About
53
Publications
4,749
Reads
How we measure 'reads'
A 'read' is counted each time someone views a publication summary (such as the title, abstract, and list of authors), clicks on a figure, or views or downloads the full-text. Learn more
197
Citations
Introduction
Additional affiliations
January 2007 - present
January 2003 - December 2006
January 1999 - December 2002
Publications
Publications (53)
Intraoperative neurophysiological monitoring (IONM) is needed for evaluating and demonstrating the integrity of the central and peripheral nervous system during surgical manoeuvres that take place in proximity to eloquent motor and somatosensory nervous structures. The integrity of the monitored motor pathways is not always followed by consistent c...
Different studies identified the presence of several altered genes in familial and sporadic amyotrophic lateral sclerosis (ALS) forms. The experimental data, together with the epidemiological data, would seem to suggest the existence of molecular mechanisms (e.g., axonal transport) related to these genes, together with a susceptibility of the same...
Background:
The etiopathogenesis of amyotrophic lateral sclerosis (ALS) is still largely unknown.
Methods:
We performed a case-control study (33 cases and 35 controls) in Umbria, Italy. We investigated associations between common lifestyle, clinical factors, as well as environmental exposures potentially implicated with ALS onset. Face-to-face i...
Background: Amyotrophic lateral sclerosis (ALS) is a chronic
neurodegenerative rare disease that aects motor neurons in the brain,
brainstem, and spinal cord, resulting in progressive weakness and atrophy
of voluntary skeletal muscles. Although much has been achieved in
understanding the disease pathogenesis, treatment options are limited,
and in...
Background
Advanced cell therapeutics are emerging as potentially effective treatments for chronic neurological diseases, including secondary progressive multiple sclerosis (SPMS). Here we report the results of a phase I trial in which good manufacturing practice-grade foetal allogeneic human neural stem cells (hNSCs) were implanted via intracerebr...
Objective
The aim of this systematic review (SR) was to gather all available epidemiological evidence on former participation in any type of sport, at a professional and varsity level, as a potential risk factor for neurodegenerative diseases (NDs) and neurocognitive disorders (NCDs).
Design
Systematic searches were performed on PubMed, the Cochra...
Recent advances in technology, information technology, Internet networks, and, more recently, fiber optics in industrialized countries allow the exchange of a huge amount of data, in real time, across the globe. The acquisition of increasingly sophisticated technologies has made it possible to develop telemedicine, by which the specialist's evaluat...
A 71 years old female patient referred to her Physician for left hip and abdominal, nigh-time worsening pain. For this reason, she underwent a lumbosacral vertebral MRI, that highlighted the presence of L3-S1 left radiculopathy. After two weeks, she developed a left VI and VII cranial (peripheral) nerves palsy. Admitted to hospital, she underwent b...
Terni S. Maria Hospital Neurophysiology Division successfully performed experimental trial for innovative Telemedicine service, using patented remote-EEG system.
The Neurophysiologist can be connected from everywhere to the hospital information system through virtual private network and remote device. EEG-passive electrode device is effectively con...
In many countries Telemedicine is regularly employed, i.e.: US, Canada. Although, Telemedicine use has been planned in the “Digital Agenda 2020”, only few countries in Europe extensively adopt it (France, Norway, Finland, Denmark). In Italy Telemedicine services show different development levels and they are widespread in few Regions (Emilia Romagn...
The minimally invasive lateral transpsoas approach to the lumbar spine is a valid and recent alternative to interbody placement at levels L1–L5 in the setting of degenerative disc disease, spondylolisthesis, and scoliotic or kyphotic deformity. The benefits over traditional open surgery include reduced blood loss, decreased postoperative pain and n...
Amiotrophic lateral sclerosis (ALS) is a neurodegenerative disease with a prevalence rate of up to 7.4/100,000 and the overall risk of developing ALS over a lifetime is 1:400. Most patients die from respiratory failure following a course of progressive weakness. There is no effective therapy. Novel therapeutic strategies might be directed at replac...
The minimally invasive lateral transpsoas approach to the lumbar and spine has become an increasingly popular approach for achieving interbody fusion. The reported advantages include minimally invasive access to the spine, absent manipulation of aorta and vena cava, less blood loss compared to open procedures, decreased operative times, shorter hos...
A 19 years old female patient was referred for assessment of head and cervical pain, upper limbs dysesthesias, diplopia, visual impairment (mainly in left eye) and postural instability. Initial examination revealed left ptosis, left abducent nerve palsy, diffuse hyporeflexia and limb ataxia. At admission lumbar puncture was performed with a normal...
Isolated monophasyc whyte matter lesion could have a demyelinating or neoplastic origin. A 26 years old woman, at the 6th week of pregnancy, acutely presented motor deficit to the right side, and aphasia. MRI showed a left temporal lesion in the subcortical white matter, without edema, and with dishomogeneous enhancement. Spectroscopic MR pointed o...
Chondromyxoid fibroma is a rare benign bone tumor, often misdiagnosed. A 39 years old woman, during first months of pregnancy, referred bilateral lumbar pain, with irradiation to the right leg, and painful paresthesias with radicular distribution (bilateral L5/S1). Symptomatology modified with a circadian rhythm, with a nocturnal exacerbation. Clin...
Cyanotoxins (CTX) are widely produced by several cyanobacteria (CB), increasingly spreading in most water bodies and terrestrial habitats, and represent a risk for human health. CB are prokaryotes, and although mostly autotrophic, several examples of heterotrophy in symbiotic relationship with different organisms have been described. In addition to...
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder affecting motor neurons. We describe a novel L67P mutation located in exon 3 of the Cu/Zn superoxide dismutase gene in a patient with pure lower motor neuron signs. To date, 11 mutations involving exon 3 of SOD1 have been described, including the present one. Our data c...
La spasticità può essere definita come un aumento della resisten-za, velocità dipendente, allo stiramento passivo di un muscolo, essendo maggiore la resistenza a diversi gradi di velocità di stira-mento. Essa è una frequente complicanza nei pazienti con lesione del midollo spinale (spinal cord injury: SCI), cosicché la sua riduzio-ne rappresenta un...
The available epidemiological data for amyotrophic lateral sclerosis (ALS) support an infectious etiology and lead us to propose a new hypothesis. We examined older epidemiological data concerning categories of the population with increased incidence (aged people, people living in rural areas, farmers, breeders), more recent epidemiological reports...
The present study was aimed at investigating changes in brain metabolites due to visual cortex activation in migraineurs and normal subjects by (1)H-magnetic resonance spectroscopy (MRS). Twenty-two migraine patients with aura, 22 migraine patients without aura, and 10 control subjects were assessed. The volume of interest (about 8 cm(3)) was place...
We previously reported that a permanent transection of adult rat sciatic and hypoglossal nerves resulted in distinct changes in the levels of both low-affinity nerve growth factor receptor (p75) and choline acetyltransferase in the corresponding motoneurons as determined by immunoreactivity. Permanent axotomy of hypoglossal motoneurons induced a pr...
