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Citations since 2016
7 Research Items
In glaucoma participants, both structural and functional brain changes have been observed, but we still have insufficient understanding of how these changes also affect the integrity of cortical functional networks, and how these changes relate to visual function. This is relevant, as functional network integrity may affect the applicability of fut...
Recent brain imaging studies have shown that the degenerative eye damage generally observed in the clinical setting, also extends intracranially. Both structural and functional brain changes have been observed in glaucoma participants, but we still lack an understanding of whether these changes also affect the integrity of cortical functional netwo...
The measurement of retinal sensitivity at different visual field locations–perimetry–is a fundamental procedure in ophthalmology. The most common technique for this scope, the Standard Automated Perimetry, suffers from several issues that make it less suitable to test specific clinical populations: it can be tedious, it requires motor manual feedba...
Purpose: To explore the feasibility of using various easy-to-obtain biomarkers to monitor non-compliance (measurement error) during visual field assessments. Methods: Forty-two healthy adults (42 eyes) and seven glaucoma patients (14 eyes) underwent two same-day visual field assessments. An ordinary webcam was used to compute seven potential bio...
Perimetry, the mapping of the sensitivity of different visual field locations, is an essential procedure in ophthalmology. Unfortunately, standard automated perimetry (SAP), suffers from some practical issues: it can be tedious, requires manual feedback and a high level of patient compliance. These factors limit the effectiveness of perimetry in so...
Purpose: To describe, refine, evaluate, and provide normative control data for two freely available tablet-based tests of real-world visual function, using a cohort of young, normally-sighted adults. Methods: Fifty young (18-40 years), normally-sighted adults completed tablet-based assessments of (1) face discrimination and (2) visual search. Ea...
Cognitive reserve (CR) is the phenomenon where older adults with more cognitively stimulating environments show less age-related cognitive decline. The right-lateralized fronto-parietal network has been proposed to significantly contribute to CR and visual attention in ageing. In this study we tested whether plasticity of this network may be harnes...
EGRET is the training environment for 15 highly talented Early Stage Researchers. The individual and collaborative outputs of their work contribute to the following aims: a) acquiring new, quantitative knowledge on glaucoma and the ageing visual system; and b) applying this new knowledge to boost innovation in glaucoma care in both the public and private sectors.
EGRET-plus is the training environment for 15 highly talented Early Stage Researchers. The individual and collaborative outputs of their work contribute to the following aims: a) acquiring new, quantitative knowledge on glaucoma and the ageing visual system; and b) applying this new knowledge to boost innovation in glaucoma care in both the public and private sectors. For more information about EGRET+ and its fellows, please visit www.egret-plus.eu
The current gold standard for functional testing of the visual system in glaucoma, standard automated perimetry, cannot be used in very young and old patients, patients with motor problems (Parkinson disease) and cognitive limitations (as part of aging, including Alzheimer disease, or congenital). In this project we will evaluate a new objective functional test developed by partner NCO (multifocal pupillographic objective perimetry), a new form of attentional perimetry developed by partner OCU (Ocusweep), and several other alternatives for standard automated perimetry in healthy subjects, patients with glaucoma, and in patients with limited motor and/or cognitive performance – with and without glaucoma or other diseases affecting the visual field. We will focus on learning effects, sensitivity and specificity, intra- and inter-device variability, testing time, and feasibility in the various subgroups, and initiate a longitudinal assessment.