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Introduction
Publications
Publications (38)
Differential diagnosis of Alzheimer's disease (AD) and dementia with Lewy bodies (DLB) remains challenging; currently the best discriminator is striatal dopaminergic imaging. However this modality fails to identify 15–20% of DLB cases and thus other biomarkers may be useful. It is recognised electroencephalography (EEG) slowing and relative medial...
Objectives The aim of this study was to develop and test, for the first time, a multivariate diagnostic classifier of attention deficit hyperactivity disorder (ADHD) based on EEG coherence measures and chronological age.
Setting The participants were recruited in two specialised centres and three schools in Reykjavik.
Participants The data are from...
Background:
The cholinergic hypothesis is well established and has led to the development of pharmacological treatments for Alzheimer's disease (AD). However, there has previously been no physiological means of monitoring cholinergic activity in vivo.
Methods:
An electroencephalography (EEG)-based acetylcholine (Ach) index reflecting the choline...
Background:
There is still a need for simple, noninvasive, and inexpensive methods to diagnose the causes of cognitive impairment and dementia. In this study, contemporary statistical methods were used to classify the clinical cases of cognitive impairment based on electroencephalograms (EEG).
Methods:
An EEG database was established from seven...
To use multivariate statistical analysis of EEG data in order to separate EEGs of patients with Alzheimer's disease (AD) from controls. A group of individuals with mild cognitive impairment (MCI) was evaluated using the same methodology. Additionally, the effects of scopolamine on this separation are studied.
Statistical pattern recognition (SPR) i...
The problem of finding minimum energy paths and, in particular, saddle points on high dimensional potential energy surfaces
is discussed. Several different methods are reviewed and their efficiency compared on a test problem involving conformational
transitions in an island of adatoms on a crystal surface. The focus is entirely on methods that only...
Large databases that can be used in the search for new materials with specific properties remain an elusive goal in materials science. The search problem is complicated by the fact that the optimal material for a given application is usually a compromise between a number of materials properties and the price. In this letter we present a database co...
We find that the initial effects of scopolamine on the alpha frequency band (7-13 Hz) part of an electroencephalogram (EEC) in healthy human subjects can be characterized using a first order decay model for the relative power contained in the band. We have studied the effects on EEG immediately after injection of scopolamine (i.v.) using an auditor...
A combined electronic structure and evolutionary search approach to materials design was studied. It was shown that the theoretical methods based on density functional theory have reached a level of accuracy and speed where they can be used to search more systematically for new materials. This approach was illustrated by finding the most suitable f...
A method for systematically finding the optimal orientation and location of a hyperplanar dividing surface during a transition state theory calculation of a transition rate is presented. The optimization can be carried out during a reversible work evaluation of the free energy barrier. An application to Al adatom diffusion on an Al(100) surface is...
Thesis (Ph. D.)--University of Washington, 2000 Theoretical calculations of rate constants are important in chemistry and condensed matter physics. They provide information about the reaction mechanism at the atomic level, which is difficult if not impossible to achieve in an experiment. Typical transitions are very slow compared with vibrational m...
Rotational contours of the (2 + 1) resonance enhanced multiphoton ionization (REMPI) spectra of the vibrational bands corresponding to the 2 ¹Π g← X transitions in ³⁵Cl 2, ³⁵Cl ³⁷Cl, and ³⁷Cl 2for the natural abundance of isotopes have been recorded at room temperature. Vibrational bands consist of contributions from all three isotopomers with vary...
Partly rotationally resolved (2 + 1) resonance-enhanced multiphoton ionization contour spectra of the vibrational bands corresponding to the transition in iodine, recorted at room temperature, have been analyzed. Irregular band spectral structures could be simulated by assuming rotational line strengths to be dependent on rotational quantum number...
Partly rotationally resolved (2 + 1) resonance-enhanced multiphoton ionization spectra of the vibrational bands corresponding to the b[2Π1/2]c6s;1 ← X transitions in IiBr (i = 79, 81) for the natural abundance of isotopes have been recorded at room temperature. Vibrational bands consist of contributions from both isotopomers with varying degrees of...
Rotational contours of the (2+1) REMPI spectra of iodine due to resonance excitation to the []c5d; 1g Rydberg state have been recorded at room temperature. Rotational parameters, B̄itv, were estimated from the band-head structure and used to derive the band origin by spectral simulations. Te=59683.9±1.5 cm−1 and ωe=248.5±0.6 cm−1 were obtained from...
