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  • Giuseppe Lippi
Giuseppe Lippi

Giuseppe Lippi
University of Verona | UNIVR · Department of Neurological, Neuropsychological, Morphological and Movement Sciences

Doctor of Medicine
Laboratory Medicine, biomarkers validation, COVID-19, thrombosis and hemostasis, preanalytical variability.

About

2,441
Publications
1,254,676
Reads
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63,462
Citations
Introduction
Professor of Clinical Biochemistry, Director of the Service of Laboratory Medicine at the University Hospital of Verona and Dean of Medical School at the University of Verona. Has published over 2050 articles in internationally indexed journals, along with 6 books and 30 chapters. IF is over 14600, H-index is 121 and citations are >80000. Has delivered over 330 lectures at national & international meetings. He is currently Chair of IFCC Task Force on COVID-19.
Additional affiliations
October 2015 - February 2022
University of Verona
Position
  • Full Professor of Cinical Biochemistry; President of the School of Medicine
Description
  • Full Professor of Clinical Biochemistry, President of the School of Medicine
January 2001 - September 2009
University of Verona
Position
  • Associate Professor of Cinical Biochemistry
Description
  • Associate Professor of Clinical Biochemistry
September 1993 - December 1994
North West Lipid Research Laboratories
Position
  • Visiting Scientist
Education
September 1986 - July 1992
University of Verona
Field of study
  • Medicine

Publications

Publications (2,441)
Article
Full-text available
Background: Quantification of SARS-CoV-2 antigens by means of rapid, high-throughput and fully-automated techniques has been proposed as a feasible alternative to overcome the current shortage of resources for routine molecular diagnostics. To this end, we provide here a systematic review of diagnostic accuracy of DiaSorin Liaison SARS-CoV-2 antige...
Article
Full-text available
Background: In this serosurveillance study, we investigated the variation of total anti-SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) antibodies in healthcare workers receiving primary BNT162b2 vaccination and homologous booster. Methods: A total number of 524 subjects (median age, 46 years; 65.3% females), were studied. All received...
Preprint
Full-text available
Background: Since SARS-CoV-2 has undergone a considerable genetic evolution over time, we investigated its infectivity in the province of Verona (Italy), during the month of July of the first three pandemic years (i.e., 2020, 2021 and 2022). Methods: The daily number of new COVID-19 diagnoses in the province of Verona between July 1-27 of the years...
Article
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Background: The research aimed to investigate the incidence of SARS-CoV-2 breakthrough infections and their determinants in a large European cohort of more than 60,000 health workers. Methods: A multicentric retrospective cohort study, involving 12 European centers, was carried out within the ORCHESTRA project, collecting data up to 18 November 202...
Article
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The platelet function analyser (PFA) is a prevalent platelet function screening instrument, and comes in two models–the original PFA-100 and the contemporary PFA-200. The instruments have ‘identical’ output, being a ‘closure time’ (CT). Moreover, normal reference ranges provided by the manufacturer, for the specific test cartridges, are the same fo...
Article
Full-text available
The infectious respiratory condition COVID-19 manifests a clinical course ranging from mild/moderate up-to critical systemic dysfunction and death linked to thromboinflammation. During COVID-19 infection, neutrophil extracellular traps participating in cytokine storm and coagulation dysfunction have emerged as diagnostic/prognostic markers. The cha...
Preprint
Background: Preliminary evidence suggests that the rate of cracked teeth managed in endodontists’ practices has considerably increased during the coronavirus disease 2019 (COVID-19) pandemic compared to the period before. Methods: We conducted an electronic search in Google Trends, using the search term “Cracked Teeth”, with the geographical area s...
Article
Full-text available
Circulating miRNAs are increasingly studied and proposed as tumor markers with the aim of investigating their role in monitoring the response to therapy as well as the natural evolution of primary or secondary brain tumors. This study aimed to evaluate the modulation of the expression of three miRNAs, miR-21, miR-222 and miR-124-3p, in the serum ex...
Article
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Among the various conditions that may strongly influence the immunogenicity of COVID-19 vaccines, immunosuppression plays a key role. Several lines of evidence now attest that patients taking a kaleidoscope of immunosuppressant agents display considerably lower vaccine immunogenicity, as reflected by a blunted generation of anti-SARS-CoV-2 neutrali...
Article
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The median value of weekly Google Trends score recorded for each of the four benzodiazepines “Alprazolam,” “Bromazepam,” “Clonazepam,” and “Lorazepam" was significantly higher after the emergence of the COVID-19 pandemic in Italy (i.e., after March 1, 2020) compared to the period before (all comparisons, p < 0.001). The Google searches increased by...
Article
Full-text available
Purpose Little is known about the association between plasma adiponectin levels and nonalcoholic fatty liver disease (NAFLD) in patients with type 2 diabetes mellitus (T2DM). We examined whether there is an association between lower plasma adiponectin levels and the presence/severity of NAFLD in people with T2DM. Methods We cross-sectionally recru...
Article
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D-dimers reflect a breakdown product of fibrin. The current narrative review outlines how D-dimers can arise in normal individuals, as well as in patients suffering from a wide range of disease states. D-dimers in normal individuals without evident thrombosis can arise from background fibrinolytic activity in various tissues, including kidney, mamm...
Article
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Almost 10 years ago, in an editorial published in Clinical Chemistry and Laboratory Medicine (CCLM), we celebrated an important event in the history of the journal, coinciding with the 50th anniversary of its founding. At that time, we included a representative figure, showing how much the prestige, popularity and value of the journal had increased...
Article
The final study population consisted of 67 baseline seronegative (i.e. pre-vaccination) healthcare workers, 14 with (median age, 42 years; IQR, 31-48 years; 29% of females) or 53 without (median age, 46 years; IQR, 34-54 years, 60% of females) a diagnosis of SARS-CoV-2 infection within 4 weeks after receiving the homologous booster vaccine dose. No...
Article
Full-text available
D-dimer is a fibrin degradation product encompassing multiple cross-linked D domains and/or E domains present in the original fibrinogen molecule, whose generation is only theoretically possible when hemostasis and fibrinolysis pathways are concomitantly activated. D-dimer measurement has now become a pillar in the diagnosis/exclusion and prognosti...
Article
Full-text available
Background: Although ceramides are involved in the pathophysiology of cardiovascular disease and other inflammation-associated disorders, there is a paucity of data on the association between plasma ceramides and inflammatory biomarkers in type 2 diabetes mellitus (T2DM). Therefore, we explored whether there was an association between plasma leuci...
Article
Many clinical studies and the derived guidelines and recommendations have for long included exercise programs aimed at generating improvements in patient fitness and/or cardiovascular rehabilitation, with the underlying assumption that raising HDL-C would be always beneficial. Nonetheless, it is now time to plan additional studies investigating the...
Article
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This study aimed to compare the clinical progression of COVID-19 in high-risk outpatients treated with the monoclonal antibodies (mAb) bamlanivimab, bamlanivimab-etesevimab and casirivimab-imdevimab. This is an observational, multi-centre, prospective study conducted from 18 March to 15 July 2021 in eight Italian tertiary-care hospitals including m...
Article
Full-text available
Peripheral blood smear is a simple laboratory tool, which remains of invaluable help for diagnosing primary and secondary abnormalities of blood cells despite advances in automated and molecular techniques. Red blood cells (RBCs) abnormalities are known to occur in many viral infections, typically in the form of mild normo-microcytic anemia. While...
Article
We investigated Google Trends (Google Inc. Mountain View, CA, US) with the search terms “anosmia” and “ageusia”, setting geographical location to “worldwide” and within a period comprising the past 5 years (i.e., between July 2017 and July 2022). The weekly Google Trends score for both terms “anosmia” and “ageusia”, thus mirroring their worldwide W...
Article
Welcome to the latest issue of Seminars in Thrombosis and Hemostasis (STH) published under the “banner” of “Editorial Compilation,” this being the twelfth such issue. Although Seminars in Thrombosis and Hemostasis is historically a theme-driven publication, ongoing opportunities emerge to disseminate wide-ranging contributions of current interest o...
Article
Full-text available
The analytical quality of laboratory results, and particularly the improvement due to better efforts to comply with analytical performance specifications and to adopt better internal quality control and external quality assessment/proficiency testing systems, should be notified in some universally agreed means to clinicians, to allow better and mor...
Article
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Human monkeypox is a zoonotic orthopoxvirus with presentation similar to smallpox. Monkeypox is transmitted incidentally to humans when they encounter infected animals. Reports have shown that the virus can also be transmitted through direct contact (sexual or skin-to-skin), respiratory droplets, and via fomites such as towels and bedding. Multiple...
Article
Full-text available
Purpose of review: The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) mostly uses the angiotensin-converting enzyme 2 (ACE-2) as cellular receptor for entering the host cells. Some, but not all, animal studies have shown that renin--angiotensin--aldosterone system (RAAS) inhibitors can increase ACE-2 expression. On that premise, it wa...
Article
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We would like to raise some concerns about the assumption that excess mortality directly translates into COVID-19–related deaths. The first important aspect to be considered is that many countries have established strict restrictive measures to limit virus spread that have limited personal freedom (i.e., prohibition of mass gatherings or public eve...
Article
Full-text available
Objectives. Coronavirus disease 2019 (COVID-19) is a life-threatening infectious disorder characterized by a sustained prothrombotic state. Since homocysteine is a potential biomarker of thrombotic diseases, the aim of this article is to provide an updated overview on the possible role played by hyperhomocysteinemia in influencing an unfavorable CO...
Article
Full-text available
Although the efficacy of the second COVID-19 vaccine booster for preventing mild Omicron infections remains uncertain in the general healthy population, we cannot feasibly continue to boost antibody responses forever. Several studies reveal that it is now challenging to identify threshold values of anti-SARS-CoV-2 neutralizing antibodies (measured...
Preprint
Full-text available
Background: There is emerging evidence that headache may be a frequent common symptom in patients diagnosed with coronavirus disease 2019 (COVID-19), thus paving the way to further epidemiological studies to better evaluate this potential association. Methods: We conducted an electronic search in Google Trends with the keyword “headache” (i.e., “m...
Article
The coronavirus disease 19 (COVID-19) pandemic is a major challenge for all healthcare systems, as well as for social stability and the economy. The clinical spectrum of COVID-19 is: asymptomatic; mild to moderate; severe; and critical disease, leading to different fatality rates. Although countless studies have been published to better understand...
Article
Full-text available
Objective: In this work we monitored both total and IgG anti-SARS-CoV-2 antibodies responses after BNT162b2 vaccine booster immunization in a cohort of ostensibly healthy healthcare workers. Methods: The study population consisted of 266 subjects (median age, 46 years and interquartile range (IQR), 35–52 years; 168 females) undergoing homologous 30...
Poster
Full-text available
Background-aim Bile acids (BAs), the amphipathic primary end-products of cholesterol metabolism, help the digestion process and participate in signal transduction in several hepatic and enteric pathways. Characterization of plasma BAs profile abnormalities induced by jaundice is necessary for accurate interpretation of data obtained in studies eval...
Article
Importance Dose-reduced regimens of direct oral anticoagulants (DOACs) may be used for 2 main purposes: dose-adjusted treatment intended as full-intensity anticoagulation (eg, for stroke prevention in atrial fibrillation [AF] in patients requiring dose reduction) or low-intensity treatment (eg, extended-duration treatment of venous thromboembolism...
Article
Full-text available
Resumen Objetivos En el presente estudio investigamos la respuesta de los anticuerpos IgA a la vacunación primaria con BNT162b2 y una dosis de refuerzo homóloga, en profesionales sanitarios inicialmente seronegativos. Métodos La población de estudio consistió en 69 receptores sanos de la vacuna BNT162b2 (dos dosis), seguida de una única dosis de...
Article
Full-text available
Objectives: We investigated here the response of anti-SARS-CoV-2 IgA antibodies to BNT162b2 primary vaccination followed by administration of a homologous booster dose in baseline seronegative healthcare workers. Methods: The study population included 69 healthy recipients of primary BNT162b2 vaccination (two doses) followed by administration of a...
Article
Full-text available
We analyzed here the clinical efficacy of mRNA-based coronavirus disease 2019 (COVID-19) vaccines among Italian children aged 5-11 years using data published by the National Institute of Health. Vaccination status was associated with a reduced risk of COVID-19 related hospitalizations and ICU admissions, which were 41% (odds ratio, 0.59; 95%CI, 0.4...
Article
Although the worldwide usage of direct oral anticoagulants has continuously increate over the past decade, heparin remains an important weapon in the current arsenal of anticoagulant drugs. Parenteral heparin administration (i.e., either intravenously or subcutaneously) has represented for decades the only possible route for generating a significan...
Article
COVID-19 is now established to be associated with a thrombotic phenomenon, now called COVID-19 associated coagulopathy (CAC). Anti-Endothelial Cell Antibodies (AECA) are a heterogenous group of autoantibodies targeting various endothelial cell antigens or antigens adhering to endothelial cells, They are commonly observed in a variety of auto-immune...
Article
Full-text available
The current cohort comprises 240 SARS-CoV-2 baseline seronegative subjects (median age 48 years, range 23–72 years; 151 females), who underwent primary COVID-19 vaccination with Comirnaty (two 30 µg doses, at 3-week interval), and subsequent administration of single homologous booster dose (30 µg) more than 8 months afterwards. A decline in the ser...
Chapter
Malgrado sia oggi incontestabile che la diagnostica di laboratorio sia sostanzialmente vulnerabile ad un certo grado di inappropriatezza e sprechi, e che le dimensioni del problema siano quantomeno eterogenee, esiste peraltro la forte consapevolezza che questa disciplina medica ha più di altre intrapreso un percorso virtuoso. E’ altresì palese che,...
Article
Full-text available
Background Dysregulation of complement system is thought to be a major player in development of multi-organ damage and adverse outcomes in patients with coronavirus disease 2019 (COVID-19). This study aimed to examine associations between complement system activity and development of severe acute kidney injury (AKI) among hospitalized COVID-19 pati...
Article
Full-text available
Objectives: The development and use of artificial intelligence (AI) methodologies, especially machine learning (ML) and deep learning (DL), have been considerably fostered during the ongoing coronavirus disease 2019 (COVID-19) pandemic. Several models and algorithms have been developed and applied for both identifying COVID-19 cases and for assessi...
Article
Full-text available
This document, endorsed by the IFCC Working Group on SARS-CoV-2 Variants, aims to update previous indications for diagnosing acute SARS-CoV-2 infection, taking into consideration the evidence that has emerged after the origin and spread of new lineages and sub-lineages of the virus characterized by mutated genetics and altered biochemical, biologic...
Article
Full-text available
Introduction: Neutrophil extracellular traps (NETs) release (i.e., NETosis) has been recently implicated in the pathomechanism underlying severe end-organ damage in Coronavirus Disease 2019 (COVID-19) and could present a novel therapeutic target. We aimed to determine whether circulating levels of cell-free DNA (cfDNA), a surrogate for NETosis, may...
Article
Background: we report here data on humoral immune response post-BNT162b2 primary vaccination and booster in pre-vaccination baseline severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) seronegative and seropositive subjects. Methods: the study population consisted in 51 baseline SARS-CoV-2 seronegative and 11 baseline SARS-CoV-2 seroposit...
Article
Full-text available
Introduction: Characterizing immunological response following COVID-19 vaccination is an important public health issue. The objectives of the present analysis were to investigate the proportion, level and the determinants of humoral response from 21 days to three months after the first dose in vaccinated healthcare workers (HCWs). Methods: We ab...
Article
Full-text available
Shwachman-Diamond syndrome (SDS) is one of the most commonly inherited bone marrow failure syndromes (IBMFS). In SDS, bone marrow is hypocellular, with marked neutropenia. Moreover, SDS patients have a high risk of developing myelodysplastic syndrome (MDS), which in turn increases the risk of acute myeloid leukemia (AML) from an early age. Most SDS...
Article
Full-text available
One of the major challenges for healthcare systems during the Coronavirus-2019 (COVID-19) pandemic was the inability to successfully predict which patients would require mechanical ventilation (MV). Angiotensin-Converting Enzyme 2 (ACE2) and TransMembrane Protease Serine S1 member 2 (TMPRSS2) are enzymes that play crucial roles in SARS-CoV-2 entry...
Article
Full-text available
We present here a critical literature review and meta-analysis on the accuracy of the LumiraDX SARS-CoV-2 Antigen Test for diagnosing acute SARS-CoV-2 infection. An electronic search was conducted in the Scopus and Medline databases using the keywords “LumiraDX” AND “COVID-19” OR “SARS-CoV-2”, without date (i.e., up to 1 February 2022) or language...
Article
The almost relentless worldwide diffusion of severe acute respiratory syndrome coronavirus (SARS-CoV-2) is deeply engaging the minds of many scientists, clinicians and laboratory professionals, who struggle to identify the possible short- and long-term consequences of coronavirus disease 2019 (COVID-19) in the general population, as well as in spec...
Article
Background: We explored here the impact that baseline inflammation on post-vaccine anti-SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) antibodies response after BNT162b2 vaccine booster administration. Materials and Methods: The population consisted of 78 healthcare workers of Pederzoli Hospital in Peschiera del Garda (Italy), who rec...
Article
Full-text available
Background: This study aimed at monitoring the kinetics of serum total anti-SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) antibodies in a cohort of healthcare workers after voluntary vaccination with Pfizer-BioNTech coronavirus disease 2019 (COVID-19) mRNA-based vaccine. Methods: The study population consisted of 787 healthcare wo...
Preprint
Full-text available
Background: We explored here the impact that baseline inflammation on post-vaccine anti-SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) antibodies response after BNT162b2 vaccine booster administration. Materials and Methods: The population consisted of 78 healthcare workers of Pederzoli Hospital in Peschiera del Garda (Italy), who rec...
Article
Full-text available
Background: This article is aimed to provide an updated landscape of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) genomic mutations emerged since its first identification and sequencing. Methods: We downloaded and analyzed all mutations within the SARS-CoV-2 RNA genome submitted up to February 8, 2022 to the website of the National...
Article
Full-text available
Although several pre-analytical (i.e., specimen collection, preservation, storage, transportation, preparation, inactivation and RNA extraction), analytical (e.g., analytical sensitivity and interfering substances, usage of different gene targets and diverse amplification and detection techniques) and postanalytical (e.g., calibration, test results...
Article
Full-text available
Several studies shed light on the interplay among inflammation, thrombosis, multi-organ failures and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Increasing levels of both free and/or circulating histones have been associated to coronavirus disease 2019 (COVID-19), enhancing the risk of heart attack and stroke with coagul...
Article
Full-text available
COVID-19 is now established to be associated with a thrombotic phenomenon, now called COVID-19 associated coagulopathy (CAC). Anti-Endothelial Cell Antibodies (AECA) are a heterogenous group of autoantibodies targeting various endothelial cell antigens or antigens adhering to endothelial cells, They are commonly observed in a variety of auto-immune...
Preprint
Full-text available
Background: In this serosurveillance study, we investigated the variation of total anti-SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) antibodies in healthcare workers receiving primary BNT162b2 vaccination and homologous booster. Methods: A total number of 524 subjects (median age, 46 years; 65.3% females), were studied. All received...
Article
In keeping with recent data attesting that the volume of exhaled viral particles is magnified in patients infected by the Omicron lineage, it seems advisable not only to reinforce a mask-wearing advice, but also to suggest that more efficient respirators (like N95 or similar) would be preferable to grant major protection against highly infective SA...
Article
Contrary to the inherent meaning of the term, smartphones are no longer devices used for only making phone calls, as their usage is now widespread for hundreds (thousands?) of other reasons. Smartphones are probably the devices that we use most frequently in our day-to-day lives. Smartphones are always with us, and they hence represent the most pra...
Article
To summarize the currently available evidence on the possible contribution of Lp(a) to the pathogenesis of COVID-19, we carried out an electronic search in PubMed and Scopus to identify all clinical studies where Lp(a) concentration was measured in patients with SARS-CoV-2 infection and compared with healthy controls or correlated with the risk of...
Article
We retrieved information on progression of COVID-19 vaccination and newly diagnosed cases of SARS-CoV-2 infection from the weekly report of the Italian National Institute of Health (Istituto Superiore di Sanità, ISS; Last available update, January 1, 2022). The rate of SARS-CoV-2 infections in non-vaccinated, vaccinated with primary cycle <120 days...
Article
Full-text available
We retrieved data from the online database of the Italian Ministry of Health concerning the previous and ongoingwaves of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) epidemic in Italy. We analyzed theprevalence of variants, the number of SARS-CoV-2 diagnoses, hospitalization, and intensive care unit (ICU) ad-missions for patients wi...
Article
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Background: We provide here an updated analysis of an ongoing serosurveillance study, presenting data on the effect of a third dose of Pfizer/BioNTech BNT162b2 vaccine on serum anti-SARS-CoV-2 IgG antibodies. Methods: We tested baseline SARS-CoV-2 seronegative healthcare workers undergoing primary vaccination with the mRNA-based COVID-19 Comirnaty...
Article
Full-text available
We carried out a digital search in the two scientific databases Medline (PubMed interface) and Scopus, using the following keywords: “S-PLEX” AND “COVID-19” OR “SARS-CoV-2”, without no language or date (i.e., up to February 17, 2022) restrictions. Four studies (totalling 657 clinical samples) were included in our analysis. The cumulative diagnostic...
Preprint
Full-text available
Background: We provide here an updated analysis of an ongoing serosurveillance study, presenting data on the effect of a third dose of Pfizer/BioNTech BNT162b2 vaccine on serum anti-SARS-CoV-2 IgG antibodies. Methods: We tested baseline SARS-CoV-2 seronegative healthcare workers undergoing primary vaccination with the mRNA-based COVID-19 Comirnaty...
Article
Full-text available
We provide here a pooled analysis of accuracy of Fujirebio Lumipulse SARS-CoV-2 Antigen chemiluminescent immunoassay for diagnosing acute SARS-CoV-2 infections. An electronic search was conducted in Scopus and Medline with the keywords “Lumipulse” AND “antigen” AND “SARS-CoV-2” or “COVID-19”, up to January 21, 2022, for identifying clinical investi...
Article
Full-text available
Accumulating evidence shows a progressive decline in the efficacy of coronavirus disease 2019 (SARS-CoV-2) mRNA vaccines such as Pfizer-BioNTech (mRNA BNT161b2) and Moderna (mRNA-1273) in preventing breakthrough infections due to diminishing humoral immunity over time. Thus, this review characterizes the kinetics of anti-SARS-CoV-2 (Severe Acute Re...
Article
Welcome to the latest issue of Seminars in Thrombosis and Hemostasis (STH) published under the “banner” of “Editorial Compilation,” this being the 11th such issue. Although Seminars in Thrombosis and Hemostasis is historically a theme-driven publication, ongoing opportunities emerge to disseminate wide-ranging contributions of current interest or c...
Article
By analysing the association between SARS-CoV-2 infection and immune-mediated neuropathies, we herein observed that (i) a significant number of patients with PNS disorders of suspected autoimmune origin occurring during the COVID-19 pandemic had antecedent SARS-CoV-2 infection; (ii) peripheral neuropathies are not always associated with severe COVI...