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Introduction
Skills and Expertise
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November 2019 - February 2023
Education
September 2017 - July 2019
September 2014 - September 2017
Publications
Publications (10)
Relative Biological Effectiveness (RBE) variations are thought to be one of the primary causes of unexpected normal tissue toxicities during tumor treatments with charged particles. Unlike carbon therapy, where the treatment planning is optimized on the basis of the RBE-weighted dose, a constant RBE value of 1.1 is currently used in proton therapy....
Purpose:
To present our technique for liver cancer treatments with proton therapy in pencil beam scanning mode and to evaluate the impact of uncertainties on plan quality.
Materials and methods:
17 patients affected by liver cancer were included in this study. Patients were imaged and treated in forced breath-hold using the Active Breathing Coor...
Purpose:
Proton pencil beam scanning (PBS) represents an interesting option for the treatment of breast cancer (BC) patients with nodal involvement. Here we compare tangential 3D-CRT and VMAT to PBS proton therapy (PT) in terms of secondary cancer risk (SCR) for the lungs and for contralateral breast.
Methods:
Five BC patients including supraclavi...
Objective: In this paper, we present MONAS (MicrOdosimetry-based modelliNg for relative biological effectiveness (RBE) ASsessment) toolkit. MONAS is a TOPAS Monte Carlo extension, that combines simulations of microdosimetric distributions with radiobiological microdosimetry-based models for predicting cell survival curves and dose-dependent RBE.
A...
Introduction:
Mediastinal lymphoma (ML) is a solid malignancy affecting young patients. Modern combined treatments allow obtaining good survival probability, together with a long life expectancy, and therefore with the need to minimize treatment-related toxicities. We quantified the expected toxicity risk for different organs and endpoints in ML p...
Introduction: The main rationale for using protons in cancer treatment is based on the highly conformal dose distribution and normal tissue spearing compared to conventional radiotherapy. The main limit of proton therapy is the particle range uncertainty due to patient setup, dose calculation and imaging. To account for this, a safety margin is add...
Purpose: Using microdosimetry, we investigated the relative biological effectiveness (RBE) and quality factor (Q¯) variations in- and out-of-field as a function of radiation quality for clinical protons.
Methods and Materials: we irradiated a water phantom with a Spread-Out-Bragg-Peak (SOBP) and acquired microdosimetric spectra at several distal an...
Space agencies have recognized the risks of astronauts’ exposure to space radiation and are developing complex model-based risk mitigation strategies. In the foundation of these models, there are still significant gaps of knowledge concerning nuclear fragmentation reactions which need to be addressed by ground-based experiments. There is a lack of...
