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Giorgio Alfredo Spedicato

Giorgio Alfredo Spedicato
Unipol Gruppo Finanziario · Leitha SRL

Ph.D, FCAS, FSA, CSPA, CStat
Data Science and Actuarial Manager

About

93
Publications
52,985
Reads
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553
Citations
Citations since 2016
76 Research Items
537 Citations
2016201720182019202020212022050100150
2016201720182019202020212022050100150
2016201720182019202020212022050100150
2016201720182019202020212022050100150
Introduction
Giorgio Alfredo Spedicato holds a MSc in Statistics, Economics and Actuarial Science, a Ph.D in Actuarial Science. In addition he is Fellow of the Casualty Actuarial Society (FCAS), as well as of the Society of Actuaries (FSA) and of the Italian Actuarial Professional Body. He is also Chartered Statistician (Royal Society of Statistics, RSS) and Certified Professional in Predictive Analytics (CSPA). He is currently employed in the Data Lab of a mayor Italian financial conglomerate where he manages projects on data science and predictive modeling. He is a professional R programmer and he knows Python and some C++ as well. His publications comes from independent research in: actuarial science, medical and dentistry fields (as independent statistical advisor).
Additional affiliations
January 2014 - March 2020
Independent Researcher
Independent Researcher
Position
  • Analyst
July 2006 - December 2006
Università Cattolica del Sacro Cuore
Position
  • Research Assistant
July 2006 - October 2022
Independent Researcher
Independent Researcher
Position
  • Analyst
Education
November 2007 - May 2011
Sapienza University of Rome
Field of study
  • Actuarial Science
September 2004 - July 2006
Università Cattolica del Sacro Cuore
Field of study
  • Actuarial Science

Publications

Publications (93)
Article
Full-text available
The markovchain package aims to fill a gap within the R framework providing S4 classes and methods for easily handling discrete time Markov chains, homogeneous and inhomogeneous. The S4 classes for handling and analysing discrete time Markov chains are presented, as well as functions and method for performing probabilistic and statis-tical analysis...
Article
Full-text available
Background: The use of fractional exhaled nitric oxide (FeNO) has been proposed for identifying and monitoring eosinophilic airway inflammation in chronic obstructive pulmonary disease (COPD). To explore the clinical utility of FeNO in COPD, we aimed to assess its short-term variability in a clinically stable COPD cohort. Methods: Consecutive CO...
Article
Full-text available
Background Endothelial dysfunction has been proposed to play a key role in the pathogenesis of coronavirus disease 2019 (COVID-19) and its post-acute sequelae. Flow-mediated dilation (FMD) is recognized as an accurate clinical method to assess endothelial function. Thus, we performed a meta-analysis of the studies evaluating FMD in convalescent COV...
Article
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Introduction: The objective of this study was to test the precision of in-vivo indirect bracket placement via medium-soft, transparent, broad-coverage, computer-aided designed and manufactured transfer trays using an automated digital method. Methods: Seventeen patients requiring vestibular fixed appliances were consecutively recruited, and bond...
Article
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Objectives: To provide clinical information on overcorrection to be included in the initial digital setup to make clear aligner therapy (CAT) more efficient. Materials and methods: Prescription data for 150 patients (80 women and 70 men; mean age 33.7 ± 12.7 years) treated successfully with CAT (F22 Aligners, Sweden & Martina, Due Carrare, Italy...
Article
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The aim of the present study was to identify a cutoff of c-reactive protein (c-RP) potentially predictive of high-lethality suicide attempts (SA) in an inpatient psychiatric sample. After attempting suicide, subjects were admitted to the emergency ward of the IRCCS Ospedale Policlinico San Martino and later to the section of Psychiatry from 1st Aug...
Article
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Background Regardless of the treatment protocol, stability in Class III patients always represents a major concern. The aim of this study was to assess the short and long-term skeletal and dentoalveolar modifications in a group of class III patients treated with hybrid rapid maxillary expander (RME) and facemask (FM). Indeed, no long-term studies h...
Article
Purpose: To evaluate the role of different healing abutment designs in compensating for the buccolingual volumetric tissue change that occurs following flapless single-tooth immediate extraction placement in the molar area. Materials and methods: Patients in need of extraction and replacement of a first or second molar in the mandible or maxilla...
Article
Study question: Can the possibility of having at least one euploid blastocyst for embryo transfer and the total number of euploid blastocysts be predicted for couples before they enter the IVF programme? Summary answer: Ovarian reserve and female age are the most important predictors of having at least one euploid blastocyst and the total number...
Article
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Background The purpose of the present in vivo study was to compare the accuracy, in terms of trueness, between full-arch digital impressions of different intraoral scanning systems, using as a reference the ideality of the conventional impression technique. Methods Polyvinyl siloxane (PVS) two-step technique impressions of 27 subjects were taken,...
Article
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Objective The stability of the transverse expansion in passive self-ligating bracket treatments is a debated topic in orthodontics. However, to date, only 3 reports are available in the literature, with the maximum follow-up of 3 years after the end of therapy. The present study aims to evaluate the stability of orthodontic treatment with self-liga...
Article
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Background Subthreshold hypomania during a major depressive episode challenges the bipolar-unipolar dichotomy. In our study we employed a cross-diagnostic cluster analysis - to identify distinct subgroups within a cohort of depressed patients. Methods A k-means cluster analysis— based on the domain scores of the Mood Spectrum Self-Report (MOODS-SR...
Article
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Objectives Upper urinary tract urothelial carcinoma (UTUC) represents about 5–10% of all urothelial malignancies with an increasing incidence. The standard diagnostic tools for the detection of UTUC are cytology, computed tomography (CT) urography, and ureterorenoscopy (URS). No biomarker to be included in the daily clinical practice has yet been i...
Article
Full-text available
Objective This study aims to evaluate success factors implicated in clinical orthodontic miniscrew stability after their interradicular placement in maxilla.Materials and methodsSix hundred seventy-six miniscrews were inserted in maxillary interradicular sites in a sample of 276 patients (109 males and 167 females; mean age 19 ± 1.7 years) and imme...
Article
Monitoring general practitioner prescribing costs is an important topic in order to efficiently allocate National Health Insurance resources. Using generalized additive models for location, scale, and shape with random effects, we investigate how second-order variables, related to patients, contribute to estimating the frequency, severity, and henc...
Article
Full-text available
AimTo evaluate the impact of cataract surgery on cognitive function in very elderly patients (≥ 85 years).MethodsA prospective, nonrandomized, comparative study of very elderly patients (≥ 85 years), and elderly patients (≥ 65 < 85 years) scheduled for first time cataract surgery. Cognitive function, quality of life (QoL), best corrected visual acu...
Article
Full-text available
Recommender systems are machine learning algorithms typically employed to support marketing decisions, as they identify statistically validated associations between products and consumers. These tools have been successfully adopted in many fields; however, not much has been done for the insurance industry. The paper aims to fill that gap by giving...
Article
Full-text available
Introduction The objective was to describe the dental and skeletal changes obtained using the Carriere Motion Appliance (CMA), lateral cephalogram, and the corresponding cephalometric tracings. Methods A sample of 29 patients with Class II malocclusion (mean age, 12.6 ± 1.7 years) was retrospectively selected. All patients were treated at a single...
Article
Full-text available
Purpose: This study evaluates if the addition of a curcumin formulation with a polyvinylpyrrolidone-hydrophilic carrier (CHC; Diabec ® , Alfa Intes, Italy) to intravitreal injections of dexamethasone (DEX-IVT) can affect the morphological retinal characteristics, extending the steroid re-treatment period in patients with diabetic macular edema (DME...
Article
Background The criteria of the Diagnostic and Statistical Manual of Mental Disorders 5th edition “with mixed features specifier” (DSM-5 MFS) are considered controversial since they include only typical manic symptoms. By contrast, Koukopoulos developed an alternative model of mixed depression (MxD) focusing primarily on the excitatory component. O...
Article
Full-text available
Background. Chronic cough is a disabling condition with a high proportion of diagnostic and therapeutic failures. Fractional exhaled nitric oxide (FeNO) has been considered a useful biomarker for predicting inhaled corticosteroids (ICS) response. We evaluated the relationship between FeNO and ICS response in chronic cough by performing a systematic...
Article
Full-text available
Background: Endothelial dysfunction has a key role in the pathogenesis of coronavirus disease 2019 (COVID-19) and its disabling complications. We designed a case-control study to assess the alterations of endothelium-dependent flow-mediated dilation (FMD) among convalescent COVID-19 patients. Methods: COVID-19 patients referred to a Pulmonary Re...
Article
Full-text available
Objective: To evaluate how the lower arch spontaneously change after upper rapid palatal expansion in a group of patients with transversal skeletal deficit. Material and Methods: Twenty-four patients treated by the same orthodontist with a rapid palatal expander (RPE) bounded on a deciduous molar have been selected. The sample was divided into two...
Article
Full-text available
Objective: The aim of our study is to verify the prognostic role of Computed Tomography (CT) in early (2 days after symptoms onset) and delayed (>7 days) phase of moderately severe and severe acute pancreatitis (AP) based on revised Atlanta 2012 classification (RAC) in a tertiary care Italian Hospital. Methods: We retrospectively reviewed 1412 pati...
Article
Full-text available
Background: Growing evidence points to a key role of endothelial dysfunction in the pathogenesis of COVID-19. In this study, we evaluated changes in endothelium-dependent flow-mediated dilation (FMD) in a cohort of convalescent COVID-19 patients undergoing pulmonary rehabilitation (PR). Methods: After swab test negativization, convalescent COVID...
Article
Objectives To compare the degree of accuracy of the Face Hunter facial scanner and the Dental Pro application for facial scanning, with respect to both manual measurements and each other. Materials and Methods Twenty-five patients were measured manually and scanned using each device. Six reference markers were placed on each subject's face at the...
Article
Full-text available
Objective: To assess the effects of thermoforming on aligner thickness and gap width in six aligner systems with the same nominal thickness. Methods: Six passive upper aligners of different brands were adapted to a single printed cast. Each sample was evaluated with high-resolution micro-computed tomography. To investigate aligner thickness and...
Article
Background Endothelial dysfunction is a key mechanism in the development of cardiac remodeling and diastolic dysfunction in heart failure with preserved ejection fraction (HFpEF). Flow‐mediated (FMD) and nitrate‐mediated dilation (NMD) are noninvasive methods to assess endothelial function. We performed a meta‐analysis evaluating the impact of HFpE...
Article
Aims: Xpert® Bladder Cancer Monitor is a urinary marker based on the evaluation of five target mRNAs overexpressed in patients with bladder cancer (BC). The aim of our study is to update our results regarding the diagnostic accuracy of the Xpert® Bladder Cancer Monitor test in the follow-up of patients with non-muscle invasive bladder cancer (NMIB...
Article
Objective The twofold aim of the present investigation was to: 1. evaluate the degree of mid-palatal suture (MPS) maturation via CBCT in relation to patient age, and 2. to determine whether there was a correlation between quantitative (i.e., suture density) and qualitative (i.e., suture morphology) analysis. Materials and methods The stage of mid-...
Preprint
Full-text available
Vehicle Symbols group vehicle types into homogeneous clusters for motor insurance rate making. Despite their relevance in the motor insurance industry, little attention has been paid to their determination throughout actuarial literature. The paper reviews existing approaches and presents suitable machine learning algorithms that can be used to fin...
Article
Full-text available
How to cite: Palone M. Panzeri P. Cremonini F. Spedicato GA. Squarci V. Albertini P. Effect of conventional versus passive self-ligating vestibular appliances on torque, tip and transverse dental changes in patients affected by class I malocclusion: a retrospective study. Pesqui Bras Odontopediatria Clín Integr. 2021; 21(supp1):e0031. ABSTRACT Obje...
Article
Full-text available
Objective: To verify the existence of a correlation between the mesio-distal size of teeth and the arch width by analyzing the data separately for maxillary and mandibular arch in patients with ideal occlusion. Material and Methods: 58 patients with ideal occlusion were studied, for a total of 276 files analyzed. Dental casts were then scanned usin...
Article
Full-text available
How to cite: Palone M, Latini MC, Cremonini F, Ghislanzoni LTH, Spedicato GA, Albertini P. Digital assessment of dental parameters in italian and mozambican subjects with ideal occlusion and permanent dentition. Pesqui Bras Odontopediatria Clín Integr. 2021; 21(supp1):e0030. https://doi. ABSTRACT Objective: To obtain reference values for tip, torqu...
Article
Background: Female age is the strongest predictor of embryo chromosomal abnormalities and has a non linear relationship with the blastocyst euploidy rate: with advancing age there is an acceleration in the reduction of blastocyst euploidy. Aneuploidy was found to significantly increase with maternal age from 30% in embryos from young women to 70%...
Article
Statement of problem Adjusting an interim screw-retained crown made of acrylic resin for maintenance of peri-implant soft tissues after immediate implant insertion requires accuracy and time. Assessments of these factors by using digital techniques are sparse. Purpose The purpose of this clinical study was to describe a technique to fabricate an ac...
Article
Objective The purpose of this study was to evaluate the biomechanical properties of miniscrews of 5 different lengths, 2 different diameters, and different combinations of insertion used for palatal skeletal anchorage. Materials and methods Twenty-four different combinations of a total of 120 miniscrews of two different diameters (2.0 mm and 2.3 m...
Article
This article aims to evaluate the effect of anatomically designed, single-unit provisional restorations on soft tissue preservation following immediate implant placement. Patients in need of a single-tooth replacement in the esthetic area were recruited for this study. An immediate provisional restoration with a transmucosal area anatomically desig...
Article
Full-text available
Background: Complications of coronavirus disease 2019 (COVID-19) include coagulopathy. We performed a meta-analysis on the association of COVID-19 severity with changes in hemostatic parameters. Methods: Data on prothrombin time (PT), activated partial thromboplastin time (aPTT), D-Dimer, platelets (PLT), or fibrinogen in severe versus mild COVI...
Article
Background Nasal nitric oxide(nNO) is considered a biomarker of nasal inflammation. Objective. To perform a systematic review with meta-analysis and meta-regressions on the association between nNO levels and allergic rhinitis (AR). Methods PubMed, Web of Science, Scopus and EMBASE databases were systematically searched. Differences between cases a...
Article
Full-text available
Background: To investigate and compare the gap (i.e. fit) and thickness of six aligner systems (Airnivol, ALL IN, Arc Angel, F22, Invisalign and Nuvola) using industrial computed tomography (CT). The null hypothesis was that there would be no detectable differences in either measurement between the aligners investigated. Materials and methods: P...
Article
Full-text available
Purpose: The goal of this study was to evaluate the cumulative survival rate and marginal bone loss (MBL) of extra-short (5- and 6-mm-long) and short (6.5-mm-long) implants inserted into severely atrophic, partially edentulous posterior maxillae and mandibles that were immediately restored with provisional fixed dental prostheses. Materials and m...
Article
Objective: To assess the effectiveness of home videogame-based exercise (exergaming) as an additional rehabilitative tool in young patients with rheumatoid arthritis (RA). Materials and Methods: After a baseline (T0) evaluation, 40 RA inpatients (18-35 years of age) underwent both a 4-week-lasting traditional rehabilitation program and a training...
Article
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Obiettivi: valutare il livello di consapevolezza di un gruppo di bambini della stessa scuola (età media 11,15 anni) sulle proprie conoscenze in merito all'igiene orale, prima e dopo una lezione sulla salute orale. Valutare quanto una lezione sia in grado di influenzare le abitudini dei soggetti in esame. Metodi: attraverso un questionario sono stat...
Article
Objective: To assess the prevalence of diffuse idiopathic skeletal hyperostosis and its relationship with vascular risk factors among patients with congestive heart failure. Design: Population-based cross-sectional study. Participants: A total of 584 consecutive patients admitted to a Rehabilitative Cardiology Unit. Methods: Chi-square Autom...
Article
Full-text available
Introduction: The aim of this study was to investigate the vestibular anatomy of teeth in samples of adult Italian and Mozambican subjects in ideal occlusion and permanent dentition and identify any anatomic characteristics that may influence bonding in the straight-wire technique. Methods: Linear measurements and coordinates of each curve repre...
Article
Background: The objective of the current study was to compare the diagnostic accuracy of 2 new real-time polymerase chain reaction-based urinary markers with each other and with urinary cytology, cystoscopy, and/or histology in patients being followed for non-muscle-invasive bladder cancer. Methods: A total of 487 patients were enrolled in the s...
Article
Full-text available
Background and aims: There has been a recent growing interest in the role of nasal nitric oxide (nNO) as a biomarker for osteomeatal complex obstruction in paranasal sinus diseases. By using meta-analysis, we systematically reviewed the literature to establish the possible link between nNO concentration and chronic rhinosinusitis with nasal polyps...
Article
Full-text available
Objectives The aim of this study is to investigate and compare the characteristics of as received and retrieved NiTi archwires at a constant temperature by plotting their load/deflection graphs and quantifying three parameters describing the discharge plateau phase. Materials and methods Two hundred four NiTi archwires, traditional and heat-activa...
Article
Objectives: To explore the impact of a Mindfulness-Based Stress Reduction (MBSR) intervention for people with metastatic cancer integrated in Early Palliative Care (EPC). Design: Mixed-method study. Settings/Location: EPC Service integrated with Oncology Unit, Carpi General Hospital, Italy from January to October 2017. The MBSR intervention took pl...
Article
Plain-language-summary Nowadays, drug-induced sleep endoscopy is widely recognised as a valid tool for diagnosis and treatment planning of obstructive sleep apnoea syndrome (OSAS), as it allows a direct visualisation of sites and patterns of collapse of the upper airways (UA). Various classifications have been proposed in the literature to describe...
Preprint
Tesi di Manuel Caccone da cui è stato generato un bozza di paper.
Article
Full-text available
As the level of competition increases, pricing optimization is gaining a central role in most mature insurance markets, forcing insurers to optimise their rating and consider customer behaviour; the modeling scene for the latter is one currently dominated by frameworks based on Generalised Linear Models (GLMs). In this paper, we explore the applica...
Thesis
Il test DDE-2 è uno strumento diagnostico di estrema importanza per la diagnosi della dislessia in età evolutiva. I criteri normativi di interpretazione dei punteggi sono basati su assunzioni di distribuzione gaussiana dei punteggi. Tale assunzione però non è empiricamente verificata. Lo studio mostra che l’utilizzo di tecniche statistiche non para...
Presentation
Full-text available
My presentation at UNISACT 2018 on Machine Learning workflows
Presentation
Full-text available
My presentation at UNISACT 2018 on Machine Learning for Actuaries
Article
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The aim of our study is to evaluate the technical and oncological feasibility of laparoscopic gastroectomy with extended lymph node dissection (LND) for cancer, in a western series of patients, regarding all oncological stages.
Article
Purpose: The aim of this study was to evaluate the buccopalatal volumetric tissue change that occurs following flapless single-tooth immediate extraction placement in the esthetic area and to analyze the role of four different variables. Materials and methods: Patients in need of a single-tooth replacement in the anterior maxillary or mandibular...
Article
Full-text available
BACKGROUND: The orthodontics industry has paid great attention to the aesthetics of orthodontic appliances, seeking to make them as invisible as possible. There are several advantages to clear aligner systems, including aesthetics, comfort, chairside time reduction, and the fact that they can be removed for meals and oral hygiene procedures. METHOD...
Presentation
Full-text available
Quick notes on meta-analysis
Article
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The markovchain package aims to provide S4 classes and methods to easily handle Discrete Time Markov Chains (DTMCs), filling the current CRAN repository gap. In this paper, I provide a comprehensive description of the main functions included in the package, as well as several examples.
Presentation
Full-text available
Statistical properties of a new questionnaire to detect OSAS
Presentation
Full-text available
Using the R package markovchain to actuarially evaluate Long Term Care (LTC) insurance