Giuditta Ferretti

Giuditta Ferretti
University of Bologna | UNIBO

About

80
Publications
9,484
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1,465
Citations
Citations since 2016
50 Research Items
1306 Citations
2016201720182019202020212022050100150200250
2016201720182019202020212022050100150200250
2016201720182019202020212022050100150200250
2016201720182019202020212022050100150200250

Publications

Publications (80)
Article
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Background PEEP selection in severe COVID-19 patients under extracorporeal membrane oxygenation (ECMO) is challenging as no study has assessed the alveolar recruitability in this setting. The aim of the study was to compare lung recruitability and the impact of PEEP on lung aeration in moderate and severe ARDS patients with or without ECMO, using c...
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Targeting neovessels in chronic tendinopathies has emerged as a new therapeutic approach and several embolization agents have been reported. The aim of this study was to investigate the feasibility of embolization with different agents in a porcine model of patellar tendinopathy and evaluate their safety and efficacy. Eight 3-month-old male piglets...
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Background Occupational asbestos exposure is associated with pleural plaques (PP), a benign disease often seen as a marker of past exposure to asbestos and lung cancer. The association between these two diseases has not been formally proved, the aim of this study was to evaluate this association in the asbestos-related disease cohort (ARDCO) cohort...
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Background Since the latest 2017 French guidelines, knowledge about idiopathic pulmonary fibrosis has evolved considerably. Methods Practical guidelines were drafted on the initiative of the Coordinating Reference Center for Rare Lung Diseases, led by the French Language Pulmonology Society (SPLF), by a coordinating group, a writing group, and a r...
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Purpose To evaluate the effectiveness and safety of temporary proximal uterine artery embolization (UAE) for the treatment of highly vascularized retained products of conception (RPOC). Materials and methods This retrospective analysis included women who underwent vaginal bleeding after abortion, miscarriage or delivery with highly vascularized RP...
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Background: Since the previous French guidelines were published in 2017, substantial additional knowledge about idiopathic pulmonary fibrosis has accumulated. Methods: Under the auspices of the French-speaking Learned Society of Pulmonology and at the initiative of the coordinating reference center, practical guidelines for treatment of rare pul...
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CT registration-derived indices provide data on regional lung functional changes in COPD. However, because unlike spirometry which involves dynamic maximal breathing maneuvers, CT-based functional parameters are assessed between two static breath-holds, it is not clear how regional and global lung function parameters relate to each other. We assess...
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Résumé Contexte Depuis les précédentes recommandations françaises publiées en 2017, les connaissances concernant la fibrose pulmonaire idiopathique ont évolué sur de nombreux aspects. Méthodes Des recommandations pratiques ont été établies à l’initiative du Centre coordonnateur de référence des maladies pulmonaires rares, sous l’égide de la Socié...
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Objective: This study aimed to develop and validate an automated artificial intelligence (AI)-driven quantification of pleural plaques in a population of retired workers previously occupationally exposed to asbestos. Methods: CT scans of former workers previously occupationally exposed to asbestos who participated in the multicenter APEXS (Asbes...
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Introduction : Stage III NSCLC comprises a heterogeneous population. Different treatment strategies are available, including surgery, radiotherapy, and chemotherapy. The PACIFIC trial results represented a significant change and improvement in the therapeutic strategy for these patients. We aimed to compare the different treatment strategies employ...
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Background: Therapeutic strategies targeting neovessels responsible for musculoskeletal chronic pain have emerged, including neovessels embolization. Our study aimed to develop a large animal model of patellar tendinopathy with neovascularization. Methods: Nine 3-month-old male piglets (18 patellar tendons) received percutaneous injections of in...
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Introduction Lung cancer (LC) is more prevalent and has poorer prognosis in liver transplant (LT) patients with a history of smoking than in the general smoking population. In 2012, we launched a chest computed tomography (CT) scan program for early detection of LC in LT patients with a history of smoking. Here, we describe the CT features of LC in...
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Objective: the aim of this study was to evaluate the association between interstitial lung abnormalities, asbestos exposure and age in a population of retired workers previously occupationally exposed to asbestos. Methods: previously occupationally exposed former workers to asbestos eligible for a survey conducted between 2003 and 2005 in four r...
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Background Nasal high flow (NHF) is a non-invasive breathing therapy that is based on the delivery via a large-caliber nasal cannula of heated and humidified air at flow rates that exceed peak inspiratory flow. It is thought that positive airway pressure generated by NHF can help reduce gas trapping and improve regional lung ventilation. There are...
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NUT carcinoma of the thorax is a rare and very aggressive tumor, whose definition is based on the demonstration of a nuclear protein in testis (NUTM1; also known as NUT) gene fusion on 15q14 with different partners from the bromodomain-containing proteins gene family. This fusion results in an activation of MYC oncoprotein responsible for the tumor...
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Purpose : The purpose of this study was to create an algorithm to detect and classify pulmonary nodulesin two categories based on their volume greater than 100 mm3or not, using machine learning and deep learning techniques. Materials and method : The dataset used to train the model was provided by the organization teamof the SFR (French Radiologica...
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Background: BRAF mutations occurring in 1%-5% of patients with non-small-cell lung cancer (NSCLC) are therapeutic targets for these cancers but the impact of the exact mutation on clinical activity is unclear. The French National Cancer Institute (INCA) launched the AcSé vemurafenib trial to assess the efficacy and safety of vemurafenib in cancers...
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Objectives: Bone is a common location for lung cancer metastasis. Clinicians are often reluctant to biopsy bone metastases, as they are known to require a decalcification process that damages nucleic acids, which makes it incompatible with molecular testing. We performed this study to assess the diagnostic performance of histopathology and molecul...
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Résumé Cette revue a pour objectif d’orienter le clinicien dans l’interprétation des nodules thoraciques découverts au scanner thoracique. Deux situations sont traitées de manière distincte: la découverte fortuite d’un nodule sur une imagerie, et la découverte au cours d’un examen de dépistage. Il s’agit en effet de situations distinctes en terme d...
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Résumé La fibrose pulmonaire idiopathique (FPI) est une maladie pulmonaire interstitielle diffuse (PID) d’étiologie inconnue touchant principalement des hommes fumeurs de plus de 60 ans. Elle correspond à l’entité « pneumopathie interstitielle commune (PIC) » en anatomopathologie et en scanner. Les recommandations de 2011, communes à l’American Tho...
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IMPORTANCE Interpretation of chest radiographs is a challenging task prone to errors, requiring expert readers. An automated system that can accurately classify chest radiographs may help streamline the clinical workflow. OBJECTIVES To develop a deep learning–based algorithm that can classify normal and abnormal results from chest radiographs with...
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Résumé Introduction La ponction transbronchique à l’aiguille guidée par écho-endoscopie bronchique (PTBA EEB) est une technique mini-invasive ayant une bonne performance pour prélever et analyser les ganglions lymphatiques médiastinaux. Le taux de complications après une PTBA EEB est faible et estimé entre 0,22 % et 1,44 %. L’étude des différentes...
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Résumé Le cancer broncho-pulmonaire (CBP) est la première cause de mortalité par cancer en France avec un taux de survie à 5 ans tous stades confondus de 15 %. La réduction de la mortalité par cancer bronchique devrait être un objectif majeur de santé publique. La lutte contre le tabagisme (prévention primaire) est engagée par une politique tarifai...
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Purpose: The purpose of this study was to evaluate the usefulness of computed tomography-texture analysis (CTTA) in differentiating between in-situ and minimally-invasive from invasive adenocarcinomas in subsolid lung nodules (SSLNs). Material and methods: Two radiologists retrospectively reviewed 49 SSLNs in 44 patients. There were 27 men and 1...
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Purpose: Losses of peripheral muscle mass and ectopic fat accumulation have been associated with cardiometabolic morbidity in COPD. We aimed at identifying the relationship between quadriceps muscle fat infiltration and cardiovascular risk. Materials and methods: From 2009 to 2014, 78 COPD patients (64 ± 8 years; 80% male) were prospectively inc...
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Background Nivolumab, a monoclonal antibody targeting the programmed death-1 receptor, is indicated in locally advanced or metastatic non-small cell lung cancer, with progression after platinum-based chemotherapy. Up-to-now, few data are available concerning brain activity of this treatment and concomitant use of corticosteroids. Case presentation...
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Résumé Le cancer du poumon est la première cause de décès par cancer en France. Plus de la moitié des cas se présentent à un stade évolué. De nouvelles thérapeutiques du cancer bronchique non à petites cellules, en complément ou association avec la chimiothérapie classique, ont été validées ces dernières années et sont appelés traitements « personn...
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Pulmonary artery pseudoaneurysms (PAPs) are uncommon but potentially lethal. They may be incidentally discovered on imaging, or following massive hemoptysis if they rupture, with high risk of mortality. The most frequent causes of PAP are trauma and infectious disease. Vasculitis, in particular Behçet's disease, neoplasm, congenital disease and pul...
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Objectives: To evaluate the differences between filtered back projection (FBP) and model-based iterative reconstruction (MBIR) algorithms on semi-automatic measurements in subsolid nodules (SSNs). Methods: Unenhanced CT scans of 73 SSNs obtained using the same protocol and reconstructed with both FBP and MBIR algorithms were evaluated by two rad...
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Introduction: CT-guided transthoracic core-needle biopsy (TTNB) is frequently used for the diagnosis of lung nodules. The aim of this study is to describe TTNBs' complications and to investigate predictive factors of complications. Methods: All consecutive TTNBs performed in three centers between 2006 and 2012 were included. Binary logistic regr...
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Adenocarcinoma is the most common histologic type of lung cancer. Recent lung adenocarcinoma classifications from the International Association for the Study of Lung cancer, the American Thoracic Society and the European Respiratory Society (IASLC/ETS/ERS, 2011) and World Health Organization (WHO, 2015) define a wide range of adenocarcinoma types a...
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Résumé L’adénocarcinome est la forme histologique la plus fréquente de cancer bronchopulmonaire. Les nouvelles classifications des adénocarcinomes pulmonaires proposées récemment par l’International Association for the Study of Lung cancer, l’American Thoracic Society et l’European Respiratory Society (IASLC/ETS/ERS, 2011), ainsi que l’Organisation...
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Contexte Dans les suites de la conférence de consensus de 1999 sur le suivi médical des personnes ayant été exposées à l’amiante, un programme expérimental multirégional a été mis en place, avec constitution de la cohorte asbestos-related diseases cohort (ARDCO). Objectif Ce travail étudie l’association entre plaques pleurales identifiées sur exam...
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Objective: To identify computed tomography (CT) predictors of malignancy, from a retrospective study of preoperative CT scans of patients with solitary fibrous tumors (SFT) of the pleura. Patients and methods: The CT scans of 56 patients with histopathologically confirmed SFT (33 women and 23 men; mean age, 60years) who underwent surgery between...
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Objectives: To evaluate the differences in semi-automatic measurements of CT attenuation and volume of part-solid nodules (PSNs) between unenhanced and enhanced CT scans. Materials and methods: CT scans including unenhanced and enhanced phases (slice thickness 0.625 and 1.25mm, respectively) for 53 adenocarcinomas presenting as PSNs in 50 patien...
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Lung cancer is the leading cause of deaths due to cancer in France. More than half of lung cancers are discovered at an advanced-stage. New anticancer treatment strategies (i.e., the so-called personalized or targeted therapy) have recently been introduced and validated for non-small-cell lung cancer (NSCLC), in addition to or in association with s...
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MPM (Malignant Pleural Mesothelioma) is an aggressive tumor with no effective therapy. However PD-L1/PD-1 immunity checkpoint therapies gave encouraging results; TLR3 is a programmed death factor, which triggering up-regulates PD-L1. As PD-1/PD-L1 blocking antibodies could restore antitumor immune responses alone or in combination with TLR3 agonist...
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Venous thromboembolism (VTE), including pulmonary embolism (PE) and deep venous thrombosis (DVT), is a common and severe complication of critical illness. Although well documented in the general population, the prevalence of PE is less known in the ICU, where it is more difficult to diagnose and to treat. Critically ill patients are at high risk of...
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Diagnosis of pleural plaques is commonly straightforward, especially when a typical appearance is observed in a context of previous asbestos exposure. Nevertheless, numerous causes of focal pleural thickening may be seen in routine practice. They may be related to normal structures, functional pleural thickening, previous tuberculosis, pleural meta...
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Idiopathic pulmonary fibrosis (IPF) is the most frequent and severe idiopathic interstitial pneumonia, with typical high-resolution computed tomography (HRCT) features and histologic pattern of usual interstitial pneumonia (UIP); its main differential diagnosis is fibrotic nonspecific interstitial pneumonia (F-NSIP). Usual interstitial pneumonia wa...
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To analyze the short- and long-term results of an original aortic fenestration method using the funnel technique during aortic dissection complicated by malperfusion syndrome. The funnel technique consists of deployment of an uncovered aortic stent graft placed from the false to the right lumen through an intimal flap aortic fenestration made by ba...
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La perte de masse musculaire peripherique et l’accumulation excessive de graisse sont associes a la mortalite et morbidite cardiovasculaire chez le sujet BPCO. Notre objectif etait d’identifier la place de l’infiltration graisseuse musculaire au sein des marqueurs du risque cardiometabolique. Les parametres metaboliques et inflammatoires de 78 suje...
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Objective: To retrospectively investigate the diagnostic value of pre-operative CT-features between pre/minimally invasive and invasive lesions in part-solid persistent pulmonary ground glass nodules in a Caucasian population. Materials and methods: Retrospective review of two pre-operative CTs for 31 nodules in 30 patients. There were 10 adenoc...
Article
CT-guided transthoracic core-needle biopsy (TTNB) is frequently used for the diagnosis of lung nodules, but the clinical value of negative results has not been sufficiently investigated. We sought to determine the negative predictive value (NPV) of TTNB and investigate predictive factors of negative results. All consecutive TTNBs performed in three...
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Full-text available
Response Evaluation Criteria in Solid Tumors (RECIST) are widely used to assess the effect of chemotherapy in patients with cancer. We hypothesised that the change in unidimensional tumour size handled as a continuous variable was more reliable than RECIST in predicting overall survival (OS). The prospective Pharmacogenoscan study enrolled consecut...
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Rationale: Although asbestos is a well-known lung carcinogen, the pleural plaque-lung cancer link remains controversial. Objectives: This study was designed to examine this link in asbestos-exposed workers. Methods: A 6-year follow-up was conducted to study lung cancer mortality in the 5,402 male subjects participating in an asbestos-related d...
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Objectives To investigate inter-reader agreement for the detection of pleural and parenchymal abnormalities using CT in a large cross-sectional study comprising information on individual cumulative exposure to asbestos. Methods The project was approved by the hospital ethics committee, and all patients received information on the study and gave the...
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Idiopathic pulmonary fibrosis (IPF) is the most frequent chronic idiopathic interstitial pneumonia in adults. The management of rare diseases in France has been organised by a national plan for rare diseases, which endorsed a network of expert centres for rare diseases throughout France. This article is an overview of the executive summary of the F...
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We thank the author for his interesting comment and update on anticoagulation in oncologic patients. This topic of anticoagulation in cancer patients and in venous diseases is controversial and still debated.We should first notice that the risk of thrombosis in the superior vena cava (SVC) system is lower than in the inferior vena cava system, due...
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To understand why the false channel (FC) remains patent after surgery of type A acute aortic dissection (TAAAD). Postoperative contrast-enhanced computed tomography scans of 129 patients operated for TAAAD were analyzed, and a color-Doppler ultrasound examination (CDUS) of the supra-aortic vessels (SAVs) was performed in 12 patients. The FC remaine...
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La découverte en scanner d’un nodule pulmonaire est une situation fréquente qui doit conduire à une prise en charge standardisée afin de ne pas méconnaître un cancer bronchique et retarder son exérèse, tout en évitant d’être inutilement invasif s’il s’agit d’une lésion bénigne. Au cours de la dernière décennie, d’importantes avancées ont été réalis...
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Lung nodules are commonly found on computed tomography (CT) and need a standardized approach in order to avoid misdiagnosing lung cancer and delaying surgical excision whilst simultaneously avoiding unnecessary invasive procedures if the lesions prove to be benign. Great advances have been made in the last decade in various areas affecting the mana...