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Giuseppe Di Bella

Giuseppe Di Bella
Fondazione Di Bella

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46
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341
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Publications

Publications (46)
Research Proposal
Full-text available
Despite all the new developments in cancer therapy, the life expectancy of patients with sarcoma remains short. Since it was established as a cancer therapy, the Di Bella Method (DBM) has been able to increase survival rate and life quality, without overt toxicity, in comparison to what is described in the literature for the treatment of sarcoma wi...
Article
Full-text available
Despite all the new developments in cancer therapy, the life expectancy of patients with malignant anaplastic brain tumors and glioblastoma multiform (GBM) remains short. Since the establishment of the Di Bella Method (DBM) in cancer therapy, DBM was able to increase the survival rate and life quality, without overt toxicity, in comparison to what...
Conference Paper
Full-text available
BACKGROUND & HYPOTHESIS: Overall evaluation and ongoing statistical processing of preliminary data on 502 evaluable cases of breast cancer on 11,300 patients who have been treated with DBM since 2004. METHODS: Administration of DBM to patients with breast cancer: somatostatin / octreotide, estrogenic and prolactin inhibitors, Melatonin, Retinoid so...
Conference Paper
Full-text available
Complete and stable objective response of 12 prostate cancer patients who were neither operated nor chemo-radiotreated but treated only with Di Bella Method (DBM) as first-line therapy. OBJECTIVE: To evaluate the objective clinical, biochimical and metabolical response and the safety of the combined administration of Di Bella Method (DBM) in patien...
Article
Full-text available
BACKGROUND Vitamin C (Vit C) is an important physiological antioxidant with growing applications in cancer. Somatostatin (SST) is a natural peptide with growth inhibitory effect in several mammary cancer models. OBJECTIVE The combined effects of SST and Vit C supplementation have never been studied in breast cancer cells so far. METHODS We used M...
Article
Full-text available
We used MCF-7 and MDA-MB231 breast cancer cells incubated with Curcumin and Quercetin for 24h, in the absence and presence of Somatostatin, at their EC50 concentrations, to evaluate membrane fatty acid-based functional lipidomics together with the follow-up of EGFR and MAPK signaling pathways. The two cell lines gave different membrane free fatty a...
Article
Full-text available
The natural peptide somatostatin has hormonal and cytostatic effects exerted by the binding to specific receptors in various tissues. Therapeutic uses are strongly prevented by its very short biological half-life of 1–2 min due to enzymatic hydrolysis, therefore encapsulation methodologies are explored to overcome the need for continuous infusion r...
Book
Nel libro "La Scelta Antitumore, prevenzione , terapia farmacologica stile di vita " ho spiegato come estendere alla prevenzione i principi antitumorali formulati dal Prof. Luigi Di Bella e spiegare le basi scientifiche e razionali del Suo Metodo (MDB):-. Vengono trattati spiegati , i seguenti argomenti -in che cosa consiste la multiterapia biolo...
Article
Full-text available
The interaction between pituitary hormones, GH-PRL, and Growth Factors, GF, plays a fundamental role in the physiological and neoplastic mechanisms of growth, the latter using these factors to a much greater extent compared to the former, with a direct dose-dependent effect on the speed of local or metastatic expansion. In hormone-dependent tumours...
Preprint
Full-text available
The interaction between pituitary hormones, GH-PRL, and Growth Factors, GF, plays a fundamental role in the physiological and neoplastic mechanisms of growth, the latter using these factors to a much greater extent compared to the former, with a direct dose-dependent effect on the speed of local or metastatic expansion. In hormone-dependent tumours...
Article
Full-text available
Abstract Background: The interaction between pituitary hormones (Growth Hormone-Prolactin), ovarian hormones (Estradiol) and growth factors forms the basis of the mechanisms underlying the growth of tumors of the breast. The literature contains reports of the increased expression of the mitogenic GH (Growth Hormone)/IGF1 (Insulin-Like Growth Factor...
Article
Full-text available
Background: Breast cancer is still the leading cause of death in women worldwide. Study question: Our purpose is to improve survival, objective response and qualityof life with a non-toxic biological therapy. Study design: The DBM (Di Bella Method) with MLT (Melatonin), Retinoids,solubilized in vitamin E, D3, and C, Folates, proteoglycans and calci...
Conference Paper
Full-text available
Improvement of survival, objective response and improved quality of life with a non-toxic biological therapy, considering the fact that breast cancer is still the leading cause of death in women world-wide. The GH / IGF-1 axis is the main mediator of somatic growth, and during puberty it plays an essential role in the development of the mammary gla...
Article
Full-text available
Breast cancer is the most common cancer and the leading cause of cancer death among women. Despite all efforts, about 11,939 deaths and 50,000 new diagnoses for breast cancer were estimated among Italian women in 2016. Therefore new approaches are needed to improve the survival and higher remission rates. We present a case of a woman with carcinoma...
Article
Full-text available
Melatonin has shown the potential to inhibit growth of different tumors, both in vitro and in vivo. There is clear evidence that the administration of melatonin alone or in combination with chemo and radiotherapy in cancer patients with advanced solid tumors has been associated with improved outcomes of tumor regression and survival. Moreover, chem...
Article
Full-text available
At birth, a male child presented a 6 cm tumour in the right leg. The tumour was partially removed after just 12 days. Histology showed a congenital fibrosarcoma associated with reactive lymphadenitis. A first cycle of adjuvant chemotherapy did not prevent the rapid progression of the disease. Subsequent evaluation for surgical removal raised seriou...
Article
Full-text available
Objective: The aim of the liposoluble vitamin solution in the DBM formulation is to enhance the biovailability, the stability, the half-life and the therapeutic efficacy of the components without resorting to excessive or toxic doses. Method: The DBM vitamin solution contains 0.5 grams of vitamin A palmitate ester, 0.5 grams of all-trans-retinoi...
Article
Full-text available
In a 41 year old man, with Glioblastoma Multiforme (Grade IV - WHO 2007) and loco-regional recurrence, treated conventionally with surgery, radio-therapy and Temolozomide, a complete objective response was subsequently achieved by means of the well-tolerated concomitant administration of Somatostatin + slow-release Octreotide, Melatonin, Retinoids...
Article
Full-text available
The current strategies for the treatment of breast cancer are essentially based on surgery, preceded and/or followed by chemotherapy often supplemented by radiotherapy and/or the administration of hormonal therapy and monoclonal antibodies. Their combined use has made it possible to increase an overall survival but they are still penalized by adver...
Article
Full-text available
Melatonin (N-acetyl-5-methoxytryptamine, MLT), the main hormone produced by the pineal gland, not only regulates circadian rhythm, but also has antioxidant, anti-ageing and immunomodulatory properties. MLT plays an important role in blood composition, medullary dynamics, platelet genesis, vessel endothelia, and in platelet aggregation, leukocyte fo...
Article
Full-text available
Abstract: Melatonin (N-acetyl-5-methoxytryptamine, MLT), the main hormone produced by the pineal gland, not only regulates circadian rhythm, but also has antioxidant, anti-ageing and immunomodulatory properties. MLT plays an important role in blood composition, medullary dynamics, platelet genesis, vessel endothelia, and in platelet aggregation, le...
Article
Full-text available
Objective: To evaluate the objective clinical response and the safety of the combined administration of somatostatin, melatonin, retinoids, vitamin D3, dopamine subtype 2 receptor (D2R) agonists and low doses of cyclophosphamide, associated with androgen ablation, in patients with a histological diagnosis of prostate adenocarcinoma (Pac). Materia...
Article
Full-text available
Objectives: Lymphomas are the main form of haematological neoplasms, representing 55.6% of all tumours of the blood. Overall, they account for 5.3% of all malignant tumours (excluding basal and squamous cell skin cancer) in Italy with a prevalence constantly increasing at a rate of 3% per year. From a histological point of view, they represent a v...
Article
Full-text available
Objectives: To increase the efficacy and reduce the toxicity of cancer therapy. Method: The DBM with MLT (melatonin), Retinoids, vitamins E, D3, and C has a differentiating, cytostatic, antiangiogenic, immunomodulating, factorially synergic effect, at the same time reinforcing those functions that Physiology considers essential for life. With So...
Article
Full-text available
On the centennial of the birth of Luigi Di Bella, the desire to memorialise, at least in part, his thoughts has prompted us to write this tribute, in the hope that one day his dreams may come true. Throughout his research for a treatment of cancer, he deemed it necessary to employ a complex array of substances that, by acting centripetally on neopl...
Article
Full-text available
In 23 cases of carcinoma of the head and neck, the combined use of Somatostatin and/or its analogue Octreotide, prolactin inhibitors, Melatonin, Retinoids, Vitamin E, Vitamin D3, Vitamin C, Calcium, chondroitin-sulphate, and minimal oral doses of cyclophosphamide (50-100 mg/day) led to a decided increase in survival with respect to the median value...
Poster
Full-text available
Study of objective response, survival rate and performance status following DBM biological treatment. Increase the efficacy and reduce the toxicity of cancer therapy.
Conference Paper
Full-text available
A 5-year retrospective observational clinical study conducted on 122 cases of mammary carcinoma treated with the biological therapy
Conference Paper
Full-text available
Razionale del MDB, risultati su 553 casi di 29 istotipi diversi. Scopo del MDB è cercare di superare l'elevata tossicità e la limitata efficacia delle attuali terapie mediche del cancro valorizzando molecole biologiche di elevata efficacia e bassa tossicità oggi sottovalutate in oncoterapia, il cui documentato effetto antitumorale è esaltato dal re...
Conference Paper
Full-text available
Obiettivi: scopo del MDB è superare l’elevata tossicità e bassa efficacia delle attuali terapie mediche del cancro. Metodo: con MLT, Retinoidi ,vitamine E, D3, C, componenti della ECM, il MDB potenzia quei mezzi che la Fisiologia considera essenziali per la vita. Queste molecole esercitano sinergicamente, un ruolo differenziante e antiproliferativo...
Article
Full-text available
the aim of the Di Bella Method (DBM) is to try to overcome the high toxicity level and the limited efficacy of the current medical treatments for cancer. using Melatonin, Retinoids, and vitamins E, D3, and C, components of the extracellular matrix, the DBM reinforces those means that Physiology considers essential for life. Acting together, these d...
Article
Full-text available
The combined use (MDB) of Somatostatin, Melatonin, Retinoids, Vitamins E, C, and D3, with Calcium, Chondroitin sulfate, and microdoses of Cyclophosphamide in a seven-month old baby affected by a voluminous retroperitoneal neuroblastoma measuring 4 x 8 cm produced a 50% objective response in six months, an almost total response in one year and a com...
Article
Full-text available
The synergetic use of Somatostatin, Melatonin, Retinoids, Vitamins C, D3, and E, Calcium, sulphated Aminoglucosides, and minimum doses of cyclophosphamide in a 70-year old male patient with inoperable scarcely differentiated oesophageal carcinoma, has provided, from the beginning of treatment in 1995 to the present date, an excellent quality of lif...
Conference Paper
Full-text available
Ho ritenuto che potesse essere di qualche interesse sul piano scientifico, etico e sociale, la segnalazione del caso di una donna nella cui mammella sinistra erano state individuate obiettivamente e confermate mediante ecografia e mammografia tre lesioni neoplastiche che avevano provocato adenopatie satelliti ascellari e sospette lesioni osteolitic...
Article
Full-text available
In this case presentation, a woman with breast carcinoma who chose to try Prof. L. DiBella's biological therapy (MDB), was found, after seven months, to have a 50% reduction in objective measures of her carcinoma and was totally cured after 14 months. The patient's recovery extended to bilateral axillary adenopathies, and took place without the tox...
Book
Il successo della prima edizione, andata presto esaurita, e la necessità di illustrare compiutamente anche il “modulo variabile” del Metodo Di Bella, sono all’origine di questa seconda edizione dell’opera riveduta, ampliata ed arricchita di una vasta ed esauriente bibliografia generale. Queste pagine vogliono essere la fedele esposizione delle evid...
Book
Sintesi e fine di questo libro sono tentare d'indurre a cambiare strada nella prevenzione e terapia dei tumori. E' arduo rimuovere mentalità cristallizzate e metodi organizzati che godono di appoggi politici, economici , organizzativi. I principi esposti per la prevenzione dei tumori poggiano su solide basi scientifiche tratte da ampia e completa r...
Book
Atti del convegno a Reggio Calabria, del primo convegno nazionale sul tema : " Melatonina : dalla ricerca agli interventi.Aspeti anatomo-fisiologici, clinico-terapeutici e problematiche sanitarie
Book
Scopo di questo libro è tentare di indurre a cambiare strada nella terapia dei tumori. È difficile rimuovere metodi perfettamente organizzati che godono di appoggi politici, economici ed organizzativi ma anche David osò combattere contro Golia. Ho raggiunto buoni traguardi in silenzio, ignoto a molti ma non ai pazienti ed ai parecchi colleghi che h...
Book
Atti del XXIV Congresso Nazionale A.O.O.I. del 1971
Article
Full-text available
Relazione: Target therapy: Risposta alla terapia biologica di 18 carcinomi della testa e del collo Nell'ambito ORL non si osservano sensibili difformità di risposte cliniche tra mono o polichemioterapie, che possono anche ridurre temporaneamente (durata della risposta inferiore a 2 mesi), il volume delle neoplasie, senza alcuna possibilità di incre...

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