Giorgio Clarotti

European Commission | ec · Research and Innovation (RTD)

Ce travail est financé par la bourse nº ST2*35I du programme Stimulation de la Commission des Communautés Européennes

The results of this work show a new asymmetric membrane very performant, characterized by an exceptional deformability, a good pressure strength, a high permeability and a satisfactory permselectivity. Its interesting specific anticoagulant activity is a contribution to the realization of a “new bio-artificial pancreas”.

The deposition of films from an argon plasma containing a mixture of ethylene oxide or hydrogen and perfluorohexane was tried to obtain very hydrophobic, less hydrophobic and intermediate coatings. This paper studies more extensively the deposition of a thin coating from a perfluorohexane and hydrogen plasma on polysulfone and polyhydroxybutyrate m...

The haemocompatibility of a material can be evaluated through the study of the adsorption of proteins stimulating the thrombus formation.Films of polyhydroxybutyrate (PHB) and copolymers thereof containing respectively 9% and 22% of hydroxyvalerate (HV) were treated by perfluorohexane (PHF) and PHF + H2 plasmas to study protein adsorption.It has be...

The deposition of films from an argon plasma containing a mixture of ethylene oxide or hydrogen and perfluorohexane was tried to obtain very hydrophobic, less hydrophobic and intermediate coatings. This paper studies more extensively the deposition of a thin coating from a perfluorohexane and hydrogen plasma on polysulfone and polyhydroxybutyrate m...

Poly(hydroxybutyrate) films and inorganic glass slides were treated by cold plasma. The composition of the gas mixture of perfluorohexane and hydrogen was varied to obtain controlled surface coatings of different hydrophobicities. The analysis by weight variation, scanning electron microscopy (SEM), electron spectroscopy for chemical analysis (ESCA...

Poly (hydroxybutyrate) membranes were used as substrates for cold plasma treatment with perfluorohexane. By varying a gas mixture of perfluorohexane and hydrogen, surface coatings of different hydrophobicity were obtained. In addition, inorganic glass slides were treated correspondingly. The plasma-treated samples were analyzed by ESCA with respect...

The polymerization of gases present in a low temperature plasma is a technique particularly well suited for biomedical material processing. Therefore, the possibilities this technique offers to increase the biocompatibility and haemocompatibility of polysulphone and poly(hydroxybutyrate) membranes to be used in a new bioartificial pancreas device w...

Polyhydroxybutyrate membranes have been obtained by solvent-casting of a mixture of two polymers, one of which is the porous agent. By this process, we have been able to synthesize semipermeable membranes used in a bio-artificial pancreas.

Ultrafiltration membranes based on polyhydroxybutyrate have been synthesized and their hydrodynamic properties have been optimized. Study of the factors affecting the porosity allowed the development of a permselective membranes to be used in an insulin biodistributor.

Plasma polymerization of gases present in a low temperature plasma is a “clean” technique that is particularly well suited for biomedical material processing. This paper presents the first results of a project which studies the possibilities offered by this technique to prepare commercial lowcost membranes with the required bio- and hemocompatibili...