Giuseppe De Vito

Giuseppe De Vito
University of Padova | UNIPD · Department of Biomedical Sciences - DSB

Medicine and Surgery, PhD Exercise Physiology, Specialisation in Sports Medicine
"APPETITE" Project direct at investigating innovative plant protein fibre and prevent undernutrition in older adults.

About

189
Publications
72,833
Reads
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6,354
Citations
Citations since 2016
69 Research Items
3778 Citations
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Introduction
Giuseppe De Vito is currently Director of Vallisneri Biomedical Campus and full Professor of Human Physiology in the Department of Biomedical Sciences at University of Padova, Italy. He was, from 2007 until 2019, Professor and Dean in the School of Public Health, Physiotherapy & Sports Science at University College Dublin (Head of School between 2014 and 2019 ). Giuseppe does research in Human and Exercise Physiology .
Additional affiliations
June 2007 - October 2019
University College Dublin
Position
  • Professor (Full)
June 2007 - May 2010
University of Stirling
Position
  • Professor of Exercise Medicine
Description
  • part time position
June 2007 - October 2019
University College Dublin
Position
  • Professor
Education
January 1991 - February 1994
Sapienza University of Rome
Field of study
  • Physio-pathology of movement
October 1987 - July 1989
Sapienza University of Rome
Field of study
  • Sports medicine
October 1977 - April 1986
Sapienza University of Rome
Field of study
  • Medicine

Publications

Publications (189)
Article
Full-text available
Purpose To assess the intra-rater reliability of static wide field of view ultrasound to quantify the architectural characteristics of the hamstring muscles. Methods Twenty amateur male athletes were recruited. Their left hamstring muscles were assessed using static wide field of view ultrasound on two separate occasions. Static ultrasound images...
Article
Full-text available
Electrophysiological alterations of the neuromuscular junction (NMJ) and motor unit potential (MUP) with unloading are poorly studied. We aimed to investigate these aspects and the underlying molecular mechanisms with short-term unloading and active recovery (AR). Eleven healthy males underwent a 10-day unilateral lower limb suspension (ULLS) perio...
Article
Full-text available
Background: Efforts to enhance diagnostic measures for sarcopenia have led to an increased focus on the screening utility of blood-based biomarkers. In this regard, circulating neurofilament light chain (NfL) levels are a potent indicator of axonal damage and have been linked with several neurological disorders. However, despite the strong neuroge...
Article
Full-text available
IntroductionHigh intensity functional trainings (HIFT), a recent development of high intensity trainings, includes in the same training session components of endurance exercises, elements of Olympic weightlifting and powerlifting, gymnastics, plyometrics and calisthenics exercises. Therefore, subjects practicing this type of activity are supposed t...
Article
Full-text available
Objectives The mechanisms of hamstring strain injuries (HSIs) in professional Rugby Union are not well understood. The aim of this study was to describe the mechanisms of HSIs in male professional Rugby Union players using video analysis. Methods All time-loss acute HSIs identified via retrospective analysis of the Leinster Rugby injury surveillan...
Article
Full-text available
Key points: Type 1 diabetes negatively affects skeletal muscle health; however, the effect of structured exercise training on markers of mitochondrial function, inflammation and regeneration is not known. Even though participants with type 1 diabetes and healthy control were comparable for cardiorespiratory fitness (VO2 max) and muscle strength at...
Article
Full-text available
Older adults with poor appetite are at higher risk of undernutrition due to the role of appetite as a key driver of food intake. Dietary protein and fibre are critical nutrients in this population, and enhancing their intake is vital to preventing undernutrition and maintaining organ function and health. In APPETITE, a transdisciplinary consortium...
Article
This study investigated the effects of dynamic knee extension and flexion fatiguing task on torque and neuromuscular responses in young and older individuals. Eighteen young (8 males; 25.1 ± 3.2 years) and 17 older (8 males; 69.7 ± 3.7 years) volunteered. Following a maximal voluntary isometric contraction test, participants performed a fatiguing t...
Article
Full-text available
Weak grip strength is a strong predictor of multiple adverse health outcomes and an integral diagnostic component of sarcopenia. However, the limited availability of normative data for certain populations impedes the interpretation of grip performance across adulthood. This study aimed to establish normative data and low grip strength thresholds in...
Article
Hamstring strains are the most prevalent injury sustained by field-sport athletes. Insufficiencies in the architectural characteristics of the hamstring muscles can heighten an athlete's risk of incurring a hamstring strain. To evaluate the influence of hamstring muscle architectural characteristics (i. e., fascicle length, pennation angle, muscle...
Article
Full-text available
Difficulties in walking, controlling balance, and performing activities of daily living are common problems encountered by individuals affected by Parkinson disease. Scientific evidence suggests that exercise performed with music or auditory or rhythmical cues facilitates movement and improves balance, gait, mobility, and activities of daily living...
Article
Full-text available
Barriers associated with direct muscle quantification have prevented a consistent implementation of therapeutic measures for sarcopenia. Recently, the relevance of circulating C-terminal agrin fragment (CAF) as an accessible screening method alternative for sarcopenia has gained credence. Accordingly, this study aimed to verify the pertinence of pl...
Article
Full-text available
Background: Leucine-enriched protein (LEU-PRO) and long-chain (LC) n-3 (ω-3) PUFAs have each been proposed to improve muscle mass and function in older adults, whereas their combination may be more effective than either alone. Objective: The impact of LEU-PRO supplementation alone and combined with LC n-3 PUFAs on appendicular lean mass, strengt...
Article
Full-text available
This secondary analysis was designed to evaluate the independent effect of physical activity (PA) on hemoglobin A1c (HbA1c) level in Chinese patients with type 2 diabetes mellitus (T2DM). A total of 799 T2DM patients from eight communities of Shanghai, China, were randomized into one control arm and three intervention arms receiving 1-year interven...
Article
Six months of supplementation with a multi-ingredient nutrition supplement was investigated in older adults with low skeletal muscle mass given the recently purported benefits of such approaches. Community-dwelling older adults (age, 74.9 ± 3.6 y; M/F, 18/19) participated in a double-blind, placebo-controlled, randomized trial involving daily consu...
Article
Full-text available
Background There is a paucity of reliability data for walking speed tests in complex conditions to assess functioning in healthy older individuals.AimsTo evaluate the absolute intra- and intertest reliability of walking speed performed in basic and complex conditions in healthy older individuals.Methods Fifty-two men and women of mean age 69.7 ± 3....
Article
Background: Loss of balance control is commonly experienced by older individuals. Despite the large amount of research on the effects of exercise on balance the optimal exercise regime is yet to be identified. Most studies have concentrated on strength training due to associations between muscle weakness, balance disfunction and fall risk. The eff...
Article
Age-related impairments in motor performance are caused by a deterioration in mechanical and neuromuscular functions, which have been investigated from the macro-level of muscle-tendon unit to the micro-level of the single muscle fiber. When compared to the healthy young skeletal muscle, aged skeletal muscle is: (1) weaker, slower and less powerful...
Data
Analysis and Biophysics of Surface EMG for Physiotherapists and Kinesiologists: Toward a Common Language With Rehabilitation Engineers https://doi.org/10.3389/fneur.2020.576729
Data
Analysis and Biophysics of Surface EMG for Physiotherapists and Kinesiologists: Toward a Common Language With Rehabilitation Engineers https://doi.org/10.3389/fneur.2020.576729
Data
Analysis and Biophysics of Surface EMG for Physiotherapists and Kinesiologists: Toward a Common Language With Rehabilitation Engineers https://doi.org/10.3389/fneur.2020.576729
Article
Full-text available
Recent decades have seen a move toward evidence-based medicine to inform the clinical decision-making process with reproducible findings from high-quality research studies. There is a need for objective, quantitative measurement tools to increase the reliability and reproducibility of studies evaluating the efficacy of healthcare interventions, par...
Preprint
Purpose To compare the effect of high-intensity aerobic (AER), resistance (RES), and combined (COMB: RES + AER) exercise, on interstitial glucose (IG) variability and skeletal muscle signalling pathways in type 1 diabetes (T1D). Methods T1D participants (6 M/6F) wore a flash glucose monitoring system in four randomized sessions: one control (CONT),...
Article
Purpose To compare the effect of high-intensity aerobic (AER), resistance (RES), and combined (COMB: RES + AER) exercise, on interstitial glucose (IG) variability and skeletal muscle signalling pathways in type 1 diabetes (T1D). Methods T1D participants (6 M/6F) wore a flash glucose monitoring system in four randomized sessions: one control (CONT),...
Article
Full-text available
Age-related skeletal muscle degradation known as ‘sarcopenia’ exerts considerable strain on public health systems globally. While the pathogenesis of such atrophy is undoubtedly multifactorial, disruption at the neuromuscular junction (NMJ) has recently gained traction as a key explanatory factor. The NMJ, an essential communicatory link between ne...
Article
Sarcopenia is a muscle disease rooted in adverse muscle changes that accrue across a lifetime. It is an independent risk factor for numerous adverse health outcomes. In 2010, the European Working Group on Sarcopenia in Older People (EWGSOP) published a definition for the identification of people with sarcopenia (EWGSOP1). In 2018, this definition w...
Article
Full-text available
The COVID-19 pandemic is an unprecedented health crisis as entire populations have been asked to self-isolate and live in home-confinement for several weeks to months, which in itself represents a physiological challenge with significant health risks. This paper describes the impact of sedentarism on the human body at the level of the muscular, car...
Article
This two-part narrative review aims to provide an insight into the age-related mechanical and neuromuscular factors contributing to: (1) decreased maximal muscle strength and power; (2) decreased force control; and (3) increased fatigability. Structural and functional changes from the macro-level of the muscle-tendon unit to the micro-level of the...
Article
Full-text available
Aims: Safety and tolerability of prolonged supplementation with a vitamin D, calcium and leucine-enriched whey protein medical nutrition drink (WP-MND) was evaluated in sarcopenic older adults. Methods: A 13-week double-blinded, randomized, isocaloric placebo-controlled trial (PROVIDE study; n = 380) was extended with a voluntary 13-week open-la...
Article
Full-text available
Background: Diet quality and physical activity positively impact pregnancy outcomes among women with obesity, but successful lifestyle interventions require intense clinician time. We aimed to investigate the impact of a behavioral-lifestyle intervention (PEARS) supported by a smartphone app among pregnant women with overweight and obesity, on nutr...
Article
Introduction Osteoarthritis (OA) is characterised by synovial joint pain, functional disability and affects ∼13% of people worldwide, of which ∼16-27% report Knee-OA (KOA). Glucosamine (Glu) is the most widely used nutraceutical treatment for OA despite a lack of scientific consensus, therefore alternative nutraceutical treatments are required. The...
Article
Full-text available
The age-related decline in skeletal muscle mass, strength and function known as ‘sarcopenia’ is associated with multiple adverse health outcomes, including cardiovascular disease, stroke, functional disability and mortality. While skeletal muscle properties are known to be highly heritable, evidence regarding the specific genes underpinning this he...
Article
The purpose of this study was to investigate the age-related alterations in the ability to exert maximal and to sustain submaximal isometric muscle torques after a fatiguing concentric exercise conducted with knee extensor (KE) and flexor (KF) muscles. Sixteen young (aged 19–30 years; 8 women) and 17 older (aged 65–75 years; 9 women) volunteers par...
Article
Full-text available
Purpose Neuromotor exercise, which stimulates motor fitness components (balance, agility, coordination), has been less investigated than other forms of exercise such as resistance or aerobic training to counteract the age-related impairment in mobility. The aim of the study was to verify whether neuromotor exercise was as effective as resistance tr...
Article
Introduction: Fat free mass, of which skeletal muscle is a major component, correlates positively with energy intake at energy balance. This is due to the effects of metabolically active tissue on energy expenditure which in itself appears to signal to the brain a drive to eat to ensure cellular energy homeostasis. The mechanisms responsible for th...
Article
Purpose: This study investigated the effect of knee joint angle and age on torque steadiness of knee extensors (KE) at varying submaximal isometric contractions. Methods: 22 young (24.0 ± 2.6 years; 11 women) and 22 older (69.4 ± 2.4 years; 10 women) healthy men and women participated. Maximal voluntary isometric contraction (MVIC) of the KE and fl...
Article
Full-text available
Minerals and trace elements (MTEs) are micronutrients involved in hundreds of biological processes. Deficiency in MTEs can negatively affect athletic performance. Approximately 50% of athletes have reported consuming some form of micronutrient supplement; however, there is limited data confirming their efficacy for improving performance. The aim of...
Article
Background The influence of different exercise modalities, intensities and durations on glucose control has yet to be fully explored in people living with type‐1 diabetes (T1D). Aims The aim was to review existing literature to establish evidence of outcomes of acute exercise on glucose control T1D. Research Design and Methods We searched the onl...
Article
Full-text available
Stepping exercise can be used as a scalable form of high intensity exercise to enhance important aspects of physical fitness in older populations. The addition of supplementary weights increases the resistive element of stepping, with the potential for training improvements in muscular strength, power, and functional abilities alongside other fitne...
Article
Full-text available
The complexities and heterogeneity of the ageing process have slowed the development of consensus on appropriate biomarkers of healthy ageing. The Medical Research Council-Arthritis Research UK Centre for Integrated research into Musculoskeletal Ageing (CIMA) is a collaboration between researchers and clinicians at the Universities of Liverpool, Sh...
Article
• Heat Shock Response (HSR) is similar in healthy middle-aged and elderly people, but is blunted in aged individuals with T2DM. • Visceral Adipose Tissue (VAT) is increased with age, and the increased VAT is correlated with a lower HSR. • Resistance training (RT) is an efficient intervention to restore the HSR and reduce inflammation in aged indi...
Article
Full-text available
Objectives: To investigate the impact of a six-month multi-ingredient nutrition supplement intervention (Smartfish®), containing omega-3 polyunsaturated fatty acids (PUFAs), vitamin D, resveratrol, and whey protein, on cognitive function in Irish older adults. Design: Double-blind, randomised controlled trial (ClinicalTrials.gov: NCT02001831). A...
Article
Many chronic diseases and illnesses are caused by the lifestyle, including the physical activity habits, of an individual. As such, consistent high levels of exercise should be encouraged across the lifespan, to limit the risk of developing one of these conditions and allowing for healthy aging to occur. Exercise prescriptions that encourage high c...
Conference Paper
High levels of physical activity are paramount in ensuring individuals maintain or improve health outcomes, function and quality of life. However, physical activity continues to be low worldwide and rates of conditions associated with sedentary lifestyles are increasing. Furthermore, adherence to exercise prescriptions in individuals whose conditio...
Article
Full-text available
Purpose: To examine the effect of acute quercetin (Q) ingestion on neuromuscular function, biomarkers of muscle damage, and rate of perceived exertion (RPE) in response to an acute bout of resistance training. Methods: 10 young men (22.1 ± 1.8 years, 24.1 ± 3.1 BMI) participated in a randomized, double-blind, crossover study. Subjects consumed Q...
Article
Full-text available
This is a brief review (in Italian) of the ageing related modifications of cardiovascular and muscle systems and how the exercise training can modulate these responses
Article
Objective: To evaluate the effect of a healthy lifestyle package (an antenatal behavior change intervention supported by smartphone application technology) on the incidence of gestational diabetes mellitus (GDM) in overweight and obese women. Methods: Women with body mass indexes (BMIs) 25-39.9 were enrolled into this randomized controlled trial...
Article
Full-text available
Purpose: The effect of carbohydrate (CHO), or CHO supplemented with either sodium caseinate protein (CHO-C) or a sodium caseinate protein hydrolysate (CHO-H) on the recovery of skeletal muscle glycogen and anabolic signaling following prolonged aerobic exercise was determined in trained male cyclists [n = 11, mean ± SEM age 28.8 ± 2.3 years; body...
Poster
Full-text available
Exercise induced hypoglycemia or hyperglycemia can be detrimental to both the immediate and long-term health in people with Type 1 diabetes (T1D). Establishing exercise intensity, duration and modality that is both safe and beneficial is vital. The aim of this study was to determine the effects of Aerobic, Resistance and Combined exercise intervent...
Article
Full-text available
Creatine monohydrate represents one of the largest sports supplement markets. Enhancing creatine (CRE) stability in aqueous solutions, such as with microencapsulation, represents innovation potential. Ten physically active male volunteers were randomly assigned in a double-blind design to either placebo (PLA) (3-g maltodextrin; n = 5) or microencap...
Article
Full-text available
Background: During incremental exercise, heart rate variability (HRV) has been shown to display distinct stabilization and inflection points, which have been used to indirectly detect the ventilatory threshold (VT). Methods: Ten moderately trained males (26·5 ± 5·9 years: VO2peak 48·7 ± 4·1 ml min(-1 ) kg(-1) ) performed an incremental test on a...
Article
Full-text available
Background: As muscle capillarization is related to the oxidative capacity of the muscle and the size of muscle fibres, capillary rarefaction may contribute to sarcopenia and functional impairment in older adults. Therefore, it is important to assess how ageing affects muscle capillarization and the interrelationship between fibre capillary supply...
Article
Full-text available
BACKGROUND: As muscle capillarization is related to the oxidative capacity of the muscle and the size of muscle fibres, capillary rarefaction may contribute to sarcopenia and functional impairment in older adults. Therefore, it is important to assess how ageing affects muscle capillarization and the interrelationship between fibre capillary supply...
Article
Key points: Loss of muscle mass and strength in the growing population of elderly people is a major health concern for modern societies. This condition, termed sarcopenia, is a major cause of falls and of the subsequent increase in morbidity and mortality. Despite numerous studies on the impact of ageing on individual muscle fibres, the contributi...
Article
Purpose: This study investigated the effect of knee joint angle and contraction intensity on the co-activation of the hamstring muscles (when acting as antagonists to the quadriceps) in young and older individuals of both sexes. Methods: 25 young (24 ? 2.6 years) and 26 older (70 ? 2.5 years) healthy men and women participated. Maximal voluntary...
Article
Background Stiffness properties of the knee joint and landing biomechanics are important factors linked to injury risk. Neuromuscular training may mitigate the risk injury and simultaneously improve sports performance. Objective To investigate the effect of neuromuscular training on the stiffness properties of the knee joint and landing biomechani...
Article
An examination of the determinants of low muscle mass and low muscle strength in older adults in Ireland - Volume 76 Issue OCE3 - E. Flanagan, A.M. McMorrow, H. Cummins, K. McElroy, M.J. McGowan, S. Rafferty, B. Egan, G. De Vito, S.N. McCarthy, C.A. Corish, C.H. Murphy, H. Roche