
Giuseppe AngellottiItalian National Research Council | CNR · Institute of Nanostructured Materials ISMN
Giuseppe Angellotti
PhD
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48
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Publications (48)
Citrus flavonoids are highly bioactive compounds exerting numerous health benefits including anticancer, antioxidant, antimicrobial, anti‐inflammatory, mitoprotective and neuroprotective activity. Research on their broad‐scope bioactivity experienced a renaissance in the early 2000s and further accelerated after COVID‐19, including research on thei...
Citrus IntegroPectin bioconjugates obtained through acoustic cavitation in water of different citrus fruit (lemon, red orange, and sweet orange) processing waste show substantial anticancer activity in vitro against human non- small cell lung cancer cells. Dissolved in aqueous phase at different concentrations, all IntegroPectin phytocomplexes test...
Template-driven sol-gel microencapsulation of rosemary (Rosmarinus officinalis) essential oil within submicron SiO2 microspheres affords a new solid biopesticide (SiliRosm) that can be readily formulated in water enhancing the stability and bioactivity of the non-formulated essential oil. Comparing two microencapsulation routes to optimize encapsul...
Background/Objectives: Following tooth extraction, resveratrol (RSV) can support healing by reducing inflammation and microbial risks, though its poor solubility limits its effectiveness. This study aims to develop a solid nanocomposite by embedding RSV in lipid nanoparticles (mLNP) within a hydrophilic matrix, to the scope of improving local deliv...
We posed selected questions on open access (OA) to Stevan Harnad thirty years after his “subversive proposal” to maximize research impact by self-archiving scholarly articles in university-hosted or disciplinary online repositories to make published articles openly available. Self-archiving, however, was adopted by a small minority of active schola...
Citrus flavonoids are highly bioactive compounds exerting numerous health benefits including anticancer, antioxidant, antimicrobial, anti-inflammatory, mitoprotective and neuroprotective activity. Research on their broad-scope bioactivity experienced a renaissance in the early 2000s and further accelerated after COVID-19, including research on thei...
Supplementary Information
Pectin is a bioactive polysaccharide widely investigated for its therapeutic properties as well as in tissue engineering and regenerative medicine for its gelling behavior, wound healing ability and high biocompatibility. First isolated in 2019 via hydrodynamic cavitation carried out in water only of the by-product of the industrial process of manu...
Used since decades to produce pectin, citrus processing waste poor in lignin and rich in hemicellulose obtained from lemon and orange juice industrial manufacturing is ideally suited also as microcrystalline cellulose and nanocellulose raw material. The study merges the outcomes of chemistry and bioeconomy research between 2007 and early 2024 with...
Cavitation in water only, no matter whether hydrodynamic or acoustic, is a zero-waste circular economy process to convert industrial citrus processing waste into high-performance polysaccharides in high demand in a single-step at room temperature and ambient pressure using a modest amount of electricity as the only energy input. Following previous...
Showing broad scope pesticidal properties, the Origanum vulgare essential oil is highly volatile, limiting effective agricultural applications. Aiming to develop new environmentally friendly and effective biopesticide based on O. vulgare essential oil we carried out its template-assisted sol-gel microencapsulation within silica microcapsules. The m...
Imparted with uniquely high and broad-scope bioactivity including antioxidant, anti-inflammatory, cardioprotective, neuroprotective, antimicrobial and anticancer properties, the IntegroPectin phytocomplex obtained from citrus processing waste via hydrodynamic cavitation (HC) was investigated via Density Functional Theory. The main flavonoids of gra...
The outcomes of applying the zero‐waste extraction “LimoFish” process based on defatting fish processing waste with limonene to leftovers of European sardine (Sardina pilchardus) and European anchovy (Engraulis encrasicolus), compared to conventional extraction with oil‐derived solvents such as n‐hexane and with petroleum ether, show that the proce...
Endowed with exceptional chemical and physical properties that make it potentially useful in a wide array of industrial sectors, nanocellulose remains a niche industrial product chiefly manufactured in the form of microfibrillated cellulose for low value utilization in paper and cardboard products. This study first shows that the case of nanocellul...
Chemistry is a reproducible science whose pillars - synthesis and analysis - actually comprise a huge collection of highly reproducible experimental methods to synthesize and analyze substances. The historical development of chemistry, furthermore, shows that reproducibility of methods has been the companion of novelty and creative innovation. The...
The outcomes of applying the zero-waste extraction process based on defatting fish processing waste with limonene to leftovers of European sardine (Sardina pilchardus) and European anchovy (Engraulis encrasicolus), compared to conventional extraction with oil-derived solvents such as n-hexane and with petroleum ether, show that the biobased “LimoFi...
Acoustic cavitation applied to untreated citrus processing waste converts it in one pot in highly bioactive “IntegroPectin” pectin and highly micronized cellulose “CytroCell” of low crystallinity. Starting from pigmented sweet orange (Citrus sinensis) biowaste, we use an industrial sonicator to demonstrate the general viability of cavitation carrie...
Chestnut tannin, extracted from the bark or wood of chestnut trees, possesses unique properties that make it valuable in various industries. It serves as a natural source of tannins, which are widely used in the production of leather, textiles, and wood preservation. As research continues to explore its potential applications, chestnut tannin remai...
Used since decades to produce pectin, citrus processing waste poor in lignin and rich in hemicellulose obtained from lemon and orange juice industrial manufacturing is ideally suited also as microcrystalline cellulose and nanocellulose raw material. The study merges the outcomes of chemistry and bioeconomy research between 2007 and early 2024 with...
Enhancement of alkaline water electrolysis requires to develop anion exchange membranes (AEMs) combining high permselectivity with low resistance to ions transport and stability during prolonged contact with concentrated alkaline solution. We now report that CytroCell@PIL, a mixed matrix membrane obtained by a synergic combination of CytroCell micr...
Chestnut tannin, extracted from the bark or wood of chestnut trees, possesses unique properties that make it valuable in various industries. It serves as a natural source of tannins, which are widely used in the production of leather, textiles, and wood preservation. As research continues to explore its potential applications, chestnut tannin remai...
To investigate the vitamin content in an AnchoisOil sample stored at − 20 °C under N 2 for more than four years, we have developed a new HPLC method for simultaneous identification and quantification of vitamins in anchovy fish oil that is efficient and applicable in practice. Coupled to full retention of the original visual appearance (orange colo...
Showing broad scope pesticidal properties, the Origanum vulgare essential oil is highly volatile, limiting effective agricultural applications. Aiming to develop new environmentally friendly and effective biopesticide based on O. vulgare essential oil we carried out its template-assisted sol-gel microencapsulation within silica microcapsules. The m...
Answers of Stevan Harnad to selected questions on open access (OA) thirty years after his “subversive proposal” to self-archive scholarly articles in university-hosted or disciplinary online repositories to make published articles openly available to all and thus maximize research impact. This, however, did not happen, and in 2022 the ~800,000 “gre...
Economically viable green chemistry processes are the technology enablers of the bioeconomy. Access to an economically viable green chemistry production route, however, is not per se sufficient for successful bioproduction. The cases of synthetic amorphous silica, pectin, polysaccharide nanofibers, pelargonic acid, hydrogen peroxide electrochemical...
Sicily hosts a significant and ancient citrus agroindustry, which includes more than 42 000 farming companies and around 20 citrus fruit‐processing companies. This study critically analyzes the citrus economy in Sicily in the early bioeconomy era with the aim to identify outcomes of general relevance for bioeconomy researchers and bioeconomy compan...
Overpromising has been a constant trait of the nanosciences, and the case of nanocellulose makes no exception. Regardless of substantial academic and industrial research efforts re-started in the early 2000s, global production nanocellulose in 2018 amounted to less than 40,000 tonnes, chiefly in the form of microfibrillated cellulose for low value...
Chemistry is a reproducible science whose pillars - synthesis and analysis - actually comprise a huge collection of highly reproducible experimental methods to synthesize and analyze substances. The historical development of chemistry, furthermore, shows that reproducibility of methods has been the companion of novelty and creative innovation. The...
Oral Mucositis (OM) is the most common side effect due to chemotherapy and radiotherapy, which are the conventional treatment options for head and neck cancers. OM is a severe inflammatory condition characterized by multifactorial etiopathogenesis. It further negatively affects patients’ quality of life by severe impairment of normal oral functions...
According to the UN Agenda 2030, several actions could be taken to act synergistically towards various areas of critical importance for both the humanity and the planet. Among them, the application of a circular economy model based on the valorisation of the wastes from the local resources could be a virtuous attitude. In this view, this work propo...
Coupled to full retention of the original visual appearance (orange color and transparency), the relatively high concentrations of lipid-soluble vitamin Q (coenzyme Q10) and vitamin A (retinol) in AnchoisOil extracted with d-limonene from European anchovy fillet leftovers more than four years after extraction point to remarkable stability of this m...
Citation-based metrics such as the h-index and the journal impact factor continue to play a key role in the evaluation of scholarships for employment, promotion, and tenure in academia, as well as in funding decisions. As happens with most scientometric aspects concerning their discipline, knowledge of citation patterns in chemistry in the chemistr...
Economically viable green chemistry processes are the technology enablers of the bioeconomy. Access to an economically viable green chemistry production route, however, is not per se sufficient for a successful bioproduction. The cases of synthetic amorphous silica, pectin, polysaccharide nanofibers, pelargonic acid, hydrogen peroxide electrochemic...
Sicily hosts a significant and old citrus industry that includes more than 42,000 farming companies and around 20 fruit processing companies. Critically analyzing the citrus economy in Sicily in the early bioeconomy era, this study aims to identify outcomes of general value that may assist the work of bioeconomy practitioners engaged in the full va...
Citations in chemistry at the dawn of open science - Dataset for 10 selected papers from ChemComm 50/2023
The well-being of skin and mucous membranes is fundamental for the homeostasis of the body and thus it is imperative to treat any lesion quickly and correctly. In this view, polyphenols might assist and enhance a successful wound healing process by reducing the inflammatory cascade and the production of free radicals. However, they suffer from disa...
Oral squamous cell carcinoma (OSCC) is one of the most prevailing and aggressive head and neck cancers, featuring high morbidity and mortality. The available conventional treatments suffer from several adverse effects and are often inefficient in terms of their survival rates. Thus, seeking novel therapeutic agents and adjuvants is of the utmost im...
In an ever-growing perspective of circular economy, the development of conscious, sustainable and environmental-friendly strategies to recycle the waste products is the key point. The scope of this work was to validate the waste bentonite from the grape processing industries as a precious matrix to extract polyphenols by applying a waste-to-market...
Cytisine (CYT) is a powerful anti-smoking compound which could greatly benefit from transbuccal delivery because of both its unfavorable pharmacokinetics after oral administration and its intrinsic ability to permeate the buccal mucosa. This work aims to design CYT-loaded buccal thin films suitable for transbuccal drug delivery due to its capabilit...
The comparison of grapefruit IntegroPectin powders isolated via spray drying and via freeze drying in terms of phenolic content, quantification of the most representative flavonoids (naringin and hesperidin), radical scavenging activity, total protein content and pH of the aqueous solutions provides relevant information. Except for the protein cont...
Cytisine (CYT) has emerged as a promising molecule to treat nicotine addiction, since it acts as a partial agonist of nicotinic acetylcholine receptors. However, its unfavorable pharmacokinetic properties lead to multiple administrations per day, reducing the patient’s compliance and increasing the side effects. To overcome these drawbacks, CYT buc...
The comparison of grapefruit IntegroPectin powders isolated via spray drying and via freeze drying in terms of phenolic content, quantification of the most representative flavonoids (naringin and hesperidin), radical scavenging activity, total protein content and pH of the aqueous solutions provides relevant information. Except for the protein cont...
Immediate implant placement is a single-stage restorative approach for missing teeth widely used to overcome the ridge remodeling process occurring after dental extractions. The success of this procedure relies on opportune osseointegration in the surrounding tissues. To support this process, a multifunctional nanocomposite, to be applied in the fr...
Resveratrol (RSV) is a natural polyphenol with several interesting broad-spectrum pharmacological properties. However, it is characterized by poor oral bioavailability, extensive first-pass effect metabolism and low stability. Indeed, RSV could benefit from the advantage of the sublingual route of administration. In this view, RSV attitudes to cros...
The restoration and prosthetic rehabilitation of missing teeth are commonly performed using dental implants, which are extremely effective and long-lasting techniques due to their osteointegration ability with the preimplant tissues. Quercetin is a phytoestrogen-like flavonoid well known for its several positive effects on human health, mostly link...
Teeth extractions are often followed by alveolar bone reabsorption, although an adequate level of bone is required for reliable rehabilitations by dental implants. Leukocyte and platelet-rich fibrin (L-PRF) has been widely applied in regenerative procedures and with antibiotic and antioxidant agents could play an essential role in hard and soft tis...
The development of efficacious means of delivering antioxidant polyphenols from natural sources for the treatment of skin diseases is of great interest for many cosmetic and pharmaceutical companies. Resveratrol (RSV) and Limonene (LIM) have been shown to possess good anti-inflammatory and antibacterial properties against Staphylococcus aureus infe...
Periodontitis treatment is usually focused on the reduction or eradication of periodontal pathogens using antibiotics against anaerobic bacteria, such as metronidazole (MTR). Moreover, recently the correlation between periodontal diseases and overexpression of reactive oxygen species (ROS) led to the introduction of antioxidant biomolecules in ther...