Giuseppe Lippi

Giuseppe Lippi
Verified
Giuseppe verified their affiliation via an institutional email.
Verified
Giuseppe verified their affiliation via an institutional email.
University of Verona | UNIVR · Department of Engineering for Innovation Medicine

Doctor in Medicine
Laboratory Medicine, biomarkers validation, COVID-19, thrombosis and hemostasis, preanalytical variability.

About

2,772
Publications
1,565,747
Reads
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91,302
Citations
Introduction
Professor of Clinical Biochemistry, Director of Department of Laboratory Medicine at University Hospital of Verona and Dean of the Medical Faculty at University of Verona. Has published 2317 articles in internationally indexed journals, with 6 books and 31 chapters. IF is 9390, H-index is 140 and citations are over 112,000. Has delivered 373 lectures at national & international meetings. Chair of EFLM Task Force on Lab Emergencies and SIBioC Task Force on COVID-19.
Additional affiliations
October 2015 - February 2022
University of Verona
Position
  • Full Professor of Cinical Biochemistry; President of the School of Medicine
Description
  • Full Professor of Clinical Biochemistry, President of the School of Medicine
January 2001 - September 2009
University of Verona
Position
  • Associate Professor of Cinical Biochemistry
Description
  • Associate Professor of Clinical Biochemistry
September 1993 - December 1994
North West Lipid Research Laboratories
Position
  • Visiting Scientist
Education
September 1986 - July 1992
University of Verona
Field of study
  • Medicine

Publications

Publications (2,772)
Article
The findings of this study indicate that the frequency of side effects following booster vaccination with the Ancestral/BA.4–5 bivalent Pfizer-BioNTech BNT162b2 mRNA vaccine is not significantly associated with baseline humoral immune response except for mild reactions such as chills, injection site reactions and musculoskeletal pain. Based on thes...
Article
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Monitoring individuals’ laboratory data is essential for assessing their health status, evaluating the effectiveness of treatments, predicting disease prognosis and detecting subclinical conditions. Currently, monitoring is performed intermittently, measuring serum, plasma, whole blood, urine and occasionally other body fluids at predefined time in...
Article
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Amid recent clinical trial results, the regulatory landscape for tecovirimat in the treatment of mpox has become increasingly complex. The US FDA's decision to not proceed with the approval of tecovirimat for mpox appears well-founded, given the lack of significant clinical benefits observed in large-scale trials. Meanwhile, Japan's broad approval...
Article
Crystals in urinary sediment are commonly recognized structures, typically identified by a combination of crystal morphology and urine pH. In this paper, we present the first reported case of EDDP (2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidene) crystals, the primary metabolite of methadone, in a 67-year-old male with hepatorenal syndrome. Routi...
Article
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Laboratory testing has played a pivotal role throughout the coronavirus disease 2019 (COVID-19) pandemic, exemplifying the importance of in vitro diagnostics in addressing public health threats posed by outbreaks of infectious diseases. This article aims to present key insights from our expertise, derived from evidence gathered during the COVID-19...
Article
Objectives: The aim of the study was to evaluate the predictive value of cell population data (CPD) parameters in comparison with procalcitonin (PCT) and C-reactive protein (CRP) for an early diagnosis of sepsis in intensive care unit (ICU). The effect of renal function on CPD, PCT and CRP, in septic and non-septic patients was also investigated. M...
Article
The results of our analysis show that the early phase of the COVID-19 pandemic has likely had a negative impact on early mortality from colorectal cancer in the US, as shown by the significant increase in the age-adjusted death rate recorded in 2021, reversing the otherwise favorable downward trend of the previous three years. A further, although n...
Article
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Background: The assessment of immunity to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) includes both humoral and cellular immunity. The T-cell response plays a key role in reducing the risk of developing severe forms of coronavirus disease 2019 (COVID-19). Similar to other aspects of physiology and immune system, the adaptive immune...
Article
Purpose: To verify whether the trend of AMI mortality throughout the different months of the year may have recently changed in the US due to the coronavirus disease 2019 (COVID-19) pandemic and climate changes. Methods: We examined monthly mortality trends for acute myocardial infarction (AMI) in the U.S. from 2018 to 2022 by conducting an electron...
Article
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Previous studies in sports science suggested that regular exercise has a positive impact on human health. However, the effects of endurance sports and their underlying mechanisms are still not completely understood. One of the main debates regards the modulation of immune dynamics in high‐intensity exercise. As part of the “Run 4 Science” project i...
Article
The results of our epidemiological analysis show that the age-adjusted mortality rate for lung cancer in the US decreased gradually but intermittently over time, from 56.07 (95%CI, 55.79 to 56.35) in 1999 to 30.05 (95% CI, 29.88 to 30.21) in 2022. This downward trend was partially interrupted in the second year of the COVID-19 pandemic, but then de...
Article
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Background: The coronavirus disease 2019 (COVID-19) pandemic has generated profound health, societal, and economic consequences, which have been further compounded by long-term sequelae commonly referred to as post-COVID-19 or long-COVID syndrome. Understanding the real-world impact of post-COVID-19 mortality is therefore critical for effective hea...
Article
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The number of physicians who have chosen to specialize in Laboratory Medicine (i.e., Clinical Pathology and Clinical Biochemistry) in Italy has continued to decline over time, reaching its lowest point this academic year. The first warnings about the shortage of laboratory professionals were made almost 20 years ago. However, an (often demagogic) p...
Preprint
Background: The coronavirus disease 2019 (COVID-19) pandemic has generated profound health, societal and economic consequences, further compounded by long-term sequelae commonly referred to as post COVID or long-COVID syndrome. Understanding the real-world impact of post COVID mortality is hence critical for effective healthcare planning and resour...
Article
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Although ChatGPT-4.0 shows potential in supporting blood cell classification activities, its performance remains inadequate for adoption as a standalone diagnostic tool or as replacement for the current generation of hematological digital imaging software.
Article
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This study analyzed the relationship between bibliometric metrics-specifically the H-index and citation counts-obtained from Google Scholar and Scopus, two widely used databases for assessing research impact. The analysis was based on data from 30 academics affiliated with the University of Verona. Strong correlations within each database were obse...
Article
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The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its global spread have left an indelible mark, disrupting multiple aspects of human life. It is therefore crucial to retrospectively analyze the factors that have contributed more to the initial inefficiency of the global response, thus enhancing preparedness and proa...
Article
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Background: Spirulina, a type of blue-green algae, has been recognized for its dense nutritional profile and purported health benefits. Furthermore, the effects of spirulina on individuals who are obese have been a subject of interest in scientific research. Objective: This study was to examine the impact of spirulina supplements on obese females i...
Article
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Taken together, our data could hence confirm that self-harm leading to suicide was higher on Mondays in the US between 2018-2022, as already reported in Austria. Moreover, we also found that the trend in suicides in the US declined significantly on weekends, reaching a minimum on Saturday. Whether differential exposure to stressful events and socia...
Article
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Liu et al. demonstrated that increased consumption of dark, but not milk, chocolate was associated with a seemingly lower risk of developing type 2 diabetes in prospective cohort studies (1). While these findings suggest a potential dose-dependent relationship between dark chocolate intake and reduced diabetes risk, they should be interpreted with...
Article
The acquisition and evolution of cardiovascular (CV) adaptation to physical activity or exercise training are critical in enhancing cardiorespiratory fitness (CRF) and reducing CV disease (CVD) risk. CV adaptations to exercise occur through structural, functional, and molecular changes that enhance cardiac efficiency. These adaptations, such as inc...
Article
Overall, the connection between mental health and cardiovascular disease is a critical area of research that requires greater emphasis in clinical practice and public health policy. By recognizing the interplay between psychological factors and cardiovascular health, healthcare providers can develop more effective prevention and treatment strategie...
Article
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The clinical laboratory test market shows a consistent upward trajectory, reflecting a robust and sustained expansion over time, with projections indicating that this industry is set to nearly double by 2030. The ongoing expansion of the clinical laboratory test market is expected to have important implications for laboratory professionals, hospita...
Article
The results of our analysis suggest that the age-adjusted death rate for aortic rupture or dissection did not change significantly during the early phase of the COVID-19 pandemic in the US. Thus, neither direct biological injury or indirect damage due to by delayed diagnosis and treatment appear to have influenced the outcome of aortic pathologies.
Article
Full-text available
Resumen Objetivos El análisis de orina es ampliamente utilizado y frecuentemente solicitado desde los servicios de urgencias para evaluar la presencia de hipovolemia, infecciones del tracto urinario, diabetes, cetoacidosis y hematuria. Nuestro objetivo era evaluar el impacto de informar el sedimento urinario en muestras enviadas desde el servicio...
Article
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Background and Objective: Obtaining reliable and up-to-date information on mortality causes is essential for the planning and implementation of effective preventive interventions. We present here an analysis of the leading causes of death in the US in 2022. Material and Methods: We conducted an electronic search of the US Centers for Control and Pr...
Article
Full-text available
The rising number of Mpox cases, particularly those caused by Clade 1b in Africa and globally, underscores the urgent need for the development and commercialization of rapid, cost-effective diagnostic tests. Lateral flow immunoassays (LFAs) are particularly well-suited for diagnosing Mpox and differentiating between its clades. This challenge is wi...
Article
Background: The measurement of fasting glucose is a common practice for lowering the risk of hyperglycemia before an oral glucose tolerance test (OGTT). In this study we analyze advantages and limitations of near-patient measurement of capillary fasting glucose with a portable glucometer or blood sampling and measurement of plasma glucose with labo...
Article
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The results of our analysis in Scopus show that articles on COVID-19 (or SARS-CoV-2) have not been retracted more frequently than those involving other common pathologies such as cancer, sepsis, trauma, Alzheimer’s disease and even diabetes. Nonetheless, the trend of article retractions on COVID-19 and/or SARS-CoV-2 has gradually increased between...
Article
Neurofilament light chain (NfL) is a promising biomarker for neurodegenerative diseases, measurable in both CSF and blood upon neuroaxonal damage. While CSF analysis was traditionally used, blood-based assays now offer a less invasive alternative. NfL levels correlate with disease severity and progression in conditions like Alzheimer's disease, amy...
Article
We conducted an electronic search using the CDC WONDER (Wide-Ranging, Online Data for Epidemiologic Research) online database. The age-adjusted death rate (×100 000) for acute appendicitis in the United States was 0.060 (95%CI, 0.055-0.065) in the pre-COVID-19 period (2018-2019) but increased to 0.081 (95%CI, 0.074-0.087) in the COVID-19 peak perio...
Article
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One of the key lessons we have learned during the ongoing COVID-19 pandemic is that the availability of rapid diagnosis of infectious diseases through AG-RDTs is a cost-effective pillar of any strategy aimed at mitigating the impact of infectious diseases on the population, particularly for individuals at higher risk of developing severe forms of i...
Article
Objectives. Benign fasciculation syndrome (BFS) is a challenging clinical condition that causes great concern to patients, as the sudden onset of fasciculations often raises suspicion of the presence or future development of motor neuron diseases. This article hence aims to provide a systematic literature review of clinical studies that investigate...
Article
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Mpox, caused by the monkeypox virus (MPXV), is categorized into two primary clades: Clade I and Clade II, with notable outbreaks linked to Clade IIb. Historically endemic in Africa, recent years have seen significant global spread. The World Health Organization (WHO) declared mpox a Public Health Emergency of International Concern in August 2024, h...
Article
Sticky platelet syndrome (SPS) is a plausible but often disputed condition that is said to reflect hereditary platelet hyperreactivity that can potentially lead to a prothrombotic risk. SPS is strongly believed in by a small cohort of some very active research teams, but is met with general skepticism by the majority of mainstream thrombosis resear...
Article
Coronavirus disease 2019 (COVID-19) negatively impacts the progression of Alzheimer’s disease. The aim of this study was to determine whether mortality from Alzheimer’s disease has changed during the COVID-19 pandemic. We searched the WONDER database, to obtain cumulative and sex-specific age-adjusted death rates of Alzheimer’s disease between the...
Article
We conducted an electronic search on the WONDER website using the combined ICD-10 code for pancreatic cancers throughout 2003-2022. The cumulative, age-adjusted mortality rate for pancreatic cancer (with 95% confidence interval; 95%CI) has increased steadily over the last 20 years, from 10.54 per 100,000 in 2003 to 11.24 per 100,000 in 2022. A clea...
Article
ADAMTS13 (a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13), also called von Willebrand factor (VWF) cleaving protease, acts as a moderator of VWF activity. ADAMTS13 cleaves VWF multimers, thereby reducing VWF activity in blood. When ADAMTS13 is absent (e.g., in patients with TTP [thrombotic thrombocytopenia purpura...
Article
Given the potential impact on the general population of mpox, especially with human-to-human transmission being the predominant mode of spread, it is crucial to address the critical measures necessary to avoid repeating some of the mistakes made during the coronavirus disease 2019 (COVID-19) pandemic. Although the current epidemiological trend does...
Article
Full-text available
Objective This scoping review protocol describes the strategy for a scoping review that aims to provide a comprehensive overview of published guidelines for the prescription of standard laboratory tests performed in intensive care unit (ICU) patients. Background The use of clinical laboratories is constantly increasing. However, there is evidence...
Article
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In cancer screening, there is probably not a one-fits-all solution. On the contrary, screening interventions should be tailored individually to reflect, among others, patient history, comorbidities and environmental risk factors, and any MCED testing should be used in the context of this paradigm. In conclusion, the jury is still out on the utility...
Preprint
Full-text available
Background and Objective: Obtaining reliable and up-to-date information on mortality causes is essential for planning and implementation of effective preventive interventions. We present here an analysis of the leading causes of death in the US in 2022. Material and Methods: We conducted an electronic search of the US Centers for Control and Preven...
Article
Full-text available
At the beginning of the COVID-19 pandemic, an ad hoc organisational framework was established between academic, local government and community partners to implement the “Sentinella – Identify, Trace and Prevent” screening programme in Verona, north-east Italy. Between September 2020 and May 2021, key populations not covered by any screening policie...
Article
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Thyroid cancer is relatively rare in the general population compared to other malig-nancies, but its incidence appears to have increased in recent decades. In a recent article, Lee at al. conducted a search of the US National Cancer Database to investigate whether major disruptions in cancer diagnosis during the coronavirus disease 2019 (COVID-19)...
Article
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We performed an electronic search in CDC WONDER online database (years 2018-2022) to explore whether the higher risk of dying during the weekends may be related to complications of medical and surgical care. One-way ANOVA and Tukey's HSD multiple comparison test revealed no significant variation in mean number of deaths during the seven days of the...
Article
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It is not true to conclude that there was no logical reason to die of diabetes during the COVID-19 pandemic, as there are many SARS-CoV-2-realted factors that may have worsened the health of this particular population, including weakened immune response to the pathogen, pro-inflammatory state (up to the so-called “cytokine storm”), higher risk of d...
Article
We accessed five of the most widely used, freely available generative artificial intelligence tools available on the Web on July 29, 2024, formulating the specific question: ‘Which are the leading risk factors for venous thrombosis?’ (the term ‘venous thrombosis’ was preferred to ‘venous thromboembolism’ as it is likely more familiar to patients)....
Preprint
Full-text available
Shwachman-Diamond syndrome (SDS) is characterized by exocrine pancreatic insufficiency, neutropenia, and a high risk of myeloid malignancy. Most patients with SDS harbor nonsense mutations in Shwachman-Bodian-Diamond syndrome gene ( SBDS) , which encodes a ribosome assembly factor. We investigated the translational read-through effect of ataluren i...
Article
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Background: The use of laboratory resources has seen a substantial increase in recent years, driven by automation and emerging technologies. However, inappropriate use of laboratory testing, encompassing both overuse and underuse, poses significant challenges. Content: This review explores the complex interplay between patient safety, economic, an...
Article
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The age-adjusted mortality rate (×100,000) for of digestive organs cancers decreased from 45.33 (95%CI, 45.09-45.98) in 2003 to 38.90 (95%CI, 38-72-39.10) in 2022 (-14.2%), with a notable break in 2021, corresponding to the second “wave” of COVID-19. The stomach cancer age-adjusted mortality also showed a significant and continuous decline over the...
Article
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Nella prospettiva certamente indesiderabile che mpox si possa trasformare in una grossa epidemia, o addirittura in una pandemia, diviene imperativo non farsi prendere dal panico, ma essere preparati al peggio, perché “errare humanum est, perseverare autem diabolicum” (10). La prima misura da adottare è la tutela del personale sanitario, soprattutto...
Article
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The ultimate goal of value-based laboratory medicine is maximizing the effectiveness of laboratory tests in improving patient outcomes, optimizing resources and minimizing unnecessary costs. This approach abandons the oversimplified notion of test volume and cost, in favor of emphasizing the clinical utility and quality of diagnostic tests in the c...
Article
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Laboratory medicine has undergone a deep and multifaceted revolution in the course of human history, in both organizational and technical terms. Over the past century, there has been a growing recognition of the need to centralize numerous diagnostic activities, often similar or identical but located in different clinical departments, into a common...
Article
The results of our US nationwide analysis of mortality for acute pancreatitis before and during the COVID-19 pandemic show a concerning increase. Specifically, compared to the last pre-pandemic year (2019), the age-adjusted death rate for acute pancreatitis increased by 16.5% and 21.1% in 2020 and 2021, respectively.
Conference Paper
Full-text available
Frailty is commonly defined as a state of increased vulnerability to stressors due to decline in physiological reserve and function across multiple organ systems. Coronavirus disease 2019 (COVID-19) and frailty have a complex relationship, as the virus tends to disproportionately affect older adults and individuals with underlying health derangemen...
Conference Paper
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Introduction This abstract examines the measures adopted by the Modena Local Health Authority (Azienda USL di Modena) following the ransomware attack on 28 November 2023. The organisation, located in Emilia-Romagna, Italy, with over 5,400 employees, serves a large regional area with a population of 690,000 inhabitants. The increasing incidence of r...
Article
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Four years after the spread of the COVID-19 pandemic, with a worldwide epidemiology largely under control thanks to widespread immunity against SARS-CoV-2 achieved through infections, vaccinations or both, another threat is on the horizon. The increase in monkeypox (mpox) cases documented in the Democratic Republic of the Congo and some neighboring...
Article
Several lines of evidence suggest that breast cancer screening and treatment may have been compromised during the early phase of the COVID-19 pandemic. Using data from the US Centers for Disease Control and Prevention (CDC) WONDER database, we estimated the age-adjusted mortality rates for female breast cancer between 2018 and 2023. We found that t...
Article
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To better describe the current diagnostic alternatives for diagnosing mpox, a search was conducted on the FIND initiative website, the global alliance for diagnostics. As of September 1, 2024, the FIND website lists 131 mpox diagnostic tests. The majority of 98 (74.8%) tests are based on DNA detection using NAATs, while 18 (13.7%) tests detect mpox...
Article
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Background and aims: The aim of this study was to investigate the possible preanalytical effect of incomplete filling of blood tubes on molecular biology assays. Materials and methods: The study population consisted of 13 healthy volunteers from whom 11 mL of whole blood was collected and then distributed in different volumes (1.5, 3.0, and 6.0 mL,...
Article
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We planned a series of experiments to investigate the possible role of spike protein of different SARS-CoV-2 variants in influencing erythrocyte biology. The values of erythrocyte count, hemoglobin, and mean corpuscular hemoglobin (MHC) did not vary across all samples challenged with both concentrations of the four different SARS-CoV-2 recombinant...
Article
The age-adjusted mortality for melanoma in the US was 2.087 × 100 000 in 2018, 2.006 × 100 000 in 2019, 1.996 × 100 000 in 2020, and 2.035 × 100 000 in 2021, respectively. Neither the cumulative variation between the prepandemic and postpandemic period (analysis of variance: f = 0.84; P = 0.359) nor the comparison between the different years achiev...
Article
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Corisin, a 19 amino acid proapoptotic peptide derived from the lung microbiota (i.e., by Staphylococci), is implicated in the pathogenesis of acute lung injury and exacerbation of pulmonary fibrosis. Recent evidence also suggests that this molecule may have a role in lung thrombosis, as its concentration correlates with a prothrombotic state. It ha...
Article
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Background: Low-volume blood tubes offer several advantages in facilitating blood collection, reducing iatrogenic anemia and spurious hemolysis, but their clinical reliability must be validated. We planned this investigation for establishing the reliability of routine hematologic testing in low-volume tubes before their implementation into clinical...
Article
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We performed an electronic search in CDC-WONDER online database (years 2018–2022) (2), using “year” as the first variable (from 2018 to 2022) and the specific ICD-10 code for malignant prostate cancer as the second variable (C61: malignant neoplasm of prostate). The age-adjusted death rate ×100,000 for malignant prostate cancer decreased from 2018...
Article
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We performed an electronic search on the website of the Italian National Institute of Statistics (ISTAT), under the menu item “Number of pathologies for initial cause of death”. The search focused on COVID-19 and on the two leading causes of death in Italy and the rest of the world (i.e., cardiovascular disease and cancer) during the first two year...
Article
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Official statistics on the impact of the COVID-19 pandemic on diabetes mortality in the US were obtained from the Wonder (Wide-Ranging, Online Data for Epidemiologic Research) database, a repository maintained by the US Centers for Disease Control and Prevention (CDC) that allows specific queries to analyze the unique causes of death of the entire...
Article
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Artificial intelligence (AI), especially generative AI, has become a valuable resource in daily life and in many professions, including healthcare and laboratory medicine. On July 26, 2024 we queried the latest version of five of the most common and freely available generative AI online software tools (Chat-GPT; Perplexity; Google Gemini; Cohere; a...
Article
Although further studies are needed, preliminary findings suggest the possible clinical efficacy of heparin in improving post-traumatic stress disorders (PTSD) symptoms, and potentially averting subsequent thrombotic sequalae. Regardless of the mechanistic relationship between heparin and the pathogenesis of PTSD, there are some plausible biologica...
Article
Hypereosinophilic syndromes (HES) represent a group of rare dis-immune conditions characterized by blood hyper-eosinophilia and eosinophilic related burden. Especially the idiopathic subtype (I-HES) is particularly difficult to diagnose because of its heterogeneous clinical presentation, the lack of specific findings on physical exam, lab tools, an...
Article
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The healthcare systems are a prime target for cyber-attacks due to the sensitive nature of the information combined with the essential need for continuity of care. Medical laboratories are particularly vulnerable to cyber-attacks for a number of reasons, including the high level of information technology (IT), computerization and digitization. Base...
Article
It is not clear if disruption of diagnostic and care pathways for hepatocellular carcinoma (HCC) may have translated into a higher mortality for this type of cancer in the United States during the first period of the pandemic. To this end, we have planned this epidemiological analysis on the CDC WONDER online database to address this important dile...
Article
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Objectives Urinalysis is widely used and is also frequently requested in emergency situations for screening hypovolemia, urinary tract infections, diabetes, ketoacidosis and hematuria. Our aim was to evaluate the impact of reporting urinary sediment in emergency department specimens with the Sysmex UN system. Methods We evaluated urinalyses reques...
Article
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We accessed the US CDC online database Wonder, which provides nationwide statistics on causes of death between the years 2018-2022. The crude mortality rate for sudden cardiac death (SCD) increased in parallel with age in both sexes, reaching the highest value in subjects aged 85 years or older. In all age groups, the crude death rate was always si...
Article
The risk of developing venous thromboembolism is considerably high during an acute SARS-CoV-2 infection, tends to decrease over time, but remains higher than in people without COVID-19 for months afterwards. Nevertheless, recent clinical studies have convincingly shown that this trend could be at least partially reversed. In particular, the risk of...
Article
We planned a real-world analysis using official data from the US Centers for Disease Control and Prevention (CDC) to investigate whether the mortality for pulmonary embolism (PE) has changed significantly during the COVID-19 pandemic. The age-adjusted mortality for PE was 2.30 (2.25–2.35) × 100,000 in 2018, decreased slightly to 2.20 (2.16–2.25) ×...
Article
Full-text available
Objective The long-lasting persistence of autoantibodies stands as one of the hypotheses explaining the multisystemic manifestations seen in individuals with post-COVID-19 condition. The current review offers restricted insights into the persistence of autoantibodies in plasma/serum in people with post-COVID symptoms. Methods PubMed/MEDLINE, CINAH...
Technical Report
L'evoluzione tecnologica nel settore della diagnostica e dei Dispositivi Medico-Diagnostici in vitro (IVD) si sta intensificando, portando con sé un impatto significativo sul carico di lavoro per le valutazioni di merito, l’accesso delle nuove tecnologie nel mercato e la relativa tariffazione. La pressione generata dal “volume” dell’innovazione da...
Article
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There is now indisputable evidence that the coronavirus disease 2019 (COVID-19) pandemic has not only had a dramatic impact on healthcare, society and the economy, but has also disrupted the world of scientific publishing. It is therefore not surprising that, especially in the initial phase of the pandemic, a few seminal papers have attracted an en...
Article
Full-text available
The Task Force Preparation of Labs for Emergencies (TF-PLE) of the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM) has conducted a specific survey to determine the current state-of-the art on cyber-attacks of laboratory medicine in Europe. The first three questions concerned respondents' familiarity with malware, cyber-atta...
Article
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Screening is generally defined as an intervention aimed at identifying individuals with apparently good health, who may be at higher risk of developing health problems or diseases, so that early clinical management could be offered. Screening is also one of the most important aspects of laboratory medicine, but the use of laboratory tests for preve...
Chapter
Coronavirus disease 2019 (COVID-19) occurs as a result of infection by the severe acute respiratory syndrome coronavirus (SARS-CoV-2) virus. COVID-19 shows high morbidity and mortality rates, in part determined by various factors and the presence of other comorbidities. To reduce infection rates, help prevent COVID-19, and reduce COVID-19 related m...
Article
Routine laboratory screening is typically performed at initial evaluation of the vast majority of presentations to the emergency department (ED). These laboratory results are crucial to the diagnostic process, as they may influence up to 70% of clinical decisions. However, despite the usefulness of biological assessments, many tests performed are i...
Article
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Point-of-care testing (POCT) is becoming an increasingly popular way to perform laboratory tests closer to the patient. This option has several recognized advantages, such as accessibility, portability, speed, convenience, ease of use, ever-growing test panels, lower cumulative healthcare costs when used within appropriate clinical pathways, better...
Preprint
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It can be assumed that a reduction in patient access to colorectal cancer screening and early management during the coronavirus disease 2019 (COVID-19) pandemic could have generated a negative impact on subsequent diagnoses and survival probabilities. We report here the recent statistics on colorectal cancer-related deaths in the US. We searched th...
Article
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The unpredictable evolutionary trajectory of SARS-CoV-2 variants poses significant challenges to develop clinically effective vaccines and therapies, such as antivirals and monoclonal antibodies. What has become clear with SARS-CoV-2 is that what was biologically plausible yesterday may not be today, as a new variant may have replaced the former. A...
Article
Introduction: urine osmolality, a crucial test for differential diagnosis of hydro-electrolytic disorders, is mainly assessed by measuring the colligative properties of solutes. Many approaches were attempted to assess urine osmolality without this reference technique, mainly based on the use of formulas. In this study the performance of the Sysmex...
Article
Since it is still undetermined as to whether all these aspects may have influenced the death rate for lip and oral cavity cancers during the COVID-19 pandemic, we performed an electronic search using the latest version of the online CDC Wonder database, which reports the underlying causes of death between the years 2018 and 2022 in the US (Centers...
Article
Full-text available
There are now several lines of evidence that millions of people around the world use bicycles as a routine means of transportation. In the US alone, for example, the website Statista estimates that 55 million people use bicycles as primary or complementary mode of transportation, with a trend that has been steadily increasing over the past decade....