate the influence of different heat treatments and temperatures on the cyclic fatigue resistance of 2Shape instruments (Micro Mega, Besancon, France) with the same design.Materials and methodsA total of 80 2Shape TS1 (#25/.04) and 80 TS2 (#25/.06) files with different heat treatments (no heat-treated, NHT; C-Wire; T-Wire; CM-Wire...

We compared the mechanical properties of 2Shape mini TS2 (Micro-Mega, Besançon, France) obtained from 1.0 diameter nickel-titanium (NiTi) wires and 2Shape TS2 from 1.2 diameter nickel-titanium (NiTi) wires differently thermally treated at room and body temperature. We used 120 NiTi TS2 1.0 and TS2 1.2 files made from controlled memory (CM) wire and...

Introduction To evaluate torsional, dynamic and static cyclic fatigue resistance of the reciprocating One Reci (OR, Micromega, Besançon, France), WaveOne Gold (WOG, Dentsply Maillefer, Ballaigues, Switzerland), rotary One Curve (OC, MicroMega, Besançon, France) and ProTaper Next X2 (PTN X2, Dentsply Sirona, Ballaigues, Switzerland) instruments. Me...

To evaluate the filling ability of two orthograde obturation techniques followed by the apical resection with or without retrograde obturation through micro‐computed tomography (CT). Thirty‐two single‐rooted permanent teeth were prepared and randomised into four groups (n = 8) according to the orthograde obturation technique (single cone technique...

Objectives: This study aimed to evaluate the production of customized composite veneers starting from a two-dimensional (2D) digital preview using the Digital Smile System (DSS). MATERIAL AND METHODS: A photographic examination of 30 patients was performed by taking two digital pictures of the face and a digital preview through the DSS. Moreover,...

Background: To evaluate the voids percentage and the retreatability by different supplementary irrigation techniques of a matched-taper single cone and epoxy resin-based sealer. Methods: A total of 72 single-rooted premolars were prepared and filled with gutta-percha and MM-Seal. The percentage of voids in the whole root canal and each anatomica...

Background: To compare the accuracy of 3 different devices for facial images acquisition, useful for prosthodontic esthetic preview. Methods: Bidimensional extraoral photographs (Nikon D300), facial scans (Bellus3D) and 3D digital stereophotogrammetry photos (3dMD Face System) were acquired from 15 patients. The intraoral impressions of all subj...

To compare the cutting efficiency of F6 Sky Taper (F6ST) and One Curve (OC) with different kinematics and cutting inclinations. Cutting efficiency of 80 new F6ST and OC was tested at 90° and 70° inclination in relation to the sample, in continuous rotation and reciprocation, against standardised gypsum samples for 120 seconds using a customised dev...

Background: To assess the influence of multiple uses on the cyclic flexural fatigue and torsional resistance of Reciproc R25 (REC25) instruments. Methods: Overall, 256 canals (two for each mandibular molar) were prepared using Reciproc R25 instruments. A total of 96 25-mm-long Reciproc R25 instruments were divided in six groups (N.=8) on the bas...

Aim: To evaluate the surface tension and wetting ability (contact angle) of endodontic irrigants as 5.25% sodium hypochlorite (NaOCl) and 17% ethylenediaminetetraacetic acid (EDTA) with and without addition of surfactants. Methodology: Eighty halves of single-root teeth were randomly distributed into five groups (n=16) to investigate surface tensio...

Background Despite the clear risks of tobacco use, millions of people continue to smoke. Electronic nicotine delivery systems (ENDS), commonly called e-cigarettes, have been proposed as a substitute for those who are unwilling or unable to quit. Current systematic and narrative reviews on the health effects of ENDS use, particularly respiratory and...

To compare the influence of different temperatures and curvature radii on the cyclic fatigue resistance of F6 SkyTaper (F6ST) and One Curve (OC) single file nickel-titanium rotary instruments. Methods: A total of 120 instruments of F6ST and OC #25.06 were evaluated in 5 mm and 3 mm curvature radii at two temperatures (20 °C ± 1 °C and 37 °C ± 1 °C)...

BACKGROUND Despite the clear risks of tobacco use, millions of people continue to smoke. Electronic nicotine delivery systems (ENDS), commonly called e-cigarettes, have been proposed as a substitute for those who are unwilling or unable to quit. Current systematic and narrative reviews on the health effects of ENDS use, particularly respiratory and...

Different viral agents, such as herpesviruses, human papillomavirus, and Coxsackie virus, are responsible for primary oral lesions, while other viruses, such as human immunodeficiency virus, affect the oral cavity due to immune system weakness. Interestingly, it has been reported that coronavirus disease 2019 (COVID-19) patients can show cutaneous...

The purpose of this study was to evaluate the influence of surrounding temperature and angle of file access on cyclic fatigue resistance of F6 SkyTaper (F6ST) and One Curve (OC). 120 new files #25.06 were tested at two insertion angles (0° and 20°) at room (20°C ± 1°C) and body (35°C ± 1°C) temperatures in a 16‐mm stainless steel artificial canal (...

Objectives To compare the percentage of voids in matched-taper single-cone fillings with GuttaFlow Bioseal or BioRoot RCS root canal sealers, using micro-computed tomography.Materials and methodsForty-eight single-rooted mandibular premolars were prepared using rotary files and randomly allocated into 2 groups (n = 24), wherein the canals were fill...

Cutting efficiency of Reciproc R25 (REC) and Reciproc blue R25 (REB) at different inclinations was evaluated. Sixty new files were tested at 90°, 70° and 45° of inclination in relation to the sample (n = 10), using a customised machine. All files were activated in reciprocation against standardised gypsum blocks for 120 s. Cutting efficiency was de...

To investigate the influence of pre-endodontic coronal wall restoration on smear layer removal during different root canal irrigation strategies, single-root premolars were prepared with a mesio-occlusal cavity. Half were left untreated (G1), while the mesial walls of the remaining half were reconstructed using a resin composite (G2). The specimens...

Featured Application The proposed customized device could represent a way to standardize cyclic fatigue tests of nickel-titanium instruments in the presence of irrigant solutions. Future studies could pursue laboratory investigations on nickel-titanium instrument surface exposed to irrigant solutions under these standardized methodological conditio...

To evaluate the properties of two nickel–titanium (NiTi) reciprocating endodontic instruments (commercially known as Procodile and Reziflow), a total of 40 size 25 and 0.06 taper new Procodile and Reziflow instruments (n = 20) were subjected to cyclic fatigue tests (60° angle of curvature, 5-mm radius) at 20 °C and 37 °C and a torsional test based...

Matrix metalloproteinases (MMPs) are tissue-enzymes that play a key role during the remodeling process, such as in inflammatory diseases. MMP-7 and MMP-9 have been shown to be implicated in extracellular matrix homeostasis and in joint disc remodeling. The objective of this study was to determine the relation of MMP-7 and MMP-9 expression with seve...

Oral squamous cell carcinoma (OSCC) is the leading cause of mortality for oral cancer. Numerous risk factors mainly related to unhealthy habits and responsible for chronic inflammation and infections have been recognized as predisposing factors for oral carcinogenesis. Recently, even microbiota alterations have been associated with the development...

Introduction: The aim of this study was to compare the influences from different access angles and curvature radii on cyclic fatigue resistance of nickel-titanium rotary files. Methods: Two file systems (2Shape [TS; MicroMega, Besançon, France] and HyFlex CM [HCM; Coltène/Whaledent, Allstätten, Switzerland]) were used. A total of 192 instruments...

To evaluate the influence of a different order of dentin and enamel layers on stratification appearance of different resin composites. 144 Dentin (D) and Enamel (E) composite samples (Clearfil Majesty ES-2 Premium, Brilliant EverGlow, Estelite Asteria), 1 mm thick, were divided into 12 configurations for each composite, with Enamel–Dentin–Dentin–En...

Aim: To compare the cutting efficiency of several glide path files: HyFlex EDM Glidepath File (HEGF), One G (OG), R-Pilot (RP) and WaveOne Gold Glider (WOGG) at different cutting inclinations. Methodology: Cutting efficiency of 120 new HEGF, OG, RP and WOGG were tested at 90°, 70° and 45° inclination in relation to the sample. Depending on manuf...

Aim: The aim of the present study was to evaluate the immediate and residual antimicrobial activity of cordless sonic or ultrasonic devices on Enterococcus faecalis (E faecalis)-infected teeth. Methods: A total of 140 single-rooted extracted teeth with E faecalis were grouped as follows (N = 15): conventional syringe irrigation with 3% sodium hy...

Background: Oral cancer is one of the most prevalent cancers worldwide. Despite that the oral cavity is easily accessible for clinical examinations, oral cancers are often not promptly diagnosed. Furthermore, to date no effective biomarkers are available for oral cancer. Therefore, there is an urgent need to identify novel biomarkers able to improv...

Introduction The purpose of this study was to compare the cyclic fatigue of Reciproc (REC; VDW, Munich, Germany) and Reciproc blue (REB, VDW) with different angles of file access. Methods The cyclic fatigue resistance of 120 new REC R25 and REB R25 (REB) files was tested. Instruments were divided into 8 groups on the basis of the access angle insi...

Objectives To evaluate the mechanical properties and metallurgical characteristics of the M3 Rotary and M3 Pro Gold files (United Dental). Materials and Methods One hundred and sixty new M3 Rotary and M3 Pro Gold files (sizes 20/0.04 and 25/0.04) were used. Torque and angle of rotation at failure (n = 20) were measured according to ISO 3630-1. Cyc...

Introduction: The purpose of this study was to assess the effects of sodium hypochlorite (NaOCl) immersion and sterilization on the cyclic fatigue resistance of heat-treated nickel-titanium (NiTi) rotary instruments. Methods: Two hundred ten new 25/.06 Twisted Files (TFs; SybronEndo, Orange, CA) and Hyflex CM (Coltene Whaledent, Cuyahoga Falls,...

Objective: Different single-file instruments and kinematics have been introduced on the market. It is important to know the cyclic fatigue performance of these instruments in these new kinematics such as reciprocation of Optimum Torque Reverse (OTR) motion. The aim of this study was to evaluate the resistance to cyclic fatigue of F6 SkyTaper and O...

Aim: To evaluate the resistance to cyclic fatigue of ProTaper Next (PTN; Dentsply Sirona, Ballaigues, Switzerland), Revo-S (Micro-Mega, Besançon, France), Mtwo (Sweden & Martina, Padova, Italy), Twisted Files (TF, SybronEndo, Orange, CA, USA) and EndoWave (J Morita Corporation, Osaka, Japan) used in continuous rotation or in reciprocation of Optim...

Accurate color reproduction in conservative dentistry is fundamental to the aesthetic success of the restorations. The need to specify the color objectively has been known for some years, and this article aims to make a contribution to this field. This work is part of a multidisciplinary research project, and it has a double aim. The first purpose...

Introduction: The purpose of this study was to compare the formation of microcracks after canal preparation performed with different single-file systems as One Shape (Micro-Mega, Besancon, Cedex, France), F6 SkyTaper (Komet Italia Srl, Milan, Italy), HyFlex EDM (Coltene/Whaledent AG, Altstatten, Switzerland), WaveOne (Dentsply Maillefer, Ballaigue...