Giulia Menculini

Giulia Menculini
Università degli Studi di Perugia | UNIPG · Section of Psychiatry

MD Psychiatrist PhD Candidate
Researcher at the Section of Psychiatry, University of Perugia

About

71
Publications
5,325
Reads
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274
Citations
Citations since 2016
71 Research Items
274 Citations
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Introduction
Neuroscience PhD student at University of Perugia since November 2020. Graduated in Medicine at University of Perugia in 2013. Resident in Psychiatry at University of Perugia from December 2014 until December 2019. Research attachment at the Bipolar Disorders Unit, Hospital Clinic (Barcelona) from September 2017 until March 2018.

Publications

Publications (71)
Article
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Background Use of social media (SM) has exponentially grown particularly among youths in the past two years, due to COVID-19-related changing lifestyles. Based on the Italian COvid Mental hEalth Trial (COMET), we investigated the association between SM use and depressive symptoms among Italian young adults (aged 18–24). Methods The COMET is a nati...
Article
Many European countries have seen increasing refugee populations and asylum applications over the past decade. Forcibly displaced persons (FDPs) are known to be at higher risk of developing mental disorders and are in need of specific care. Thus, specific training for mental health professionals is recommended by international health organizations....
Article
Background Anxiety represents one of the most prevalent psychiatric symptoms in multiple sclerosis (MS), impacting the overall disease burden and quality of life. This psychopathological feature can be expressed as state (S-ANX) and trait (T-ANX) anxiety, but few studies specifically evaluated these two components in MS. The present study was aimed...
Article
Background: The aim of the present paper was to summarize the role of dysphoria in the development of suicidality. We performed an exploratory study to evaluate dysphoria dimensions in inpatients suffering from borderline personality disorder (BPD), mood disorders, and schizophrenia spectrum disorders who were evaluated due to suicidal ideation or...
Article
Affective disorders represent psychopathological entities lying on a continuum, characterized by high prevalence and functional impairment. A delay in treatment initiation might increase the burden associated with affective spectrum disorders. The present study was aimed at analyzing the correlates of a long duration of untreated illness (DUI) in t...
Article
Objective The Repeatable Battery for the Assessment of Neuropsychological Status (RBANS), widely used for detecting cognitive impairment in different neuropsychiatric conditions, is increasingly applied for measuring cognitive functioning in older individuals. Available normative data for RBANS Italian version suffer from under-representation of th...
Article
Urbanisation processes and anthropogenic actions led to a significant increase in pollution levels, with relevant consequences on global health. In particular, noise pollution demonstrated an association with cardiovascular, metabolic, and respiratory diseases. Furthermore, increasing evidence underlined the possible role of air and noise pollution...
Article
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Introduction Dissociative symptoms have been recently related to bipolar disorder (BD) symptomatology. Moreover, the disease burden carries on a share of perceived self-stigma that amplifies the BD impairment. Internalized stigma and dissociative symptoms often seem overlapping, leading toward common outcomes, with reduced treatment seeking and poo...
Article
This work aim is to classify main psychiatric disorders in the perinatal period to the present day, highlighting their main nosographic characteristics. Moreover to show the problem of mental health during pregnancy and repercussions on the current social network, on the organizational health network and on global health.
Article
Background The mental health of the Italian population declined at the onset of the COVID-19 pandemic. However, nationwide population prevalence estimates may not effectively reproduce the heterogeneity in distress responses to the pandemic. In particular, contextual determinants specific to COVID-19 pandemic need to be considered. We thus aimed to...
Article
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Introduction Sex differences were demonstrated in bipolar disorders (BD) concerning epidemiological, clinical, and psychopathological characteristics, but consensus is lacking. Moreover, data concerning the influence of sex on treatment response in BD is contrasting. The present cross-sectional study aimed to analyze sex differences in a population...
Article
Gut microbiota regulates neurotransmission, neurogenesis, neuroinflammation, and neuroendocrine signaling. The aim of the present review is to analyze the literature concerning gut microbiota dysregulation and mood symptoms, with the specific hypothesis that such alterations play a role in the onset of mood disorders. Here, in fact, we review recen...
Article
Background The aim of this study was to explore the psychopathological burden related to COVID-19 together with coping strategies in healthcare workers, focusing on differences between frontline and second-line workers. Methods This is a cross-sectional study part of the COvid Mental hEalth Trial (COMET). Participants' socio-demographic and COVID-...
Article
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Introduction Adolescents and young adults represent a vulnerable population in the context of the Coronavirus disease 2019 (COVID-19) pandemic. The present retrospective study aims to investigate the pandemic’s psychological impact on adolescents and young adults by analyzing data from an outpatient mental health service dedicated to youths in Umbr...
Article
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The COVID-19 pandemic led to the implementation of digital psychiatry (DP), resulting in the need for a new skilled healthcare workforce. The purpose of this study was to investigate the level of training, knowledge, beliefs, and experiences of young mental health professionals and medical students in DP. An ad hoc cross-sectional survey was admini...
Article
Objectives: This study aims to explore the long-term efficacy of a psychoeducational family intervention (PFI) in bipolar I disorder at one and five years post-intervention in terms of improvement of: 1) patients' symptoms and global functioning; 2) relatives' objective and subjective burden and coping strategies. Methods: This is a multicentre,...
Article
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COVID-19 pandemic and its related containment measures have been associated with increased levels of stress, anxiety and depression in the general population. While the use of digital media has been greatly promoted by national governments and international authorities to maintain social contacts and healthy lifestyle behaviors, its increased acces...
Article
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Background: When facing a traumatic event, some people may experience positive changes, defined as posttraumatic growth (PTG). Methods: Understanding the possible positive consequences of the pandemic on the individual level is crucial for the development of supportive psychosocial interventions. The present paper aims to: 1) evaluate the levels...
Article
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Introduction: Bipolar disorder (BD) onset typically occurs between 15 to 30 years, being diagnosed under the age of 50 in 90% of cases, named ‘non-late onset BD’ (non-LOBD). However, clinical observation of late-onset BD (LOBD) raised some concern regarding a differential psychopathological pattern, outcomes and treatment, including a specific affe...
Article
Background Substance use disorders (SUD) in bipolar disorders (BD) present relevant impact on psychopathological features and illness course. The present study was aimed at analyzing the clinical correlates of this comorbidity. Methods In- and outpatients suffering from BD were recruited. Socio-demographic and clinical characteristics were collect...
Chapter
Affective disorders, particularly Depressive and Bipolar Disorders, represent serious psychiatric conditions that may lie on a continuum and may thus be described under a dimensional aspect. Circadian rhythms, such as sleep-wake, eating, social, activity, and hormonal patterns, may be frequently disrupted in the context of affective spectrum disord...
Article
Background: The Coronavirus disease 2019 (COVID-19) is an infectious disease caused by the Severe Acute Respiratory Syndrome-CoronaVirus-2 (SARS-CoV-2). Beyond the most common clinical features of COVID-19, mainly represented by respiratory symptoms, other systems may be interested by the infection. Among these, through a neurotropic pathway, the...
Article
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The COVID-19 pandemic has affected the mental and physical health of the general population at any age, but it is expected to have a protracted and severe consequences for younger populations. The pandemic has had several consequences on mental health including anger and irritability, depressive symptoms and somatic complaints, insomnia, lack of mo...
Chapter
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Sleep disturbances and changes in circadian rhythms are commonly observed in pregnant women. These disorders can result from anatomical, physiological, psychological, and hormonal alterations that can influence sleeping during this phase. Sleep disorders during pregnancy can be responsible for detrimental effects on both mother and foetus. In this...
Article
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The COVID-19 pandemic represents an unprecedented public health emergency, with consequences at the political, social, and economic levels. Mental health services have been called to play a key role in facing the impact of the pandemic on the mental health of the general population. In the period March–May 2020, an online survey was implemented as...
Article
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The effects of the COVID-19 pandemic on mental health are now well documented, however, few studies have been focused on the role of coping strategies and resilience in counterbalancing these detrimental effects. Data are derived from the COvid Mental hEalth Trial (COMET), a national multicentric trial carried out in the Italian general population....
Article
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The Covid-19 outbreak are generating relevant consequences under several aspects. Covid-19 pandemic together with air pollution and a dysfunctional anthropization/urbanization might affect public and mental health with a synergistic effect. The current paper explore hypothesis about existing links among Covid-19, air pollution and mental illness.
Article
Background: Candidates for bariatric surgery undergo a multidisciplinary evaluation in the pre-operative phase, including a psychiatric visit aimed at the screening for psychiatric comorbidities, including feeding and eating disorders (FEDs), which are shortcomings to the intervention or predictors of worse prognosis. The presence of FEDs, such as...
Article
Background: Suicidality is a widespread phenomenon with a dramatic burden worldwide. The Coronavirus disease 2019 (Covid-19) pandemic determined a relevant impact on mental health, due to the infection itself and its socio-economic consequences. The present study is aimed at analyzing the prevalence of suicidality during the Covid-19 pandemic amon...
Article
Background: The present study investigates the impact of the Coronavirus diseases 2019 (Covid-19) pandemic on the subjective experience of pregnant women, as well as the impact of the pandemic on this population in terms of psychopathological correlates. Subjects and methods: Pregnant women referring to the Section of Obstetrics and Gynecology o...
Article
Background: The present cross-sectional study investigates the relationship between post-traumatic spectrum comorbidity and the severity of symptoms in subjects diagnosed with Bipolar Disorders (BD). Subjects and methods: In- and outpatients diagnosed with BD according to the Diagnostic and Statistical Manual of Mental Disorders, 5th edition (DS...
Article
The revolving door (RD) phenomenon refers to subjects who undergo frequent rehospitalizations in psychiatric units. The main aim of this study was to analyze clinical factors associated with RD in acute inpatient psychiatric ward. In a 5-year cohort study, subjects hospitalized three or more times in 12 months (revolving door subjects-RDS) were ide...
Article
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Background and Objectives: Emotional dysregulation is central to the problem of the overlap between attention-deficit/hyperactivity disorder (ADHD) and cyclothymia. The aim of the study was to evaluate comorbidity rates between ADHD and cyclothymic disorder and to explore demographic and clinical differences among the groups, focusing on affective...
Article
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Background and Objectives: Affective disorders, namely bipolar (BDs) and depressive disorders (DDs) are characterized by high prevalence and functional impairment. From a dimensional point of view, BDs and DDs can be considered as psychopathological entities lying on a continuum. A delay in treatment initiation might increase the burden associated...
Article
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Different psychopathological manifestations, such as affective, psychotic, obsessive-compulsive symptoms, and impulse control disturbances, may occur in most central nervous system (CNS) disorders including neurodegenerative and neuroinflammatory diseases. Psychiatric symptoms often represent the clinical onset of such disorders, thus potentially l...
Article
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The coronavirus disease 2019 (COVID-19) pandemic caused a crisis worldwide, due to both its public health impact and socioeconomic consequences. Mental health was consistently affected by the pandemic, with the emergence of newly diagnosed psychiatric disorders and the exacerbation of pre-existing ones. Urban areas were particularly affected by the...
Article
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Introduction Smart healthcare monitoring allows detecting health conditions using Big Data, namely aggregated data concerning physiological and behavioral parameters. The continuous collection of data from smart-devices performed by the Ecological Momentary Assessment approach represents a promising application of Big Data. Objectives This prelimi...
Article
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Post-Traumatic Stress Disorder (PTSD) is a complex disorder involving dysregulation of stress-related hormones and neurotransmitter systems. Research focused on the endocannabinoid system (eCBS) for anxiety and stress regulation, cognitive and emotional responses modulation and aversive memories extinction, leading to the hypothesis that it could r...
Article
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Background and objectives: A deeper comprehension of the role that environmental risk factors play in the development of adolescent Bipolar Disorder (BD), as well as in the evolution of high-risk states for BD, may entangle further prevention and treatment advances. The present systematic review is aimed at critically summarizing evidence about the...
Article
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G.B., 21-year-old patient of Albanian origin suffering from acute psychotic burning on schizotypal personality disorder induced by substance abuse, was admitted to the Psychiatric Service at Perugia' General Hospital, Italy. On admission, antipsychotic therapy was set up which had the role to reduced delusional and hallucinatory symptoms but the su...
Article
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Background: Gender is a crucial factor in the development of mental illnesses, with an essential influence on clinical characteristics and not only on the prevalence of each disorder. Gender differences in cannabinoid-related disorders are highlighted by different research fields (preclinical, clinical, socio-demographic studies), but few studies...
Article
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Background: The present retrospective study is aimed at exploring the impact of gender differences in a sample of inpatients with dual diagnosis. Subjects and methods: The study was carried out at the Psychiatric Service of the General Hospital/University of Perugia (Italy). Patients were recruited from January 2015 until December 2018. The samp...
Article
Introduction: The present retrospective study investigated clinical correlates of the revolving door (RD) phenomenon in a population of subjects affected by Bipolar Disorders (BDs). Subjects and methods: Medical records of subjects with BDs admitted to a psychiatric inpatient unit over a 5-year period of time were retrospectively reviewed and cl...
Article
Dual diagnosis (DD) is a complex clinical entity, resulting from the interaction of several determinants. Integrated treatments represent the gold-standard in the pathways of care for subjects with serious mental illnesses in comorbidity with substance related disorders. In the present overview, literature about outcomes of non-pharmachological int...
Article
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Background Air pollution is a major environmental risk to health. Exposure to xenobiotic heavy metals such as lead and cadmium—constituents of air pollution such as particulate matter and nitrogen and sulfur oxides, organic solvents, and other environmental pollutants—could be component causes for schizophrenia and other psychotic disorders. Long-t...
Article
Folie à deux, also known as shared psychotic disorder, shows intrinsic differences when compared to other psychiatric disorders. Literature about this condition is scanty and findings about its clinical correlates are not univocal. The present systematic review aimed at critically summarizing the existing evidence about folie à deux, also focussing...
Article
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Aims. Aim of the current study is to investigate the associations between daily levels of air pollutants (particulate matter, ozone, carbon monoxide, nitrogen dioxide) and daily admissions for mental disorders to the emergency department of two general hospitals in Umbria region (Italy). Methods. We collected data about daily admissions to psychiat...
Poster
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Introduzione: L'elevata incidenza di sintomi ossessivo-compulsivi (OCS) nei disturbi dello spettro della schizofrenia (SSD) contribuisce alla complessità di tale classe diagnostica (1,2). Il presente studio ha la finalità di valutare la prevalenza di OCS e la relazione degli stessi con le caratteristiche psicopatologiche contestuali in un campione...
Article
Background: A link between abnormalities in circadian rhythms and the development of eating disorders was extensively hypothesized, mainly in consideration of the influence of the circadian clock on eating behavior. The present review is aimed at summarizing the evidence about biological rhythms disruptions in eating disorders, possibly clarifying...
Poster
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I disturbi dello spettro della schizofrenia (SSDs) ed i disturbi dello spettro autistico (ASD), pur costituendo entità nosografiche a sè stanti, presentano diverse aree di overlap per quanto concerne aspetti genetici ed anatomofunzionali, ma anche in termini di presentazione clinica. E’ stata pertanto ipotizzata l’esistenza di un sottogruppo di paz...
Article
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Objectives Obsessive-compulsive symptoms (OCS) have often been described in schizophrenia spectrum disorders, contributing to the overall complexity of the clinical presentation, over and above the canonical symptom dimensions. The main aim of this study is to investigate the prevalence of OCS and its relationship with contextual psychopathology in...
Article
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Early identification and timely intervention are crucial issues in contemporary psychiatry, both in terms of improved outcome and optimal treatment delivery as well as service reform. Although the field has advanced substantially in the last 25 years, there is a constant need to revise and ponder the core constructs that have been developed and fie...
Article
Resistance and worsening of depression in response to antidepressants (ADs) are major clinical challenges. In a large international sample of patients with major depressive disorder (MDD), we aim to explore the possible associations between different patterns of response to ADs and bipolarity. A total of 2811 individuals with a major depressive epi...
Article
Objective: This post hoc analysis of the BRIDGE-II-MIX study is aimed at evaluating affective lability (AL) as a possible clinical feature of mixed depression and assessing the relationship with atypical depressive features, particularly mood reactivity (MR). Methods: In the BRIDGE-II-MIX multicenter, cross-sectional study, 2,811 individuals suffer...
Article
Background: The present retrospective study is aimed at assessing the clinical and psychopathological correlates of violent behaviors in a sample of acute involuntary committed inpatients. Subjects and methods: Involuntary inpatients were retrospectively assessed for the presence of violent behaviors. Patients with and without overt hetero-aggre...
Article
Background: The present systematic review was aimed at critically summarizing the evidence about interventions focused on circadian rhythms and mood symptoms in seasonal affective disorder (SAD). Methods: A systematic search of the electronic databases PUBMED, PsycINFO and Web of Science was conducted according to the Preferred Reporting Items f...
Poster
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The existence of gender differences in schizophrenia spectrum disorders has received wide support in several studies, showing great variability in socio-demographic, clinical and psychopathological characteristics.The present retrospective study involved inpatients with diagnosis of “Schizophrenia spectrum and other psychotic disorders” according t...
Article
Introduction The “schizophrenia spectrum” concept allowed better identifying the psychopathology underpinning disorders including schizophrenia, schizoaffective disorder (SZA) and cluster A personality disorders (PD). Aims To compare the clinical portrait of the schizophrenia spectrum disorders, focusing on the impact of the affective dimension....
Poster
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Introduction: The term “revolving door” (RD), used to define chronic patients with frequent readmissions to psychiatric units, is often associated to shorter length of stay (LOS) and poor compliance to therapy. Methods: We selected patients with 2 or more hospitalizations from 1/7/15 to 30/6/16 in SPDC-Perugia. We analyzed socio-demographic and cli...
Article
Only few studies have compared the psychopathological features in first episode psychosis (FEP) and chronic schizophrenia (CS) patients. The aim of our study was to compare sociodemographic and clinical aspects of FEP and CS inpatients using the Positive and Negative Syndrome Scale (PANSS) and the Brief Psychiatric Rating Scale (BPRS) in order to b...
Poster
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lntroduction:The term schizo-obsessive disorder was coined to describe schizophrenia patients who are also affected by OCD or OCS. OCD and OCS occur in a proportion of 12% and 30% of schizophrenia patients, respectively (1). Also, OCD and OCS were observed in 14.1% and 51.1% of inpatients with schizophrenia, respec­ tively (2). Aim of this study is...